Pubblicazioni

 

  1. Simoni, D.; Rizzi, M.; Rondanin, R.; Baruchello, R.; Marchetti, P.; Invidiata, F.P.; Labbozzetta, M.; Poma, P.; Carina, V.; Notarbartolo, M.; Alaimoc, A.; D’Alessandro, N. Antitumor effects of curcumin and structurally b-diketone modified analogs on multidrug resistant cancer cells. Bioorg. Med. Chem. Lett. 2008, 18, 845–849.

 

  1.  Simoni, D.; Romagnoli, R.; Baruchello, R.; Rondanin, R.; Grisolia,  G.; Eleopra, M.; Rizzi, M.; Giannini, G.; Aloatti, D.; Castorina, M.; Marcellini, M.; Pisano C.Novel A-Ring and B-Ring Modified Combretastatin A-4 (CA-4) Analogs Endowed with Interesting Cytotoxic Activity. J. Med. Chem. 2008, 51, 6211-6215.

 

  1. Simoni, D.; Gebbia, N.; Invidiata, F.P.; Eleopra, M.; Marchetti, P.; Rondanin, R.; Baruchello, R.; Tolomeo, M.; Marinelli,L.; Limongelli, V.; Novellino, E.; Buccheri, S.; Caccamo, N.; Dieli, F. Design and Synthesis of Novel Aminobisphosphonates (N-BPs) Possessing in Vivo Antitumor Activity Through a gd-T Lymphocytes-Mediated Activation Mechanism. J. Med. Chem. 2008, 51, 6800-6807.

 

  1. Simoni, D.; Rondanin, R.; Baruchello, R.; Rizzi, M.; Grisolia, G.; Eleopra, M.; Grimaudo, S.; Di Cristina, A.; Pipitone, M.R.; Bongiorno, M.R.; Aricò, M.; Invidiata, F.P.; Tolomeo, M. Novel Terphenyls and 3,5-Diaryl Isoxazole Derivatives Endowed with Growth Supporting and Antiapoptotic Properties. J. Med. Chem. 2008 51, 4796-4803.

 

  1. Simoni, D.; Roberti, M.; Invidiata, F. P.; Aiello, E.; Aiello, S.; Marchetti, P.; Baruchello, R.; Eleopra, M.; Di Cristina, A.; Grimaudo, S.; Gebbia, N.; Crosta, L.; Dieli, F.; Tolomeo, M. Stilbene-based anticancer agents: Resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism. Bioorg. Med. Chem. Lett. 2006, 16, 3245-3248.

 

  1. Simoni, D.; Romagnoli, R.; Baruchello, R.; Rondanin, R.; Rizzi, M.; Pavani, M. G.; Alloatti, D.; Giannini, G.; Marcellini, M.; Riccioni, T.; Castorina, M.; Guglielmi, M. B.; Bucci, F.; Carminati, P.; Pisano, C. Novel combretastatin analogues endowed with antitumor activity. J. Med. Chem. 2006, 49, 3143-3152.

 

  1. Simoni, D.; Rossi, M.; Rondanin, R.; Baruchello, R.; Grisolia, G.; Eleopra, M.; Giovannini, R.; Bozzoli, A.; Davalli, S.; Di Fabio, R.; Donati, D. A practical entry to C18-constrained-E-ring analogues of methyllycaconitine (MLA): a concise new stereoselective approach to 8-oxa-decahydroisoquinolines accompanied by a simple microwaves-assisted synthesis of the succinimidobenzoate appendage of MLA. Tetrahedron Lett. 2005, 46, 759-762.

 

  1. Simoni, D.; Grisolia, G.; Giannini, G.; Roberti, M.; Rondanin, R.; Piccagli, L.; Baruchello, R.; Rossi, M.; Romagnoli, R.; Invidiata, F. P.; Grimaudo, S.; Jung, M. K.; Hamel, E.; Gebbia, N.; Crosta, O. L.; Abbadessa, O. V.; Di Cristina, A.; Dusonchet, L.; Meli, M.; Tolomeo, M. Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines. J. Med. Chem. 2005, 48, 723-736. 

 

  1. Tolomeo, M.; Grimaudo, S.; Di C., A.; Roberti, M.; Pizzirani, D.; Meli, M.; Dusonchet, L.; Gebbia, N.; Abbadessa, V.; Crosta, L.; Baruchello, R.; Grisolia, G.; Invidiata, F.; Simoni, D. Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells. Int. J. Biochem. Cell Biol. 2005, 37, 1709-1726.

 

  1. Simoni, D.; Giannini, G.; Roberti, M.; Rondanin, R.; Baruchello, R.; Rossi, M.; Grisolia, G.; Invidiata, F. P.; Aiello, S.; Marino, S.; Cavallini, S.; Siniscalchi, A.; Gebbia, N.; Crosta, L.; Grimaudo, S.; Abbadessa, V.; Di Cristina, A.; Tolomeo, M. Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells. J. Med. Chem. 2005, 48, 4293-4299.

