Gian Luca Colussi, MD
Department of Internal Medicine
University of Udine
P.le S.Maria della Misericordia 1, 33100 Udine, Italy
Personal italian phone: +39(0)434932782
Italian Mobile: +39(0)3293532098
American cell phone: 415-939-5052
e-mail: gianluca.colussi@uniud.it
Nationality: Italian
Birth Date: April 27th, 1975
Sex: male
Marital status: married (one son)
Education and training
1990-1994 Technical Industrial Institute “J.F. Kennedy” High School (Pordenone – Italy)
Degree: Qualified Chemist
Final mark: 57/60
1994-2002 University of Udine (Udine - Italy) – School of Medicine
Awarded: Doctor of Medicine
Thesis title: “Effects of omega-3 polyunsaturated fatty acids on plasma lipoprotein(a) levels in hypertensive patients”
Final mark: 103/110
Courses attended includes: biochemistry, cell and molecular biology, embryology, histology, microbiology, physiology, bioinformatics, biophysics, biostatistics, general pathology, physiopathology, cardiology and cardiovascular pathology.
Training:
• laboratory of microbiology with experience in culture techniques and PCR analysis
• hypertension laboratory with experience in general laboratory techniques
2002-2007 University of Udine, Department of Internal Medicine – Resident in Internal Medicine
Awarded: Specialist in Internal Medicine
Dissertation title: “Plasma aldosterone levels are associated to insulin resistance in essential hypertensive patients”
Final mark: 70/70 with distinction
2003-2004 Fellow at the Department of Angio-Cardio-Neurology, NEUROMED Institute, Pozzilli (IS) – Italy. Working field: physiopathology of cardiovascular disease
Comment: experience with animal and cellular models of cardiovascular disease. Studies on vascular biology: oxidative stress and nitric oxide physiology; calcium signalling; insulin, angiotensin II and aldosterone in vascular dysfunction and remodelling. Attended projects: “Role of PI3Kgamma in angiotensin II mediated vasculotoxic and hypertensive response in knock out mouse and cellular models”, “Role of omega-3 polyunsaturated fatty acids in the homeostasis of blood pressure and in the prevention of hypertensive target organ damage in transgenic mouse and cellular models”
2008-now Medical researcher at the Department of Internal Medicine of the University of Udine, Udine, Italy
Employment experience:
Dec 2007 – June 2008 Attending physician, “Azienda Ospedaliera Santa Maria degli Angeli”, Department of Internal Medicine, Pordenone, Italy.
Skills and competencies
Technical:
• General mouse and rat surgery, in particular aortic and mesenteric arteries dissection, renal artery stenosis, endovascular catheterization, transthoracic aortic coartaction and subcutaneous mini osmotic pumps application.
• Mouse and rat blood pressure measurement by tail cuff or radiotelemetry.
• Vascular reactivity studies (myograph, Mulvany’s system)
• Protein expression and general analytical techniques
• Lipid extraction and analysis by thin layer chromatography and gas chromatography
• Immunohistochemical techniques
• Image analyzing
• Experimental design
• Data analysis and presentation
• Color-Doppler ultrasound
Computer:
• Windows system: Word, Excell, PowerPoint, Access, Publisher, File Maker Pro 8.5, Systat 11.0, Stata 9.2, Graph Pad Prism 4.0, Endnote 9, Adobe Photoshop 8.0, GIMP, ImageJ, Biopac AcqKnowledge 3.8
• Linux system (Ubuntu, Debian) open source software
Languages:
• Native Italian; good English (written and spoken)
Honours and Awards
2003 European Society of Hypertension Travel Grant
2004 National Fellowship in Research on Hypertension by the Italian Society of Hypertension
2005 Italian Society of Hypertension Travel Grant
2007 American Society of Hypertension Travel Grant
2007 Italian Society of Hypertension Travel Grant
2008 American Society of Hypertension Travel Grant
Scientific Interest:
A) basic research:
• Molecular mechanisms of insulin action in experimental models of hypertension
• Mechanisms of blood pressure regulation and target organ damage prevention of the omega-3 polyunsaturated fatty acids in animal models
• Oxidative stress and nitric oxide modulation of the endothelial function in transgenic animal models of cardiovascular disease
• Role of the benzodiazepines in the modulation of vascular function in normal and hypertensive mouse.
B) clinical research:
• Effects of “Minor” cardiovascular risk factors in the development of target organ damage of hypertensive patients
• Effects of omega-3 polyunsaturated fatty acid on “minor” cardiovascular risk factors and in development of target organ damage in hypertension
• Effects of hyperinsulinemia and insulin resistance on the renin-angiotensin-aldosterone system in obesity and hypertension
The scientific activity of Dr. Colussi is constituted by 55 congress abstracts and 18 publications. Total Impact Factor (with letters to the editor) is 113.116
Poster and Communication
1. Colussi G, Catena C, Baroselli S, Varutti R, Dotto L, Novello M, Cavarape A, Sechi LA. n-3 polyunsaturated fatty acids (PUFA) decrease lipoprotein(a) levels in hypertensive patiens. World Congress of Nephrology, Berlin, Germany, Abstract p.88, 2003. (Poster)
2. Colussi G, Catena C, Baroselli S, Varutti R, Cavarape A, Sechi L. Effects of n-3 polyunsaturated fatty acids (PUFA) on “minor” cardiovascular risk factors in hypertension. Thirteenth European Meeting on Hypertension, Milan, Italy, Abstract p.S62, 2003. (Poster)
3. Colussi G, Piconi L, Catena C, Baroselli S, Dotto L, Novello M, Cavarape A, Ceriello A, Sechi L. n-3 polyunsaturated fatty acids (PUFA) decrease markers of oxidative stress in hypertensive patients. Thirteenth European Meeting on Hypertension, Milan, Italy, Abstract p.S63, 2003. (Poster)
4. Colussi G, Catena C, Baroselli S, Varutti R, Dotto L, Novello M, Cavarape A, Sechi LA. Effects of ω-3 PUFA on plasma lipoprotein(a) in hypertensive patients. XX Congresso Nazionale della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, High Blood Press Cardiovasc Prev 2003;10(2):129. (Poster)
5. Colussi G, Quagliaro L, Catena C, Piconi L, Baroselli S, Novello M, Cavarape A, Ceriello A, Sechi LA. Effects of ω-3 PUFA on oxidative stress in hypertensive patients. XX Congresso della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, High Blood Press Cardiovasc Prev 2003; 10(2):129. (Poster)
