Pubblicazioni

ARTICLES
  1. Spiropiperidine-based oligomycin-analog ligands to counteract the ischemia reperfusion injury in a renal cell model. Turrin, Giulia; Lo Cascio, Ettore; Giacon, Noah; Fantinati, Anna; Cristofori, Virginia; Illuminati, Davide; Preti, Delia; Morciano, Giampaolo; Pinton, Paolo; Agyapong, Esther Densu; et al. Journal of Medicinal Chemistry (2024), 67(1), 586-602.
  2. Non-neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats. De Logu, Francesco; De Siena, Gaetano; Landini, Lorenzo; Marini, Matilde; Souza Monteiro de Araujo, Daniel; Albanese, Valentina; Preti, Delia; Romitelli, Antonia; Chieca, Martina; Titiz, Mustafa; et al. British Journal of Pharmacology (2023), 180(9), 1232-1246.
  3. Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer. Albanese, Valentina; Missiroli, Sonia; Perrone, Mariasole; Fabbri, Martina; Boncompagni, Caterina; Pacifico, Salvatore; De Ventura, Tiziano; Ciancetta, Antonella; Dondio, Giulio; Kricek, Franz; Pinton, Paolo; Guerrini, Remo; Preti, Delia*; Giorgi, Carlotta. Journal of Medicinal Chemistry (2023), 66(7), 5223-5241.
  4. Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase. Fantinati, Anna; Morciano, Giampaolo; Turrin, Giulia; Pedriali, Gaia; Pacifico, Salvatore; Preti, Delia; Albanese, Valentina; Illuminati, Davide; Cristofori, Virginia; Giorgi, Carlotta; et al. Bioorganic & Medicinal Chemistry Letters (2022), 72, 128822.
  5. Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene derivatives as potent apoptosis-inducing agents. Romagnoli, Romeo; Preti, Delia; Hamel, Ernest; Bortolozzi, Roberta; Viola, Giampietro; Brancale, Andrea; Ferla, Salvatore; Morciano, Giampaolo; Pinton, Paolo. Bioorganic Chemistry (2021), 112, 104919.
  6. Novel mixed NOP/opioid receptor peptide agonists. Pacifico, Salvatore; Albanese, Valentina; Illuminati, Davide; Marzola, Erika; Fabbri, Martina; Ferrari, Federica; Holanda, Victor A. D.; Sturaro, Chiara; Malfacini, Davide; Ruzza, Chiara;Trapella, Claudio; Preti, Delia* et al. Journal of Medicinal Chemistry (2021), 64(10), 6656-6669.
  7. Structure-Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity. Albanese, Valentina; Ruzza, Chiara; Marzola, Erika; Bernardi, Tatiana; Fabbri, Martina; Fantinati, Anna; Trapella, Claudio; Reinscheid, Rainer K.; Ferrari, Federica; Sturaro, Chiara…..and Preti, Delia. Journal of Medicinal Chemistry (2021), 64(7), 4089-4108.
  8. Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH2. Pacifico, Salvatore; Ferrari, Federica; Albanese, Valentina; Marzola, Erika; Neto, Joaquim Azevedo; Ruzza, Chiara; Calo, Girolamo; Preti, Delia*; Guerrini, Remo. Journal of Medicinal Chemistry (2020), 63(19), 10782-10795.
  9. Discovery of novel fetal hemoglobin inducers through small chemical library screening. Breveglieri, Giulia; Pacifico, Salvatore; Zuccato, Cristina; Cosenza, Lucia Carmela; Sultan, Shaiq; D’Aversa, Elisabetta; Gambari, Roberto; Preti, Delia; Trapella, Claudio; Guerrini, Remo; et al. International Journal of Molecular Sciences (2020), 21(19), 7426.
  10. Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors. Pacifico, Salvatore; Albanese, Valentina; Illuminati, Davide; Fantinati, Anna; Marzola, Erika; Ferrari, Federica; Neto, Joaquim Azevedo; Sturaro, Chiara; Ruzza, Chiara; Calo, Girolamo; Preti, Delia* and Guerrini, Remo.  Bioconjugate Chemistry (2019), 30(9), 2444-2451.
  11. Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice. Noroes, Maira Macedo; Santos, Larissa Gonzaga; Gavioli, Elaine Cristina; de Paula Soares Rachetti, Vanessa; Otuki, Michel Fleith; de Almeida Cabrini, Daniela; da Silveira Prudente, Arthur; Oliveira, Janiana Raiza Jentsch Matias; de Carvalho Goncalves, Muryel; Ferreira, Juliano; Preti, Delia; et al. European Journal of Pharmacology (2019), 858, 172460.
  12. Synthesis and biological activity of peptide α-ketoamide derivatives as proteasome inhibitors. Pacifico, Salvatore; Ferretti, Valeria; Albanese, Valentina; Fantinati, Anna; Gallerani, Eleonora; Nicoli, Francesco; Gavioli, Riccardo; Zamberlan, Francesco; Preti, Delia*; Marastoni, Mauro. ACS Medicinal Chemistry Letters (2019), 10(7), 1086-1092.
  13. The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel. De Logu, Francesco; Li Puma, Simone; Landini, Lorenzo; Tuccinardi, Tiziano; Poli, Giulio; Preti, Delia; De Siena, Gaetano; Patacchini, Riccardo; Tsagareli, Merab G.; Geppetti, Pierangelo; et al. Pharmacological Research (2019), 142, 127-139.
