Publication

  1. Zaghi, A.; Ragno, D.; Di Carmine, G.; De Risi, C.; Bortolini, O.; Giovannini, P. P.; Fantin, G.; Massi, A. Electron-transfer-initiated benzoin- and Stetter-like reactions in packed-bed reactors for process intensification, Beilstein Journal of Organic Chemistry, 2016, 12, 2719–2730.
  2. Giovannini, P. P.; Lerin, L. A.; Müller, M.; Bernacchia, G.; De Bastiani, M.; Catani, M.; Di Carmine, G.; Massi, A. (S)-Selectivity in Phenylacetyl Carbinols Synthesis Using the Wild-Type Enzyme Acetoin:Dichlorophenolindophenol Oxidoreductase from Bacillus licheniformis, Advanced Synthesis & Catalysis, in press, DOI 10.1002/adsc.201600359.
  3. Giovannini, P. P.; Bortolini, O.; Massi, A. Thiamine-Diphosphate-Dependent Enzymes as Catalytic Tools for the Asymmetric Benzoin-Type Reaction. European Journal of Organic Chemistry, DOI: 10.1002/ejoc.201600228.
  4. Donvito, A.; Fantin, G.; Fogagnolo, M.; Giovannini, P. P.; Scoponi, M. Novel tri- and tetrafunctional cholic acid-based initiators for the synthesis of star-shaped poly(Llactide)s. Designed Monomers and Polymers, 2016, 19, 535-544.
  5. Lerin, L. A.; Catani, M.; Oliveira, D.; Massi, A.; Bortolini, O.; Cavazzini, A.; Giovannini, P. P. Continuous ion-exchange resin catalysed esterification of eugenol for the optimized production of eugenyl acetate using a packed bed microreactor. RSC Advances, 2015, 5, 76898–76903.
  6. Bernacchia, G.; Bortolini, O.; De Bastiani, M.; Lerin, L. A.; Loschonsky, S.; Massi, A.; Müller, M.; GiovanniniP. P. “Enzymatic Chemoselective Aldehyde–Ketone Cross-Couplings through the Polarity Reversal of Methylacetoin”. Angewandte Chemie-International Edition 2015, 54, 7171-7175.
  7. Ragno, D.; Bortolini, O.; Fantin, G.; Fogagnolo, M.; Giovannini, P. P.;  Massi, A. Nucleophilic and Electrophilic Double Aroylation of Chalcones with Benzils Promoted by the Dimsyl Anion as a Route to All Carbon Tetrasubstituted Olefins. Journal of Organic Chemistry, 2015, 80, 1937−1945.
  8. Loschonsky, S.; Wacker, T. Waltzer, S.; Giovannini, P. P.; McLeish, M. J.; Andrade, S. L. A.; Müller, M. Extended Reaction Scope of Thiamine Diphosphate Dependent Cyclohexane-1,2-dione Hydrolase: From C-C Bond Cleavage to C-C Bond Ligation. Angewandte Chemie-International Edition 2014, 53, 14402-14406.
  9. Giovannini, P. P.; Bortolini, O.; Cavazzini, A.; Greco, R.; Fantin, G.; Massi, A. Expanding the scope of enzymatic carboligation reactions in flow-mode: production of optically active tertiary alcohols with packed-bed micro-bioreactors. Green Chemistry, 2014, 16, 3904–3915.
  10. Ragno, D.; Bortolini, O.; Giovannini, P. P.; Massi, A.; Pacifico, S.; Zaghi, A. One-pot, two-step desymmetrization of symmetrical benzils catalyzed by the methylsulfinyl (dimsyl) anion. Organic & Biomolecular Chemistry, 2014, 12, 5733–5744.
  11. Bortolini, O.; Chiappe, C.; Fogagnolo, M.; Giovannini, P. P.; Massi, A.; Pomelli C. S.; Ragno, D. An insight into the mechanism of the aerobic oxidation of aldehydes catalyzed by N-heterocyclic carbenes. Chemical Communications, 2014, 50, 2008-2011.