6. Sechi LA, Catena C, Novello M, Baroselli S, Somma MC, Dotto L, Colussi G, Lapenna R, Mansutti E. Renal abnormalities in primary aldosteronism. 1st International Workshop on Endocrine Hypertension, Ancona, Italy, Abstract p.59-60, 2004. (Oral communication)
7. Colussi G, Vecchione C, Lembo G. Gli acidi grassi ω-3 attenuano la vasocostrizione arteriosa mediante l'aumentata produzione di ossido nitrico. XXI Congresso della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, Abstract p.103, 2004. (Oral communication)
8. Vecchione C, Marino G, Colussi G, Aretini A, Poulet R, Lembo G. L'isoforma gamma della fosfatidilinositolo-3-chinasi riduce il danno vascolare nel diabete mellito. XXI Congresso Nazionale della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, Abstract p.99, 2004. (Oral communication)
9. Vecchione C, Marino G, Storto M, Colussi G, Cifelli G, Bettarini U, Lembo G. L'isoforma gamma della fosfatidilinositolo-3-chinasi modula il flusso del calcio indotto dall'angiotensina II mediante i canali L-type. XXI Congresso Nazionale della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, Abstract p.129, 2004. (Poster)
10. Colussi G, Aretini A, Vecchione C, Lembo G. Polar products of air oxidation of omega-3 PUFA ethyl esters impair vascular contraction. XXI Latin Meeting on Vascular Research, Udine, Italy, Abstract p.48, 2005. (Oral communication)
11. Baroselli S, Colussi G, Catena C, Lapenna R, Novello M, Nadalini E, Sechi LA. Effect of omega-3 polyunsaturated fatty acid on novel cardiovascular risk factors in hypertension. XXI Latin Meeting on Vascular Research, Udine, Italy, Abstract p.47, 2005. (Oral communication)
12. Baroselli S, Lapenna R, Novello M, Colussi G, Nadalini E, Catena C, Sechi LA. Neoplasia neuroendocrina del timo: risposta alla terapia radiometabolica. 106° Congresso Nazionale della Società di Medicina Interna, Rome, Italy, Abstract p.73S, 2005. (Poster)
13. Catena C, Nadalini E, Baroselli S, Lapenna R, Colussi G, Somma MC, Sechi LA. Ipertensione arteriosa e poliglobulia in paziente con stenosi multiple delle arterie renali. 106° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Abstract p.74S, 2005. (Poster)
14. Lapenna R, Baroselli S, Catena C, Nadalini E, Novello M, Colussi G, Verriello L, Sechi LA. Vasculite dei vasa-nervorum: risposta alla terapia immunosoppressiva. 106° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Abstract p.78S, 2005. (Poster)
15. Lapenna R, Dotto L, Catena C, Baroselli S, Colussi G, Novello M, Nadalini E, Sechi LA. Sindrome extrapiramidale e dermatite da ipocorticosurrenalismo. 106° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Abstract p.79S, 2005. (Poster)
16. Novello M, Baroselli S, Colussi G, Lapenna R, Nadalini E, Catena C, Sechi LA. Trombosi venose recidivanti in paziente con mesotelioma peritoneale maligno metastatico. 106° Congresso Nazionale della Società di Medicina Interna, Rome, Italy, Abstract p.81S, 2005. (Poster)
17. Colussi G, Catena C, Baroselli S, Lapenna R, Novello M, Nadalini E, Sechi LA. Relazione tra livelli di aldosterone plasmatico e parametri di insulino-resistenza nell'ipertensione essenziale. 106° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Abstract p. 2005. (Poster)
18. Colussi G, Catena C, Baroselli S, Lapenna R, Novello M, Nadalini E, Sechi LA. Relazioni tra parametri di insulino-resistenza e livelli plasmatici di aldosterone in pazienti ipertesi. XXII Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Turin, Italy, Abstract p.148, 2005. (Poster)
19. Catena C, Baroselli S, Lapenna R, Novello M, Colussi G, Nadalini E, Soardo G, Cavarape A, Sechi LA. I nuovi fattori di rischio cardiovascolare nei pazienti con iperaldosteronismo primitivo. Poster al XXII Congresso Nazionale della Società dell'Ipertensione Arteriosa, Turin, Italy, Abstract p.133, 2005. (Poster)
20. Colussi G, Catena C, Adragna V, Morana G, Verriello L, Baroselli S, Lapenna R, Novello M, Nadalini E, Sechi LA. Alterazioni del profilo pressorio delle 24 ore e della funzione diastolica in pazienti con distrofia miotonica di Steinert. 66° Congresso Nazionale della Società Italiana di Cardiologia, Rome, Italy, 2005. (Oral communication)
21. Catena C, Baroselli S, Novello M, Colussi G, Lapenna R, Nadalini E, Favret G, Sechi LA. Alterazioni morfofunzionali del ventricolo sinistro nell’iperaldosteronismo primitivo alla diagnosi e dopo trattamento. 66° Congresso Nazionale della Società Italiana di Cardiologia, Rome, Italy, 2005. (Poster)
22. Catena C, Colussi G, Baroselli S, Nadalini E, Novello M, Lapenna R, Verriello L, Ceccotti L, Adragna V, Sechi LA. Abnormal 24-hour blood pressure profile and left ventricular geometry in patients with myotonic dystrophy. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S57, 2006. (Poster)
23. Colussi G, Catena C, Favret G, Baroselli S, Nadalini E, Lapenna R, Novello M, Soardo G, Sechi LA. Relationship between parameters of the metabolic syndrome and plasma aldosterone levels in hypertensive subjects. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S220, 2006. (Poster)
24. Catena C, Chiuch A, Colussi G, Nadalii E, Lapenna R, Novello M, Baroselli S, Favret G, Soardo G, Cavarape A, Sechi LA. The new cardiovascular risk factors in hypertensive patients with the metabolic syndrome. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S221, 2006. (Poster)
25. Lapenna R, Catena C, Novello M, Baroselli S, Nadalini E, Colussi G, Favret G, Cavarape A, Sechi LA. The emergent cardiovascular risk factors in patients with primary aldosteronism. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S361, 2006. (Poster)
26. Catena C, Novello M, Lapenna R, Baroselli S, Nadalini E, Colussi G, Favret G, Sechi LA. Long-term outcome of renal function in primary aldosteronism. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S362, 2006. (Poster)
27. Catena C, Nadalini E, Baroselli S, Lapenna R, Novello M, Colussi G, Chiuch A, Favret G, Sechi LA. La funzione renale nell'iperaldosteronismo primitivo: una rivisitazione del concetto di “renin escape”. 107° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy Intern Emerg Med 2006;1(Suppl2-3):74S. (Poster)
28. Novello M, Catena C, Baroselli S, Lapenna R, Nadalini E, Colussi G, Favret G, Chiuch A, Sechi LA. Follow-up a lungo termine delle cisti renali in pazienti con iperaldosteronismo primitivo. Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Intern Emerg Med 2006;1(Suppl2-3):77S. (Poster)
