Pubblicazioni
Penolazzi L, Lambertini E, Scussel Bergamin L, Gandini C4, Musio A, De Bonis P, Cavallo M, Piva R
Reciprocal Regulation of TRPS1 and miR-221 in Intervertebral Disc Cells.
Cells. 2019 Sep 28;8(10). pii: E1170. DOI: 10.3390/cells8101170.
Penolazzi L., Bonaccorsi G., Gafà R, Ravaioli N., Gabriele D., Bosi C., Lanza G., Greco P., Piva R.
Slug/HIF1-a/miR-221 regulatory circuit in endometrial cancer. Gene 2019; 711: 143938. DOI: 10.1016/j.gene.2019.06.028
Gallo S., Arcidiacono M.V.b, Tisato V., Piva R., Penolazzi L, Bosi C., Feo C.V., Gafà R., Secchiero P.
Upregulation of the alternative splicing factor NOVA2 in colorectal cancer vasculature.
OncoTargets and Therapy 2018; 11: 6049-6056. DOI: 10.2147/OTT.S171678
Lambertini E, Penolazzi L, Angelozzi M, Bergamin LS, Manferdini C, Vieceli Dalla Sega F, Paolella F, Lisignoli G, Piva R Hypoxia preconditioning of human MSCs: A direct evidence of HIF-1α and collagen type XV correlation.
Cellular Physiology and Biochemistry 2018; 51 (5): 2237-2249. DOI: 10.1159/000495869
Penolazzi L, Lambertini E, Bergamin LS, Roncada T, De Bonis P, Cavallo M, Piva R.
MicroRNA-221 silencing attenuates the degenerated phenotype of intervertebral disc cell
Aging 2018; 10 (8): 2001-2015. DOI: 10.18632/aging.101525
Gabusi E, Paolella F, Lambertini E, Penolazzi L, Piva R AND Lisignoli G Immunoelectron microscopic localization of Collagen type XV during human mesenchymal stem cells mineralization.
Connect Tissue Res 2018 Dec;59(sup1):42-45. DOI: 10.1080/03008207.2017.1408600
Lambertini E, Penolazzi L, Angelozzi M, Grassi F, Gambari L, Lisignoli G, De Bonis P, Cavallo M, and Piva R The expression of cystathionine γ-lyase is regulated by estrogen receptor alpha in human osteoblasts.
Oncotarget, 2017 Oct 4;8(60):101686-101696. DOI: 10.18632/oncotarget.21514
Mandatori D, Penolazzi L, Pipino C, Di Tomo P, Di Silvestre S, Di Pietro N, Trevisani S, Angelozzi M, Ucci M, Piva R, Pandolfi A Menaquinone-4 enhances osteogenic potential of human Amniotic Fluid Mesenchymal Stem Cells Cultured in a 2D and 3D dynamic culture system.
J Tissue Eng Regen Med. 2017 May 16. DOI: 10.1002/term.2471
Lolli A, Penolazzi L, Narcisi R, van Osch GJVM, Piva R. Emerging potential of gene silencing approaches targeting anti-chondrogenic factors for cell-based cartilage repair.
Cell Mol Life Sci. 2017 74(19), pp. 3451-3465. DOI: 10.1007/s00018-017-2531-z
Lisignoli G, Lambertini E, Manferdini C, Gabusi E, Penolazzi L, Paolella F, Angelozzi M, Casagranda V, Piva R. Collagen type XV and the 'osteogenic status'.
J Cell Mol Med. 2017 21(9), pp. 2236-2244. DOI: 10.1111/jcmm.13137
Angelozzi M, Penolazzi L, Mazzitelli S, Lambertini E, Lolli A, Piva R, Nastruzzi C Dedifferentiated Chondrocytes in Composite Microfibers As Tool for Cartilage Repair. Front Bioeng Biotechnol. 2017 Jun 13;5:35. DOI:10.3389/fbioe.2017.00035
Penolazzi L, Lolli A, Sardelli L, Angelozzi M, Lambertini E, Trombelli L, Ciarpella F, Vecchiatini R, Piva R. Establishment of a 3D-dynamic osteoblasts-osteoclasts co-culture model to simulate the jawbone microenvironment in vitro.