  14. Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction. Morciano, Giampaolo; Preti, Delia; Pedriali, Gaia; Aquila, Giorgio; Missiroli, Sonia; Fantinati, Anna; Caroccia, Natascia; Pacifico, Salvatore; Bonora, Massimo; Talarico, Anna; et al. Journal of Medicinal Chemistry (2018), 61(16), 7131-7143.
  15. Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies. Ruzza, Chiara; Ferrari, Federica; Guerrini, Remo; Marzola, Erika; Preti, Delia; Reinscheid, Rainer K.; Calo, Girolamo. Pharmacology Research & Perspectives (2018), 6(6), e00445/1-e00445/11
  16. Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3’,4’,5’-trimethoxyphenyl)-3-(2’-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach. Preti, Delia; Romagnoli, Romeo; Rondanin, Riccardo; Cacciari, Barbara; Hamel, Ernest; Balzarini, Jan; Liekens, Sandra; Schols, Dominique; Estevez-Sarmiento, Francisco; Quintana, Jose; et al. Journal of Enzyme Inhibition and Medicinal Chemistry (2018), 33(1), 1225-1238.
  17. Naphthoquinone amino acid derivatives, synthesis and biological activity as proteasome inhibitors. Marastoni, Mauro; Trapella, Claudio; Scotti, Alessandra; Fantinati, Anna; Ferretti, Valeria; Marzola, Erika; Eleonora, Gallerani; Gavioli, Riccardo; Preti, Delia*. Journal of Enzyme Inhibition and Medicinal Chemistry (2017), 32(1), 865-877.
  18. Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands. Pacifico, Salvatore; Carotenuto, Alfonso; Brancaccio, Diego; Novellino, Ettore; Marzola, Erika; Ferrari, Federica; Cerlesi, Maria Camilla; Trapella, Claudio; Preti, Delia; Salvadori, Severo; et al. Scientific Reports (2017), 7, 45817.
  19. Neuropeptide S receptor ligands: a patent review (2005-2016). Ruzza, Chiara; Calo, Girolamo; Di Maro, Salvatore; Pacifico, Salvatore; Trapella, Claudio; Salvadori, Severo; Preti, Delia*; Guerrini, Remo. Expert Opinion on Therapeutic Patents (2017), 27(3), 347-362.
  20. Ozone-induced hypertussive responses in rabbits and guinea pigs. Clay, Emlyn; Patacchini, Riccardo; Trevisani, Marcello; Preti, Delia; Brana, Maria Pia; Spina, Domenico; Page, Clive. Journal of Pharmacology and Experimental Therapeutics (2016), 357(1), 73-83.
  21. The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives. Nassini, Romina; Fusi, Camilla; Materazzi, Serena; Coppi, Elisabetta; Tuccinardi, Tiziano; Marone, Ilaria M.; De Logu, Francesco; Preti, Delia; Tonello, Raquel; Chiarugi, Alberto; et al. British Journal of Pharmacology (2015), 172(13), 3397-3411.
  22. History and Perspectives of A2A Adenosine Receptor Antagonists as Potential Therapeutic Agents. Preti, Delia; Baraldi, Pier Giovanni; Moorman, Allan R.; Borea, Pier Andrea; Varani, Katia. Medicinal Research Reviews (2015), 35(4), 790-848.
  23. Transient receptor potential ankyrin 1 (TRPA1) antagonists. Preti, Delia; Saponaro, Giulia; Szallasi, Arpad. Pharmaceutical Patent Analyst (2015), 4(2), 75-94.
  24. Design, Synthesis, and Biological Evaluation of Novel 2-((2-(4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamido-adenosines as Potent and Selective Agonists of the A2A Adenosine Receptor. Preti, Delia; Baraldi, Pier Giovanni; Saponaro, Giulia; Romagnoli, Romeo; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Cosconati, Sandro; Bruno, Agostino; Novellino, Ettore; Vincenzi, Fabrizio; et al. Journal of Medicinal Chemistry (2015), 58(7), 3253-3267.
  25. Synthesis and Biological Evaluation of Pyrazolo[3,4-b]pyridin-4-ones as a New Class of Topoisomerase II Inhibitors. Tabrizi, Mojgan Aghazadeh; Baraldi, Pier Giovanni; Baraldi, Stefania; Prencipe, Filippo; Preti, Delia; Saponaro, Giulia; Romagnoli, Romeo; Gessi, Stefania; Merighi, Stefania; Stefanelli, Angela; et al. Medicinal Chemistry (Sharjah, United Arab Emirates) (2015), 11(4), 342-353.
  26. Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-​Amino-​3-​(4'-​Chlorobenzoyl)​-​4-​Substituted-​5-​Arylethynyl Thiophene. Romagnoli, Romeo; Baraldi, Pier Giovanni; IJzerman, Adriaan P.; Massink, Arnault; Cruz-Lopez, Olga; Lopez-Cara, Luisa Carlota; Saponaro, Giulia; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Moorman, Allan R.; Vincenzi, Fabrizio; Borea, Pier Andrea; Varani, Katia. Journal of Medicinal Chemistry (2014), 57(18), 7673-7686.
  27. The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-​like actions in mice. Cavalcante de Moura, Juliana; Noroes, Maira Macedo; Rachetti, Vanessa de Paula Soares; Soares, Bruno Lobao; Preti, Delia; Nassini, Romina; Materazzi, Serena; Marone, Ilaria Maddalena; Minocci, Daiana; Geppetti, Pierangelo; Gavioli, Elaine Cristina; Andre, Eunice. British Journal of Pharmacology (2014), 171(18), 4289-4299.