29. Catena C, Chiuch A, Colussi G, Nadalini E, Lapenna R, Baroselli S, Novello M, Favret G, Sechi LA. I fattori di rischio cardiovascolare emergenti in pazienti ipertesi essenziali con sindrome metabolica. 107° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy Intern Emerg Med 2006;1(Suppl 2-3):109S. (Poster)
30. Catena C, Colussi G, Baroselli S, Nadalini E, Lapenna R, Novello M, Adragna V, Sechi LA. Profilo pressorio delle 24 ore e geometria ventricolare sinistra in pazienti con distrofia miotonica di Steinert. 107° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Intern Emerg Med 2006;1(Suppl 2-3):131S. (Poster)
31. Catena C, Colussi G, Baroselli S, Nadalini E, Chiuch A, Lapenna R, ad ragna V, Sechi LA. Left ventricular geometry and ambulatory blood pressure in patients with Steinert disease. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A83. (Poster)
32. Catena C, Colussi G, Nadalini E, Chiuch A, Baroselli S, Lapenna R, Sechi LA. Relationships of plasma renin and aldosterone levels with renal function in patients with primary aldosteronism. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A130. (Poster)
33. Novello M, Catena C, Nadalini E, Colussi G, Baroselli S; Chiuch A, Lapenna R, Sechi LA. Renal cysts and hypokalemia in primary aldosteronism: results of long-term follow-up after treatment. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A140. (Poster)
34. Catena C, Chiuch A, Colussi G, Lapenna R, Nadalini E, Favret G, Cavarape A, Soardo G, Sechi LA. Association of a prothrombotic state with the metabolic syndrome in essential hypertensive patients. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A191. (Poster)
35. Colussi G, Catena C, Chiuch A, Baroselli S, Lapenna R, Nadalini E, Sechi LA. Plasma aldosterone levels are related with parameters of insulin resistance in essential hypertension. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A191. (Poster and Slides)
36. Catena C, Colussi G, Baroselli S, Lapenna R, Nadalini E, Chiuch A, Sechi L. Relationships of plasma renin with renal function in primary aldosteronism: revisiting the concept of renin escape. Seventeenth European Meeting on Hypertension, Milan, Italy, J Hypertens 2007;25(Suppl 2):S332. (Poster)
37. Colussi G, Catena C, Baroselli S, Lapenna R, Nadalini E, Chiuch A, Favret G, Sechi L. Plasma aldosterone is associated with insulin resistance in hypertensive patients. Seventeenth European Meeting on Hypertension, Milan, Italy, J Hypertens 2007;25(Suppl 2):S249. (Poster)
38. Catena C, Nadalini E, Lapenna R, Baroselli S, Chiuch A, Colussi G, Sechi L. Comparison of cardiac outcomes in patients with primary aldosteronism after treatment with adrenalectomy or aldosterone antagonist. Seventeenth European Meeting on Hypertension, Milan, Italy, J Hypertens 2007;25(Suppl 2):S249. (Poster)
39. Novello M, Catena C, Nadalini E, Colussi G, Baroselli S, Chiuch A, Lapenna R, Sechi L. Long-term outcome of renal cysts in primari aldosteronism. Seventeenth European Meeting on Hypertension, Milan, Italy, J Hypertens 2007;25(Suppl 2):S. (Oral communication)
40. Sechi L, Colussi G, Valeri M, Catena C. Cardiac and renal damage in primary aldosteronism. LIAC Latin Meeting on Vascular Research, Barcelona, Spain, 2007. Abstract (Oral communication)
41. Colussi G, Catena C, Baroselli S, Lapenna R, Nadalini E, Chiuch A, Sechi LA. I livelli di aldosterone sono associati all’insulino-resistenza nell’ipertensione essenziale. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy, Abstract p.126, 2007 (Oral communication)
42. Colussi G, Di Fabio A, Catena C, Sechi LA. Effetti vascolari delle benzodiazepine: evidenza in-vitro di una azione endotelio-indipendente. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy. Abstract p.174, 2007 (Poster)
43. Catena C, Colussi G, Lapenna R, Baroselli S, Chiuch A, Nadalini E, Sechi LA. Studio longitudinale dell’outcome cardiovascolare in pazienti con iperaldosteronismo primitivo dopo trattamento. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy, Abstract p.178, 2007 (Poster)
44. Catena C, Nadalini E, Baroselli S, Lapenna R, Chiuch A, Colussi G, Sechi LA. Follow-up ecocardiografico a lungo termine in pazienti con iperaldosteronismo primitivo trattati con surrenectomia o antagonisti dell’aldosterone. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy, Abstract p.178, 2007 (Poster)
45. Catena C, Bragagnini W, Colussi G, Lapenna R, Chiuch A, Nadalini E, Sechi LA. Relazioni tra patologia carotidea e indici di insulino-resistenza nell’ipertensione arteriosa: dati di una analisi retrospettiva. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy, Abstract p.180, 2007 (Poster)
46. Colussi G, Di Fabio A, Catena C, Sechi LA. In vitro study of vascular effects of benzodiazepines. 23rd Annual Scientific Meeting and Exposition of American Society of Hypertension, New Orleans, LA, USA. J Clin Hypertens 2008;10(suppl A): p.A17-18 (Poster)
47. Catena C, Bragagnini W, Colussi G, Lapenna R, Chiuch A, Nadalini E, Sechi LA. Retrospective analysis of the relationship between carotid IMT and the metabolic syndrome in hypertensive patients. 23rd Annual Scientific Meeting and Exposition of American Society of Hypertension, New Orleans, LA, USA. J Clin Hypertens 2008;10(suppl A): p.A97 (Poster)
48. Catena C, Colussi G, Chiuch A, Nadalini E, Lapenna R, Sechi LA. Prospective assessment of cardiovascular outcomes in patients with primary aldosteronism after surgical or medical treatment. 23rd Annual Scientific Meeting and Exposition of American Society of Hypertension, New Orleans, LA, USA. J Clin Hypertens 2008;10(suppl A): p.A159-160 (Poster)
49. Sechi LA, Colussi G, Nadalini E, Chiuch A, Valeri M, Lapenna R, Catena C. Reversal of left ventricular hypertrophy after treatment is related to severity of disease in patients with primary aldosteronism. 23rd Annual Scientific Meeting and Exposition of American Society of Hypertension, New Orleans, LA, USA. J Clin Hypertens 2008;10(suppl A): p.A163 (Poster)
50. Catena C, Braganini W, Colussi G, Lapenna R, Chiuch A, Nadalini E, Sechi LA. Retrospective evaluation of the relationship between carotid IMT and insulin resistance in hypertensive patients. 18th Scientific Meeting of European Society of Hypertension, Berlin, Germany. Abstract p.S50, 2008 (Poster)
