ALESSANDRA PECORELLI
WORK ADDRESS
University of Ferrara
Dept. of Environmental and Prevention Sciences
Via Luigi Borsari, 46
44121 Ferrara, Italy
E-mail: pcrlsn1@unife.it; ale.pecorelli@gmail.com; apecore@ncsu.edu
Mobile Phone: +39 333 3299724
NATIONALITY: Italian
EDUCATION
Ph.D. in Cell Biology and Pathophysiology (Pathophysiology and Cellular Pathology Section), University of Siena, Siena, Italy. 13 February 2013.
Pharm.D. degree, 110/110 Magna Cum Laude, University of Siena, Siena, Italy. 15 December 2004.
ACADEMIC APPOINTMENTS
Associate Professor (GSD 06/MEDS-08 - Endocrinologia, Nefrologia e Scienze dell'Alimentazione e del Benessere, SSD MEDS-08/C - Scienza dell'Alimentazione e delle Tecniche Dietetiche Applicate; SSD 2015, MED/49, SC 2015, 06/D2) at University of Ferrara, Dept. of Environmental and Prevention Sciences, Ferrara, Italy. From 01/10/25- Present.
Adjunct Professor. Department of Food, Bioprocessing and Nutrition Sciences, College of Agriculture and Life Sciences, Plants for Human Health Institute, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 1st December 2023 - Present.
PREVIOUS ACADEMIC AND PROFESSIONAL APPOINTMENTS
-Assistant Professor (Ricercatore a tempo determinato L.240/10 tipo B, GSD 06/MEDS-08 - Endocrinologia, Nefrologia e Scienze dell'alimentazione e del Benessere, SSD MEDS-08/C - Scienza dell'alimentazione e delle tecniche dietetiche applicate) at University of Ferrara, Dept. of Environmental and Prevention Sciences, Ferrara, Italy, NC, USA. From 01/10/22- 30/09/2025.
-Short Term Research Scholar. Plants for Human Health Institute, College of Agriculture and Life Sciences, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 05/05/25 to 04/09/25.
-Visiting Scholar. Plants for Human Health Institute, College of Agriculture and Life Sciences, Department of Animal Science, Valacchi’s Laboratory, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 10/02/25 to 14/02/25.
Short Term Research Scholar. Plants for Human Health Institute, College of Agriculture and Life Sciences, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 02/03/24 to 21/06/24.
Short Term Research Scholar. Plants for Human Health Institute, College of Agriculture and Life Sciences, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 05/05/23 to 13/08/23.
Senior Research Scholar (PI status). Plants for Human Health Institute, Animal Science Department, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 03/19- 09/22.
Postdoctoral Research Scholar. Plants for Human Health Institute, Animal Science Department, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 01/18- 02/19.
Temp Research Tech'n/Paraprof. Plants for Human Health Institute, Animal Science Department, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 12/16- 12/17.
Research Scholar. Child Neuropsychiatry Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy. From 03/2016 – to 11/2016.
Research Scholar. Department of Life Science and Biotechnologies, University of Ferrara, Ferrara, Italy. From 10/2015 – to 12/ 2015.
Research Scholar. Child Neuropsychiatry Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy. From 12/2014 - to 09/2015.
Research Scholar. Child Neuropsychiatry Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy. From 11/2012 - to 08/2014.
Ph.D. Student in “Cell Biology and Pathophysiology” graduate program, Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. From 10/2009 - to 09/2012.
Research Fellow. Department of Physiology, University of Siena, Siena, Italy. From 09/2005 - to 08/2009.
TEACHING EXPERIENCE
[52657] COMMUNITY NUTRITION, Module of [52673] ORGANIZATION OF COLLECTIVE CATERING SERVICES, Degree Program: DIETETICS (QUALIFYING FOR THE HEALTHCARE PROFESSION OF DIETITIAN), (2025/2026), University of Ferrara, Ferrara, Italy.