  28. Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents. Romagnoli, Romeo; Baraldi, Pier Giovanni; Lopez-Cara, Carlota; Salvador, Maria Kimatrai; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Balzarini, Jan; Nussbaumer, Peter; Bassetto, Marcella; Brancale, Andrea; et al. Bioorganic & Medicinal Chemistry (2014),  22(18), 5097-5109.
  29. Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A1 adenosine receptor. Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cruz-Lopez, Olga; Cara, Carlota Lopez; Saponaro,Giulia; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Baraldi, Stefania; Moorman, Allan R.; et al. Bioorganic & Medicinal Chemistry (2014), 22(1), 148-166.
  30. Concise Synthesis and Biological Evaluation of 2 Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents. Romagnoli, Romeo; Baraldi, Pier Giovanni; Lopez-Cara, Carlota; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Balzarini, Jan; Bassetto, Marcella; Brancale, Andrea; Fu, Xian-Hua; Gao, Yang; et al. Journal of Medicinal Chemistry (2013), 56(22), 9296-9309.
  31. Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4-substituted thiophenes as allosteric enhancers of the A1 adenosine receptor. Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Lopez Cara, Carlota; Kimatrai Salvador, Maria; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Moorman, Allan R.; Vincenzi, Fabrizio; Borea, Pier Andrea; et al. European Journal of Medicinal Chemistry (2013), 67, 409-427.
  32. 7-oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB2 cannabinoid receptor ligands: structural investigation around a novel class of full agonists. Baraldi, Pier Giovanni; Saponaro, Giulia; Preti, Delia; Baraldi, Stefania; Ruggiero, Emanuela; Borea, Pier Andrea; Tabrizi, Mojgan Aghazadeh. Chimica e l'Industria. (2013), 95(4), 118-120.
  33. Discovery of 7-Oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists. Aghazadeh Tabrizi, Mojgan; Baraldi, Pier Giovanni; Saponaro, Giulia; Moorman, Allan R.; Romagnoli, Romeo; Preti, Delia; Baraldi, Stefania; Ruggiero, Emanuela; Tintori, Cristina; Tuccinardi, Tiziano; et al. Journal of Medicinal Chemistry (2013), 56(11), 4482-4496.
  34. Synthesis and Biological Evaluation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines as New Potent Anticancer Agents. Romagnoli, Romeo; Baraldi, Pier Giovanni; Kimatrai Salvador, Maria; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Bassetto, Marcella; Brancale, Andrea; Hamel, Ernest; Castagliuolo, Ignazio; Bortolozzi, Roberta; et al. Journal of Medicinal Chemistry (2013), 56(6), 2606-2618.
  35. Design, Synthesis, and Pharmacological Properties of New Heteroarylpyridine/Heteroarylpyrimidine Derivatives as CB2 Cannabinoid Receptor Partial Agonists. Aghazadeh Tabrizi, Mojgan; Baraldi, Pier Giovanni; Saponaro, Giulia; Moorman, Allan R.; Romagnoli, Romeo; Preti, Delia; Baraldi, Stefania; Corciulo, Carmen; Vincenzi, Fabrizio; Borea, Pier Andrea; et al. Journal of Medicinal Chemistry (2013), 56(3), 1098-1112.
  36. Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents. Romagnoli, Romeo; Baraldi, Pier Giovanni; Salvador, Maria Kimatrai; Camacho, M. Encarnacion; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Bassetto, Marcella; Brancale, Andrea; Hamel, Ernest; Bortolozzi, Roberta; et al. Bioorganic & Medicinal Chemistry (2012), 20(24), 7083-7094.
  37. Synthesis and Biological Evaluation of 2-Amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-Modification on Allosteric Enhancer Activity at the A1 Adenosine Receptor. Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cara, Carlota Lopez; Cruz-Lopez, Olga; Salvador, Maria Kimatrai; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Moorman, Allan R.; Vincenzi, Fabrizio; et al. Journal of Medicinal Chemistry (2012), 55(17), 7719-7735.
  38. Activation of TRPA1 on dural afferents: A potential mechanism of headache pain. Edelmayer, Rebecca M.; Le, Larry N.; Yan, Jin; Wei, Xiaomei; Nassini, Romina; Materazzi, Serena; Preti, Delia; Appendino, Giovanni; Geppetti, Pierangelo; Dodick, David W.; et al. Pain (2012), 153(9), 1949-1958.
  39. 7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists. Baraldi, Pier Giovanni; Saponaro, Giulia; Moorman, Allan R.; Romagnoli, Romeo; Preti, Delia; Baraldi, Stefania; Ruggiero, Emanuela; Varani, Katia; Targa, Martina; Vincenzi, Fabrizio; et al. Journal of Medicinal Chemistry (2012), 55(14), 6608-6623.
