Pubblicazioni

 

 

Pubblicazioni su Rivista

 

  1. G. Cozza, A. Gianoncelli, P. Bonvini, E. Zorzi, R. Pasquale, A. Rosolen, L.A. Pinna, F. Meggio, G. Zagotto, S. Moro. “Urolithin as a Converging Scaffold Linking Ellagic acid and Coumarin Analogues: Design of Potent Protein Kinase CK2 Inhibitors”. ChemMedChem. 2011 doi: 10.1002/cmdc.201100338.
  2. R. Battistutta, G. Cozza, F. Pierre, E. Papinutto, G. Loll, S. Sarno, S.E. O'Brien, A. Siddiqui-Jain, M. Haddach, K. Anderes, D.M. Ryckman,  F. Meggio, L.A. Pinna “Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.” Biochemistry  2011 50:8478-8488.
  3. S. Sarno, M. Mazzorana, R. Traynor, M. Ruzzene, G. Cozza, MA Pagano, F. Meggio, G. Zagotto, R. Battistutta, LA Pinna. “Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A.” Cell Mol Life Sci. 2011 DOI: 10.1007/s00018-011-0758-7.
  4. G. Cozza, F. Meggio, S. Moro “The dark side of protein kinase CK2 inhibition” Current Med Chem 2011 8:2867-2884.
  5. A. Cristiani, G. Costa, G. Cozza, S.Moro “ The role of N-terminal domain in the regulation of “constitutively active” conformation of protein kinase CK2α: new insight from a molecular dynamics investigation”. Chem Med Chem 2011 6:1207-1216. doi: 10.1002/cmdc.201100046.
  6. G. Zagotto, M. Radaelli, R. Pasquale, D. D’Avella, G. Cozza, L. Denaro, F. Pizzato, C. Mucignat-Caretta “8-Hydroxynaphthalene-1,4-dione Derivative as Novel Compound for Glioma Treatment” Bioorganic & Medicinal Chemistry Letters. 2011 21:2079-2082
  7. A. Piovan, G. Cozza; R. Caniato; S. Moro, R. Filippini “A novel glucosyltransferase from Catharanthus roseus cell suspensions” Proc. Biochemistry DOI:10.1016/j.peocbio.20q0.12.014.
  8. A. Venerando, O. Marin, G. Cozza, V.H. Bustos, S. Sarno, L.A. Pinna. “Isoform specific phosphorylation of p53 by protein kinase CK1” Cell Mol Life Sci. 2011. DOI 10-1007/s00018-009-0236-7.
  9. M.A. Pagano, O. Marin, G. Cozza, S. Sarno, F. Meggio, K.J. Treharne, A. Mehta, L.A. Pinna “Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2. Biochem. J. 2010 426:19-29.
  10. L. Flhoè, S. Toppo, G.Cozza. F.Ursini  “A Comparison of Thiol Peroxidase Mechanisms.” Antioxid Redox Signal  2010 doi:10.1089/ars.2010.3397
  11. G. Cozza, A. Bortolato, E. Menta, E. Cavalletti, S. Spinelli, S. Moro. “ATP non-competitive ser/thr kinase inhibitors as potential anticancer agents.”  Anticancer Agents Med Chem. 2009 9:778-786.
  12. A. Gianoncelli, G. Cozza, A. Orzeszko, F. Meggio, Z. Kazimierczuk, L.A. Pinna “Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2.”  Bioorg Med Chem. 2009 17:7281-7289.
  13. G. Cozza, A. Bortolato, S. Moro “How druggable is protein kinase CK2?”  Med Res Rev. 2009. DOI 10.1002/med.20164
  14. M. Lebska, J. Szczegielniak, G. Dobrowolska, G. Cozza, S. Moro, G. Muszyńska “A novel splicing variant encoding putative catalytic alpha subunit of maize protein kinase CK2.”  Physiol Plant. 2009 136:251-263.
  15. N. Zonta, G. Cozza, A. Gianoncelli, O. Korb, T.E. Exner, F. Meggio, G. Zagotto, S. Moro  ”Scouting Novel Protein Kinase A (PKA) Inhibitors by Using a Consensus Docking-Based Virtual Screening Approach.” Lett. Drug Design & Discovery. 2009 6:327-333.
  16. G. Cozza, M. Mazzorana, E. Papinutto, J. Bain, M. Elliott, G. di Maira, A. Gianoncelli, M.A. Pagano, S. Sarno, M. Ruzzene, R. Battistutta, F. Meggio, S. Moro, G. Zagotto, L.A. Pinna  “Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2.”  Biochem J. 2009 42:387-395.
