Carlo Mischiati, PhD
Actual Position (2011-present) Associate Professor in Clinical Biochemistry and Clinical Molecular Biology (BIO/12), Faculty of Medicine, Department of Biomedical Sciences and Specialty Surgeries,
University of Ferrara
Degree. Biological Science
Doctorate. PhD in Biotechnology
Scientific publications: 85 in international journals (ISI indexed)
Scientific career.
(1988-90) Department of Biochemistry & Molecular Biology, University of Ferrara, studies on “In vitro methylation of the chromatin of the human HLA-DRA gene”
(1991-95) Doctorate in Biotechnology, studies on “Interaction of nuclear proteins with HIV-1 genome regions homologous to regulative elements of the MHC class II gene promoters”
(1995-97) Fellowship from the Italian National Institute of Health, studies on “Effects of Tat protein on survival and cell proliferation”
(1997-98) Fellowship from the Italian Association for Cancer Research (AIRC), studies on “Modulation of oncogene expression by decoy oligonucleotides”
(1998-2011) University Researcher (Aggregated Professor) in Biochemistry (BIO/10), Faculty of Pharmacy, Department of Biochemistry and Molecular Biology, University of Ferrara.
Research trends:
1. Delivery and decoy activity of PNA and PDP chimeras for Sp1 and NF-kB transcription factors in order to develop a decoy approach for gene therapy.
2. Induction of erythroid differentiation as a therapy approach to fight beta-thalassemia and sickle cells anaemia.
3. High-throughput automated molecular diagnosis of genetic diseases and genetically modified organisms by a biosensor approach based on the surface plasmon resonance.
4. Regulation of HLA-DRA gene expression in cultured cells and transgenic animals.
5. Pharmacogenomic studies by macro- and micro-arrays.
6. Identification of DNA- and RNA-binding drugs showing anti-viral and/or anti-cancer activity.
Patents:
- INTERNATIONAL PATENT n° PCT/IB2003/002632, year 2003. A novel use of rapamycin and structural analogues thereof. Inventors: Bianchi N, Borgatti M, Gambari R, MISCHIATI C.
- INTERNATIONAL PATENT n° PCT/IB02/02628, year 2002. Use of heterocyclic polyamides structurally related to the natural antibiotic distamycin A for the treatment of beta-thalaessemia. Inventors: Baraldi G, Bianchi N, Feriotto G, Gambari R, MISCHIATI C, Romagnoli R.
- INTERNATIONAL PATENT n° PCT/EP01/02804, year 2001 (already ITALIAN PATENT n° TO2000A000234). Synthetic oligonucleotides as inducers of erythroid differentiation. Inventors: Bianchi N, Feriotto G, Gambari R, MISCHIATI C.
- ITALIAN PATENT n° TO2001A000633, year 2001. Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale Distamicina A. Inventors: Baraldi G, Bianchi N, Feriotto G, Gambari R, MISCHIATI C.
- ITALIAN PATENT n° TO2000A000669, year 2000. Nuovo impiego di analoghi strutturali della distamicina. Inventors: Bianchi N, Feriotto G, Gambari R, MISCHIATI C.
Actual Position (2011-present) Associate Professor in Clinical Biochemistry and Clinical Molecular Biology (BIO/12), Faculty of Medicine, Department of Biomedical Sciences and Specialty Surgeries,
University of Ferrara
Degree. Biological Science
Doctorate. PhD in Biotechnology
Scientific publications: 85 in international journals (ISI indexed)
Scientific career.
(1988-90) Department of Biochemistry & Molecular Biology, University of Ferrara, studies on “In vitro methylation of the chromatin of the human HLA-DRA gene”
(1991-95) Doctorate in Biotechnology, studies on “Interaction of nuclear proteins with HIV-1 genome regions homologous to regulative elements of the MHC class II gene promoters”
(1995-97) Fellowship from the Italian National Institute of Health, studies on “Effects of Tat protein on survival and cell proliferation”
(1997-98) Fellowship from the Italian Association for Cancer Research (AIRC), studies on “Modulation of oncogene expression by decoy oligonucleotides”
(1998-2011) University Researcher (Aggregated Professor) in Biochemistry (BIO/10), Faculty of Pharmacy, Department of Biochemistry and Molecular Biology, University of Ferrara.
Research trends:
1. Delivery and decoy activity of PNA and PDP chimeras for Sp1 and NF-kB transcription factors in order to develop a decoy approach for gene therapy.
2. Induction of erythroid differentiation as a therapy approach to fight beta-thalassemia and sickle cells anaemia.
3. High-throughput automated molecular diagnosis of genetic diseases and genetically modified organisms by a biosensor approach based on the surface plasmon resonance.
4. Regulation of HLA-DRA gene expression in cultured cells and transgenic animals.
5. Pharmacogenomic studies by macro- and micro-arrays.
6. Identification of DNA- and RNA-binding drugs showing anti-viral and/or anti-cancer activity.
Patents:
- INTERNATIONAL PATENT n° PCT/IB2003/002632, year 2003. A novel use of rapamycin and structural analogues thereof. Inventors: Bianchi N, Borgatti M, Gambari R, MISCHIATI C.
- INTERNATIONAL PATENT n° PCT/IB02/02628, year 2002. Use of heterocyclic polyamides structurally related to the natural antibiotic distamycin A for the treatment of beta-thalaessemia. Inventors: Baraldi G, Bianchi N, Feriotto G, Gambari R, MISCHIATI C, Romagnoli R.
- INTERNATIONAL PATENT n° PCT/EP01/02804, year 2001 (already ITALIAN PATENT n° TO2000A000234). Synthetic oligonucleotides as inducers of erythroid differentiation. Inventors: Bianchi N, Feriotto G, Gambari R, MISCHIATI C.
- ITALIAN PATENT n° TO2001A000633, year 2001. Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale Distamicina A. Inventors: Baraldi G, Bianchi N, Feriotto G, Gambari R, MISCHIATI C.
- ITALIAN PATENT n° TO2000A000669, year 2000. Nuovo impiego di analoghi strutturali della distamicina. Inventors: Bianchi N, Feriotto G, Gambari R, MISCHIATI C.
