Education, training and professional experience:
12 July 1983. Scientific high school diploma at the “A.Roiti” State High School in Ferrara with a grade of 60/60.
18 July 1989. Degree in Medicine and Surgery from the University of Ferrara with a grade of 110/110 cum laude.
14 December 1989. Qualification to practice the profession of Medical Surgeon (University of Ferrara).
1 January 1991. Hiring at the Institute of Radiology, Department of Nuclear Medicine, Faculty of Medicine and Surgery - University of Ferrara, as a permanent Technical Collaborator - VII qualification, technical-scientific functional area and, from 1 September 1991, equated to the role of Hospital Medical Assistant for salary and assistance purposes.
27 October 1993. Medical specialization in Radiology (specialization in Radiodiagnostics and Imaging Science) with a grade of 50/50 at the School of Specialization - University of Ferrara.
5 November 1998. Medical specialization in Nuclear Medicine with a grade of 70/70 cum laude at the School of Specialization - University of Milan.
30 December 2002. Hiring at the Nuclear Medicine Section - Department of Clinical and Experimental Medicine - University of Ferrara, as a Confirmed Researcher under an agreement with the Arcispedale S.Anna University Hospital of Ferrara.
20 October 2003. Medical specialization in Cardiology with a grade of 50/50 cum laude at the School of Specialization - University of Ferrara.
18 December 2009. AIMN referent in the Scientific Committee of the Italian Group of Nuclear Cardiology (GICN) with appointment by the Board of Directors of the Italian Association of Nuclear Medicine (AIMN).
31 December 2010. Holder of a professional position of particular qualification “Nuclear Cardiology” within the Complex Operating Unit of Nuclear Medicine - Department of Integrated Diagnostic Imaging and Laboratory Medicine.
1 November 2013. Professional position holder of Simple Operating Unit “Nuclear Cardiology and Technological Innovation” within the Complex Operating Unit of Nuclear Medicine - Department of Integrated Diagnostic Imaging and Laboratory Medicine.
17 December 2014. Advanced Course in “Management for the Direction of Complex Healthcare Facilities” at the University of Ferrara with a grade of 30/30 cum laude.
17 October 2015 - 30 Giugno 2016. Appointment of Acting Director of the Complex Operating Unit of Nuclear Medicine of the Integrated Activity Department of Diagnostic Imaging and Laboratory Medicine by the General Management of the University Hospital of Ferrara.
15 May 2017 - 22 Settembre 2020. Coordinator of the Course of Study in “Techniques of Medical Radiology, Imaging and Radiotherapy” - University of Ferrara.
1 December 2022. Hiring at the Department of Translational Medicine - University of Ferrara, as Associate Professor MED/36 (MEDS-22/A) under an agreement with the Complex Operating Unit of Nuclear Medicine - Arcispedale S.Anna University Hospital of Ferrara.
20 December 2022. Director of the School of Specialization in Nuclear Medicine at the University of Ferrara.
May 2007 - December 2017. Member of the Board of the Department of Diagnostic Imaging and Laboratory Medicine of the S.Anna University Hospital of Ferrara.
January 2018 - 30 May 2023. Member of the Board of the Oncology Department - Medical Specialist of the S.Anna University Hospital of Ferrara.
From 1 June 2023 to date. Member of the Board of the newly established Department of Onco-Hematology of the S.Anna University Hospital of Ferrara.
Member of the Italian Association of Nuclear Medicine (AIMN) since 5 November 1990, of the Society of Nuclear Medicine (SNM) since 1 November 1992 and of the European Association of Nuclear Medicine (EANM) since 1 January 2006.
Teaching activities:
- From the Academic Year 2002/03 to date he has been the holder of teachings in the following Study Courses:
- Master’s Degree in Medicine and Surgery from the University of Ferrara;
- Bachelor's Degree in Health Professions in Medical Radiology Techniques, Imaging
and Radiotherapy at the University of Ferrara;
- Bachelor's Degree in Health Professions in Professional Education at the University
of Ferrara in collaboration with the University of Trento;
- Bachelor's Degree in Health Professions in Nursing from the University of Ferrara –
Adria Campus (RO).