51. Sechi LA, Colussi G, Nadalini E, Chiuch A, Valeri M, Lapenna R, Catena C. Decrease of left ventricular mass after treatment is related to severity of disease in patients with primary aldosteronism. 18th Scientific Meeting of European Society of Hypertension, Berlin, Germany. Abstract p.S85, 2008 (Poster)
52. Colussi G, Catena C, Chiuch A, Lapenna R, Nadalini E, Di Fabio A, Bragagnini W, Valeri M, Sechi LA. Relationship between plasma aldosterone levels and albuminuria in hypertensive patients. 18th Scientific Meeting of European Society of Hypertension, Berlin, Germany. Abstract p.S215, 2008 (Poster)
53. Colussi G, Di Fabio A, Catena C, Sechi LA. Benzodiazepines regulate the vascular tone via an endothelium-independent mechanism. 18th Scientific Meeting of European Society of Hypertension, Berlin, Germany. Abstract p.S360, 2008 (Poster)
54. Catena C, Colussi G, Chiuch A, Nadalini E, Di Fabio A, Bragagnini W, Valeri M, Sechi LA. Il trattamento dell’iperaldosteronismo primario riduce la massa ventricolare sinistra in rapporto all’entità dell’ipersecrezione ormonale. XXV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome. Abstract p.124, 2008 (Poster)
55. Colussi G, Catena C, Chiuch A, Nadalini E, Di Fabio A, Sechi LA. Aldosterone e escrezione urinaria di albumina nell’ipertensione arteriosa. XXV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome. Abstract p.151, 2008 (Poster)
Publications
1. Catena C, Giacchetti G, Novello M, Colussi G, Cavarape A, Sechi LA. Cellular mechanisms of insulin resistance in rats with fructose-induced hypertension. Am J Hypertens 2003;16:973-978. (IF=3.103)
2. Catena C, Cavarape A, Dotto L, Colussi G, Novello M, De Marchi S, Sechi LA. The emerging risk factors for cardiovascular disease: a review of the epidemiologic evidence for lipoprotein(a), homocysteine, and fibrinogen. Adv Clin Path 2003;7:3-11. Review. (IF=NA*)
3. Colussi G, Baroselli S, Sechi LA. ω3 polyunsaturated fatty acids decrease plasma lipoprotein(a) levels in hypertensive subjects. Clin Nutr 2004;23:1246-1247. Letter. (IF=2.019)
4. Catena C, Lapenna R, Baroselli S, Novello M, Nadalini E, Colussi G, Soardo G, Cavarape A, Sechi LA. The emergent cardiovascular risk factors and organ damage in arterial hypertension. Curr Hypertens Rev 2005;189-200. Review. (IF=NA)
5. Catena C, Novello M, Lapenna R, Baroselli S, Colussi G, Nadalini E, Favret G, Cavarape A, Soardo G, Sechi LA. New risk factors for atherosclerosis in hypertension: focus on the prothrombotic state and lipoprotein(a). J Hypertens 2005;23:1617-1631. Review. (IF=5.218)
6. Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, Maffei A, Gentile MT, Storto M, Azzolino O, Brancaccio M, Colussi G, Bettarini U, Altruda F, Silengo L, Tarone G, Wymann MP, Hirsh E, Lembo G. Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3K. J Exp Med 2005;8:1217-1228. (IF=13.965)
7. Sechi LA, Novello M, Lapenna R, Baroselli S, Nadalini E, Colussi G, Catena C. Long-term renal outcomes in patients with primary aldosteronism. JAMA 2006;295:2638-2645. (IF=23.175)
8. Catena C, Colussi G, Sechi LA. Renal function in primary aldosteronism. Hypertension 2006;48:e110. Letter. (IF=6.007)
9. Catena C, Lapenna R, Baroselli S, Nadalini E, Colussi G, Novello M, Favret G, Melis A, Cavarape A, Sechi LA. Insulin sensitivity in patients with primary aldosteronism: a follow-up study. J Clin Endocr Metab 2006;91:3457-3463. (IF=5.799)
10. Colussi G, Catena C, Baroselli S, Nadalini E, Lapenna R, Chiuch A, Sechi LA. Omega-3 fatty acids: from biochemistry to their clinical use in the prevention of cardiovascular disease. Recent Pat Cardiovas Drug Discov 2007;2:13-21. Review. (IF=NA)
11. Colussi G. Valutazione sperimentale degli effetti degli acidi grassi omega-3 sull’omeostasi pressoria e sul danno d’organo indotto dall’ipertensione arteriosa. Ipertensione e Prevenzione Cardiovascolare 2007;14(1):34-39. (IF=NA)
12. Novello M, Catena C, Nadalini E, Colussi G, Baroselli S, Chiuch A, Lapenna R, Bazzocchi M, Sechi LA. Renal cysts and hypokalemia in primary aldosteronism: results of long-term follow-up after treatment. J Hypertens 2007;25:1443-1450. (IF=4.021)
13. Catena C, Colussi G, Nadalini E, Chiuch A, Baroselli A, Lapenna R, Sechi LA. Relationships of plasma renin levels with renal function in patients with primary aldosteronism. Clin J Am Soc Nephrol 2007;2:722-731. (IF=NA)
14. Colussi G, Catena C, Lapenna R, Nadalini E, Chiuch A, Sechi LA. Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients. Diabetes Care 2007;30:2349-2354. (IF=7.912)
15. Catena C, Colussi G, Lapenna R, Nadalini E, Chiuch A, Gianfagna P, Sechi LA. Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in patients with primary aldosteronism. Hypertension 2007;50:911-918. (IF=6.007)
16. Colussi G, Catena C, Lapenna R, Nadalini E, Chiuch A, Sechi LA. Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients: response to Perciaccante et Al. Diabetes Care 2007;30:e107. Letter. (IF=7.912)
17. Catena C, Colussi G, Nadalini E, Chiuch A, Baroselli S, Lapenna R, Sechi LA. Cardiovascular outcomes in patients with primary aldosteronism after treatment. Arch Intern Med 2008;168:80-85. (IF=14.780)
18. Sechi LA, Novello M, Colussi G, Di Fabio A, Chuich A, Nadalini E, Casanova-Borca A, Uzzau A, Catena C. Relationship of plasma renin with a prothrombotic state in hypertension. Am J Hypertens 2008;21:1347-1353. (IF=3.102)
19. Hypertension 2009
20. Horm metab res 2010
* NA: not available
Udine, September 24th, 2009 Dr. Gian Luca Colussi
Department of Internal Medicine
University of Udine
P.le S.Maria della Misericordia 1, 33100 Udine, Italy
Personal italian phone: +39(0)434932782
Italian Mobile: +39(0)3293532098
American cell phone: 415-939-5052
e-mail: gianluca.colussi@uniud.it
Nationality: Italian
Birth Date: April 27th, 1975
Sex: male
Marital status: married (one son)
Education and training
1990-1994 Technical Industrial Institute “J.F. Kennedy” High School (Pordenone – Italy)
Degree: Qualified Chemist
Final mark: 57/60
1994-2002 University of Udine (Udine - Italy) – School of Medicine
Awarded: Doctor of Medicine
Thesis title: “Effects of omega-3 polyunsaturated fatty acids on plasma lipoprotein(a) levels in hypertensive patients”
Final mark: 103/110
Courses attended includes: biochemistry, cell and molecular biology, embryology, histology, microbiology, physiology, bioinformatics, biophysics, biostatistics, general pathology, physiopathology, cardiology and cardiovascular pathology.
