Publication

1: Gessi S, Poloni TE, Negro G, Varani K, Pasquini S, Vincenzi F, Borea PA,

Merighi S. A2A Adenosine Receptor as a Potential Biomarker and a

Possible Therapeutic Target in Alzheimer's Disease. Cells. 2021 Sep

7;10(9):2344. doi: 10.3390/cells10092344. PMID: 34571993; PMCID: PMC8469578.

2: Capone F, Salati S, Vincenzi F, Liberti M, Aicardi G, Apollonio F, Varani K,

Cadossi R, Di Lazzaro V. Pulsed Electromagnetic Fields: A Novel Attractive

Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia.

Neuromodulation. 2021 Sep 4. doi: 10.1111/ner.13489. Epub ahead of print. PMID:

34480781.

3: Pasquini S, Contri C, Borea PA, Vincenzi F, Varani K. Adenosine and

Inflammation: Here, There and Everywhere. Int J Mol Sci. 2021 Jul

19;22(14):7685. doi: 10.3390/ijms22147685. PMID: 34299305; PMCID: PMC8304851.

4: Viaro R, Longo F, Vincenzi F, Varani K, Morari M. l-DOPA promotes striatal

dopamine release through D1 receptors and reversal of dopamine transporter.

Brain Res. 2021 Oct 1;1768:147583. doi: 10.1016/j.brainres.2021.147583. Epub

2021 Jul 17. PMID: 34284020.

5: Merighi S, Poloni TE, Pelloni L, Pasquini S, Varani K, Vincenzi F, Borea PA,

Gessi S. An Open Question: Is the A2A Adenosine Receptor a Novel

Target for Alzheimer's Disease Treatment? Front Pharmacol. 2021 Mar

22;12:652455. doi: 10.3389/fphar.2021.652455. PMID: 33828485; PMCID: PMC8019913.

6: Merighi S, Battistello E, Casetta I, Gragnaniello D, Poloni TE, Medici V,

Cirrincione A, Varani K, Vincenzi F, Borea PA, Gessi S. Upregulation of Cortical

A2A Adenosine Receptors Is Reflected in Platelets of Patients with Alzheimer's

Disease. J Alzheimers Dis. 2021;80(3):1105-1117. doi: 10.3233/JAD-201437. PMID:

33646165.

7: Ferrante A, Boussadia Z, Borreca A, Mallozzi C, Pedini G, Pacini L, Pezzola

A, Armida M, Vincenzi F, Varani K, Bagni C, Popoli P, Martire A. Adenosine

A2A receptor inhibition reduces synaptic and cognitive hippocampal

alterations in Fmr1 KO mice. Transl Psychiatry. 2021 Feb 5;11(1):112. doi:

10.1038/s41398-021-01238-5. PMID: 33547274; PMCID: PMC7864914.

8: Varani K, Vincenzi F, Pasquini S, Blo I, Salati S, Cadossi M, De Mattei M.

Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis:

Signaling Pathways and Therapeutic Implications. Int J Mol Sci. 2021 Jan

15;22(2):809. doi: 10.3390/ijms22020809. PMID: 33467447; PMCID: PMC7830993.

9: Vincenzi F, Pasquini S, Battistello E, Merighi S, Gessi S, Borea PA, Varani

K. A1 Adenosine Receptor Partial Agonists and Allosteric Modulators:

Advancing Toward the Clinic? Front Pharmacol. 2020 Dec 9;11:625134. doi:

10.3389/fphar.2020.625134. PMID: 33362567; PMCID: PMC7756085.

10: Vincenzi F, Pasquini S, Borea PA, Varani K. Targeting Adenosine Receptors: A

Potential Pharmacological Avenue for Acute and Chronic Pain. Int J Mol Sci. 2020

Nov 18;21(22):8710. doi: 10.3390/ijms21228710. PMID: 33218074; PMCID:

PMC7698931.

11: Vincenzi F, Pasquini S, Setti S, Salati S, Cadossi R, Borea PA, Varani K.

Pulsed Electromagnetic Fields Stimulate HIF-1α-Independent VEGF Release in

1321N1 Human Astrocytes Protecting Neuron-Like SH-SY5Y Cells from Oxygen-Glucose

Deprivation. Int J Mol Sci. 2020 Oct 28;21(21):8053. doi: 10.3390/ijms21218053.

PMID: 33126773; PMCID: PMC7663527.

12: Colombini A, Perucca Orfei C, Vincenzi F, De Luca P, Ragni E, Viganò M,

Setti S, Varani K, de Girolamo L. A2A adenosine receptors are involved in the

reparative response of tendon cells to pulsed electromagnetic fields. PLoS One.

2020 Sep 30;15(9):e0239807. doi: 10.1371/journal.pone.0239807. PMID: 32998161;

PMCID: PMC7527253.

13: Varano F, Catarzi D, Vigiani E, Vincenzi F, Pasquini S, Varani K, Colotta V.

Piperazine- and Piperidine-Containing Thiazolo[5,4-d]pyrimidine

Derivatives as New Potent and Selective Adenosine A2A Receptor

Inverse Agonists. Pharmaceuticals (Basel). 2020 Jul 24;13(8):161. doi:

10.3390/ph13080161. PMID: 32722122; PMCID: PMC7465344.

14: Navarro G, Varani K, Lillo A, Vincenzi F, Rivas-Santisteban R, Raïch I,

Reyes-Resina I, Ferreiro-Vera C, Borea PA, Sánchez de Medina V, Nadal X, Franco

R. Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids

acting on cannabinoid CB1, CB2 and

CB1/CB2 heteromer receptors. Pharmacol Res. 2020

Sep;159:104940. doi: 10.1016/j.phrs.2020.104940. Epub 2020 May 26. PMID:

32470563.

15: Vincenzi F, Pasquini S, Gessi S, Merighi S, Romagnoli R, Borea PA, Varani K.