  40. TRP channels as therapeutic targets in airway disorders: a patent review. Preti, Delia; Szallasi, Arpad; Patacchini, Riccardo. Expert Opinion on Therapeutic Patents (2012), 22(6), 663-695.
  41. Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents. Romagnoli, Romeo; Baraldi, Pier Giovanni; Salvador, Maria Kimatrai; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Brancale, Andrea; Fu, Xian-Hua; Li, Jun; Zhang, Su-Zhan; Hamel, Ernest; et al. Journal of Medicinal Chemistry (2012), 55(11), 5433-5445.
  42. Water-Soluble Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as Human A3 Adenosine Receptor Antagonists. Baraldi, Pier Giovanni; Saponaro, Giulia; Romagnoli, Romeo; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Moorman, Allan R.; Cosconati, Sandro; Di Maro, Salvatore; Marinelli, Luciana; Gessi, Stefania; Delia Preti. Journal of Medicinal Chemistry (2012), 55(11), 5380-5390.
  43. Medicinal Chemistry of A3 Adenosine Receptor Modulators: Pharmacological Activities and Therapeutic Implications. Baraldi, Pier Giovanni; Preti, Delia; Borea, Pier Andrea; Varani, Katia. Journal of Medicinal Chemistry (2012), 55(12), 5676-5703.
  44. 7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: A promising approach for treating pain and inflammation. Baraldi, Pier Giovanni; Romagnoli, Romeo; Saponaro, Giulia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Pedretti, Pamela; Fusi, Camilla; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Preti, Delia. Bioorganic & Medicinal Chemistry (2012), 20(5), 1690-1698.
  45. Design, synthesis and biological evaluation of hybrid molecules containing conjugated styryl ketone and α-bromoacryloyl moieties. Romagnoli, Romeo; Baraldi, Pier Giovanni; Cruz-Lopez, Olga; Salvador, Maria Kimatrai; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Balzarini, Jan; Canella, Alessandro; Fabbri, Enrica; Gambari, Roberto. Letters in Drug Design & Discovery (2012), 9(2), 140-152.
  46. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Nassini Romina; Materazzi Serena; Vriens Joris; Prenen Jean; Benemei Silvia; De Siena Gaetano; la Marca Giancarlo; Andre Eunice; Preti Delia; Avonto Cristina; et al. Brain : a journal of neurology (2012), 135(Pt 2), 376-90.
  47. Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A1 adenosine receptor. Romagnoli, Romeo; Baraldi, Pier Giovanni; Carrion, Maria Dora; Cara, Carlota Lopez; Cruz-Lopez, Olga; Salvador, Maria Kimatrai; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Shryock, John C.; Moorman, Allan R.; et al. Bioorganic & Medicinal Chemistry (2012), 20(2), 996-1007.
  48. Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists. Baraldi, Pier Giovanni; Saponaro, Giulia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Romagnoli, Romeo; Moorman, Allan R.; Varani, Katia; Borea, Pier Andrea; Preti, Delia. Bioorganic & Medicinal Chemistry (2012), 20(2), 1046-1059.
  49. Novel 1,3-Dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as Potent and Selective A2B Adenosine Receptor Antagonists. Baraldi, Pier Giovanni; Baraldi, Stefania; Saponaro, Giulia; Preti, Delia; Romagnoli, Romeo; Piccagli, Laura; Cavalli, Andrea; Recanatini, Maurizio; Moorman, Allan R.; Abdel  Zaid, Naser; et al. Journal of Medicinal Chemistry (2012), 55(2), 797-811.
  50. Synthesis and Evaluation of 1,5-Disubstituted Tetrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative and Antitumor Activity. Romagnoli, Romeo; Baraldi, Pier Giovanni; Salvador, Maria Kimatrai; Preti, Delia; Aghazadeh Tabrizi, Mojgan; Brancale, Andrea; Fu, Xian-Hua; Li, Jun; Zhang, Su-Zhan; Hamel, Ernest; et al. Journal of Medicinal Chemistry (2012), 55(1), 475-488.
  51. New 2-Heterocyclyl-imidazo[2,1-i]purin-5-one Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. Baraldi, Pier Giovanni; Preti, Delia*; Zaid, Abdel Naser; Saponaro, Giulia; Tabrizi, Mojgan Aghazadeh; Baraldi, Stefania; Romagnoli, Romeo; Moorman, Allan R.; Varani, Katia; Cosconati, Sandro; Di Maro, Salvatore; Marinelli, Luciana; Novellino, Ettore; Borea, Pier Andrea. Journal of Medicinal Chemistry (2011), 54(14), 5205-5220.
  52. Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. Nassini, Romina; Gees, Maarten; Harrison, Selena; De Siena, Gaetano; Materazzi, Serena; Moretto, Nadia; Failli, Paola; Preti, Delia; Marchetti, Nicola; Cavazzini, Alberto; et al. Pain (2011), 152(7), 1621-1631.