  12. Costa S.; Giovannini, P. P.; Fantin, G.; Medici, A.; Pedrini, P. New 9,10-Secosteroids from Biotransformations of Bile Acids with Rhodococcus ruber. Helvetica Chimica Acta, 2013, 96, 2124-2133.
  13. Bortolini, O.; Fantin, G.; Ferretti, V.; Fogagnolo, M.; Giovannini, P. P.; Massi, A.; Pacifico, S.; Ragno, D. Methylsulfinyl (Dimsyl) Anion as Umpolung Catalyst for the Chemoselective Cross-Benzoin Reaction of a-Diketones with Aldehydes. Advanced Synthesis & Catalysis, 2013, 355, 3244 – 3252.
  14. Bortolini, O.; Cavazzini, A.; Dambruoso, P.; Giovannini, P. P.; Caciolli, L.; Massi, A.; Pacifico, S.; Ragno, D. Thiazolium-functionalized polystyrene monolithic microreactors for continuous-flow umpolung catalysis. Green Chemistry, 2013, 15, 2981-2992.
  15. Moreno Ruedaa, M. G.; Guerrini, A.; Giovannini, P. P.; Medicib, A.; Grandini, A.; Sacchetti, G.; Pedrini, P. Biotransformations of Terpenes by Fungi from Amazonian Citrus Plants. Chemistry & Biodiversity, 2013, 10, 1909-1919.
  16. Bortolini, O.; Cavazzini, A.; Giovannini, P. P.; Greco, R.; Marchetti, N.; Massi, A.; Pasti, L. A Combined Kinetic and Thermodynamic Approach for the Interpretation of Continuous-Flow Heterogeneous Catalytic Processes. Chemistry a European Journal, 2013, 19, 7802 – 7808.
  17. Bortolini, O.; Giovannini, P. P.; Maietti, S.; Massi, A.; Pedrini, P.; Sacchetti, G.; Venturi, V. An enzymatic approach to the synthesis of optically pure (3R)- and (3S)-enantiomers of green tea flavor compound 3-hydroxy-3-methylnonane-2,4-dione. Journal of Molecular Catalysis B: Enzymatic, 2013, 85-86, 93-98.
  18. Costa, S.; Giovannini, P. P.; Fantin, G.; Medici, A.; Pedrini, P. New 9,10-Secosteroids from Biotransformations of Hyodeoxycholic Acid with Rhodococcus spp. Helvetica Chimica Acta, 2013, 96, 1062-1071.
  19. Antognoni, F.; Iannello, C.; Mandrone, M.; Scognamiglio, M.; Fiorentino, A.; Giovannini, P. P.; Poli, F. Elicited Teucrium chamaedrys cell cultures produce high amounts of teucrioside, but not the hepatotoxic neo-clerodane diterpenoids. Phytochemistry, 2012, 81, 50-59.
  20. Bertolasi, V.; Bortolini, O.; Donvito, A.; Fantin, G.; Fogagnolo, M.; Giovannini, P. P.; Massi, A.; Pacifico, S. Unexpected reactivity of diaryl alpha-diketones with thiazolium carbenes: discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones. Organic and Biomelecular Chemistry, 2012, 10, 6579-6586.
  21. Bortolini, O.; Fantin, G.; Fogagnolo, M.; Giovannini, P. P.; Venturi, V.; Pacifico, S.; Massi, A. a-Diketones as acyl anion equivalents: a non-enzymatic thiamine-promoted route to aldehyde-ketone coupling in PEG 400 as recyclable medium. Tetrahedron, 2011, 67, 8110-8115.
  22. Massi, A.; Cavazzini, A.; Del Zoppo, L.; Pandoli, O.; Costa, V.; Pasti, L.; Giovannini, P.P. Toward the optimization of continuous-flow aldol and a-amination reactions by means of proline-functionalized silicon packed-bed microreactor. Tetrahedron Letters, 2011, 52, 619-622.
  23. Bortolini, O.; Fantin, G.; Fogagnolo, M.; Giovannini, P. P.; Massi, A.; Pacifico, S. Thiazolium-catalyzed intermolecular Stetter reaction of linear and cyclic alkyl a-diketones. Organic and Biomolecular Chemistry, 2011, 9, 8437-8444.