The Detrimental Action of Adenosine on Glutamate-Induced Cytotoxicity in PC12

Cells Can Be Shifted towards a Neuroprotective Role through A1AR

Positive Allosteric Modulation. Cells. 2020 May 18;9(5):1242. doi:

10.3390/cells9051242. PMID: 32443448; PMCID: PMC7290574.

16: Pasquini S, Vincenzi F, Casetta I, Laudisi M, Merighi S, Gessi S, Borea PA,

Varani K. Adenosinergic System Involvement in Ischemic Stroke Patients'

Lymphocytes. Cells. 2020 Apr 25;9(5):1072. doi: 10.3390/cells9051072. PMID:

32344922; PMCID: PMC7290971.

17: Varano F, Catarzi D, Vincenzi F, Pasquini S, Pelletier J, Lopes Rangel

Fietto J, Espindola Gelsleichter N, Sarlandie M, Guilbaud A, Sévigny J, Varani

K, Colotta V. Structural investigation on thiazolo[5,4-d]pyrimidines to obtain

dual-acting blockers of CD73 and adenosine A2A receptor as potential

antitumor agents. Bioorg Med Chem Lett. 2020 May 1;30(9):127067. doi:

10.1016/j.bmcl.2020.127067. Epub 2020 Feb 29. PMID: 32165041.

18: Catarzi D, Varano F, Varani K, Vincenzi F, Pasquini S, Dal Ben D, Volpini R,

Colotta V. Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors Ranging

from Pan Ligands to Combined A1/A2B Partial Agonists.

Pharmaceuticals (Basel). 2019 Oct 22;12(4):159. doi: 10.3390/ph12040159. PMID:

31652622; PMCID: PMC6958422.

19: Merighi S, Gessi S, Bencivenni S, Battistello E, Vincenzi F, Setti S,

Cadossi M, Borea PA, Cadossi R, Varani K. Signaling pathways involved in anti-

inflammatory effects of Pulsed Electromagnetic Field in microglial cells.

Cytokine. 2020 Jan;125:154777. doi: 10.1016/j.cyto.2019.154777. Epub 2019 Aug 7.

PMID: 31400640.

20: Betti M, Catarzi D, Varano F, Falsini M, Varani K, Vincenzi F, Pasquini S,

di Cesare Mannelli L, Ghelardini C, Lucarini E, Dal Ben D, Spinaci A, Bartolucci

G, Menicatti M, Colotta V. Modifications on the Amino-3,5-dicyanopyridine Core

To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity.

J Med Chem. 2019 Aug 8;62(15):6894-6912. doi: 10.1021/acs.jmedchem.9b00106. Epub

2019 Jul 26. PMID: 31306001.

21: Merighi S, Battistello E, Giacomelli L, Varani K, Vincenzi F, Borea PA,

Gessi S. Targeting A3 and A2A adenosine receptors in the fight against cancer.

Expert Opin Ther Targets. 2019 Aug;23(8):669-678. doi:

10.1080/14728222.2019.1630380. Epub 2019 Jun 12. PMID: 31189400.

22: Gessi S, Merighi S, Bencivenni S, Battistello E, Vincenzi F, Setti S,

Cadossi M, Borea PA, Cadossi R, Varani K. Pulsed electromagnetic field and

relief of hypoxia-induced neuronal cell death: The signaling pathway. J Cell

Physiol. 2019 Jan 17. doi: 10.1002/jcp.28149. Epub ahead of print. PMID:

30656694.

23: Navarro G, Varani K, Reyes-Resina I, Sánchez de Medina V, Rivas-Santisteban

R, Sánchez-Carnerero Callado C, Vincenzi F, Casano S, Ferreiro-Vera C, Canela

EI, Borea PA, Nadal X, Franco R. Cannabigerol Action at Cannabinoid

CB1 and CB2 Receptors and at CB1-CB2

Heteroreceptor Complexes. Front Pharmacol. 2018 Jun 21;9:632. doi:

10.3389/fphar.2018.00632. PMID: 29977202; PMCID: PMC6021502.

24: Varano F, Catarzi D, Vincenzi F, Falsini M, Pasquini S, Borea PA, Colotta V,

Varani K. Structure-activity relationship studies and pharmacological

characterization of N5-heteroarylalkyl-

substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives

as inverse agonists at human A2A adenosine receptor. Eur J Med Chem.

2018 Jul 15;155:552-561. doi: 10.1016/j.ejmech.2018.06.020. Epub 2018 Jun 9.

PMID: 29909340.

25: Varano F, Catarzi D, Falsini M, Vincenzi F, Pasquini S, Varani K, Colotta V.

Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human

A1 and A2A adenosine receptor antagonists/inverse

agonists. Bioorg Med Chem. 2018 Jul 23;26(12):3688-3695. doi:

10.1016/j.bmc.2018.05.048. Epub 2018 May 31. PMID: 29880250.

26: Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of

Adenosine Receptors: The State of the Art. Physiol Rev. 2018 Jul

1;98(3):1591-1625. doi: 10.1152/physrev.00049.2017. PMID: 29848236.

27: Catarzi D, Varano F, Falsini M, Varani K, Vincenzi F, Pasquini S, Dal Ben D,

Colotta V. Development of novel pyridazinone-based adenosine receptor ligands.

Bioorg Med Chem Lett. 2018 May 15;28(9):1484-1489. doi:

10.1016/j.bmcl.2018.03.086. Epub 2018 Mar 30. PMID: 29627261.

28: Betti M, Catarzi D, Varano F, Falsini M, Varani K, Vincenzi F, Dal Ben D,

Lambertucci C, Colotta V. The aminopyridine-3,5-dicarbonitrile core for the

design of new non-nucleoside-like agonists of the human adenosine A2B

receptor. Eur J Med Chem. 2018 Apr 25;150:127-139. doi:

10.1016/j.ejmech.2018.02.081. Epub 2018 Mar 6. PMID: 29525433.

29: Gessi S, Bencivenni S, Battistello E, Vincenzi F, Colotta V, Catarzi D,

Varano F, Merighi S, Borea PA, Varani K. Inhibition of A2A Adenosine

Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455.