  53. Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. Nassini R, Materazzi S, Andrè E, Sartiani L, Aldini G, Trevisani M, Carnini C, Massi D, Pedretti P, Carini M, Cerbai E, Preti D, Villetti G, Civelli M, Trevisan G, Azzari C, Stokesberry S, Sadofsky L, McGarvey L, Patacchini R, Geppetti P. FASEB J. (2010), 24(12), 4904-4916
  54. Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents. Baraldi, P G; Preti, D; Materazzi, S; Geppetti, P. J Med Chem (2010), 53(14), 5085-5107.
  55. Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents. Andre, E.; Gatti, R.; Trevisani, M.; Preti, D.; Baraldi, P. G.; Patacchini, R. British Journal of Pharmacology (2010), 159(4), 982.
  56. Adenosine Modulates HIF-1α, VEGF, IL-8, and Foam Cell Formation in a Human Model of Hypoxic Foam Cells. Gessi, S; Fogli, E; Sacchetto, V; Merighi, S; Varani, K; Preti, D; Leung, E; MacLennan, S; Borea, P A Arteriosclerosis, Thrombosis, and Vascular Biology (2010), 30(1), 90-97.
  57. α-Bromoacrylamido N-Substituted Isatin Derivatives as Potent Inducers of Apoptosis in Human Myeloid Leukemia Cells. Romagnoli, R; Baraldi, P G; Cruz-Lopez, O; Preti, D; Bermejo, J; Estevez, F. ChemMedChem (2009), 4(10), 1668-1676.
  58. Discovery of 8-methoxypyrazino[1,2-a]indole as a new potent antiproliferative agent against human leukemia K562 cells. a structure-activity relationship study. Romagnoli, R; Baraldi, P G; Carrion, M D; Cruz-Lopez, O; Cara, C L; Preti, D; Tabrizi, M A; Balzarini, J; Hamel, E; Fabbri, E;  et al. Letters in Drug Design & Discovery (2009), 6(4), 298-303.
  59. α-halogenoacrylic derivatives of antitumor agents. Romagnoli, R; Baraldi, Pi G; Cruz-Lopez, O; Lopez-Cara, C; Preti, D. Mini-Reviews in Medicinal Chemistry (2009), 9(1), 81-94.
  60. Recent improvements in the development of A2B adenosine receptor agonists. Baraldi, P G; Tabrizi, M A; Fruttarolo, F; Romagnoli, R; Preti, D. Purinergic Signalling (2009), 5(1), 3-19.
  61. Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents. Romagnoli, R; Baraldi, P G; Sarkar, T; Cara, C L; Lopez, O C; Carrion, M D; Preti, D; Tolomeo, M; Balzarini, J; Hamel, E. Medicinal Chemistry (2008), 4(6), 558-564.
  62. Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A3 adenosine receptor antagonists. Baraldi, P G; Preti, D; Tabrizi, M A; Romagnoli, R; Saponaro, G; Baraldi, S; Botta, M; Bernardini, C; Tafi, A; Tuccinardi, T;  et al. Bioorganic & Medicinal Chemistry (2008), 16(24), 10281-10294.
  63. Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[N-(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A1 Adenosine Receptor. Romagnoli, R; Baraldi, P G; Carrion, M D; Cara, C L; Cruz-Lopez, O; Iaconinoto, M A; Preti, D; Shryock, J C.; Moorman, A R.; Vincenzi, F;  et al. Journal of Medicinal Chemistry (2008), 51(18), 5875-5879.
  64. Design, synthesis, and biological evaluation of thiophene analogues of chalcones. Romagnoli, R; Baraldi, P G; Carrion, M D; Cara, C L; Cruz-Lopez, O; Preti, D; Tolomeo, M; Grimaudo, S; Di Cristina, A; Zonta, N;  et al. Bioorganic & Medicinal Chemistry (2008), 16(10), 5367-5376.
  65. The P2X7 receptor as a therapeutic target. Romagnoli, R; Baraldi, P G; Cruz-Lopez, O; Lopez-Cara, C; Preti, D; Borea, P A; Gessi, S. Expert Opinion on Therapeutic Targets (2008), 12(5), 647-661.
  66. 1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists. Tabrizi, M A; Baraldi, P G; Preti, D; Romagnoli, R; Saponaro, G; Baraldi, S; Moorman, A R.; Zaid, A N; Varani, K; Borea, P A. Bioorganic & Medicinal Chemistry (2008), 16(5), 2419-2430.
  67. Synthesis and Biological Evaluation of 1-Methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a New Class of Antimitotic Agents and Tubulin Inhibitors. Romagnoli, R; Baraldi, P Gi; Sarkar, T; Carrion, M D; Lopez C, Carlota; Cruz-Lopez, O; Preti, D; Tabrizi, M A; Tolomeo, M; Grimaudo, S;  et al. Journal of Medicinal Chemistry (2008), 51(5), 1464-1468.
  68. Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxyphenylsulfonyl)-5-aryl thiophenes as a new class of antitubulin agents. Romagnoli, R; Baraldi, P G; Remusat, V; Carrion, M D; Cara, C L; Cruz-Lopez, O; Preti, D; Fruttarolo, F; Tabrizi, M A; Balzarini, J;  et al. Medicinal Chemistry (2007), 3(6), 507-512.
  69. Microwave-assisted synthesis of substituted 2,4-diarylthiazoles and their evaluation as anticancer agents. Romagnoli, R; Baraldi, P G; Lopez, O C; Carrion, M D; Cara, C L; Preti, D; Tabrizi, M A; Balzarini, J Letters in Drug Design & Discovery (2007), 4(7), 464-466.
  70. Novel 8-heterocyclyl xanthine derivatives in drug development - an update. Baraldi, P G.; Fruttarolo, F; Tabrizi, M A.; Romagnoli, R; Preti, D. Expert Opinion on Drug Discovery (2007), 2(9), 1161-1183.