- From the Academic Year 2002/03 to date he has held teaching positions in the following Specialization Schools:
- Nuclear Medicine of the University of Ferrara;
- Nuclear Medicine of the University of Bologna;
- Cardiovascular diseases of the University of Ferrara;
- Radiodiagnostics of the University of Ferrara;
- Neurology of the University of Ferrara;
- Geriatrics of the University of Ferrara.
- From the Academic Year 1991/92 to date he has carried out regular cycles of theoretical and practical exercises in Nuclear Medicine, within the Integrated Course in “Diagnostic Imaging”, for students in the third, fourth and fifth years of the Master's Degree in Medicine and Surgery at the University of Ferrara.
- In 2005, 2006, 2008, 2010, 2012 and 2013 he was also a lecturer in the Master's Degree "Science and Technology of Radiopharmaceuticals" organized by the University of Ferrara, dealing with the topic entitled "Elements of Nuclear Medicine" for 12 hours/year.
- Supervisor of experimental theses (from the Academic Year 1991/92 to date) for the Courses:
- Master’s Degree in Medicine and Surgery from the University of Ferrara;
- Bachelor’s Degree in Health Professions in Medical Radiology Techniques,
Imaging and Radiotherapy at the University of Ferrara
- School of Specialization in Nuclear Medicine - University of Ferrara
- School of Specialization in Cardiovascular Diseases - University of Ferrara
- He has also been a speaker and/or moderator at numerous courses of national and international relevance.
Research activities:
Nuclear Cardiology
1. Preclinical Phase I and II studies in the development of new radiopharmaceuticals for myocardial perfusion investigations (99mTc-NOEt and 99mTc-DBODC).
2. Prognostic assessment of chronic ischemic heart disease by myocardial gated-SPECT applied to particular patient populations: (a) diabetic subjects; (b) pacemaker wearers.
3. Comparative studies of diagnostic efficacy between imaging methods in the field of chronic ischemic heart disease (myocardioscintigraphy vs. echotomography).
4. Myocardial scintigraphy evaluation in patients with subacute and chronic myocardial infarction subjected to stimulating factors aimed at mobilizing stem cells in the bone marrow.
5. Study on the incremental prognostic value of the evaluation of the coronary calcium score associated with the stress-rest scintigraphic study of myocardial perfusion performed with the gated-SPECT-CT technique.
6. Prognostic meaning of post-ischemic stunning assessed by gated-SPECT myocardial perfusion in patients with suspected or known ischemic heart disease.
Nuclear Neurology
1. Use of cerebral perfusion tracers in the evaluation of neurological involvement in rheumatological pathology (neuro-SLE, neuro-Behçet, antiphospholipid antibody disease).
2. Comparative studies of diagnostic efficacy between imaging methods in the field of rheumatological pathologies involving the CNS (brain scintigraphy vs. MR spectroscopy).
3. Preclinical studies evaluating the retention of 99mTc-HMPAO in nervous tissue in experimental models of acute ischemia.
4. Prospective study of perfusion variations and cerebral ventricular volumes assessed by SPECT-CT in patients with chronic cerebrospinal venous insufficiency (CCSVI) and undergoing surgery to remove venous malformation of the neck vessels by reconstruction with autologous vein patch.
5. Quantification of cerebral β-amyloid accumulation by PET-CT with 18F-Florbetapir in subjects with clinical-instrumental suspicion of involutional syndrome on a neurodegenerative basis.
6. Comparison study between cerebral PET of metabolism conducted with 18F-FDG vs cerebral flow study with early acquisition of PET images after administration of 18F-Florbetapir.
Nuclear Oncology and Radiometabolic Therapy
1. Preclinical studies on the formulation of kits for the preparation of 90Y-lipiodol and 188Re-lipiodol and subsequent preliminary clinical use in patients with hepatocarcinoma.