[73618] FOOD AND NUTRITION ACROSS DIFFERENT AGES AND PATHOLOGICAL CONDITIONS, Module of [178613] FOOD, METABOLISM AND MOVEMENT ACROSS DIFFERENT AGES, Master’s Degree Program: SCIENCES AND TECHNIQUES OF PREVENTIVE AND ADAPTED PHYSICAL ACTIVITY, (2025/2026), University of Ferrara, Ferrara, Italy.
[56509] NUTRITIONAL AND PSYCHOLOGICAL ASPECTS OF SCHOOL CATERING, Degree Program: DIETETICS (QUALIFYING FOR THE HEALTHCARE PROFESSION OF DIETITIAN), (2024/2025, 2025/2026), University of Ferrara, Ferrara, Italy.
[73618] FOOD AND NUTRITION ACROSS DIFFERENT AGES AND PATHOLOGICAL CONDITIONS, Module of [73616] METABOLISM, FOOD AND NUTRITION, Master’s Degree Program: SCIENCES AND TECHNIQUES OF PREVENTIVE AND ADAPTED PHYSICAL ACTIVITY, (2023-2024, 2024/2025), University of Ferrara, Ferrara, Italy.
[008719/1] HUMAN NUTRITION, Module of [52665] FOOD AND HUMAN NUTRITION I, Degree Program: DIETETICS (QUALIFYING FOR THE HEALTHCARE PROFESSION OF DIETITIAN), (2022-2023, 2023/2024, 2024/2025, 2025/2026), University of Ferrara, Ferrara, Italy.
[65961] OPTIMAL NUTRITION FOR SPORTS EXERCISE, Module of [65959] GENERAL PRINCIPLES OF FOOD COMPOSITION AND NUTRITION, Degree Program: SPORTS SCIENCES, (2023/2024, 2024/2025, 2025/2026), University of Ferrara, Ferrara, Italy.
“Skin Physiology” for the Master COSMAST (Scienza e Tecnologia Cosmetiche), (2016-2017; 2018-2019, 2020-2021), University of Ferrara, Ferrara, Italy.
Lectures for the Animal Ecophysiology class, “Environmental Sciences” Graduate Group in the School of Biology, (2009-2010), University of Siena, Siena, Italy.
AWARDS AND HONORS
Winner of the “2021 SfRBM Trainee Award” for the abstract titled “Aberrant Mitochondrial Bioenergetics Fuels Inflammasome Machinery in Autism Spectrum Disorder” at the “28th Annual Conference of the Society for Redox Biology & Medicine (SfRBM 2021)”. Virtual Conference. November 15-18, 2021.
Winner of the “Young Investigator Award” for the narrated communication titled “Mitochondrial dysfunction fuels inflammasome machinery in Autism Spectrum Disorder” at the “20th Biennial Meeting for the Society for Free Radical Research International (SFRRI 2021)”. Virtual Conference. March 15-18, 2021.
Winner of the “2019 SFRR Europe Catherine Pasquier Award" Society for Free Radical Research (SFRR) – Europe Meeting “Redox Homeostasis: from Signaling to Damage” in Ferrara, Italy, June 19-21, 2019.
Winner of the “Young Investigator Award” by OCC (Oxygen Club of California) for poster titled “Alteration of serum lipid profile, SRB1 loss and impaired Nrf2 activation in CDKL5 disorder” at the World Congress "Oxidants and Antioxidants in Biology", Valencia, Spain, June 24-26, 2015.
Winner of the “Young Investigator Award” by OCC (Oxygen Club of California) for poster titled “Increased Oxidative Stress Levels and MMPs Activation In Drug-resistant Epileptic Brain”. “Second International Conference on Environmental Stressors in Biology and Medicine”, Siena, Italy, October 5-7, 2011.
ORAL PRESENTATION AND INVITED TALKS
– “MAM proteomics identifies progressive ER–mitochondria signaling disfunction in Rett Syndrome”, at 2026 SFRR Europe Annual Meeting hosted by the Society for Free Radical Research Europe: “Redox Biology, Environmental Exposures and Lifestyle”. Mainz, Germany, June 03 – 05, 2026.