  71. Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and linked heterocycles as template for the adenosine receptor antagonism: medicinal chemistry approach and SAR considerations. Baraldi, P G; Romagnoli, R; El-Kashef, H; Tabrizi, M A; Preti, D; Pavani, M G; Zanella, L; Fruttarolo, F. Targets in Heterocyclic Systems (2006), 10, 175-196.
  72. From Tyrosine to Glycine: Synthesis and Biological Activity of Potent Antagonists of the Purinergic P2X7 Receptor. Romagnoli, R; Baraldi, P G; Carrion, M D; Cara, C L; Preti, D; Cruz-Lopez, O; Tabrizi, M A; Moorman, A R.; Gessi, S; Fogli, E;  et al. Journal of Medicinal Chemistry (2007), 50(15), 3706-3715.
  73. Allosteric enhancers for A1 adenosine receptor. Baraldi, P G; Iaconinoto, M A; Moorman, A R.; Carrion, M D; Cara, C L; Preti, D; Lopez, O C; Fruttarolo, F; Tabrizi, M A; Romagnoli, R. Mini-Reviews in Medicinal Chemistry (2007), 7(6), 559-569.
  74. Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and α-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukemia cells. Romagnoli, R; Baraldi, P G; Carrion, M D; Cruz-Lopez, O; Preti, D; Tabrizi, M A; Fruttarolo, F; Heilmann, J; Bermejo, J; Estevez, F. Bioorganic & Medicinal Chemistry Letters (2007), 17(10), 2844-2848.
  75. Synthesis of a new series of pyrazolo[1,5-a]pyrimidines structurally related to zaleplon. Baraldi, P G; Fruttarolo, F; Tabrizi, M A; Romagnoli, R; Preti, Delia; Ongini, E; El-Kashef, H; Carrion, M D; Borea, P A. Journal of Heterocyclic Chemistry (2007), 44(2), 355-361.
  76. Synthesis and Biological Evaluation of 2- and 3-Aminobenzo[b]thiophene Derivatives as Antimitotic Agents and Inhibitors of Tubulin Polymerization. Romagnoli, R; Baraldi, P G; Carrion, M D; Lopez C, Carlota; Preti, D; Fruttarolo, F; Pavani, Maria G; Tabrizi, M A; Tolomeo, M; Grimaudo, S;  et al. Journal of Medicinal Chemistry (2007), 50(9), 2273-2277.
  77. N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor. Baraldi, P G; Preti, D; Tabrizi, M A; Fruttarolo, F; Saponaro, G; Baraldi, S; Romagnoli, R; Moorman, A R.; Gessi, S; Varani, K;  et al. Bioorganic & Medicinal Chemistry (2007), 15(7), 2514-2527.
  78. Synthesis and Biological Evaluation of Novel 1-Deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide Derivatives as Useful Templates for the Development of A2B Adenosine Receptor Agonists. Baraldi, P G; Preti, D; Tabrizi, M A; Fruttarolo, F; Romagnoli, R; Carrion, M D; Cara, L C; Moorman, A R.; Varani, K; Borea, P A. Journal of Medicinal Chemistry (2007), 50(2), 374-380.
  79. Hybrid molecules between distamycin A and active moieties of antitumor agents. Baraldi, P G; Preti, D; Fruttarolo, F; Tabrizi, M A; Romagnoli, R. Bioorganic & Medicinal Chemistry (2007), 15(1), 17-35.
  80. Ligands for A2B adenosine receptor subtype. Baraldi, P G; Romagnoli, R; Preti, D; Fruttarolo, F; Carrion, M D; Tabrizi, M A. Current Medicinal Chemistry (2006), 13(28), 3467-3482.
  81. Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A1 receptor. Romagnoli, R; Baraldi, P G; Moorman, A R.; Iaconinoto, M A; Carrion, M D; Cara, C L; Tabrizi, M A; Preti, D; Fruttarolo, F; Baker, S P.;  et al. Bioorganic & Medicinal Chemistry Letters (2006), 16(21), 5530-5533.
  82. Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors. Romagnoli, R; Baraldi, P G; Remusat, V; Carrion, M D; Cara, C L; Preti, D; Fruttarolo, F; Pavani, M G; Tabrizi, M A; Tolomeo, M;  et al. Journal of Medicinal Chemistry (2006), 49(21), 6425-6428.
  83. Synthesis and Biological Evaluation of 2-Amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl Thiophenes as a New Class of Potent Antitubulin Agents. Romagnoli, R; Baraldi, P G; Pavani, M G; Tabrizi, M A; Preti, D; Fruttarolo, F; Piccagli, L; Jung, M. K; Hamel, E; Borgatti, M;  et al. Journal of Medicinal Chemistry (2006), 49(13), 3906-3915.
  84. Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine template: organic and medicinal chemistry approach. Baraldi, P G; Tabrizi, M A; Romagnoli, R; El-Kashef, H; Preti, D; Bovero, A; Fruttarolo, F; Gordaliza, M; Borea, P A. Current Organic Chemistry (2006), 10(3), 259-275.
  85. Hybrid molecules based on distamycin A as potential antitumor agents. Baraldi, P G; Zaid, A N; Preti, D; Fruttarolo, F; Tabrizi, M A; Iaconinoto, A; Pavani, M G; Carrion, M D; Cara, C L; Romagnoli, R. ARKIVOC (Gainesville, FL, United States) (2006), (7), 20-34.