Front Pharmacol. 2017 Dec 1;8:888. doi: 10.3389/fphar.2017.00888. PMID:

29249971; PMCID: PMC5716981.

30: Martínez-Pinilla E, Varani K, Reyes-Resina I, Angelats E, Vincenzi F,

Ferreiro-Vera C, Oyarzabal J, Canela EI, Lanciego JL, Nadal X, Navarro G, Borea

PA, Franco R. Binding and Signaling Studies Disclose a Potential Allosteric Site

for Cannabidiol in Cannabinoid CB2 Receptors. Front Pharmacol. 2017

Oct 23;8:744. doi: 10.3389/fphar.2017.00744. PMID: 29109685; PMCID: PMC5660261.

31: Ossato A, Uccelli L, Bilel S, Canazza I, Di Domenico G, Pasquali M, Pupillo

G, De Luca MA, Boschi A, Vincenzi F, Rimondo C, Beggiato S, Ferraro L, Varani K,

Borea PA, Serpelloni G, De-Giorgio F, Marti M. Psychostimulant Effect of the

Synthetic Cannabinoid JWH-018 and AKB48: Behavioral, Neurochemical, and Dopamine

Transporter Scan Imaging Studies in Mice. Front Psychiatry. 2017 Aug 4;8:130.

doi: 10.3389/fpsyt.2017.00130. PMID: 28824464; PMCID: PMC5543288.

32: Tschon M, Veronesi F, Contartese D, Sartori M, Martini L, Vincenzi F, Ravani

A, Varani K, Fini M. Effects of pulsed electromagnetic fields and platelet rich

plasma in preventing osteoclastogenesis in an in vitro model of osteolysis. J

Cell Physiol. 2018 Mar;233(3):2645-2656. doi: 10.1002/jcp.26143. Epub 2017 Sep

4. PMID: 28786478.

33: Varani K, Vincenzi F, Merighi S, Gessi S, Borea PA. Biochemical and

Pharmacological Role of A1 Adenosine Receptors and Their Modulation

as Novel Therapeutic Strategy. Adv Exp Med Biol. 2017;1051:193-232. doi:

10.1007/5584_2017_61. PMID: 28676923.

34: Canazza I, Ossato A, Vincenzi F, Gregori A, Di Rosa F, Nigro F, Rimessi A,

Pinton P, Varani K, Borea PA, Marti M. Pharmaco-toxicological effects of the

novel third-generation fluorinate synthetic cannabinoids, 5F-ADBINACA, AB-

FUBINACA, and STS-135 in mice. In vitro and in vivo studies. Hum

Psychopharmacol. 2017 May;32(3). doi: 10.1002/hup.2601. Epub 2017 Jun 9. PMID:

28597570.

35: Ravani A, Vincenzi F, Bortoluzzi A, Padovan M, Pasquini S, Gessi S, Merighi

S, Borea PA, Govoni M, Varani K. Role and Function of A2A and A₃

Adenosine Receptors in Patients with Ankylosing Spondylitis, Psoriatic Arthritis

and Rheumatoid Arthritis. Int J Mol Sci. 2017 Mar 24;18(4):697. doi:

10.3390/ijms18040697. PMID: 28338619; PMCID: PMC5412283.

36: Longo F, Mercatelli D, Novello S, Arcuri L, Brugnoli A, Vincenzi F, Russo I,

Berti G, Mabrouk OS, Kennedy RT, Shimshek DR, Varani K, Bubacco L, Greggio E,

Morari M. Age-dependent dopamine transporter dysfunction and Serine129 phospho-

α-synuclein overload in G2019S LRRK2 mice. Acta Neuropathol Commun. 2017 Mar

14;5(1):22. doi: 10.1186/s40478-017-0426-8. PMID: 28292328; PMCID: PMC5351259.

37: Varani K, Vincenzi F, Ravani A, Pasquini S, Merighi S, Gessi S, Setti S,

Cadossi M, Borea PA, Cadossi R. Adenosine Receptors as a Biological Pathway for

the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed

Electromagnetic Fields. Mediators Inflamm. 2017;2017:2740963. doi:

10.1155/2017/2740963. Epub 2017 Feb 1. PMID: 28255202; PMCID: PMC5309410.

38: Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pathological

overproduction: the bad side of adenosine. Br J Pharmacol. 2017

Jul;174(13):1945-1960. doi: 10.1111/bph.13763. Epub 2017 Mar 31. PMID: 28252203;

PMCID: PMC6398520.

39: Squarcialupi L, Betti M, Catarzi D, Varano F, Falsini M, Ravani A, Pasquini

S, Vincenzi F, Salmaso V, Sturlese M, Varani K, Moro S, Colotta V. The role of

5-arylalkylamino- and 5-piperazino- moieties on the

7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and

A2A receptor affinity and selectivity profiles. J Enzyme Inhib Med

Chem. 2017 Dec;32(1):248-263. doi: 10.1080/14756366.2016.1247060. PMID:

28114825; PMCID: PMC6009979.

40: Vincenzi F, Borea PA, Varani K. Anxiolytic properties of A1 adenosine

receptor PAMs. Oncotarget. 2017 Jan 31;8(5):7216-7217. doi:

10.18632/oncotarget.13802. PMID: 28055953; PMCID: PMC5352310.

41: Merighi S, Bencivenni S, Vincenzi F, Varani K, Borea PA, Gessi S.

A2B adenosine receptors stimulate IL-6 production in primary murine

microglia through p38 MAPK kinase pathway. Pharmacol Res. 2017 Mar;117:9-19.

doi: 10.1016/j.phrs.2016.11.024. Epub 2016 Dec 11. PMID: 27974241.

42: Varano F, Catarzi D, Vincenzi F, Betti M, Falsini M, Ravani A, Borea PA,

Colotta V, Varani K. Design, Synthesis, and Pharmacological Characterization of

2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly

Potent A2A Adenosine Receptor Inverse Agonists with Antinociceptive

Activity. J Med Chem. 2016 Dec 8;59(23):10564-10576. doi:

10.1021/acs.jmedchem.6b01068. Epub 2016 Nov 29. PMID: 27933962.