– “Targeting exposome-induced oxinflammatory responses: bioactives as a strategy for improved human health”, I Congresso de Medicina da UFV / IX Semana Acadêmica de Medicina (SAM): “Medicine and the New World: Health, Technology, and Well-Being in the 21st Century”, at the Federal University of Viçosa (UFV), Brazil, November 7th, 2025. (Invited Speaker)
– “Unraveling the Role of mitochondrial-associated ER membranes (MAMs) Proteins in RTT Brain Signaling”, Seminar at North Carolina State University, Plants for Human Health Institute, NC Research Campus, Kannapolis, NC, USA. August 1st, 2025.
– “Abnormal MAMs proteins can disrupt finely tuned signaling between ER and mitochondria in RTT brain”, at 22nd SFRRI Biennial Meeting hosted by the Society for Free Radical Research – Europe: “The New Era of Redox Biology: from Basic Biochemistry to Redox Omics”. Galway, Ireland, June 03 – 06, 2025.
– “Evidence of compromised redox homeostasis and ferritinophagy in Rett syndrome”, at 22nd SFRRI Biennial Meeting hosted by the Society for Free Radical Research – Europe: “The New Era of Redox Biology: from Basic Biochemistry to Redox Omics”. Galway, Ireland, June 03 – 06, 2025.
– “Deregulated Nrf2/BACH1 axis in Autism Spectrum Disorder”, MNESYS Spoke 6 & 7 Joint Meeting, «Neuro-immune interactions in the development of neurodegenerative diseases». Università di Verona, Verona, Italy. January 31, 2025.
– “Food and Diet to modulate OxInflammatory Conditions”, 2nd International Conference BioExperience 2024. Universidade Federal de Viçosa - Viçosa - Minas Gerais – Brazil. November 18-20, 2024. (Invited Speaker)
– “Involvement of lipid peroxidation byproducts in neurological conditions: from clinical severity to pathological mechanisms”, at the “HNE Club Meeting: Lipid Oxidation: New Biochemical Insights and Clinical Applications”. Genoa, Italy. October 10-12, 2024. (Invited Speaker)
– “Cutaneous cell junctions’ responses to dietary oxysterols”, at the “11th International Conference on Oxidative Stress in Skin Medicine and Biology”. Andros, Greece. September 12-15, 2024.
– “Abnormal MAMs proteins can disrupt finely tuned signaling between ER and mitochondria in RTT brain”, Flash Talk at the “2024 IRSF Rett Syndrome Scientific Meeting”. Westminster, CO, USA. June 18-19, 2024.
– “Phytochemicals and nutritional approaches as modulators of the OxInflammation phenomenon”, Seminar for Adjunct Professor Appointment at NC State's Department of Food, Bioprocessing and Nutrition Sciences, Kannapolis, NC, USA. July 20, 2023.
– “Oxidative-mediated loss of Scavenger Receptor B1 in the brain of a Mecp2 mouse model of Rett Syndrome”, Flash Talk at the “2023 IRSF Rett Syndrome Scientific Meeting”. Nashville, TN, USA. June 5-7, 2023.
– “Dietary supplementation with omega−3 fatty acids as coadjuvant strategy to ameliorate Rett syndrome phenotype”, at the “Bioactives and Health Symposium”. Core Laboratory, NC Research Campus, Kannapolis, NC, USA. May 19, 2023. (Invited Speaker)
– “A possible role for the loss of brain Scavenger Receptor B1 (SR-B1) in Rett syndrome”, at the “Redox Biology Congress 2022”. Ghent, Belgium. August 24-26, 2022.
– “Mitochondria and inflammasome involvement in Autism Spectrum Disorder”, at “The Future in Redox Biology”. Siena, Italy. June 17-19, 2022. (Invited Speaker)
– “A possible role for the loss of brain Scavenger Receptor B1 (SR-B1) in Rett syndrome”, Flash Talk at the “2022 IRSF Rett Syndrome Scientific Meeting”. Nashville, TN, USA. April 26-27, 2022.