Training:
• laboratory of microbiology with experience in culture techniques and PCR analysis
• hypertension laboratory with experience in general laboratory techniques
2002-2007 University of Udine, Department of Internal Medicine – Resident in Internal Medicine
Awarded: Specialist in Internal Medicine
Dissertation title: “Plasma aldosterone levels are associated to insulin resistance in essential hypertensive patients”
Final mark: 70/70 with distinction
2003-2004 Fellow at the Department of Angio-Cardio-Neurology, NEUROMED Institute, Pozzilli (IS) – Italy. Working field: physiopathology of cardiovascular disease
Comment: experience with animal and cellular models of cardiovascular disease. Studies on vascular biology: oxidative stress and nitric oxide physiology; calcium signalling; insulin, angiotensin II and aldosterone in vascular dysfunction and remodelling. Attended projects: “Role of PI3Kgamma in angiotensin II mediated vasculotoxic and hypertensive response in knock out mouse and cellular models”, “Role of omega-3 polyunsaturated fatty acids in the homeostasis of blood pressure and in the prevention of hypertensive target organ damage in transgenic mouse and cellular models”
2008-now Medical researcher at the Department of Internal Medicine of the University of Udine, Udine, Italy
Employment experience:
Dec 2007 – June 2008 Attending physician, “Azienda Ospedaliera Santa Maria degli Angeli”, Department of Internal Medicine, Pordenone, Italy.
Skills and competencies
Technical:
• General mouse and rat surgery, in particular aortic and mesenteric arteries dissection, renal artery stenosis, endovascular catheterization, transthoracic aortic coartaction and subcutaneous mini osmotic pumps application.
• Mouse and rat blood pressure measurement by tail cuff or radiotelemetry.
• Vascular reactivity studies (myograph, Mulvany’s system)
• Protein expression and general analytical techniques
• Lipid extraction and analysis by thin layer chromatography and gas chromatography
• Immunohistochemical techniques
• Image analyzing
• Experimental design
• Data analysis and presentation
• Color-Doppler ultrasound
Computer:
• Windows system: Word, Excell, PowerPoint, Access, Publisher, File Maker Pro 8.5, Systat 11.0, Stata 9.2, Graph Pad Prism 4.0, Endnote 9, Adobe Photoshop 8.0, GIMP, ImageJ, Biopac AcqKnowledge 3.8
• Linux system (Ubuntu, Debian) open source software
Languages:
• Native Italian; good English (written and spoken)
Honours and Awards
2003 European Society of Hypertension Travel Grant
2004 National Fellowship in Research on Hypertension by the Italian Society of Hypertension
2005 Italian Society of Hypertension Travel Grant
2007 American Society of Hypertension Travel Grant
2007 Italian Society of Hypertension Travel Grant
2008 American Society of Hypertension Travel Grant
Scientific Interest:
A) basic research:
• Molecular mechanisms of insulin action in experimental models of hypertension
• Mechanisms of blood pressure regulation and target organ damage prevention of the omega-3 polyunsaturated fatty acids in animal models
• Oxidative stress and nitric oxide modulation of the endothelial function in transgenic animal models of cardiovascular disease
• Role of the benzodiazepines in the modulation of vascular function in normal and hypertensive mouse.
B) clinical research:
• Effects of “Minor” cardiovascular risk factors in the development of target organ damage of hypertensive patients
• Effects of omega-3 polyunsaturated fatty acid on “minor” cardiovascular risk factors and in development of target organ damage in hypertension
• Effects of hyperinsulinemia and insulin resistance on the renin-angiotensin-aldosterone system in obesity and hypertension
The scientific activity of Dr. Colussi is constituted by 55 congress abstracts and 18 publications. Total Impact Factor (with letters to the editor) is 113.116
Poster and Communication
1. Colussi G, Catena C, Baroselli S, Varutti R, Dotto L, Novello M, Cavarape A, Sechi LA. n-3 polyunsaturated fatty acids (PUFA) decrease lipoprotein(a) levels in hypertensive patiens. World Congress of Nephrology, Berlin, Germany, Abstract p.88, 2003. (Poster)
2. Colussi G, Catena C, Baroselli S, Varutti R, Cavarape A, Sechi L. Effects of n-3 polyunsaturated fatty acids (PUFA) on “minor” cardiovascular risk factors in hypertension. Thirteenth European Meeting on Hypertension, Milan, Italy, Abstract p.S62, 2003. (Poster)
3. Colussi G, Piconi L, Catena C, Baroselli S, Dotto L, Novello M, Cavarape A, Ceriello A, Sechi L. n-3 polyunsaturated fatty acids (PUFA) decrease markers of oxidative stress in hypertensive patients. Thirteenth European Meeting on Hypertension, Milan, Italy, Abstract p.S63, 2003. (Poster)
4. Colussi G, Catena C, Baroselli S, Varutti R, Dotto L, Novello M, Cavarape A, Sechi LA. Effects of ω-3 PUFA on plasma lipoprotein(a) in hypertensive patients. XX Congresso Nazionale della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, High Blood Press Cardiovasc Prev 2003;10(2):129. (Poster)
5. Colussi G, Quagliaro L, Catena C, Piconi L, Baroselli S, Novello M, Cavarape A, Ceriello A, Sechi LA. Effects of ω-3 PUFA on oxidative stress in hypertensive patients. XX Congresso della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, High Blood Press Cardiovasc Prev 2003; 10(2):129. (Poster)
6. Sechi LA, Catena C, Novello M, Baroselli S, Somma MC, Dotto L, Colussi G, Lapenna R, Mansutti E. Renal abnormalities in primary aldosteronism. 1st International Workshop on Endocrine Hypertension, Ancona, Italy, Abstract p.59-60, 2004. (Oral communication)
7. Colussi G, Vecchione C, Lembo G. Gli acidi grassi ω-3 attenuano la vasocostrizione arteriosa mediante l'aumentata produzione di ossido nitrico. XXI Congresso della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, Abstract p.103, 2004. (Oral communication)