2. Evaluation and validation of the sentinel lymph node technique and lymphoscintigraphy applied in various pathologies and body districts (breast, thyroid, prostate, vulva, penis, oral cavity tumors and cutaneous melanoma).
3. Validation of the Axillary Reverse Mapping (ARM) investigation, developed to map and preserve the lymphatic drainage of the arm during axillary drainage or even simply during sentinel lymph node removal.
4. Evaluation of SUV value variations of 18F-FDG-absorbing lung and lymph node lesions by applying different acquisition/reconstruction algorithms to images obtained using a latest-generation hybrid tomograph.
5. Value of fiberoptic bronchoscopy as an adjunct to 18F-FDG PET-CT in the differentiation of solitary pulmonary nodules.
6. Prognostic value of SUVmax assessed by 68Ga-DOTATOC PET-CT in patients with advanced neuroendocrine neoplasia.
7. Coordination of a multicenter observational study on radionuclide therapy with 89Sr-chloride for the palliation of painful bone metastases.
Health Care activities:
- From 1991 to date he has carried out regular and continuous healthcare activities under an agreement at the Complex Structure of Nuclear Medicine (currently directed by Dr. Mirco Bartolomei) of the University Hospital of Ferrara.
- During the period in question, he personally reported over 28,000 diagnostic scintigraphic investigations and performed over 200 radiometabolic treatments in an outpatient setting for hyperthyroidism or in patients for palliation of painful bone metastases with β-emitting drugs.
Since January 2014, he has been among the coordinators of the periodic meetings - aimed at the integrated discussion of clinical cases - of the “Multidisciplinary Group on Cognitive Decline” of the University Hospital of Ferrara, organized jointly by the Neurology, Geriatrics, University Internal Medicine, Neuroradiology and Nuclear Medicine Units.
Since August 2021, he has been a member of the board of the PDTA (Diagnostic Therapeutic Assistance Pathway) for the breast at the University Hospital of Ferrara.
12 July 1983. Scientific high school diploma at the “A.Roiti” State High School in Ferrara with a grade of 60/60.
18 July 1989. Degree in Medicine and Surgery from the University of Ferrara with a grade of 110/110 cum laude.
14 December 1989. Qualification to practice the profession of Medical Surgeon (University of Ferrara).
1 January 1991. Hiring at the Institute of Radiology, Department of Nuclear Medicine, Faculty of Medicine and Surgery - University of Ferrara, as a permanent Technical Collaborator - VII qualification, technical-scientific functional area and, from 1 September 1991, equated to the role of Hospital Medical Assistant for salary and assistance purposes.
27 October 1993. Medical specialization in Radiology (specialization in Radiodiagnostics and Imaging Science) with a grade of 50/50 at the School of Specialization - University of Ferrara.
5 November 1998. Medical specialization in Nuclear Medicine with a grade of 70/70 cum laude at the School of Specialization - University of Milan.
30 December 2002. Hiring at the Nuclear Medicine Section - Department of Clinical and Experimental Medicine - University of Ferrara, as a Confirmed Researcher under an agreement with the Arcispedale S.Anna University Hospital of Ferrara.
20 October 2003. Medical specialization in Cardiology with a grade of 50/50 cum laude at the School of Specialization - University of Ferrara.
18 December 2009. AIMN referent in the Scientific Committee of the Italian Group of Nuclear Cardiology (GICN) with appointment by the Board of Directors of the Italian Association of Nuclear Medicine (AIMN).
31 December 2010. Holder of a professional position of particular qualification “Nuclear Cardiology” within the Complex Operating Unit of Nuclear Medicine - Department of Integrated Diagnostic Imaging and Laboratory Medicine.
1 November 2013. Professional position holder of Simple Operating Unit “Nuclear Cardiology and Technological Innovation” within the Complex Operating Unit of Nuclear Medicine - Department of Integrated Diagnostic Imaging and Laboratory Medicine.