– “Mitochondrial impairment in Autism Spectrum Disorders”, Webinar on "Aberrant redox responses in neurodevelopmental conditions: the case of autism and Rett Syndrome” 16 December, 2021.
– “Aberrant Mitochondrial Bioenergetics Fuels Inflammasome Machinery in Autism Spectrum Disorder”, at the “28th Annual Conference of the Society for Redox Biology & Medicine (SfRBM 2021)”. Virtual Conference. November 15-18, 2021.
– “Mitochondrial dynamics and quality control pathways impairment in Rett Syndrome and Autism Spectrum Disorder”, at the “Annual Virtual Meeting SFRR-E 2021. Redox Biology in the 21st Century: A New Scientific Discipline”. Virtual Conference. Belgrade, Serbia. June 15-18, 2021.
– “A role for Mitochondrial Dysfunction in Inflammasome Activation in Autism Spectrum Disorder”, at the “2021 SfRBM & MCW Redox Biology Symposium”. Virtual Conference. Medical College of Wisconsin, Wauwatosa, WI, USA. May 13-14, 2021.
– “Proteomic profiling reveals mitochondrial alterations in Rett Syndrome”, at the “9th Annual Catalyst Spring Symposium - Looking at the big picture: the application of “-omics” techniques in health and disease”. Virtual Conference. Kannapolis, NC, USA. March 25-26, 2021.
– "Mitochondrial dysfunction fuels inflammasome machinery in Autism Spectrum Disorder", at the “20th Biennial Meeting for the Society for Free Radical Research International (SFRRI 2021)”. Virtual Conference. March 15-18, 2021.
– "Involvement of redox imbalance in Rett syndrome pathogenesis and clinical severity" Catherine Pasquier Award Lecture at the Society for Free Radical Research (SFRR) – Europe Meeting “Redox Homeostasis: from Signaling to Damage” in Ferrara, Italy, 19-21 June 2019. (Invited Speaker).
– “Evaluation of protective effects of topical vitamin C compound mixtures against ozone-induced damage in different cutaneous models” American Council for Medicinally Active Plants (ACMAP), Clemson University, Clemson, SC, USA. June 20-23, 2017. (Invited Speaker).
EDITORIAL WORK
Guest Editor for the Special Issue on "Molecular and Cellular Mechanisms Involved in Redox Responses to Environmental Pollution”. Journal: Frontiers in Molecular Biosciences. January 2021.
Guest Editor for the Special Issue on "Mitochondrial involvement in the development and progression of diseases”. Journal: Archives of Biochemistry and Biophysics. May 2020.
Review Editor for the section Molecular Diagnostics and Therapeutics of Frontiers in Molecular Biosciences. January 2021.
INTERNATIONAL JOURNAL BOARD MEMBER
Member of the Editorial Board for the journal “BioFactors”, 2022 – Present
ACADEMIC SERVICES
Examiner for the thesis titled “European Food Safety Authority (EFSA) concerns on botanicals: characterization and safety evaluation of anthraquinone and red yeast rice food supplements”, for the award of Doctor of Philosophy. Doctoral Course in Biochemistry and Molecular Biology, Department of Biotechnology, Chemistry and Pharmacy. University of Siena, Italy. February 2025.
Co-Tutor in the PhD thesis “Evaluation of new molecular and cellular mechanisms related to oxinflammatory pathways in Neurodevelopmental Disorders”, – XL Cycle - a.y. 2024/2025, Doctoral Course in Environmental and Health Sciences, University of Ferrara, Ferrara, Italy.
Co-Tutor in the PhD thesis “Modulation of inflammatory pathways in neurodevelopmental disorders by the use of in vitro, ex-vivo and in vivo approaches”, – XXXIX Cycle - a.y. 2023/2024, Doctoral Course in Environmental and Health Sciences, University of Ferrara, Ferrara, Italy.
Member of the Academic Board of the Doctoral Course in Environmental and Health Sciences, University of Ferrara, Ferrara, Italy. From 05/11/2023 – Present.