8. Vecchione C, Marino G, Colussi G, Aretini A, Poulet R, Lembo G. L'isoforma gamma della fosfatidilinositolo-3-chinasi riduce il danno vascolare nel diabete mellito. XXI Congresso Nazionale della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, Abstract p.99, 2004. (Oral communication)
9. Vecchione C, Marino G, Storto M, Colussi G, Cifelli G, Bettarini U, Lembo G. L'isoforma gamma della fosfatidilinositolo-3-chinasi modula il flusso del calcio indotto dall'angiotensina II mediante i canali L-type. XXI Congresso Nazionale della Società Italiana dell'Ipertensione Arteriosa, Rome, Italy, Abstract p.129, 2004. (Poster)
10. Colussi G, Aretini A, Vecchione C, Lembo G. Polar products of air oxidation of omega-3 PUFA ethyl esters impair vascular contraction. XXI Latin Meeting on Vascular Research, Udine, Italy, Abstract p.48, 2005. (Oral communication)
11. Baroselli S, Colussi G, Catena C, Lapenna R, Novello M, Nadalini E, Sechi LA. Effect of omega-3 polyunsaturated fatty acid on novel cardiovascular risk factors in hypertension. XXI Latin Meeting on Vascular Research, Udine, Italy, Abstract p.47, 2005. (Oral communication)
12. Baroselli S, Lapenna R, Novello M, Colussi G, Nadalini E, Catena C, Sechi LA. Neoplasia neuroendocrina del timo: risposta alla terapia radiometabolica. 106° Congresso Nazionale della Società di Medicina Interna, Rome, Italy, Abstract p.73S, 2005. (Poster)
13. Catena C, Nadalini E, Baroselli S, Lapenna R, Colussi G, Somma MC, Sechi LA. Ipertensione arteriosa e poliglobulia in paziente con stenosi multiple delle arterie renali. 106° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Abstract p.74S, 2005. (Poster)
14. Lapenna R, Baroselli S, Catena C, Nadalini E, Novello M, Colussi G, Verriello L, Sechi LA. Vasculite dei vasa-nervorum: risposta alla terapia immunosoppressiva. 106° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Abstract p.78S, 2005. (Poster)
15. Lapenna R, Dotto L, Catena C, Baroselli S, Colussi G, Novello M, Nadalini E, Sechi LA. Sindrome extrapiramidale e dermatite da ipocorticosurrenalismo. 106° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Abstract p.79S, 2005. (Poster)
16. Novello M, Baroselli S, Colussi G, Lapenna R, Nadalini E, Catena C, Sechi LA. Trombosi venose recidivanti in paziente con mesotelioma peritoneale maligno metastatico. 106° Congresso Nazionale della Società di Medicina Interna, Rome, Italy, Abstract p.81S, 2005. (Poster)
17. Colussi G, Catena C, Baroselli S, Lapenna R, Novello M, Nadalini E, Sechi LA. Relazione tra livelli di aldosterone plasmatico e parametri di insulino-resistenza nell'ipertensione essenziale. 106° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Abstract p. 2005. (Poster)
18. Colussi G, Catena C, Baroselli S, Lapenna R, Novello M, Nadalini E, Sechi LA. Relazioni tra parametri di insulino-resistenza e livelli plasmatici di aldosterone in pazienti ipertesi. XXII Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Turin, Italy, Abstract p.148, 2005. (Poster)
19. Catena C, Baroselli S, Lapenna R, Novello M, Colussi G, Nadalini E, Soardo G, Cavarape A, Sechi LA. I nuovi fattori di rischio cardiovascolare nei pazienti con iperaldosteronismo primitivo. Poster al XXII Congresso Nazionale della Società dell'Ipertensione Arteriosa, Turin, Italy, Abstract p.133, 2005. (Poster)
20. Colussi G, Catena C, Adragna V, Morana G, Verriello L, Baroselli S, Lapenna R, Novello M, Nadalini E, Sechi LA. Alterazioni del profilo pressorio delle 24 ore e della funzione diastolica in pazienti con distrofia miotonica di Steinert. 66° Congresso Nazionale della Società Italiana di Cardiologia, Rome, Italy, 2005. (Oral communication)
21. Catena C, Baroselli S, Novello M, Colussi G, Lapenna R, Nadalini E, Favret G, Sechi LA. Alterazioni morfofunzionali del ventricolo sinistro nell’iperaldosteronismo primitivo alla diagnosi e dopo trattamento. 66° Congresso Nazionale della Società Italiana di Cardiologia, Rome, Italy, 2005. (Poster)
22. Catena C, Colussi G, Baroselli S, Nadalini E, Novello M, Lapenna R, Verriello L, Ceccotti L, Adragna V, Sechi LA. Abnormal 24-hour blood pressure profile and left ventricular geometry in patients with myotonic dystrophy. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S57, 2006. (Poster)
23. Colussi G, Catena C, Favret G, Baroselli S, Nadalini E, Lapenna R, Novello M, Soardo G, Sechi LA. Relationship between parameters of the metabolic syndrome and plasma aldosterone levels in hypertensive subjects. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S220, 2006. (Poster)
24. Catena C, Chiuch A, Colussi G, Nadalii E, Lapenna R, Novello M, Baroselli S, Favret G, Soardo G, Cavarape A, Sechi LA. The new cardiovascular risk factors in hypertensive patients with the metabolic syndrome. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S221, 2006. (Poster)
25. Lapenna R, Catena C, Novello M, Baroselli S, Nadalini E, Colussi G, Favret G, Cavarape A, Sechi LA. The emergent cardiovascular risk factors in patients with primary aldosteronism. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S361, 2006. (Poster)
26. Catena C, Novello M, Lapenna R, Baroselli S, Nadalini E, Colussi G, Favret G, Sechi LA. Long-term outcome of renal function in primary aldosteronism. Sixteenth European Meeting on Hypertension, Madrid, Spain, Abstract p.S362, 2006. (Poster)
27. Catena C, Nadalini E, Baroselli S, Lapenna R, Novello M, Colussi G, Chiuch A, Favret G, Sechi LA. La funzione renale nell'iperaldosteronismo primitivo: una rivisitazione del concetto di “renin escape”. 107° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy Intern Emerg Med 2006;1(Suppl2-3):74S. (Poster)
28. Novello M, Catena C, Baroselli S, Lapenna R, Nadalini E, Colussi G, Favret G, Chiuch A, Sechi LA. Follow-up a lungo termine delle cisti renali in pazienti con iperaldosteronismo primitivo. Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Intern Emerg Med 2006;1(Suppl2-3):77S. (Poster)
