CURRICULUM OF 'SCIENTIFIC
Paolo Marchetti was born in Mantova on 13.5.1959.
December 1987 Degree in Chemistry and Pharmaceutical Technology at the Faculty of Farmacy (University of Ferrara).
THESIS TITLE: 2-Halogen-amides. Electrocarboxylation-alkylation reactions and stereochemistry studies. Advisor: Prof. Ferruccio D'Angeli.
January-October 1988 Research in the field of Organic Chemistry, as an assistant interior, at the Department of Pharmaceutical Sciences, University of Ferrara.
November 1988 - November 1991 He obtained admission to the frequency of the fourth cycle Ph.D. in Pharmaceutical Science at the Department of Pharmaceutical Sciences, University of Ferrara.
Within the PhD (supervisor: Prof. F. D'Angeli) conducts research in collaboration with the Departments of Chemistry (University of Ferrara), Physical Chemistry and Pharmacology (University of Padova), Microbiology (University of Trieste). The research was conducted along the following lines.
1) Synthesis of racemic 2-haloamides and hetero-cyclization reactions studies.
2) Synthesis of chiral 2-halonopropanamides from alanine. Chemical and stereochemical studies of the halogen replacement by nitrogen-containing nucleophiles (amines).
3) Reactions of 2-bromoisobutiramides with oxygen-containing nucleophiles (alcohols or simple monosaccharides). Synthesis of neo-glycopeptides.
4) Biological activity: interaction with receptors, opioid activity, rate of heart block; mutagenic action.
February 1992. He presented the work of the Doctoral Thesis.
THESIS TITLE: Transformation of a natural amino acid in N-alkyl derivatives via chiral 2-bromoamides. Preliminary applications to peptides and biological studies.
June 1992 He holds a Ph.D. in Pharmaceutical Science.
November 1991-March 1993 Research in the field of Organic Chemistry, as an assistant interior, at the Department of Pharmaceutical Sciences, University of Ferrara. The research on the reactions between 2-bromoamides and nitrogen-containing nucleophiles was extended and applied using as nucleophile the amine group of various natural amino acids eventually with protected side chain and/or carboxy moiety.
Since 1993 Research fellow, Organic Chemistry Group (C/O6), relating to the degree course in Chemistry and Pharmaceutical Technology, Faculty of Pharmacy, Department of Pharmaceutical Sciences.
Paolo Marchetti was born in Mantova on 13.5.1959.
December 1987 Degree in Chemistry and Pharmaceutical Technology at the Faculty of Farmacy (University of Ferrara).
THESIS TITLE: 2-Halogen-amides. Electrocarboxylation-alkylation reactions and stereochemistry studies. Advisor: Prof. Ferruccio D'Angeli.
January-October 1988 Research in the field of Organic Chemistry, as an assistant interior, at the Department of Pharmaceutical Sciences, University of Ferrara.
November 1988 - November 1991 He obtained admission to the frequency of the fourth cycle Ph.D. in Pharmaceutical Science at the Department of Pharmaceutical Sciences, University of Ferrara.
Within the PhD (supervisor: Prof. F. D'Angeli) conducts research in collaboration with the Departments of Chemistry (University of Ferrara), Physical Chemistry and Pharmacology (University of Padova), Microbiology (University of Trieste). The research was conducted along the following lines.
1) Synthesis of racemic 2-haloamides and hetero-cyclization reactions studies.
2) Synthesis of chiral 2-halonopropanamides from alanine. Chemical and stereochemical studies of the halogen replacement by nitrogen-containing nucleophiles (amines).
3) Reactions of 2-bromoisobutiramides with oxygen-containing nucleophiles (alcohols or simple monosaccharides). Synthesis of neo-glycopeptides.
4) Biological activity: interaction with receptors, opioid activity, rate of heart block; mutagenic action.
February 1992. He presented the work of the Doctoral Thesis.
THESIS TITLE: Transformation of a natural amino acid in N-alkyl derivatives via chiral 2-bromoamides. Preliminary applications to peptides and biological studies.
June 1992 He holds a Ph.D. in Pharmaceutical Science.
November 1991-March 1993 Research in the field of Organic Chemistry, as an assistant interior, at the Department of Pharmaceutical Sciences, University of Ferrara. The research on the reactions between 2-bromoamides and nitrogen-containing nucleophiles was extended and applied using as nucleophile the amine group of various natural amino acids eventually with protected side chain and/or carboxy moiety.
Since 1993 Research fellow, Organic Chemistry Group (C/O6), relating to the degree course in Chemistry and Pharmaceutical Technology, Faculty of Pharmacy, Department of Pharmaceutical Sciences.