Examiner for the thesis titled “SIRT1-Dependent Cytoprotective Effect of Resveratrol in HG-Challenged Human Endothelial Cells Involves Antiglycative and Antioxidant Responses”, for the award of Doctor of Philosophy. Doctoral Course in Cellular and Molecular Biotechnologies, Faculty of Bioscience and Technology for Food, Agriculture and Environment, Horizon 2020 MSCA-COFUND- Rep-Eat Project. University of Teramo, Italy. June 2020.
Examiner for the thesis titled “Effects of environmental ozone exposure on mice olfactory bulb. Immunochemical, electrophysiological and behavioral studies”, for the award of Doctor of Philosophy. Doctoral Course in Biomedical Sciences and Biotechnology, Department of Life Science, University of Ferrara, Italy. December 2016.
CONFERENCE ORGANIZATION
Poster Judge for the Second Annual PhD Day, PhD in Environmental and Health Sciences, Ferrara, Italy, June 26, 2025.
Chairman for the 22nd SFRRI Biennial Meeting hosted by the Society for Free Radical Research – Europe: “The New Era of Redox Biology: from Basic Biochemistry to Redox Omics”. Galway, Ireland, June 03 – 06, 2025.
Member of the Local Organizing Committee for the SFRR-E annual conference “Redox homeostasis: from signaling to damage” in Ferrara, Italy, 19-21 June 2019.
Organizer of the Symposium "Lifestyle and Nutrition as OxInflammation Modulators" at NC Research Campus, Kannapolis, USA. Speakers: Dr. Henry J Forman, University of Southern California, Los Angeles, CA, USA; Dr. Fabio Virgili, Research Centre for Food and Nutrition- Council for Agricultural Research and Economics (CREA), Rome, Italy; Dr. Giuseppe Valacchi, Plants for Human Health Institute, NC Research Campus, NC State University, NC, USA. Kannapolis, NC, USA 04/05/2017 May 4, 2017
Member of the Local Organizing Committee for the “Second International Conference on Environmental Stressors in Biology and Medicine”. University of Siena, Siena, Italy, 5-7 October 2011.
Member of the Local Organizing Committee for the “International Conference on Environmental Stressors in Biology and Medicine”. University of Siena, Siena, Italy, 4-6 June 2008.
PEER REVIEW ACTIVITIES
MANUSCRIPTS
Annals of the New York Academy of Sciences
Antioxidants
Archives of Biochemistry and Biophysics
BioFactors
BioMed Research International
Environment International
Free Radical Biology and Medicine
Frontiers in Genetics
Frontiers in Molecular Biosciences
Genes & Nutrition
Marine Drugs
Mediators of Inflammation
Nutrition Research
Oxidative Medicine and Cellular Longevity
Pharmaceuticals
SOCIETY MEMBERSHIPS
Women In Nutraceuticals (WIN) (2025 – present)
American Society for Nutrition (ASN) (2023 – present)
Society for Redox Biology and Medicine (SfRBM) (2018 - present)
SFRR Europe- Society for Free Radicals Research (2016- present)
PUBLICATIONS
Full Articles in Peer-reviewed International Journals
3. Cordone V, Vallese A, Bianchi A, Guiotto A, Pecorelli A, Valacchi G. Impaired NF κB/Nrf2 crosstalk in Rett Syndrome. The FASEB Journal. 2026
4. Alghamdi M, Gemmo L, Guiotto A, Pecorelli A, Valacchi G. FOXO3 Involvement in Neurological OxInflammation. Redox Experimental Medicine. 2026
5. Garcés M, Pecorelli A, Vallese A, Magnani N, Ferrara F, Benedusi M, Cervellati F, Evelson P, Valacchi G. Indoor pollution induced Oxinflammatory responses in lung tissues. Chemico-Biological Interactions 2026
6. Sarandy MM, Guiotto A, Ivarsson J, Pecorelli A, Valacchi G. Keratinocytes exposed to Ozone induce a bystander oxinflammatory response in dermal fibroblasts. Toxicology. 2026;523:154447. doi: 10.1016/j.tox.2026.154447
7. Ivarsson J, Guiotto A, Trinchera G, Pecorelli A, Shiota G, Valacchi G. Therapeutic Potential of Ozonized Glycerin in Skin Inflammation and Repair. Cosmetics. 2026; 13(1):42. https://doi.org/10.3390/cosmetics13010042
8. Mastaloudis A, Holcomb L, Fahey JW, Olson C, Nieman DC, Kay C, O'Donnell R, Pecorelli A, Kinney M, Li Y, Ishaq SL, Valacchi G. Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study. Sci Rep. 2026. doi: 10.1038/s41598-026-39389-4.