  17. S. Vilar, G. Cozza, S. Moro “Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery”  Curr Top Med Chem.  2008;8:1555-1572.
  18. A. Bortolato, G. Cozza, S. Moro “Protein kinase CK2 inhibitors: emerging anticancer therapeutic agents?” Anticancer Agents Med Chem. 2008; 8:798-806
  19. G. Cozza, A. Gianoncelli, M. Monopoli, L. Caparrotta, A. Venerando, F. Meggio , L.A. Pinna, G. Zagotto, S. Moro. “Identification of novel protein kinase CK1 delta (CK1delta) inhibitors through structure-based virtual screening” Bioorg Med Chem Lett. 2008 15:5672-5675.
  20. G. Poletto, O. Marin, M. A. Pagano, G. Cozza, S. Sarno, E. Itarte, L. A. Pinna and F. Meggio  “The regulatory β subunit of protein kinase CK2 partecipates to the local recognition of the substrate consensus sequence”. Biochemistry 2008 47: 8317-8325.
  21. M.A. Pagano , J. Bain, Z. Kazimierczuk, S. Sarno, M. Ruzzene, G. Di Maira, M. Elliott, A. Orzeszko, G. Cozza, F. Meggio, L.A. Pinna. “The selectivity of inhibitors of protein kinase CK2. An update”. Biochem J. 2008  415:353-365.
  22. A. Chilin, R. Battistutta, A. Bortolato, G. Cozza, S. Zanatta, G. Poletto, M. Mazzorana, G. Zagotto, E. Uriarte, A. Guiotto, L. A. Pinna, F. Meggio and S. Moro.   “Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidated the putative binding motif and explain structure- activity relationships”  J.Med.Chem. 2008 51:752-759.
  23. G. Cozza, G. Gotte, S. Moro “Elucidation of the ribonuclease A aggregation process mediated by 3D domain swapping: a computational approach reveals possible new multimeric structures.” Biopolymers 2008 89:26-39.
  24. M, A. Pagano, G. Poletto, G. Di Maira, G. Cozza, M. Ruzzene, S. Sarno, J. Bain, M. Elliott, S. Moro, G. Zagotto, F. Meggio and L. A. Pinna: “Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors” ChemBioChem 2007 8:129-139.
  25. S. Moro, F. Varano, G. Cozza, M. A. Pagano, G. Zagotto, A. Chilin, A. Guiotto, D. Catarzi, V. Colotta, L. A. Pinna, F. Meggio “Pyrazoloquinazoline Tricyclic System as Novel Scaffold to Design New Kinase CK2 Inhibitors”  Letters in Drug Design & Discovery, 2006: 281-284,
  26. G. Cozza, P. Bonvini, E. Zorzi, G. Poletto, M. A. Pagano, S. Sarno, A. Donella-Deana, G. Zagotto, A. Rosolen, L. A. Pinna, F. Meggio, and S. Moro “Identification of Ellagic Acid as Potent Inhibitor of Protein Kinase CK2: A Successful Example of a Virtual Screening Application”  J.Med.Chem. 2006 49:2363-2366
  27. M.A. Pagano, S. Sarno, G. Poletto, G. Cozza, L.A. Pinna, F. Meggio,   “Autophosphorylation at the regulatory b subunit reflects the supramolecular organization of protein kinase CK2” Mol Cell Biochem. 2005 274:23-29.
  28. F. Meggio, M. A. Pagano, S. Moro, G. Zagotto, M. Ruzzene, S. Sarno, G. Cozza, J. Bain, M. Elliott, A. D. Deana, A. M. Brunati, L. A. Pinna "Inhibition of Protein Kinase CK2 by Condesed Polyphenolic Derivates. An in Vitro and in Vivo Study"   Biochemistry 2004, 43, 12931 – 12936.

 

Pubblicazioni su Libro

  1. M. MAIORINO, V. BOSELLO, G. COZZA, A. ROVERI, S. TOPPO, F. URSINI “Selenium: its molecular biology and role in human health 3rd edition, Chapter 14: Glutathione Peroxidase-4”  Springer Edition 2011