43: Sartori M, Vincenzi F, Ravani A, Cepollaro S, Martini L, Varani K, Fini M,

Tschon M. RAW 264.7 co-cultured with ultra-high molecular weight polyethylene

particles spontaneously differentiate into osteoclasts: an in vitro model of

periprosthetic osteolysis. J Biomed Mater Res A. 2017 Feb;105(2):510-520. doi:

10.1002/jbm.a.35912. Epub 2016 Nov 3. PMID: 27667508.

44: Poli D, Falsini M, Varano F, Betti M, Varani K, Vincenzi F, Pugliese AM,

Pedata F, Dal Ben D, Thomas A, Palchetti I, Bettazzi F, Catarzi D, Colotta V.

Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor

antagonists: Structural exploration to target the A3 and

A2A subtypes. Eur J Med Chem. 2017 Jan 5;125:611-628. doi:

10.1016/j.ejmech.2016.09.076. Epub 2016 Sep 26. PMID: 27721147.

45: Vincenzi F, Ravani A, Pasquini S, Merighi S, Gessi S, Romagnoli R, Baraldi

PG, Borea PA, Varani K. Positive allosteric modulation of A1

adenosine receptors as a novel and promising therapeutic strategy for anxiety.

Neuropharmacology. 2016 Dec;111:283-292. doi: 10.1016/j.neuropharm.2016.09.015.

Epub 2016 Sep 14. PMID: 27639989.

46: Vincenzi F, Ravani A, Pasquini S, Merighi S, Gessi S, Setti S, Cadossi R,

Borea PA, Varani K. Pulsed Electromagnetic Field Exposure Reduces Hypoxia and

Inflammation Damage in Neuron-Like and Microglial Cells. J Cell Physiol. 2017

May;232(5):1200-1208. doi: 10.1002/jcp.25606. Epub 2016 Oct 7. PMID: 27639248.

47: Bortoluzzi A, Vincenzi F, Govoni M, Padovan M, Ravani A, Borea PA, Varani K.

A2A adenosine receptor upregulation correlates with disease activity in patients

with systemic lupus erythematosus. Arthritis Res Ther. 2016 Aug 26;18(1):192.

doi: 10.1186/s13075-016-1089-8. PMID: 27566294; PMCID: PMC5002091.

48: Canazza I, Ossato A, Trapella C, Fantinati A, De Luca MA, Margiani G,

Vincenzi F, Rimondo C, Di Rosa F, Gregori A, Varani K, Borea PA, Serpelloni G,

Marti M. Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on

"tetrad", sensorimotor, neurological and neurochemical responses in mice. In

vitro and in vivo pharmacological studies. Psychopharmacology (Berl). 2016

Oct;233(21-22):3685-3709. doi: 10.1007/s00213-016-4402-y. Epub 2016 Aug 15.

PMID: 27527584.

49: Squarcialupi L, Falsini M, Catarzi D, Varano F, Betti M, Varani K, Vincenzi

F, Dal Ben D, Lambertucci C, Volpini R, Colotta V. Exploring the 2- and

5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1

and A2A adenosine receptors. Bioorg Med Chem. 2016 Jun 15;24(12):2794-808. doi:

10.1016/j.bmc.2016.04.048. Epub 2016 Apr 23. PMID: 27161878.

50: Aghazadeh Tabrizi M, Baraldi PG, Ruggiero E, Saponaro G, Baraldi S, Poli G,

Tuccinardi T, Ravani A, Vincenzi F, Borea PA, Varani K. Synthesis and structure

activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2

cannabinoid receptor inverse agonists. Eur J Med Chem. 2016 May 4;113:11-27.

doi: 10.1016/j.ejmech.2016.02.032. Epub 2016 Feb 16. PMID: 26922225.

51: Varani K, Vincenzi F, Targa M, Ravani A, Bastia E, Storoni L, Brambilla S,

Almirante N, Impagnatiello F. Repeated Dosing with NCX1404, a Nitric Oxide-

Donating Pregabalin, Re-establishes Normal Nociceptive Responses in Mice with

Streptozotocin-Induced Painful Diabetic Neuropathy. J Pharmacol Exp Ther. 2016

May;357(2):240-7. doi: 10.1124/jpet.115.230193. Epub 2016 Feb 23. PMID:

26907623.

52: Ossato A, Canazza I, Trapella C, Vincenzi F, De Luca MA, Rimondo C, Varani

K, Borea PA, Serpelloni G, Marti M. Effect of JWH-250, JWH-073 and their

interaction on "tetrad", sensorimotor, neurological and neurochemical responses

in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jun 3;67:31-50. doi:

10.1016/j.pnpbp.2016.01.007. Epub 2016 Jan 15. PMID: 26780169.

53: Squarcialupi L, Catarzi D, Varano F, Betti M, Falsini M, Vincenzi F, Ravani

A, Ciancetta A, Varani K, Moro S, Colotta V. Structural refinement of

pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective

antagonists for the human A3 adenosine receptor. Eur J Med Chem. 2016 Jan

27;108:117-133. doi: 10.1016/j.ejmech.2015.11.015. Epub 2015 Nov 17. PMID:

26638043.

54: Romagnoli R, Baraldi PG, Lopez-Cara C, Cruz-Lopez O, Moorman AR, Massink A,

IJzerman AP, Vincenzi F, Borea PA, Varani K. Synthesis and biological evaluation

of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric

modulators of the A1 adenosine receptor. A position-dependent effect study. Eur

J Med Chem. 2015 Aug 28;101:185-204. doi: 10.1016/j.ejmech.2015.06.041. Epub

2015 Jun 24. PMID: 26141910.

55: Baraldi PG, Baraldi S, Saponaro G, Aghazadeh Tabrizi M, Romagnoli R,

Ruggiero E, Vincenzi F, Borea PA, Varani K. One-pot reaction to obtain

N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine

scaffold as human A3 adenosine receptor antagonists. J Med Chem. 2015 Jul

9;58(13):5355-60. doi: 10.1021/acs.jmedchem.5b00551. Epub 2015 Jun 17. PMID:

26046697.