9. Pecorelli A*, Guiotto A, Casoni A, Ruzza M, Beltrami L, Canepa B, Biasi F, Poli G, Valacchi G. Oxysterol-induced oxidative disruption of skin junction integrity. Oxysterol-induced oxidative disruption of skin junction integrity. Free Radic Biol Med. 2026:S0891-5849(26)00067-5. doi: 10.1016/j.freeradbiomed.2026.01.047 *Corresponding author
10. Mengarelli F, Cordone V, Pecorelli A, Benedusi M, Valacchi G, Morresi C, Bacchetti T, Orlando P, Tiano L, Silvestri S. Mitochondrial redox imbalance and CoQ10 deficiency in Rett syndrome: insights from patient-derived fibroblasts. Arch Biochem Biophys. 2025:110636. doi: 10.1016/j.abb.2025.110636.
11. Guiotto A, Vallese A, Cordone V, Cervellati F, Benedusi M, Hayek J, Pecorelli A*, Valacchi G*. Lipid peroxidation-induced cell death in Rett syndrome. Free Radic Biol Med. 2025; 241:243-257. doi: 10.1016/j.freeradbiomed.2025.09.033. *Co-corresponding authors
12. Vallese A, Melija S, Hayek J, Pecorelli A*, Valacchi G.* Deregulated Nrf2-Keap1-BACH1 axis in autism spectrum disorder. Redox Biol. 2025; 86:103837. doi: 10.1016/j.redox.2025.103837. *Co-corresponding authors
13. Ivarsson J, Yan X, Guiotto A, Pecorelli A, Sarandy MM, Lynch S, Anderias S, Choudhary H, White S, Ferrara F, Valacchi G. Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate Matter. J Cosmet Dermatol. 2025;24(7):e70306. doi: 10.1111/jocd.70306.
14. Ivarsson J, Pambianchi E, Pecorelli A, Lim Y, Valacchi G. Redox regulation of cutaneous AMPs by ozone in tensioned skin models. Arch Biochem Biophys. 2025;769:110409. doi: 10.1016/j.abb.2025.110409.
