Publication
Selected references of Bianchi N.:
- Bianchi N., Passadore M., Rutigliano C., Feriotto G., Mischiati C., Gambari R. (1996) Targeting of the Sp1 binding sites of HIV-1 long terminal repeat with chromomycin: disruption of nuclear factor · DNA complexes and inhibition of in vitro transcription. Biochemical Pharmacology, vol. 52, pag. 1489-1498. DOI: 10.1016/S0006-2952(96)00510-2
- Bianchi N., Rutigliano C., Passadore M., Tomassetti M., Pippo L., Mischiati C., Feriotto G., Gambari R. (1997) Targeting of the HIV-1 long terminal repeat with chromomycin potentiates the inhibitory effects of a triplex-forming oligonucleotide on Sp1-DNA interactions and in vitro transcription. Biochemical Journal, vol. 326, pag. 919-927. DOI: 10.1042/bj3260919
- Bianchi N., Osti F., Rutigliano C., Ginanni Corradini F., Borsetti E., Tomassetti M., Mischiati C., Feriotto G., Gambari R. (1999) The DNA-binding drugs mithramycin and chromomycin are powerful inducers of erythroid differentiation of human K562 cells. British Journal of Haematology, vol. 104, pag. 258-265. DOI: 10.1046/j.1365-2141.1999.01173.x
- Fibach E., Bianchi N., Borgatti M., Prus E., Gambari R. (2003) Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells. Blood, vol. 102, pag. 1276-1281. DOI: 10.1182/blood-2002-10-3096
- Bianchi N., Zuccato C., Lampronti I., Borgatti M., Gambari R. (2009) Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression. BMB Reports, vol. 42(8), pag. 493-499. DOI: 10.5483/BMBRep.2009.42.8.493
- Bianchi N., Zuccato C., Finotti A., Lampronti I., Borgatti M., Gambari R. (2012) Involvement of miRNA in erythroid differentiation. Epigenomics, vol.4(1), pag. 51-65. DOI: 10.2217/epi.11.104
- Bianchi N., Finotti A., Ferracin M., Lampronti I., Zuccato C., Breveglieri G., Brognara E., Fabbri E., Borgatti M., Negrini M., Gambari R. (2015) Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells. Plos One. 10(4):e0121567. DOI: 10.1371/journal.pone.0121567
- Brognara E., Fabbri E., Bazzoli E., Montagner G., Ghimenton C., Eccher A., Cantù C., Manicardi A., Fabbri E., Manicardi A., Tedeschi T., Sforza S., Bianchi N., Brognara E., Finotti A., Breveglieri G., Borgatti M., Corradini R., Marchelli R., Gambari R. (2011) Modulation of the biological activity of microRNA-210 with peptide nucleic acids (PNAs). ChemMedChem, vol. 6(12), pag. 2192-2202. DOI: 10.1002/cmdc.201100270
- Brognara E., Fabbri E., Bazzoli E., Montagner G., Ghimenton C., Eccher A., Cantù C., Manicardi A., Bianchi N., Finotti A., Breveglieri G., Borgatti M., Corradini R., Bezzerri V., Cabrini G., Gambari R. (2014) Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221. Journal of Neuro-Oncology, vol. 118(1), pag. 19-28. DOI: 10.1007/s11060-014-1405-6
10. Fabbri E., Montagner G., Bianchi N., Finotti A., Borgatti M., Lampronti I., Cabrini G., Gambari R. (2016) MicroRNA miR-93-5p regulates expression of IL-8 and VEGF in neuroblastoma SK-N-AS cells. Oncology Reports, vol. 35(5), pag. 2866-2872. DOI: 10.3892/or.2016.4676
11. Fabbri E., Brognara E., Montagner G., Ghimenton C., Eccher A., Cantù C., Khalil S., Bezzerri V., Provezza L., Bianchi N., Finotti A., Borgatti M., Moretto C., Chilosi M., Cabrini G., Gambari R. (2015) Regulation of IL-8 gene expression in gliomas by microRNA miR-93. BMC Cancer, vol. 15, pag. 661-676. DOI: 10.1186/s12885-015-1659-1
12. Cosenza L.C., Breveglieri G., Zuccato C., Breda L., Finotti A., Lampronti I., Borgatti M., Chiavilli F., Gamberini M.R., Stefania S., Manunza L., Demartis F.R., Moi P., Rivella R., Gambari R., Bianchi N. (2016) A validated cellular biobank for β-thalassemia. Journal of Translational Medicine, vol. 14, pag. 255-268. DOI: 10.1186/s12967-016-1016-4
13. Bianchi N., Cosenza L.C., Lampronti I., Finotti A., Breveglieri G., Zuccato C., Fabbri E., Marzaro G., Chilin A., De Angelis G., Borgatti M., Gallucci C., Alfieri C., Ribersani M., Isgrò A., Marziali M., Gaziev J., Morrone A., Sodani P., Lucarelli G., Gambari R., Paciaroni K. (2016) Structural and functional insights on an uncharacterized Aγ-globin-gene polymorphism present in four β0-thalassemia families with high fetal hemoglobin levels. Molecular Diagnosis & Therapy, vol. 20(2), pag. 161-173. DOI: 10.1007/s40291-016-0187-2
14. Breveglieri G.*, Bianchi N.*, Cosenza L.C., Gamberini M.R., Chiavilli F., Zuccato C., Montagner G., Borgatti M., Lampronti I., Finotti A., Gambari R. (2017) An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production. BMC Medical Genetics, vol. 18, pag. 93-100. DOI: 10.1186/s12881-017-0450-3
15. Bianchi N., Beninati S., Bergamini C.M. (2018) Spotlight on the transglutaminase 2 gene, a focus on genomic and transcriptional aspects. Biochemical Journal, vol. 475(9), 1643-1667. DOI: 10.1042/BCJ20170601
16. Minotti L., Baldassari F., Galasso M., Volinia S., Bergamini CM, Bianchi N. (2018) A long non-coding RNA inside the type 2 transglutaminase gene tightly correlates with the expression of its transcriptional variants. Amino Acids, vol. 50(3-4), pag 421-438. DOI: 10.1007/s00726-017-2528-9
17. Franzese O., Minotti L., Aguiari G., Corrà F., Cervellati C., Ferrari C., Volinia S., Bergamini C.M.*, Bianchi N.* (2019) Involvement of non-coding RNAs and transcription factors in the induction of Transglutaminase isoforms by ATRA. Amino Acids, vol. 51(9), 1273-1288. DOI: 10.1007/s00726-019-02766-7
Experimental methods: cell and tissue cultures, including primary cultures from human peripheral blood), molecular analysis of nucleic acids and proteins, DNA recombination, transfections, siRNA technology, ELISA, immunoblotting, protein-protein interaction studies, enzymatic activity assays, nucleic acids-protein interaction studies (RNA immunoprecipitation, Chromatin immunoprecipitation, EMSA), quantitative reverse transcription and PCRs,