56: Varano F, Catarzi D, Squarcialupi L, Betti M, Vincenzi F, Ravani A, Varani

K, Dal Ben D, Thomas A, Volpini R, Colotta V. Exploring the 7-oxo-

thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor

antagonists. Synthesis, molecular modeling studies and pharmacological

evaluation. Eur J Med Chem. 2015;96:105-21. doi: 10.1016/j.ejmech.2015.04.010.

Epub 2015 Apr 4. PMID: 25874336.

57: Preti D, Baraldi PG, Saponaro G, Romagnoli R, Aghazadeh Tabrizi M, Baraldi

S, Cosconati S, Bruno A, Novellino E, Vincenzi F, Ravani A, Borea PA, Varani K.

Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phen

ylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and

selective agonists of the A2A adenosine receptor. J Med Chem. 2015 Apr

9;58(7):3253-67. doi: 10.1021/acs.jmedchem.5b00215. Epub 2015 Mar 25. PMID:

25780876.

58: Vigolo A, Ossato A, Trapella C, Vincenzi F, Rimondo C, Seri C, Varani K,

Serpelloni G, Marti M. Novel halogenated derivates of JWH-018: Behavioral and

binding studies in mice. Neuropharmacology. 2015 Aug;95:68-82. doi:

10.1016/j.neuropharm.2015.02.008. Epub 2015 Mar 11. PMID: 25769232.

59: Borea PA, Varani K, Vincenzi F, Baraldi PG, Tabrizi MA, Merighi S, Gessi S.

The A3 adenosine receptor: history and perspectives. Pharmacol Rev.

2015;67(1):74-102. doi: 10.1124/pr.113.008540. PMID: 25387804.

60: Romagnoli R, Baraldi PG, IJzerman AP, Massink A, Cruz-Lopez O, Lopez-Cara

LC, Saponaro G, Preti D, Aghazadeh Tabrizi M, Baraldi S, Moorman AR, Vincenzi F,

Borea PA, Varani K. Synthesis and biological evaluation of novel allosteric

enhancers of the A1 adenosine receptor based on

2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene. J Med Chem.

2014 Sep 25;57(18):7673-86. doi: 10.1021/jm5008853. Epub 2014 Sep 12. PMID:

25181013.

61: Ferrante A, Martire A, Pepponi R, Varani K, Vincenzi F, Ferraro L, Beggiato

S, Tebano MT, Popoli P. Expression, pharmacology and functional activity of

adenosine A1 receptors in genetic models of Huntington's disease. Neurobiol Dis.

2014 Nov;71:193-204. doi: 10.1016/j.nbd.2014.08.013. Epub 2014 Aug 15. PMID:

25132555.

62: Squarcialupi L, Colotta V, Catarzi D, Varano F, Betti M, Varani K, Vincenzi

F, Borea PA, Porta N, Ciancetta A, Moro S.

7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations

at the 5-position to target human A₁ and A(2A) adenosine receptors. Molecular

modeling and pharmacological studies. Eur J Med Chem. 2014 Sep 12;84:614-27.

doi: 10.1016/j.ejmech.2014.07.060. Epub 2014 Jul 19. PMID: 25063944.

63: Vincenzi F, Targa M, Romagnoli R, Merighi S, Gessi S, Baraldi PG, Borea PA,

Varani K. TRR469, a potent A(1) adenosine receptor allosteric modulator,

exhibits anti-nociceptive properties in acute and neuropathic pain models in

mice. Neuropharmacology. 2014 Jun;81:6-14. doi:

10.1016/j.neuropharm.2014.01.028. Epub 2014 Jan 31. PMID: 24486382.

64: Romagnoli R, Baraldi PG, Carrion MD, Cruz-Lopez O, Cara CL, Saponaro G,

Preti D, Tabrizi MA, Baraldi S, Moorman AR, Vincenzi F, Borea PA, Varani K.

Synthesis and biological evaluation of novel

2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric

enhancers of the A₁ adenosine receptor. Bioorg Med Chem. 2014 Jan

1;22(1):148-66. doi: 10.1016/j.bmc.2013.11.043. Epub 2013 Dec 1. PMID: 24332652.

65: Casetta I, Vincenzi F, Bencivelli D, Corciulo C, Gentile M, Granieri E,

Borea PA, Varani K. A(2A) adenosine receptors and Parkinson's disease severity.

Acta Neurol Scand. 2014 Apr;129(4):276-81. doi: 10.1111/ane.12181. Epub 2013 Aug

30. PMID: 24032478.

66: Romagnoli R, Baraldi PG, Carrion MD, Lopez Cara C, Kimatrai Salvador M,

Preti D, Aghazadeh Tabrizi M, Moorman AR, Vincenzi F, Borea PA, Varani K.

Synthesis and biological effects of novel

2-amino-3-(4-chlorobenzoyl)-4-substituted thiophenes as allosteric enhancers

of the A1 adenosine receptor. Eur J Med Chem. 2013 Sep;67:409-27. doi:

10.1016/j.ejmech.2013.07.002. Epub 2013 Jul 13. PMID: 23911855.

67: Vincenzi F, Targa M, Corciulo C, Gessi S, Merighi S, Setti S, Cadossi R,

Goldring MB, Borea PA, Varani K. Pulsed electromagnetic fields increased the

anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2

chondrocytes and hFOB 1.19 osteoblasts. PLoS One. 2013 May 31;8(5):e65561. doi:

10.1371/journal.pone.0065561. PMID: 23741498; PMCID: PMC3669296.