Life Sci. 2016 May 1;152:82-93. DOI: 10.1016/j.lfs.2016.03.035
Lolli A, Narcisi R, Lambertini E, Penolazzi L, Angelozzi M, Kops N, Gasparini S, van Osch GJ, Piva R. Silencing of Antichondrogenic MicroRNA-221 in Human Mesenchymal Stem Cells Promotes Cartilage Repair In Vivo.
Stem cells 2016; 34(7):1801-11. DOI: 10.1002/stem.2350
Angelozzi M, Miotto M, Penolazzi L, Mazzitelli S, Keane T, Badylak SF, Piva R, Nastruzzi C. Composite ECM-alginate microfibers produced by microfluidics as scaffolds with biomineralization potential.
Mater Sci Eng C Mater Biol Appl. 2015;56:141-153. DOI: 10.1016/j.msec.2015.06.004
Lambertini E, Penolazzi L, Morganti C, Lisignoli G, Zini N, Angelozzi M, Bonora M, Ferroni L, Pinton P, Zavan B, Piva R. Osteogenic differentiation of human MSCs: Specific occupancy of the mitochondrial DNA by NFATc1 transcription factor.
Int J Biochem Cell Biol. 2015;64:212-9. DOI: 10.1016/j.biocel.2015.04.011
Piva R, Lambertini E, Manferdini C, Capanni C, Penolazzi L, Gabusi E, Paolella F, Lolli A, Angelozzi M, Lattanzi G, Lisignoli G. Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes.
Osteoarthritis Cartilage. 2015;23(7):1226-1230. DOI: 10.1016/j.joca.2015.03.015
José Lima Juiz P, Lucchese AM, Gambari R, Piva R, Penolazzi L, Di Ciano M, Trovatti Uetanabaro AP, Silva F, Ávila-Campos MJ Essential Oils and Isolated Compounds from Lippia alba Leaves and Flowers: Antimicrobial Activity and Osteoclast Apoptosis Int J Mol Med, 2015; 35(1): 211-217.
Vecchiatini R, Penolazzi L, Lambertini E,. Angelozzi M, Morganti C, Mazzitelli S, Trombelli L, Nastruzzi C,. Piva R Effect of dynamic three-dimensional culture on osteogenic potential of human periodontal ligament mesenchymal stem cells entrapped in alginate microbeads J Periodontal Res, 2015; 50(4): 544-553. DOI: 0.1111/jre.12225
Pipino C, DI Tomo P, Mandatori D, Cianci E, Lanuti P, Cutrona MB, Penolazzi L, Pierdomenico L, Lambertini E, Antonucci I, Sirolli V, Bonomini M, Romano M, Piva R, Marchisio M, Pandolfi A Calcium Sensing Receptor Activation by Calcimimetic R-568 in Human Amniotic Fluid Mesenchymal Stem Cells: correlation with Osteogenic differentiation. Stem Cells Dev 2014; 21 august. 10.1089/scd.2013.0627
Lolli A, Lambertini E, Penolazzi L, Angelozzi M, Morganti C, Franceschetti T, Pelucchi S, Gambari R, Piva R Pro-Chondrogenic Effect of mir-221 and Slug Depletion in Human MSCs. Stem Cell Rev 2014; 13 june. DOI: 10.1007/s12015-014-9532-1.