17 December 2014. Advanced Course in “Management for the Direction of Complex Healthcare Facilities” at the University of Ferrara with a grade of 30/30 cum laude.
17 October 2015 - 30 Giugno 2016. Appointment of Acting Director of the Complex Operating Unit of Nuclear Medicine of the Integrated Activity Department of Diagnostic Imaging and Laboratory Medicine by the General Management of the University Hospital of Ferrara.
15 May 2017 - 22 Settembre 2020. Coordinator of the Course of Study in “Techniques of Medical Radiology, Imaging and Radiotherapy” - University of Ferrara.
1 December 2022. Hiring at the Department of Translational Medicine - University of Ferrara, as Associate Professor MED/36 (MEDS-22/A) under an agreement with the Complex Operating Unit of Nuclear Medicine - Arcispedale S.Anna University Hospital of Ferrara.
20 December 2022. Director of the School of Specialization in Nuclear Medicine at the University of Ferrara.
May 2007 - December 2017. Member of the Board of the Department of Diagnostic Imaging and Laboratory Medicine of the S.Anna University Hospital of Ferrara.
January 2018 - 30 May 2023. Member of the Board of the Oncology Department - Medical Specialist of the S.Anna University Hospital of Ferrara.
From 1 June 2023 to date. Member of the Board of the newly established Department of Onco-Hematology of the S.Anna University Hospital of Ferrara.
Member of the Italian Association of Nuclear Medicine (AIMN) since 5 November 1990, of the Society of Nuclear Medicine (SNM) since 1 November 1992 and of the European Association of Nuclear Medicine (EANM) since 1 January 2006.
Teaching activities:
- From the Academic Year 2002/03 to date he has been the holder of teachings in the following Study Courses:
- Master’s Degree in Medicine and Surgery from the University of Ferrara;
- Bachelor's Degree in Health Professions in Medical Radiology Techniques, Imaging
and Radiotherapy at the University of Ferrara;
- Bachelor's Degree in Health Professions in Professional Education at the University
of Ferrara in collaboration with the University of Trento;
- Bachelor's Degree in Health Professions in Nursing from the University of Ferrara –
Adria Campus (RO).
- From the Academic Year 2002/03 to date he has held teaching positions in the following Specialization Schools:
- Nuclear Medicine of the University of Ferrara;
- Nuclear Medicine of the University of Bologna;
- Cardiovascular diseases of the University of Ferrara;
- Radiodiagnostics of the University of Ferrara;
- Neurology of the University of Ferrara;
- Geriatrics of the University of Ferrara.
- From the Academic Year 1991/92 to date he has carried out regular cycles of theoretical and practical exercises in Nuclear Medicine, within the Integrated Course in “Diagnostic Imaging”, for students in the third, fourth and fifth years of the Master's Degree in Medicine and Surgery at the University of Ferrara.
- In 2005, 2006, 2008, 2010, 2012 and 2013 he was also a lecturer in the Master's Degree "Science and Technology of Radiopharmaceuticals" organized by the University of Ferrara, dealing with the topic entitled "Elements of Nuclear Medicine" for 12 hours/year.
- Supervisor of experimental theses (from the Academic Year 1991/92 to date) for the Courses:
- Master’s Degree in Medicine and Surgery from the University of Ferrara;
- Bachelor’s Degree in Health Professions in Medical Radiology Techniques,
Imaging and Radiotherapy at the University of Ferrara
- School of Specialization in Nuclear Medicine - University of Ferrara
- School of Specialization in Cardiovascular Diseases - University of Ferrara
- He has also been a speaker and/or moderator at numerous courses of national and international relevance.
Research activities:
Nuclear Cardiology
1. Preclinical Phase I and II studies in the development of new radiopharmaceuticals for myocardial perfusion investigations (99mTc-NOEt and 99mTc-DBODC).
2. Prognostic assessment of chronic ischemic heart disease by myocardial gated-SPECT applied to particular patient populations: (a) diabetic subjects; (b) pacemaker wearers.