68: Aghazadeh Tabrizi M, Baraldi PG, Saponaro G, Moorman AR, Romagnoli R, Preti

D, Baraldi S, Ruggiero E, Tintori C, Tuccinardi T, Vincenzi F, Borea PA, Varani

K. Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and

selective CB(2) cannabinoid receptor inverse agonists. J Med Chem. 2013 Jun

13;56(11):4482-96. doi: 10.1021/jm400182t. Epub 2013 Jun 4. PMID: 23697626.

69: Vincenzi F, Corciulo C, Targa M, Casetta I, Gentile M, Granieri E, Borea PA,

Popoli P, Varani K. A2A adenosine receptors are up-regulated in lymphocytes from

amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal

Degener. 2013 Sep;14(5-6):406-13. doi: 10.3109/21678421.2013.793358. Epub 2013

May 16. PMID: 23679925.

70: Vincenzi F, Corciulo C, Targa M, Merighi S, Gessi S, Casetta I, Gentile M,

Granieri E, Borea PA, Varani K. Multiple sclerosis lymphocytes upregulate A2A

adenosine receptors that are antiinflammatory when stimulated. Eur J Immunol.

2013 Aug;43(8):2206-16. doi: 10.1002/eji.201343314. Epub 2013 Jun 3. PMID:

23661562.

71: Vincenzi F, Targa M, Corciulo C, Tabrizi MA, Merighi S, Gessi S, Saponaro G,

Baraldi PG, Borea PA, Varani K. Antinociceptive effects of the selective CB2

agonist MT178 in inflammatory and chronic rodent pain models. Pain. 2013

Jun;154(6):864-73. doi: 10.1016/j.pain.2013.02.007. Epub 2013 Feb 26. PMID:

23518609.

72: Squarcialupi L, Colotta V, Catarzi D, Varano F, Filacchioni G, Varani K,

Corciulo C, Vincenzi F, Borea PA, Ghelardini C, Di Cesare Mannelli L, Ciancetta

A, Moro S. 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and

selective human A3 adenosine receptor antagonists. Molecular modeling studies

and pharmacological evaluation. J Med Chem. 2013 Mar 28;56(6):2256-69. doi:

10.1021/jm400068e. Epub 2013 Mar 7. PMID: 23427825.

73: Aghazadeh Tabrizi M, Baraldi PG, Saponaro G, Moorman AR, Romagnoli R, Preti

D, Baraldi S, Corciulo C, Vincenzi F, Borea PA, Varani K. Design, synthesis, and

pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine

derivatives as CB(2) cannabinoid receptor partial agonists. J Med Chem. 2013 Feb

14;56(3):1098-112. doi: 10.1021/jm301527r. Epub 2013 Feb 1. PMID: 23350768.

74: Fini M, Pagani S, Giavaresi G, De Mattei M, Ongaro A, Varani K, Vincenzi F,

Massari L, Cadossi M. Functional tissue engineering in articular cartilage

repair: is there a role for electromagnetic biophysical stimulation? Tissue Eng

Part B Rev. 2013 Aug;19(4):353-67. doi: 10.1089/ten.TEB.2012.0501. Epub 2013 Mar

19. PMID: 23339690.

75: Vincenzi F, Padovan M, Targa M, Corciulo C, Giacuzzo S, Merighi S, Gessi S,

Govoni M, Borea PA, Varani K. A(2A) adenosine receptors are differentially

modulated by pharmacological treatments in rheumatoid arthritis patients and

their stimulation ameliorates adjuvant-induced arthritis in rats. PLoS One.

2013;8(1):e54195. doi: 10.1371/journal.pone.0054195. Epub 2013 Jan 11. PMID:

23326596; PMCID: PMC3543361.

76: Catarzi D, Colotta V, Varano F, Poli D, Squarcialupi L, Filacchioni G,

Varani K, Vincenzi F, Borea PA, Dal Ben D, Lambertucci C, Cristalli G.

Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as

adenosine receptor antagonists: synthesis, structure-affinity relationships and

molecular modeling studies. Bioorg Med Chem. 2013 Jan 1;21(1):283-94. doi:

10.1016/j.bmc.2012.10.031. Epub 2012 Oct 29. PMID: 23171656.

77: Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Salvador MK,

Preti D, Tabrizi MA, Moorman AR, Vincenzi F, Borea PA, Varani K. Synthesis and

biological evaluation of

2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-

thiophenes. effect of the 5-modification on allosteric enhancer activity at the

A1 adenosine receptor. J Med Chem. 2012 Sep 13;55(17):7719-35. doi:

10.1021/jm3007504. Epub 2012 Aug 28. PMID: 22889387.

78: Varani K, Vincenzi F, Targa M, Paradiso B, Parrilli A, Fini M, Lanza G,

Borea PA. The stimulation of A(3) adenosine receptors reduces bone-residing

breast cancer in a rat preclinical model. Eur J Cancer. 2013 Jan;49(2):482-91.

doi: 10.1016/j.ejca.2012.06.005. Epub 2012 Jul 5. PMID: 22770890.

79: Vincenzi F, Targa M, Corciulo C, Gessi S, Merighi S, Setti S, Cadossi R,

Borea PA, Varani K. The anti-tumor effect of A3 adenosine receptors is

potentiated by pulsed electromagnetic fields in cultured neural cancer cells.

PLoS One. 2012;7(6):e39317. doi: 10.1371/journal.pone.0039317. Epub 2012 Jun 25.

PMID: 22761760; PMCID: PMC3382599.

80: Baraldi PG, Saponaro G, Moorman AR, Romagnoli R, Preti D, Baraldi S,

Ruggiero E, Varani K, Targa M, Vincenzi F, Borea PA, Aghazadeh Tabrizi M.

7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2)

cannabinoid receptor ligands: structural investigations around a novel class of

full agonists. J Med Chem. 2012 Jul 26;55(14):6608-23. doi: 10.1021/jm300763w.

Epub 2012 Jul 11. PMID: 22738271.