  24. Giovannini,P. P.; Fantin, G.; Massi, A.; Venturi, V.; Pedrini, P. Enzymatic diastereo- and enantioselective synthesis of a-alkyl-a,b-dihydroxyketones. Organic and Biomelecular Chemistry, 2011, 9, 8038-8045.
  25. Giovannini, P. P.; Mantovani, M.; Grandini, A.; Medici, A.; Pedrini, P. New acetoin reductases from Bacillus stearothermophilus: meso- and 2R,3R-butandeiol as fermentation products. Journal of Molecular Catalysis B: Enzymatic, 2011, 69, 15-20.
  26. Bortolini, O.; Fantin, G.; Ferretti, V.; Fogagnolo, M.; Giovannini, P.P.; Medici, A. Relative acidity scale of bile acids through ESI-MS measurements. Organic and Biomolecular Chemistry, 2010, 8, 3674-3677.
  27. Giovannini, P. P.; Pedrini, P.; Venturi, V.; Fantin, G.; Medici, A. Bacillus stearothermophilus acetylacetoin synthase: a new catalyst for C-C bond formation. Journal of Molecular Catalysis B: Enzymatic, 2010, 64, 113-117.
  28. Fantin, G.; Fogagnolo, M.;Giovannini, P. P.; Synthesis and characterization of cyclotriphosphazenes bearing six bile acid arms. Zeitschrift für Naturforschung, 2009, 64b, 551-554.
  29. Pedrini, P.; Giovannini, P.P.; Mantovani, M.; Andreotti, E.; Colalongo, C. reduction screening with endophytic fungi: synthesis of homochiral secondary alcohols. Journal of Molecular Catalysis B: Enzymatic, 2009, 60, 145-150.
  30. Giovannini, P. P.; Grandini, A.;  Fantin, G.; Perrone, D.; Pedrini, P. 7a- and 12a-Hydroxysteroid dehydrogenases from Acinetobacter calcoaceticus lwoffii: a new integrated chemo-enzymatic route to ursodeoxycholic acid. Steroids, 2008, 73, 1385-1390.
  31. Pedrini, P.; Andreotti, E.; Guerrini, A.; Dean, M.; Fantin, G.; Giovannini, P.P. Xanthomonas maltophilia CBS 897.97 as a source of new 7b- and 7a-hydroxysteroid dehydrogenases and cholylglycine hydrolase: improved biotransformations of bile acids. Steroids; 2006; 71; 189-198.
  32. Fantin, G.; Giovannini, P.P.; Guerrini, A.; Maietti, S.; Medici, A.; Pedrini, P. Enatioselective Baeyer-Villiger oxidation of bicyclo[3.2.0]hept -2-en-6-one with fungi: optimization of biotransformation and use of TiO2 as support of cell growth . Biotechnology Letters, 2006; 28; 805-810.
  33. Dondoni, A.; Giovannini, P. P.; Perrone, D. Cross-metathesis of C-allyl Iminosugars with alkenyl oxazolidines as a key step in the synthesis of C-iminoglycosyl-amino acids. A route to iminosugar containing C-glycopeptides. Journal of Organic Chemistry; 2005, 70, 5508-5518.
  34. Dondoni, A.; Giovannini, P. P.; Massi, A. Assembling heterocycle-tethered C-glycosyl and a-amino acid residues via 1,3-dipolar cycloaddition reactions. Organic Letters, 2004, 6; 2929-2932.
  35. Dondoni, A.; Giovannini, P. P. Formyl C-glycoside as precursors to glycosyl nitrile oxides and nitrones. Synthesis-Stuttgart, 2002, 12, 17001-17005.
  36. Dondoni, A.; Giovannini, P. P. Perrone, D. New synthesis of pyrrolidine homoazasugars via aminohomologation of furanoses and their use for the stereoselective synthesis of aza-C-disaccharides. Journal of Organic Chemistry, 2002, 67, 7203-7214.
  37. Dondoni, A.; Giovannini, P. P. Marra, A.; Mizuno, M. Linear total synthetic routes to b-D-C-(1,6)-linked oligoglucoses and oligogalactoses up to pentoses by iterative Wittig olefination assembly. Journal of Organic Chemistry, 2002, 67, 4186-4199.