Lisignoli G, Manferdini C, Lambertini E, Zini N, Angelozzi M, Gabusi E, Gambari L, Penolazzi L, Lolli A, Facchini A, Piva R Chondrogenic Potential of Slug-Depleted Human Mesenchymal Stem Cells
Tissue Eng Part A 2014; 20 june. DOI: 10.1089/ten.TEA.2013.0343
Lambertini E, Lolli A, Vezzali F, Penolazzi L, Gambari R, Piva R Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells. BMC Cancer 2012; 12:445. DOI: 10.1186/1471-2407-12-445
Capretto L, Mazzitelli S, Colombo G, Piva R, Penolazzi L, Vecchiatini R, Zhang X, Nastruzzi C Production of polymeric micelles by microfluidic technology for combined drug delivery: application to osteogenic differentiation of human periodontal ligament mesenchymal stem cells (hPDLSCs). Int J Pharm 2013; 440:195-206. DOI: 10.1016/j.ijpharm.2012.07.057
PENOLAZZI L, MAZZITELLI S, VECCHIATINI R, TORREGGIANI E, LAMBERTINI E, JHONDON S, BADYLAK SF, PIVA R, NASTRUZZI C Human mesenchymal stem cells seeded on extracellular matrix-scaffold: viability and osteogenic potentialJ Cell Physiol 2012; 227: 857-866. DOI: 10.1002/jcp.22983
Torreggiani E, Lisignoli G, Manferdini C, Lambertini E, Penolazzi L, Vecchiatini R, Gabusi E, Chieco P, Facchini A, Gambari R, Piva R Role of Slug transcription factor in human mesenchymal stem cells. J Cell Mol Med 2012; 16:740-751. DOI: 10.1111/j.1582-4934.2011.01352.x.
Penolazzi L, Lisignoli G, Lambertini E, Torreggiani E, Manferdini C, Lolli A, Vecchiatini R, Ciardo F, Gabusi E, Facchini A, Gambari R, PIVA R. Transcription factor decoy against NFATc1 in human primary osteoblasts.
Int J Mol Med 2011; 28: 199-206. DOI: 10.3892/ijmm.2011.701
Mazzitelli S., Capretto L. Zhang XL, Penolazzi L, Lambertini E, Piva R, Nastruzzi C. Process optimization for the production af alginate microparticles containing wjmscs by a design of experiments (doe) approach. J Control Release 2010; 148: e76-77. DOI: 10.1016/j.jconrel.2010.07.014
Piva R, Manferdini C, Lambertini E, Torreggiani E, Penolazzi L, Gambari R, Pastore A, Pelucchi S, Gabusi E, Piacentini A, Filardo G, Facchini A, Lisignoli G. Slug contributes to the regulation of CXCL12 expression in human osteoblasts.Exp Cell Res. 2011; 317 (8):1159-68. DOI: 10.1016/j.yexcr.2010.12.011.
Torreggiani E, Bianchini C, Penolazzi L, Lambertini E, Vecchiatini R, Canella A, Gambari R, MagrI E, Pelucchi S, Pastore A, Piva R Osteogenic potential of cells derived from nasal septum.
Rhinology 2011; 49(2):148-54. DOI: 10.4193/Rhino10.087.
Trombelli L, Penolazzi L, Torreggiani E, Farina R, Lambertini E, Vecchiatini R, Piva R. Effect of hydroxyapatite-based biomaterials on human osteoblast phenotype.
Minerva Stomatol. 2010 Mar;59(3):103-15.
Lambertini E, Franceschetti T, Torreggiani E, Penolazzi L, Pastore A, Pelucchi S, Gambari R, Piva R. SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts.
BMC Mol Biol. 2010 Feb 3;11:13. DOI: 10.1186/1471-2199-11-13.
Penolazzi L, Vecchiatini R, Bignardi S, Lambertini E, Torreggiani E, Canella A, Franceschetti T, Calura G, Vesce F, Piva R. Influence of obstetric factors on osteogenic potential of umbilical cord-derived mesenchymal stem cells.
Reprod Biol Endocrinol. 2009 Oct 5;7:106. DOI: 10.1186/1477-7827-7-106
Lambertini E, Lisignoli G, Torreggiani E, Manferdini C, Gabusi E, Franceschetti T, Penolazzi L, Gambari R, Facchini A, Piva R. Slug gene expression supports human osteoblast maturation.