81: Dalpiaz A, Cacciari B, Vicentini CB, Bortolotti F, Spalluto G, Federico S,

Pavan B, Vincenzi F, Borea PA, Varani K. A novel conjugated agent between

dopamine and an A2A adenosine receptor antagonist as a potential anti-Parkinson

multitarget approach. Mol Pharm. 2012 Mar 5;9(3):591-604. doi:

10.1021/mp200489d. Epub 2012 Feb 9. PMID: 22292533.

82: Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Salvador MK,

Preti D, Tabrizi MA, Shryock JC, Moorman AR, Vincenzi F, Varani K, Borea PA.

Structure-activity relationships of

2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the

influence of diverse substituents at the phenyl of the arylpiperazine moiety on

allosteric enhancer activity at the A₁ adenosine receptor. Bioorg Med Chem. 2012

Jan 15;20(2):996-1007. doi: 10.1016/j.bmc.2011.11.044. Epub 2011 Dec 1. PMID:

22182575.

83: Varani K, Padovan M, Vincenzi F, Targa M, Trotta F, Govoni M, Borea PA. A2A

and A3 adenosine receptor expression in rheumatoid arthritis: upregulation,

inverse correlation with disease activity score and suppression of inflammatory

cytokine and metalloproteinase release. Arthritis Res Ther. 2011;13(6):R197.

doi: 10.1186/ar3527. Epub 2011 Dec 6. PMID: 22146575; PMCID: PMC3334647.

84: Varani K, Vincenzi F, Targa M, Corciulo C, Fini M, Setti S, Cadossi R, Borea

PA. Effect of pulsed electromagnetic field exposure on adenosine receptors in

rat brain. Bioelectromagnetics. 2012 May;33(4):279-87. doi: 10.1002/bem.20704.

Epub 2011 Oct 19. PMID: 22012856.

85: Ongaro A, Varani K, Masieri FF, Pellati A, Massari L, Cadossi R, Vincenzi F,

Borea PA, Fini M, Caruso A, De Mattei M. Electromagnetic fields (EMFs) and

adenosine receptors modulate prostaglandin E(2) and cytokine release in human

osteoarthritic synovial fibroblasts. J Cell Physiol. 2012 Jun;227(6):2461-9.

doi: 10.1002/jcp.22981. PMID: 21830213.

86: Lenzi O, Colotta V, Catarzi D, Varano F, Squarcialupi L, Filacchioni G,

Varani K, Vincenzi F, Borea PA, Dal Ben D, Lambertucci C, Cristalli G.

Synthesis, structure-affinity relationships, and molecular modeling studies of

novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.

Bioorg Med Chem. 2011 Jun 15;19(12):3757-68. doi: 10.1016/j.bmc.2011.05.001.

Epub 2011 May 6. PMID: 21616671.

87: Varani K, Maniero S, Vincenzi F, Targa M, Stefanelli A, Maniscalco P,

Martini F, Tognon M, Borea PA. A₃ receptors are overexpressed in pleura from

patients with mesothelioma and reduce cell growth via Akt/nuclear factor-κB

pathway. Am J Respir Crit Care Med. 2011 Feb 15;183(4):522-30. doi:

10.1164/rccm.201006-0980OC. Epub 2010 Sep 24. PMID: 20870754.

88: Varani K, Padovan M, Govoni M, Vincenzi F, Trotta F, Borea PA. The role of

adenosine receptors in rheumatoid arthritis. Autoimmun Rev. 2010 Dec;10(2):61-4.

doi: 10.1016/j.autrev.2010.07.019. Epub 2010 Aug 5. PMID: 20691813.

89: Varani K, Vincenzi F, Tosi A, Targa M, Masieri FF, Ongaro A, De Mattei M,

Massari L, Borea PA. Expression and functional role of adenosine receptors in

regulating inflammatory responses in human synoviocytes. Br J Pharmacol. 2010

May;160(1):101-15. doi: 10.1111/j.1476-5381.2010.00667.x. Epub 2010 Mar 19.

PMID: 20331607; PMCID: PMC2860211.

90: Varani K, De Mattei M, Vincenzi F, Tosi A, Targa M, Masieri FF, Pellati A,

Massari L, Borea PA. P2X(1) and P2X(3) purinergic receptors differentially

modulate the inflammatory response in human osteoarthritic synovial fibroblasts.

Cell Physiol Biochem. 2010;25(2-3):325-36. doi: 10.1159/000276565. Epub 2010 Jan

12. PMID: 20110693.

91: Varani K, Caramori G, Vincenzi F, Tosi A, Barczyk A, Contoli M, Casolari P,

Triggiani M, Hansel T, Leung E, Maclennan S, Barnes PJ, Chung KF, Adcock I, Papi

A, Borea PA. Oxidative/nitrosative stress selectively altered A(2B) adenosine

receptors in chronic obstructive pulmonary disease. FASEB J. 2010

Apr;24(4):1192-204. doi: 10.1096/fj.09-139485. Epub 2009 Dec 14. PMID: 20008542.

92: Varani K, Massara A, Vincenzi F, Tosi A, Padovan M, Trotta F, Borea PA.

Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid

arthritis patients by treatment with anti-tumor necrosis factor alpha but not

methotrexate. Arthritis Rheum. 2009 Oct;60(10):2880-91. doi: 10.1002/art.24794.

PMID: 19790066.

93: Varani K, Vincenzi F, Tosi A, Gessi S, Casetta I, Granieri G, Fazio P, Leung

E, MacLennan S, Granieri E, Borea PA. A2A adenosine receptor overexpression and

functionality, as well as TNF-alpha levels, correlate with motor symptoms in

Parkinson's disease. FASEB J. 2010 Feb;24(2):587-98. doi: 10.1096/fj.09-141044.

Epub 2009 Sep 23. PMID: 19776336.

94: Lenzi O, Colotta V, Catarzi D, Varano F, Poli D, Filacchioni G, Varani K,

Vincenzi F, Borea PA, Paoletta S, Morizzo E, Moro S.

2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and

selective human A3 adenosine receptor antagonists: new insights into the

receptor-antagonist recognition. J Med Chem. 2009 Dec 10;52(23):7640-52. doi:

10.1021/jm900718w. PMID: 19743865.