3. Comparative studies of diagnostic efficacy between imaging methods in the field of chronic ischemic heart disease (myocardioscintigraphy vs. echotomography).
4. Myocardial scintigraphy evaluation in patients with subacute and chronic myocardial infarction subjected to stimulating factors aimed at mobilizing stem cells in the bone marrow.
5. Study on the incremental prognostic value of the evaluation of the coronary calcium score associated with the stress-rest scintigraphic study of myocardial perfusion performed with the gated-SPECT-CT technique.
6. Prognostic meaning of post-ischemic stunning assessed by gated-SPECT myocardial perfusion in patients with suspected or known ischemic heart disease.
Nuclear Neurology
1. Use of cerebral perfusion tracers in the evaluation of neurological involvement in rheumatological pathology (neuro-SLE, neuro-Behçet, antiphospholipid antibody disease).
2. Comparative studies of diagnostic efficacy between imaging methods in the field of rheumatological pathologies involving the CNS (brain scintigraphy vs. MR spectroscopy).
3. Preclinical studies evaluating the retention of 99mTc-HMPAO in nervous tissue in experimental models of acute ischemia.
4. Prospective study of perfusion variations and cerebral ventricular volumes assessed by SPECT-CT in patients with chronic cerebrospinal venous insufficiency (CCSVI) and undergoing surgery to remove venous malformation of the neck vessels by reconstruction with autologous vein patch.
5. Quantification of cerebral β-amyloid accumulation by PET-CT with 18F-Florbetapir in subjects with clinical-instrumental suspicion of involutional syndrome on a neurodegenerative basis.
6. Comparison study between cerebral PET of metabolism conducted with 18F-FDG vs cerebral flow study with early acquisition of PET images after administration of 18F-Florbetapir.
Nuclear Oncology and Radiometabolic Therapy
1. Preclinical studies on the formulation of kits for the preparation of 90Y-lipiodol and 188Re-lipiodol and subsequent preliminary clinical use in patients with hepatocarcinoma.
2. Evaluation and validation of the sentinel lymph node technique and lymphoscintigraphy applied in various pathologies and body districts (breast, thyroid, prostate, vulva, penis, oral cavity tumors and cutaneous melanoma).
3. Validation of the Axillary Reverse Mapping (ARM) investigation, developed to map and preserve the lymphatic drainage of the arm during axillary drainage or even simply during sentinel lymph node removal.
4. Evaluation of SUV value variations of 18F-FDG-absorbing lung and lymph node lesions by applying different acquisition/reconstruction algorithms to images obtained using a latest-generation hybrid tomograph.
5. Value of fiberoptic bronchoscopy as an adjunct to 18F-FDG PET-CT in the differentiation of solitary pulmonary nodules.
6. Prognostic value of SUVmax assessed by 68Ga-DOTATOC PET-CT in patients with advanced neuroendocrine neoplasia.
7. Coordination of a multicenter observational study on radionuclide therapy with 89Sr-chloride for the palliation of painful bone metastases.
Health Care activities:
- From 1991 to date he has carried out regular and continuous healthcare activities under an agreement at the Complex Structure of Nuclear Medicine (currently directed by Dr. Mirco Bartolomei) of the University Hospital of Ferrara.
- During the period in question, he personally reported over 28,000 diagnostic scintigraphic investigations and performed over 200 radiometabolic treatments in an outpatient setting for hyperthyroidism or in patients for palliation of painful bone metastases with β-emitting drugs.
Since January 2014, he has been among the coordinators of the periodic meetings - aimed at the integrated discussion of clinical cases - of the “Multidisciplinary Group on Cognitive Decline” of the University Hospital of Ferrara, organized jointly by the Neurology, Geriatrics, University Internal Medicine, Neuroradiology and Nuclear Medicine Units.
Since August 2021, he has been a member of the board of the PDTA (Diagnostic Therapeutic Assistance Pathway) for the breast at the University Hospital of Ferrara.