Cell Mol Life Sci. 2009 Nov;66(22):3641-53. DOI: 10.1007/s00018-009-0149-5
Piva R, Penolazzi L, Borgatti M, Lampronti I, Lambertini E, Torreggiani E, Gambari R. Apoptosis of human primary osteoclasts treated with molecules targeting nuclear factor-kappaB.
Ann N Y Acad Sci. 2009 Aug;1171:448-56. DOI: 10.1111/j.1749-6632.2009.04906.x
Penolazzi L, Tavanti E, Vecchiatini R, Lambertini E, Vesce F, Gambari R, Mazzitelli S, Mancuso F, Luca G, Nastruzzi C, Piva R. Encapsulation of Mesenchymal Stem Cells from Warthon's Jelly in Alginate Microbeads.
Tissue Eng Part C Methods. 2010 Feb;16(1):141-55. DOI: 10.1089/ten.TEC.2008.0582
Bergamini P, Marchesi E, Pagnoni A, Lambertini E, Franceschetti T, Penolazzi L, Piva R. Synthesis, characterization of strontium-bile acid salts and their bioactivity vs. the anti-osteoporosis drug strontium ranelate.
J Inorg Biochem. 2009 Jun;103(6):891-7.Epub 2009 Mar 25. DOI:10.1016/j.jinorgbio.2009.03.006
PENOLAZZI L, LAMPRONTI I., BORGATTI M., KHAN MT, ZENNARO M., PIVA R., GAMBARI R. Induction of apoptosis of human primari osteoclasts treated with extracts from the medicinal plant Emblica officinalis.
BMC Complement Altern Med 2008 Oct 30 (8): 59. DOI: 10.1186/1472-6882-8-59.
Penolazzi L, Pocaterra B, Tavanti E, Lambertini E, Vesce F, Gambari R, Piva R Human osteoclasts differentiated from umbilical cord blood precursors are less prone to apoptotic stimuli than osteoclasts from peripheral blood.
Apoptosis 2008 Apr;13(4):553-61. DOI: 10.1007/s10495-008-0188-7.
Lambertini E., Tavanti E., Torreggiani E., Penolazzi L, Gambari R. and R.Piva .ER alpha and AP-1 interaction vivo with a specific sequence of the F promoter of the Human ERalpha gene in osteoblasts. J of Cell Phys. 2008, 216(1):101-10. DOI: 10.1002/jcp.21379
Penolazzi L., Lambertini E, Tavanti E, Torreggiani E, Vesce F, Gambari R, Piva R Evaluation of chemokine and cytokine profiles in osteoblast progenitors from umbilical cord blood stem cells by BIO-PLEX technology.
Cell Biol Int 2007, sep 7. DOI: 10.1016/j.cellbi.2007.08.030
Penolazzi L., Zennaro M., Lambertini E., Tavanti E., Torreggiani E., Gambari R., Piva R. Induction of estrogen receptor alpha expression with decoy oligonucleotide targeted to NFATc1 binding sites in osteoblasts. Mol Pharmacol. 2007 Jun; 71 (6):1457-62.
Lambertini E, Penolazzi L, Tavanti E, Schincaglia G P, Zennaro M, Gambari R AND Piva R Human estrogen receptor alpha gene is a target of Runx2 transcription factor in osteoblasts. Exp Cell Res. 2007 May 1;313 (8):1548-60.
Piva R., Penolazzi L., Zennaro M., Bianchini E., Magri E., Borgatti M., Lampronti I., Lambertini E., Tavanti E., Gambari R. Induction of apoptosis of osteoclasts by targeting transcription factors with decoy molecules
Ann NYAcad Sci 2006 Dec; 1091:509-61.