95: Aguiari G, Varani K, Bogo M, Mangolini A, Vincenzi F, Durante C, Gessi S,

Sacchetto V, Catizone L, Harris P, Rizzuto R, Borea PA, Del Senno L. Deficiency

of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine

receptors in human renal cells: implications for cAMP-dependent signalling and

proliferation of PKD1-mutated cystic cells. Biochim Biophys Acta. 2009

Jun;1792(6):531-40. doi: 10.1016/j.bbadis.2009.03.001. Epub 2009 Mar 11. PMID:

19285554.

96: Colotta V, Capelli F, Lenzi O, Catarzi D, Varano F, Poli D, Vincenzi F,

Varani K, Borea PA, Dal Ben D, Volpini R, Cristalli G, Filacchioni G. Novel

potent and highly selective human A(3) adenosine receptor antagonists belonging

to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis

and pharmacological studies. Bioorg Med Chem. 2009 Jan 1;17(1):401-10. doi:

10.1016/j.bmc.2008.10.018. Epub 2008 Oct 11. PMID: 18996701.

97: Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Iaconinoto MA,

Preti D, Shryock JC, Moorman AR, Vincenzi F, Varani K, Andrea Borea P. Synthesis

and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted)

piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine

receptor. J Med Chem. 2008 Sep 25;51(18):5875-9. doi: 10.1021/jm800586p. Epub

2008 Aug 26. PMID: 18729349.

98: De Mattei M, Varani K, Masieri FF, Pellati A, Ongaro A, Fini M, Cadossi R,

Vincenzi F, Borea PA, Caruso A. Adenosine analogs and electromagnetic fields

inhibit prostaglandin E2 release in bovine synovial fibroblasts. Osteoarthritis

Cartilage. 2009 Feb;17(2):252-62. doi: 10.1016/j.joca.2008.06.002. Epub 2008 Jul

18. PMID: 18640059.

99: Varani K, De Mattei M, Vincenzi F, Tosi A, Gessi S, Merighi S, Pellati A,

Masieri F, Ongaro A, Borea PA. Pharmacological characterization of P2X1 and P2X3

purinergic receptors in bovine chondrocytes. Osteoarthritis Cartilage. 2008

Nov;16(11):1421-9. doi: 10.1016/j.joca.2008.03.016. Epub 2008 Apr 29. PMID:

18448363.

100: Varani K, Surprenant A, Vincenzi F, Tosi A, Gessi S, Merighi S, Borea PA.

Binding thermodynamic characterization of human P2X1 and P2X3 purinergic

receptors. Biochem Pharmacol. 2008 Mar 1;75(5):1198-208. doi:

10.1016/j.bcp.2007.10.034. Epub 2007 Nov 9. PMID: 18076867.

101: Morizzo E, Capelli F, Lenzi O, Catarzi D, Varano F, Filacchioni G, Vincenzi

F, Varani K, Borea PA, Colotta V, Moro S. Scouting human A3 adenosine receptor

antagonist binding mode using a molecular simplification approach: from

triazoloquinoxaline to a pyrimidine skeleton as a key study. J Med Chem. 2007

Dec 27;50(26):6596-606. doi: 10.1021/jm070852a. Epub 2007 Nov 30. PMID:

18047262.

102: Varani K, De Mattei M, Vincenzi F, Gessi S, Merighi S, Pellati A, Ongaro A,

Caruso A, Cadossi R, Borea PA. Characterization of adenosine receptors in bovine

chondrocytes and fibroblast-like synoviocytes exposed to low frequency low

energy pulsed electromagnetic fields. Osteoarthritis Cartilage. 2008

Mar;16(3):292-304. doi: 10.1016/j.joca.2007.07.004. Epub 2007 Aug 16. PMID:

17698373.

103: Stasi MA, Borsini F, Varani K, Vincenzi F, Di Cesare MA, Minetti P,

Ghirardi O, Carminati P. ST 1535: a preferential A2A adenosine receptor

antagonist. Int J Neuropsychopharmacol. 2006 Oct;9(5):575-84. doi:

10.1017/S1461145705006188. Epub 2005 Nov 23. PMID: 16867213.

104: Varani K, Caramori G, Vincenzi F, Adcock I, Casolari P, Leung E, Maclennan

S, Gessi S, Morello S, Barnes PJ, Ito K, Chung KF, Cavallesco G, Azzena G, Papi

A, Borea PA. Alteration of adenosine receptors in patients with chronic

obstructive pulmonary disease. Am J Respir Crit Care Med. 2006 Feb

15;173(4):398-406. doi: 10.1164/rccm.200506-869OC. Epub 2005 Dec 1. PMID:

16322645.

105: Baraldi PG, Pavani MG, Leung E, Moorman AR, Varani K, Vincenzi F, Borea PA,

Romagnoli R. Synthesis and biological characterization of [3H]

(2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone,

the first radiolabelled adenosine A1 allosteric enhancer. Bioorg Med Chem Lett.

2006 Mar 1;16(5):1402-4. doi: 10.1016/j.bmcl.2005.11.037. PMID: 16321527.

106: Varani K, Gessi S, Merighi S, Vincenzi F, Cattabriga E, Benini A, Klotz KN,

Baraldi PG, Tabrizi MA, Lennan SM, Leung E, Borea PA. Pharmacological

characterization of novel adenosine ligands in recombinant and native human A2B

receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. doi:

10.1016/j.bcp.2005.08.018. Epub 2005 Oct 10. PMID: 16219300.

107: Varani K, Portaluppi F, Gessi S, Merighi S, Vincenzi F, Cattabriga E,

Dalpiaz A, Bortolotti F, Belardinelli L, Borea PA. Caffeine intake induces an

alteration in human neutrophil A2A adenosine receptors. Cell Mol Life Sci. 2005

Oct;62(19-20):2350-8. doi: 10.1007/s00018-005-5312-z. PMID: 16143823.

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