 

  1. Simoni, D.; Rossi, M.; Bertolasi, V.; Roberti, M.; Pizzirani, D.; Rondanin, R.; Baruchello, R.; Invidiata, F. P.; Tolomeo, M.; Grimaudo, S.; Merighi, S.; Varani, K.; Gessi, S.; Borea, P. A.; Marino, S.; Cavallini, S.; Bianchi, C.; Siniscalchi, A. Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter. J. Med. Chem. 2005, 48, 3337-3343.

 

  1. Simoni, D.; Giannini, G.; Baraldi, P. G.; Romagnoli, R.; Roberti, M.; Rondanin, R.; Baruchello, R.; Grisolia, G.; Rossi, M.; Mirizzi, D.; Invidiata, F. P.; Grimaudo, S.; Tolomeo, M. A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol. Tetrahedron Lett. 2003, 44, 3005-3008.

 

  1. Roberti, M.; Pizzirani, D.; Simoni, D.; Rondanin, R.; Baruchello, R.; Bonora, C.; Buscemi, F.; Grimaudo, S.; Tolomeo, M. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J. Med. Chem. 2003, 46, 3546-3554.

 

  1. Simoni, D.; Roberti, M.; Rondanin, R.; Baruchello, R.; Rossi, M.; Invidiata, F. P.; Merighi, S.; Varani, K.; Gessi, S.; Borea, P. A.; Marino, S.; Cavallini, S.; Bianchi, C.; Siniscalchi, A. Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter. Bioorg. Med. Chem. Lett. 2001, 11, 823-827.

 

  1. Simoni, D.; Roberti, M.; Invidiata, F. P.; Rondanin, R.; Baruchello, R.; Malagutti, C.; Mazzali, A.; Rossi, M.; Grimaudo, S.; Capone, F.; Dusonchet, L.; Meli, M.; Raimondi, M. V.; Landino, M.; D'Alessandro, N.; Tolomeo, M.; Arindam, D.; Lu, S.; Benbrook, D. M. Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells. J. Med. Chem. 2001, 44, 2308-2318.

 

  1. Simoni, D.; Rondanin, R.; Baruchello, R.; Roberti, M.; Rossi, M.; Grimaudo, S.; D'Alessandro, N.; Invidiata, F. P.; Tolomeo, M. Retinoic acid and analogs as potent inducers of differentiation and apoptosis. new promising chemopreventive and chemotherapeutic agents in oncology. Pure and Applied Chemistry 2001, 73, 1437-1444.

 

  1. Grimaudo S., Tolomeo M., Capone F., Pagliaro M., Rondanin R., Baruchello R., Simoni D., Mariani G. Effects of AC7739, a water-soluble amino derivative of combretastatin A-4, in multidrug-resistant and apoptosis-resistant leukemia cell lines. Blood 2001, 98, 445.

 

  1. Simoni, D.; Rondanin, R.; Morini, M.; Baruchello, R.; Invidiata, F. P. 1,5,7-Triazabicyclo[4.4.0]dec-1-ene (TBD), 7-methyl-TBD (MTBD) and polymer-supported TBD (P-TBD): three efficient catalysts for the nitroaldol (Henry) reaction and for the addition of dialkyl phosphites to unsaturated systems. Tetrahedron Lett. 2000, 41, 1607-1610.

 

  1. Roberti, M.; Rondanin, R.; Ferroni, R.; Baruchello, R.; Invidiata, F. P.; Andrisano, V.; Bertucci, C.; Bertolasi, V.; Grimaudo, S.; Tolomeo, M.; Simoni, D. Pig liver esterase (PLE)-mediated resolution of N-substituted 4-benzoyloxy-3-carbomethoxypiperidines: a convenient preparation of 4-hydroxy- and 4-benzoyloxy-3-carbomethoxypiperidines in enantiomerically pure form. Tetrahedron: Asymmetry 2000, 11, 4397-4405.

 

  1. Simoni, D.; Roberti, M.; Paolo Invidiata, F.; Rondanin, R.; Baruchello, R.; Malagutti, C.; Mazzali, A.; Rossi, M.; Grimaudo, S.; Dusonchet, L.; Meli, M.; Raimondi, M. V.; D'Alessandro, N.; Tolomeo, M. Programmed cell death (PCD) associated with the stilbene motif of arotinoids: discovery of novel apoptosis inducer agents possessing activity on multidrug resistant tumor cells. Bioorg. Med. Chem. Lett. 2000, 10, 2669-2673.

 

  1. Simoni, D.; Rossi, M.; Rondanin, R.; Mazzali, A.; Baruchello, R.; Malagutti, C.; Roberti, M.; Invidiata, F. P. Strong bicyclic guanidine base-promoted Wittig and Horner-Wadsworth-Emmons reactions. Organic Letters 2000, 2, 3765-3768.

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