  86. Recent improvements in the field of A3 adenosine receptor ligands. Baraldi, P G; Fruttarolo, F; Tabrizi, M A; Romagnoli, R; Preti, D; Carrion, M D; Iaconinoto, A; Borea, P A. Expert Opinion on Therapeutic Patents (2005), 15(11), 1507-1519.
  87. Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles. Romagnoli, R; Baraldi, P G; Jung, M. K; Iaconinoto, M A; Carrion, M D; Remusat, V; Preti, D; Tabrizi, M A; Francesca, F; De Clercq, E;  et al Bioorganic & Medicinal Chemistry Letters (2005), 15(18), 4048-4052.
  88. New 2-Arylpyrazolo[4,3-c]quinoline Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. Baraldi, P G; Tabrizi, M A; Preti, D; Bovero, A; Fruttarolo, F; Romagnoli, R; Zaid, N A; Moorman, A R.; Varani, K; Borea, P A. Journal of Medicinal Chemistry (2005), 48(15), 5001-5008.
  89. New Pyrrolo[2,1-f]purine-2,4-dione and Imidazo[2,1-f]purine-2,4-dione Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. Baraldi, P G; Preti, D; Tabrizi, M A; Fruttarolo, F; Romagnoli, R; Zaid, N A; Moorman, A R.; Merighi, S; Varani, K; Borea, P A. Journal of Medicinal Chemistry (2005), 48(14), 4697-4701.
  90. New heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2. Baraldi, P G; Romagnoli, R; Tabrizi, M A; Bovero, A; Preti, D; Fruttarolo, F; Moorman, A R.; Borea, P A. Farmaco (2005), 60(3), 185-202.
  91. Design, synthesis and growth inhibition activity of bis-epoxyethyl derivatives of stallimycin modified on the amidino moiety. Romagnoli, R; Baraldi, P G; Pavani, M G; Fruttarolo, F; Preti, D; Bovero, A; Tabrizi, M A; Bianchi, N; Gambari, R. Medicinal Chemistry Research (2004), 13(5), 282-296.
  92. Synthesis and Biological Evaluation of Novel N6-[4-(Substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 Adenosine Receptor Agonists. Baraldi, P G; Fruttarolo, F; Tabrizi, M A; Romagnoli, R; Preti, D; Bovero, A; Pineda de Infantas, M J; Moorman, A; Varani, K; Borea, PA. Journal of Medicinal Chemistry (2004), 47(22), 5535-5540.
  93. DNA minor groove binders as potential antitumor and antimicrobial agents. Baraldi, P G; Bovero, A; Fruttarolo, F; Preti, D; Tabrizi, M A; Pavani, M G; Romagnoli, R. Medicinal Research Reviews (2004), 24(4), 475-528.
  94. [3H]-MRE 2029-F20, a selective antagonist radioligand for the human A2B adenosine receptors. Baraldi, P G; Aghazadeh T, M; Preti, D; Bovero, A; Fruttarolo, F; Romagnoli, R; Moorman, AR.; Gessi, S; Merighi, S; Varani, K;  et al Bioorganic & Medicinal Chemistry Letters (2004), 14(13), 3607-3610.
  95. Design, Synthesis, and Biological Evaluation of New 8-Heterocyclic Xanthine Derivatives as Highly Potent and Selective Human A2B Adenosine Receptor Antagonists. Baraldi, PG; Tabrizi, M A; Preti, D; Bovero, A; Romagnoli, R; Fruttarolo, F; Zaid, N A; Moorman, A R.; Varani, K; Gessi, S;  et al. Journal of Medicinal Chemistry (2004), 47(6), 1434-1447.
  96. New strategies for the synthesis of A3 adenosine receptor antagonists. Baraldi, P G; Bovero, A; Fruttarolo, F; Romagnoli, R; Tabrizi, M A; Preti, D; Varani, K; Borea, P A; Moorman, A R. Bioorganic & Medicinal Chemistry (2003), 11(19), 4161-4169.
  97. Structure-activity relationships around the KN-62, a potent antagonist of the P2X7 receptor. P.G. Baraldi, Preti, D; M.G. Pavani, A. Bovero, A. Iaconinoto, M.A. Tabrizi, F. Fruttarolo, F. Di Virgilio, R. Romagnoli. Minerva Biotec, 2004, 16, 109-118.
  98. Recent developments in the field of A3 adenosine receptor antagonists. Baraldi, P G; Tabrizi, M A; Fruttarolo, F; Bovero, A; Avitabile, B; Preti, D; Romagnoli, R; Merighi, S; Gessi, S; Varani, Katia;  et al Drug Development Research (2003), 58(4), 315-329.
  99. Recent developments in the field of A2A and A3 adenosine receptor antagonists. Baraldi, P G; Tabrizi, M A; Bovero, A; Avitabile, B; Preti, D; Fruttarolo, F; Romagnoli, R; Varani, K; Borea, P A. European Journal of Medicinal Chemistry (2003), 38(4), 367-382.
  100. DNA minor-groove binders. Design, synthesis, and biological evaluation of ligands structurally related to CC-1065, distamycin, and anthramycin. Baraldi, PG; Tabrizi, M A; Preti, D; Fruttarolo, F; Avitabile, B; Bovero, A; Pavani, G; Nunez Carretero, M C; Romagnoli, R. Pure and Applied Chemistry (2003), 75(2-3), 187-194.
  101. Design, Synthesis, and Biological Evaluation of C9- and C2-Substituted Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as New A2A and A3 Adenosine Receptor Antagonists. Baraldi, P G; Fruttarolo, F; Tabrizi, M A; Preti, D; Romagnoli, R; El-Kashef, H; Moorman, A; Varani, K; Gessi, S; Merighi, S;  et al. Journal of Medicinal Chemistry (2003), 46(7), 1229-1241.