29. Catena C, Chiuch A, Colussi G, Nadalini E, Lapenna R, Baroselli S, Novello M, Favret G, Sechi LA. I fattori di rischio cardiovascolare emergenti in pazienti ipertesi essenziali con sindrome metabolica. 107° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy Intern Emerg Med 2006;1(Suppl 2-3):109S. (Poster)
30. Catena C, Colussi G, Baroselli S, Nadalini E, Lapenna R, Novello M, Adragna V, Sechi LA. Profilo pressorio delle 24 ore e geometria ventricolare sinistra in pazienti con distrofia miotonica di Steinert. 107° Congresso Nazionale della Società Italiana di Medicina Interna, Rome, Italy, Intern Emerg Med 2006;1(Suppl 2-3):131S. (Poster)
31. Catena C, Colussi G, Baroselli S, Nadalini E, Chiuch A, Lapenna R, ad ragna V, Sechi LA. Left ventricular geometry and ambulatory blood pressure in patients with Steinert disease. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A83. (Poster)
32. Catena C, Colussi G, Nadalini E, Chiuch A, Baroselli S, Lapenna R, Sechi LA. Relationships of plasma renin and aldosterone levels with renal function in patients with primary aldosteronism. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A130. (Poster)
33. Novello M, Catena C, Nadalini E, Colussi G, Baroselli S; Chiuch A, Lapenna R, Sechi LA. Renal cysts and hypokalemia in primary aldosteronism: results of long-term follow-up after treatment. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A140. (Poster)
34. Catena C, Chiuch A, Colussi G, Lapenna R, Nadalini E, Favret G, Cavarape A, Soardo G, Sechi LA. Association of a prothrombotic state with the metabolic syndrome in essential hypertensive patients. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A191. (Poster)
35. Colussi G, Catena C, Chiuch A, Baroselli S, Lapenna R, Nadalini E, Sechi LA. Plasma aldosterone levels are related with parameters of insulin resistance in essential hypertension. 22nd Annual Scientific Meeting and Exposition of American Society of Hypertension, Chicago, IL, USA, J Clin Hypertens 2007;5(Suppl A): A191. (Poster and Slides)
36. Catena C, Colussi G, Baroselli S, Lapenna R, Nadalini E, Chiuch A, Sechi L. Relationships of plasma renin with renal function in primary aldosteronism: revisiting the concept of renin escape. Seventeenth European Meeting on Hypertension, Milan, Italy, J Hypertens 2007;25(Suppl 2):S332. (Poster)
37. Colussi G, Catena C, Baroselli S, Lapenna R, Nadalini E, Chiuch A, Favret G, Sechi L. Plasma aldosterone is associated with insulin resistance in hypertensive patients. Seventeenth European Meeting on Hypertension, Milan, Italy, J Hypertens 2007;25(Suppl 2):S249. (Poster)
38. Catena C, Nadalini E, Lapenna R, Baroselli S, Chiuch A, Colussi G, Sechi L. Comparison of cardiac outcomes in patients with primary aldosteronism after treatment with adrenalectomy or aldosterone antagonist. Seventeenth European Meeting on Hypertension, Milan, Italy, J Hypertens 2007;25(Suppl 2):S249. (Poster)
39. Novello M, Catena C, Nadalini E, Colussi G, Baroselli S, Chiuch A, Lapenna R, Sechi L. Long-term outcome of renal cysts in primari aldosteronism. Seventeenth European Meeting on Hypertension, Milan, Italy, J Hypertens 2007;25(Suppl 2):S. (Oral communication)
40. Sechi L, Colussi G, Valeri M, Catena C. Cardiac and renal damage in primary aldosteronism. LIAC Latin Meeting on Vascular Research, Barcelona, Spain, 2007. Abstract (Oral communication)
41. Colussi G, Catena C, Baroselli S, Lapenna R, Nadalini E, Chiuch A, Sechi LA. I livelli di aldosterone sono associati all’insulino-resistenza nell’ipertensione essenziale. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy, Abstract p.126, 2007 (Oral communication)
42. Colussi G, Di Fabio A, Catena C, Sechi LA. Effetti vascolari delle benzodiazepine: evidenza in-vitro di una azione endotelio-indipendente. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy. Abstract p.174, 2007 (Poster)
43. Catena C, Colussi G, Lapenna R, Baroselli S, Chiuch A, Nadalini E, Sechi LA. Studio longitudinale dell’outcome cardiovascolare in pazienti con iperaldosteronismo primitivo dopo trattamento. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy, Abstract p.178, 2007 (Poster)
44. Catena C, Nadalini E, Baroselli S, Lapenna R, Chiuch A, Colussi G, Sechi LA. Follow-up ecocardiografico a lungo termine in pazienti con iperaldosteronismo primitivo trattati con surrenectomia o antagonisti dell’aldosterone. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy, Abstract p.178, 2007 (Poster)
45. Catena C, Bragagnini W, Colussi G, Lapenna R, Chiuch A, Nadalini E, Sechi LA. Relazioni tra patologia carotidea e indici di insulino-resistenza nell’ipertensione arteriosa: dati di una analisi retrospettiva. XXIV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome, Italy, Abstract p.180, 2007 (Poster)
46. Colussi G, Di Fabio A, Catena C, Sechi LA. In vitro study of vascular effects of benzodiazepines. 23rd Annual Scientific Meeting and Exposition of American Society of Hypertension, New Orleans, LA, USA. J Clin Hypertens 2008;10(suppl A): p.A17-18 (Poster)
47. Catena C, Bragagnini W, Colussi G, Lapenna R, Chiuch A, Nadalini E, Sechi LA. Retrospective analysis of the relationship between carotid IMT and the metabolic syndrome in hypertensive patients. 23rd Annual Scientific Meeting and Exposition of American Society of Hypertension, New Orleans, LA, USA. J Clin Hypertens 2008;10(suppl A): p.A97 (Poster)
48. Catena C, Colussi G, Chiuch A, Nadalini E, Lapenna R, Sechi LA. Prospective assessment of cardiovascular outcomes in patients with primary aldosteronism after surgical or medical treatment. 23rd Annual Scientific Meeting and Exposition of American Society of Hypertension, New Orleans, LA, USA. J Clin Hypertens 2008;10(suppl A): p.A159-160 (Poster)
49. Sechi LA, Colussi G, Nadalini E, Chiuch A, Valeri M, Lapenna R, Catena C. Reversal of left ventricular hypertrophy after treatment is related to severity of disease in patients with primary aldosteronism. 23rd Annual Scientific Meeting and Exposition of American Society of Hypertension, New Orleans, LA, USA. J Clin Hypertens 2008;10(suppl A): p.A163 (Poster)