Penolazzi L., Magri E., Lambertini E., Cozzani M., Siciliani G., Piva R., Gambari R. Local “In vivo” administration of NF-kB decoy Induces Apoptosis of Osteoclasts after application of orthodontic forces to rat teeth.
Int Journal of Mol Medicine, 2006 Nov 18 (5):807-11.
Penolazzi L., Magri E., Lambertini E., Bianchini E., Gambari R. “In vivo” local transfection of a cis element decoy mimicking an estrogen receptor alpha gene promoter region induces apoptosis of osteoclasts following application of orthodontic forces to rat teeth. Apoptosis, 2006 sep; 11(9):1653-6.
Cozzani M, Giovannini I, Naccari R, Penolazzi L, Lambertini E, Borgatti M, Piva R, Gambari R., Siciliani G. Transcription Factor Decoy (TFD) as a novel approach for the control of osteoclastic resorption. Progress in Orthodontics (6:238-247, 2005).
Penolazzi L, Bianchini E., Lambertini E, Baraldi PG, R. Romagnoli R, Piva R, Gambari R. N-Arylpiperazine Modified Analogues of the P2X7 Receptor KN-62 Antagonist are Potent Inducers of Apoptosis of Human Primary Osteoclasts J. Biomed. Science, (12:1013-1020, 2005). DOI: 10.1007/s11373-005-9029-7
Piva R, Penolazzi L, Lambertini E,Giordano S, Gambari R Induction of apoptosis of human primary osteoclasts treated with a transcription factor decoy mimicking a promoter region of estrogen receptor a.
Apoptosis (10(5):1079-94, 2005). DOI: 10.1007/s10495-005-0618-8
Lambertini E, Penolazzi L, Magaldi S, Giordano S, Barioni G, del Senno L, Piva R Transcription factor decoy against promoter C of estrogen receptor a gene induces functional ERa protein in breast cancer cells.
Breast Cancer Res Treat (92:125-132, 2005). DOI: 10.1007/s10549-005-2413-1
E. Lambertini, I. Lampronti, Penolazzi L, M.T.H. Khan, A. Ather, G. Giorgi, R. Gambari, R. Piva Expression of estrogen receptor a gene in breast cancer cells treated with transcription factor decoy is modulated by Bangladeshi natural plant extracts. Oncology Research, (15:69-79, 2005).
M.Borgatti, A.Finotti A.Romanelli, M.Saviano, N.Bianchi, I.Lampronti, E.Lambertini, Penolazzi L, C.Nastruzzi, C;Mischiati, R.Piva, C.Pedone, R.Gambari Peptide Nucleic Acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression.
Curr. Drug Targets, (5:553-558, 2004). DOI: 10.2174/1389450043345155
Penolazzi L, M.Borgatti, E.Lambertini, C.Mischiati, A.Finotti, A.Romanelli, M.Saviano, C.Pedone, R.Piva , R.Gambari Peptide nucleic acid-DNA decoy chimeras targeting NF-kB transcription factors: Induction of apoptosis in human primary osteoclasts.
Int. J. Mol. Med., (14:145-152, 2004). DOI: 10.3892/ijmm.14.2.145
Penolazzi L, E. Lambertini, S. Giordano, V. Sollazzo, G. Traina, L. del Senno, R. Piva Methylation analysis of the promoter F of estrogen receptor a gene: effects on the level of transcription on human osteoblastic cells.
J. of Steroid Biochem. and Mol. Biol., (91:1-9, 2004). DOI: 10.1016/j.jsbmb.2004.02.005
Penolazzi L, E. Lambertini, M.Borgatti, R.Piva, M.Cozzani, I.Giovannini, R.Naccari, G.Siciliani, R.Gambari Decoy oligodeoxynucleotides targeting NF-kappaB transcription factors: induction of apoptosis in human primary osteoclasts. Biochemical Pharm, (66: 1189-1198, 2003). DOI: 10.1016/S0006-2952(03)00470-2
E. Lambertini, Penolazzi L, S. Giordano, L. Del Senno, R.Piva Expression of human estrogen receptor a { alpha } gene is regulated by promoter F in MG63 osteoblastic cells. Biochemical J , (372: 831-9,2003). DOI: 10.1042/BJ20021633
E. Lambertini, Penolazzi L, G. Aguiari, L. Del Senno, F. Pezzetti, V. Sollazzo, R. Piva Osteoblastic differentiation induced by transcription factor decoy against estrogen receptor a gene.