 

BOOK CHAPTERS

  1. NOP-Targeted Peptide Ligands. Preti, Delia; Calo, Girolamo; Guerrini, Remo. Handbook of Experimental Pharmacology (2019), 254, 17-36.
  2. Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering. Jacobson, K A.; Klutz, A M.; Tosh, D K.; Ivanov, A A.; Preti, D; Baraldi, P G. Handbook of Experimental Pharmacology (2009), 193(Adenosine Receptors in Health and Disease), 123-159.
  3. A3 Adenosine Receptor Antagonists: History and Future Perspectives. Pier Giovanni Baraldi, Romeo Romagnoli, Giulia Saponaro, Stefania Baraldi, Mojgan Aghazadeh Tabrizi, Delia Preti. In A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics, SPRINGER, 2010, pp 121-147

 

PATENTS

1) Compounds as NLRP3 inflammasome inhibitors and their use as medicaments.

Inventors: Pinton, Paolo; Giorgi, Carlotta; Missiroli, Sonia; Perrone, Mariasole; Pacifico, Salvatore; Albanese, Valentina.

Assignee: MAM - AGE S.R.L.

Patent N°: WO2023209109. A1. Nov 02, 2023.

2) Composti solfonammidici come inibitori dell’inflammasoma NLRP3 e loro uso come medicamenti.

Inventori: Carlotta Giorgi, Paolo Pinton, Delia Preti, Salvatore Pacifico, Valentina Albanese, Sonia Missiroli, Mariasole Perrone.

Assignee: MAM - AGE SRL, Italy.

Patent N°: 102022000008246. A1. Oct 27, 2023.

3) Composti pirrolidinici e piperidinici come inibitori dell’inflammasoma NLRP3 e loro uso come medicamenti.

Inventori: Carlotta Giorgi, Paolo Pinton, Delia Preti, Salvatore Pacifico, Valentina Albanese, Sonia Missiroli, Mariasole Perrone.

Assignee: MAM - AGE SRL, Italy.

Patent N°: 102022000008294. Oct 27, 2023

4) Composti tetraidroisochinolinici come inibitori dell’inflammasoma NLRP3 e loro uso come medicamenti.

Inventori: Carlotta Giorgi, Paolo Pinton, Delia Preti, Salvatore Pacifico, Valentina Albanese, Sonia Missiroli, Mariasole Perrone.

Assignee: MAM - AGE SRL, Italy..

Patent N°: 102022000008321. Oct 27, 2023

5) Derivati ureidici per il trattamento del danno da riperfusione.

Inventori: Pinton, Paolo; Giorgi, Carlotta; Preti, Delia; Tremolini, Elena; Trapella, Claudio; Morciano, Giampaolo.

Assignee: Maria Cecilia Hospital SpA, Italy.

Patent N°: 102022000002426. A1. Aug 10, 2023.

6) Nuovi agonisti misti mu/nop di tipo peptidico.

Inventori: Salvatore Pacifico, Valentina Albanese, Davide Illuminati, Claudio Trapella, Erika Marzola, Chiara Ruzza, Girolamo Calò, Delia Preti, Remo Guerrini.

Assignee: UFPEPTIDES SRL, Italy.

Patent N°: 102020000025972. A1. May 02, 2022.

7) 1,3,8-Triazaspiro compounds and their use as medicaments for the treatment of reperfusion injury.

Inventors: Pinton, Paolo; Ferrari, Roberto; Giorgi, Carlotta; Trapella, Claudio; Preti, Delia; Morciano, Giampaolo.

Assignee: Maria Cecilia Hospital SpA, Italy.

Patent N°: WO 2020021378. A1. Jan 30, 2020.

8) Composti 1,3,8-triazaspiro e loro uso come medicamenti.

Inventori: Pinton, Paolo; Ferrari, Roberto; Giorgi, Carlotta; Trapella, Claudio; Preti, Delia; Morciano, Giampaolo.

Assignee: Maria Cecilia Hospital SpA., Italy.

Patent N°: 102018000007580. Jan 27, 2020

9) Adenosine A3 receptor modulators.

Inventors: Baraldi, Pier Giovanni; Borea, Pier Andrea; Preti, Delia; Tabrizi, Mojgan Aghazadeh.

Assignee: King Pharmaceuticals Research and Development, Inc, USA.

Patent N°: US 7435740. B2. Oct 14, 2008.

10) Adenosine A2B receptor agonists.

Inventors: Baraldi, Pier Giovanni; Borea, Pier Andrea; Moorman, Allan R.; Preti, Delia.

Assignee: King Pharmaceuticals Research and Development, Inc, USA.

Patent N°: US 20070281902. A1. Dec 6, 2007.

11) Novel adenosine A3 receptor modulators.

Inventors: Baraldi, Pier; Borea, Pier Andrea; Preti, Delia; Tabrizi, Mojgan Aghazadeh.

Assignee: King Pharmaceuticals Research and Development, Inc, USA.

Patent N°: WO 2006083916. A2. Aug 10, 2006.