50. Catena C, Braganini W, Colussi G, Lapenna R, Chiuch A, Nadalini E, Sechi LA. Retrospective evaluation of the relationship between carotid IMT and insulin resistance in hypertensive patients. 18th Scientific Meeting of European Society of Hypertension, Berlin, Germany. Abstract p.S50, 2008 (Poster)
51. Sechi LA, Colussi G, Nadalini E, Chiuch A, Valeri M, Lapenna R, Catena C. Decrease of left ventricular mass after treatment is related to severity of disease in patients with primary aldosteronism. 18th Scientific Meeting of European Society of Hypertension, Berlin, Germany. Abstract p.S85, 2008 (Poster)
52. Colussi G, Catena C, Chiuch A, Lapenna R, Nadalini E, Di Fabio A, Bragagnini W, Valeri M, Sechi LA. Relationship between plasma aldosterone levels and albuminuria in hypertensive patients. 18th Scientific Meeting of European Society of Hypertension, Berlin, Germany. Abstract p.S215, 2008 (Poster)
53. Colussi G, Di Fabio A, Catena C, Sechi LA. Benzodiazepines regulate the vascular tone via an endothelium-independent mechanism. 18th Scientific Meeting of European Society of Hypertension, Berlin, Germany. Abstract p.S360, 2008 (Poster)
54. Catena C, Colussi G, Chiuch A, Nadalini E, Di Fabio A, Bragagnini W, Valeri M, Sechi LA. Il trattamento dell’iperaldosteronismo primario riduce la massa ventricolare sinistra in rapporto all’entità dell’ipersecrezione ormonale. XXV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome. Abstract p.124, 2008 (Poster)
55. Colussi G, Catena C, Chiuch A, Nadalini E, Di Fabio A, Sechi LA. Aldosterone e escrezione urinaria di albumina nell’ipertensione arteriosa. XXV Congresso Nazionale della Società Italiana dell’Ipertensione Arteriosa, Rome. Abstract p.151, 2008 (Poster)
Publications
1. Catena C, Giacchetti G, Novello M, Colussi G, Cavarape A, Sechi LA. Cellular mechanisms of insulin resistance in rats with fructose-induced hypertension. Am J Hypertens 2003;16:973-978. (IF=3.103)
2. Catena C, Cavarape A, Dotto L, Colussi G, Novello M, De Marchi S, Sechi LA. The emerging risk factors for cardiovascular disease: a review of the epidemiologic evidence for lipoprotein(a), homocysteine, and fibrinogen. Adv Clin Path 2003;7:3-11. Review. (IF=NA*)
3. Colussi G, Baroselli S, Sechi LA. ω3 polyunsaturated fatty acids decrease plasma lipoprotein(a) levels in hypertensive subjects. Clin Nutr 2004;23:1246-1247. Letter. (IF=2.019)
4. Catena C, Lapenna R, Baroselli S, Novello M, Nadalini E, Colussi G, Soardo G, Cavarape A, Sechi LA. The emergent cardiovascular risk factors and organ damage in arterial hypertension. Curr Hypertens Rev 2005;189-200. Review. (IF=NA)
5. Catena C, Novello M, Lapenna R, Baroselli S, Colussi G, Nadalini E, Favret G, Cavarape A, Soardo G, Sechi LA. New risk factors for atherosclerosis in hypertension: focus on the prothrombotic state and lipoprotein(a). J Hypertens 2005;23:1617-1631. Review. (IF=5.218)
6. Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, Maffei A, Gentile MT, Storto M, Azzolino O, Brancaccio M, Colussi G, Bettarini U, Altruda F, Silengo L, Tarone G, Wymann MP, Hirsh E, Lembo G. Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3K. J Exp Med 2005;8:1217-1228. (IF=13.965)
7. Sechi LA, Novello M, Lapenna R, Baroselli S, Nadalini E, Colussi G, Catena C. Long-term renal outcomes in patients with primary aldosteronism. JAMA 2006;295:2638-2645. (IF=23.175)
8. Catena C, Colussi G, Sechi LA. Renal function in primary aldosteronism. Hypertension 2006;48:e110. Letter. (IF=6.007)
9. Catena C, Lapenna R, Baroselli S, Nadalini E, Colussi G, Novello M, Favret G, Melis A, Cavarape A, Sechi LA. Insulin sensitivity in patients with primary aldosteronism: a follow-up study. J Clin Endocr Metab 2006;91:3457-3463. (IF=5.799)
10. Colussi G, Catena C, Baroselli S, Nadalini E, Lapenna R, Chiuch A, Sechi LA. Omega-3 fatty acids: from biochemistry to their clinical use in the prevention of cardiovascular disease. Recent Pat Cardiovas Drug Discov 2007;2:13-21. Review. (IF=NA)
11. Colussi G. Valutazione sperimentale degli effetti degli acidi grassi omega-3 sull’omeostasi pressoria e sul danno d’organo indotto dall’ipertensione arteriosa. Ipertensione e Prevenzione Cardiovascolare 2007;14(1):34-39. (IF=NA)
12. Novello M, Catena C, Nadalini E, Colussi G, Baroselli S, Chiuch A, Lapenna R, Bazzocchi M, Sechi LA. Renal cysts and hypokalemia in primary aldosteronism: results of long-term follow-up after treatment. J Hypertens 2007;25:1443-1450. (IF=4.021)
13. Catena C, Colussi G, Nadalini E, Chiuch A, Baroselli A, Lapenna R, Sechi LA. Relationships of plasma renin levels with renal function in patients with primary aldosteronism. Clin J Am Soc Nephrol 2007;2:722-731. (IF=NA)
14. Colussi G, Catena C, Lapenna R, Nadalini E, Chiuch A, Sechi LA. Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients. Diabetes Care 2007;30:2349-2354. (IF=7.912)
15. Catena C, Colussi G, Lapenna R, Nadalini E, Chiuch A, Gianfagna P, Sechi LA. Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in patients with primary aldosteronism. Hypertension 2007;50:911-918. (IF=6.007)
16. Colussi G, Catena C, Lapenna R, Nadalini E, Chiuch A, Sechi LA. Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients: response to Perciaccante et Al. Diabetes Care 2007;30:e107. Letter. (IF=7.912)
17. Catena C, Colussi G, Nadalini E, Chiuch A, Baroselli S, Lapenna R, Sechi LA. Cardiovascular outcomes in patients with primary aldosteronism after treatment. Arch Intern Med 2008;168:80-85. (IF=14.780)
18. Sechi LA, Novello M, Colussi G, Di Fabio A, Chuich A, Nadalini E, Casanova-Borca A, Uzzau A, Catena C. Relationship of plasma renin with a prothrombotic state in hypertension. Am J Hypertens 2008;21:1347-1353. (IF=3.102)
19. Hypertension 2009
20. Horm metab res 2010
* NA: not available
Udine, September 24th, 2009 Dr. Gian Luca Colussi