  38. Dondoni, A.; Giovannini, P. P.; Marra, A. A concise C-glycosyl amino acid synthesis by alkenyl C-glycoside-viniyloxazolidine cross-methatesis. Synthesis of glycosyl serine, asparagine and hydroxynorvaline isosters. J. Chem Soc., Perkin Trans. 1, 2001, 2380-2388.
  39. Dondoni, A.; Giovannini, P. P.; Marra, A. Convergent synthesis of pyrrolidine-based (1–›6)-and (1–›5)-aza-C-disaccharides. Tetrahedron Letters, 2000, 41, 6195 – 6199.
  40. Bianchini, E.; Chinaglia, N.; Dean, M.; Giovannini, P. P.; Medici, A.; Pedrini, P.; Poli, S. Regiospecific oxidoreductions catalyzed by a new Pseudomonas paucimobilis Hydroxysteroid Dehydrogenase. Tetrahedron, 1999, 55, 1391-1398.
  41. Rippa, M.; Giovannini, P. P.; Barrett, M. P.; Dallocchio, F.; Hanau, S. 6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species. Biochimica et Biophysica Acta, 1998, 1429, 83-92.
  42. Fogagnolo, M.; Giovannini, P. P.; Guerrini, G.; Medici, A.; Pedrini, P.; Colombi, N. Homochiral (R)- and (S)-1-Heteroaryl and 1-aryl-2-propanols via microbial redox. Tetrahedron: Asymmetry, 1998, 9, 2317-2327.
  43. Giovannini, P.P.; Rippa, M.; Dallocchio, F.; Teteud, M.; Barret, M.P.; Hanau, S. The cross-linking by o-phtalaldehyde of the two amino acid residues at the active site of 6-phosphogluconate dehydrogenase. Biochemistry and Molecular Biology International, 1997, 43, 153-160.
  44. Bortolini, O.; Fantin, G.; Fogagnolo, M.; Giovannini,P.P.; Guerrini, A.; Medici, A. An easy approach to the synthesis of optically active vic-diols: a new single-enzyme system. Journal of Organic Chemistry, 1997, 62, 1854-1856.
  45. Medici, A.; Fantin, G.; Fogagnolo, M.; Giovannini, P.P.; Pedrini, P.; Gardini, F.; Lancinotti, R. Anti-Prelog microbial redduction of prochiral carbonyl compounds. Tetrahedron, 1996, 52, 3547-3552.
  46. Giovannini, P.P.; Hanau, S.; Rippa, M.; Bortolini, O.; Fogagnolo, M.; Medici, A. Bacillus stearothermophilus Alcohol Dehydrogenase: A new Catalyst to obtain enantiomerically pure bicyclic octen- and hepten-ols and –ones. Tetrahedron, 1996, 52, 1669-1676.
  47. Giovannini, P. P.; Medici, A.; Bergamini, C. M.; Rippa, M. Properties of Diacetyl (Acetoin) Reductase from Bacillus stearothermphilus. Bioorganic and Medicinal Chemistry, 1996, 4, 1997-1201.
  48. Fantin, G.; Fogagnolo, M., Giovannini, P.P.; Medici, A.; Pedrini, P.; Poli, S. Oxidation with Bacillus stearothermophilus in HeptanE. Tetrahedron Letters, 1995, 36, 441-442.
  49. Fantin, G.; Fogagnolo, M.; Giovannini, P.P., Medici, A.; Pedrini, P. Combined microbial oxidation and reduction: a new approach to the high-yield synthesis of homochiral unsatured secondary alcohols from racemates. Tetrahedron: Asymmetry, 1995, 12,3047-3053.
  50. Fantin, G.; Fogagnolo, M., Giovannini, P.P.; Medici, A.; Pagnotta, E.; Pedrini, P.; Trincone, A. Synthesis of homochiral syn- and anti-a-(hydroxyethyl)-g-butyrolactones via microbial reductions. Tetrahedron: Asymmetry, 1994, 5, 1631-1634.