Biochem Biophys Res commun. (292: 761-770, 2002). DOI: 10.1006/bbrc.2002.6708
E. Lambertini, Penolazzi L, V. Sollazzo, F. Pezzetti, M. De Mattei, L. Del Senno, GC. Traina, R. Piva Modulation of gene exression in human osteoblasts by targeting a distal promoter region of estrogen receptor-alpha gene.
J Endocrinology (172: 683-693, 2002). DOI: 10.1677/joe.0.1720683
R. Piva, L. Del Senno, E. Lambertini, Penolazzi L, C. Nastruzzi Modulation of estrogen receptor gene expression in breast cancer cells by liposome delivered decoy molecules. J. of Steroid Biochem. and Mol. Biol.(75:121-128, 2000). DOI: 10.1016/S0960-0760(00)00181-3
G. Aguiari, S.Savelli, M.Garbo, A.Bozza, G.Augello, Penolazzi L, E.De Paoli Vitali, C.La Torre, G.Cappelli, R.Piva, Del Senno L. Novel Slicing and missense mutations in Autosomal dominant polycystic Kidney Disease (PKD1) gene: expression of mutated genes. Human Mutation 16(5), pp. 444-445.
DOI: 10.1002/1098-1004(200011)16:5<444::AID-HUMU11>3.0.CO;2-C
Penolazzi L, E. Lambertini, G. Aguiari, L. Del Senno, R. Piva Cis element "decoy" against the upstream promoter of the human estrogen receptor gene. BBA (1492: 560-567, 2000). DOI: 10.1016/S0167-4781(00)00145-7
G. Aguiari, E. Manzati, Penolazzi L, F. Micheletti G. Augello, E. De Paoli Vitali, G. Cappelli, Y. Cai, D. Reynolds, S. Somlo, R. Piva, L. Del Senno Mutations in autosomal dominant polycystic kidney disease 2 gene: reduced expression of PKD2 protein in lymphoblastoid cells. American Jounal of Kidney Diseases (33: 880-885, 1999). DOI: 10.1016/S0272-6386(99)70420-8
Penolazzi L, E. Lambertini , G. Aguiari, L. Del Senno, R. Piva Modulation of estrogen receptor gene expression in human breast cancer cells: a decoy strategy with specific PCR - generated DNA fragments.
Breast Cancer Research and Treatment (49: 227-235, 1998). DOI: 10.1023/A:100606052
R. Piva, E. Lambertini, Penolazzi L, M.C. Facciolo, A. Lodi, G. Aguiari, C. Nastruzzi, L. Del Senno “In vitro” stability of PCR - generated DNA fragments in serum and cell extracts. Biochemical Pharmacology (56: 703-708, 1998). DOI: 10.1016/S0006-2952(98)00057-4
Penolazzi L, M. C. Facciolo, G. Aguiari, L. Del Senno, R. Piva Direct transfection of polymerase chain reaction-generated DNA fragments into mammalian cells employing ethidium bromide indicator and ultrafiltration.
Analytical Biochemistry (248: 190-193, 1997). DOI: 10.1006/abio.1997.2107
Book Chapter:
Mazzitelli S., Vecchiatini R., Penolazzi L., Lambertini E., Piva R., Nastruzzi C. (2012). Microencapsulation Procedures for the Immunoisolation of Wharton's Jelly Mesenchymal Stem Cells: A Review. Stem Cell Canc Stem Cel 2012, 4: 175-191.
DOI: 10.1007/978-94-007-2828-8