15. Valacchi G, Pecorelli A*. Role of Scavenger Receptor B1 (SR-B1) in Improving Food Benefits for Human Health. Annu Rev Food Sci Technol. 2025;16(1):403-432. doi: 10.1146/annurev-food-111523-121935. *Corresponding author
16. Pula W, Pepe A, Ferrara F, Bondi A, Mariani P, Ortore MG, Pecorelli A, Ivarsson J, Valacchi G, Esposito E. In situ forming gels as subcutaneous delivery systems of curcumin and piperine. Sci Rep. 2025;15(1):3046. doi: 10.1038/s41598-025-87750-w
17. Guiotto A, Pecorelli A*, Draelos ZD, Gueniche A, Yatskayer M, Nelson DB. Reversing Oxinflammation Associated with Glycative Stress and Formation of Advanced Glycation End Products with a Dietary Supplement Containing Rosemary Extract. J Clin Aesthet Dermatol. 2025;18(3):34-38. *Corresponding author
18. Ivarsson, J; Pecorelli, A; Guiotto, A; Souza, M M; Choundhary, H; Brieva, P; Ferrara, F; Valacchi, G. Comparing UV and diesel damage in cutaneous tissue and the protective role of a topical antioxidant containing vitamin C, E and ferulic acid against premature skin aging. Exp Dermatol. 2025;34(3):e70069. doi: 10.1111/exd.70069
19. Vallese A, Cordone V, Ferrara F, Guiotto A, Gemmo L, Cervellati F, Hayek J, Pecorelli A*, Valacchi G*. NLRP3 inflammasome-mitochondrion loop in autism spectrum disorder. Free Radic Biol Med. 2024 Nov 20;225: 581-594. doi: 10.1016/j.freeradbiomed.2024.10.297. *Co-corresponding authors
20. Cordone V, Guiotto A, Bucay V, Pecorelli A, Valacchi G. Evidence of altered redox homeostasis in trichothiodystrophy. Redox Experimental Medicine. 2024. DOI: 10.1530/REM-24-0010
21. Venezia V, Pota G, Argenziano R, Alfieri ML, Moccia F, Ferrara F, Pecorelli A, Esposito R, Di Girolamo R, D'Errico G, Valacchi G, Luciani G, Panzella L, Napolitano A. Design of a hybrid nanoscaled skin photoprotector by boosting the antioxidant properties of food waste-derived lignin through molecular combination with TiO2 nanoparticles. Int J Biol Macromol. 2024;280(Pt 3):135946. doi: 10.1016/j.ijbiomac.2024.135946
22. Pignatelli A, Benedusi M, Barbieri M, Pecorelli A, Valacchi G. Tropospheric ozone effect on olfactory perception and olfactory bulb dopaminergic interneuron excitability. Neurotoxicology. 2024;104:36-44. doi: 10.1016/j.neuro.2024.07.003
23. Ivarsson J, Bennett A, Ferrara F, Strauch R, Vallese A, Iorizzo M, Pecorelli A, Lila MA, Valacchi G. Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage. Food Funct. 2024;15(15):7849-7864. doi: 10.1039/d4fo01874e
24. Esposito E, Pecorelli A, Ferrara F, Lila MA, Valacchi G. Feeding the Body Through the Skin: Ethosomes and Transethosomes as a New Topical Delivery System for Bioactive Compounds. Annu Rev Food Sci Technol. 2024 Jun;15(1):53-78. doi: 10.1146/annurev-food-072023-034528.
25. Ferrara F, Yan X, Pecorelli A, Guiotto A, Colella S, Pasqui A, Ivarrson J, Lynch S, Anderias S, Choundhary H, White S, Valacchi G. Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study. J Cosmet Dermatol. 2024. doi: 10.1111/jocd.16321
26. Ferrara F, Pecorelli A, Pambianchi E, White S, Choudhary H, Casoni A, Valacchi G. Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multipollutant exposure. Exp Dermatol. 2024;33(1):e15000. doi: 10.1111/exd.15000
27. Esposito E, Ferrara F, Drechsler M, Bortolini O, Ragno D, Toldo S, Bondi A, Pecorelli A, Voltan R, Secchiero P, Zauli G, Valacchi G. Nutlin-3 Loaded Ethosomes and Transethosomes to Prevent UV-Associated Skin Damage. Life (Basel). 2024;14(1):155. doi: 10.3390/life14010155
28. El-Khodor BF, Zang W, Gorby H, Dominique A, Hamrock M, Metzer B, Pecorelli A, Varadharaj S, Valacchi G. A Plant-Based Dietary Supplement Improves Measures of Metabolic Detoxification and the Quality of Life: A Phase II Multicenter Randomized, Blinded, Placebo-Controlled Clinical Trial. Integr Med (Encinitas). 2023;22(5):28-39
29. Pasqui A, Cicaloni V, Tinti L, Guiotto A, Tinti C, Mori A, Bruttini M, Hayek J, Pecorelli A, Salvini L, Valacchi G. A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways. Arch Biochem Biophys. 2024; 752:109860. doi: 10.1016/j.abb.2023.109860
30. Ivarsson J, Ferrara F, Vallese A, Guiotto A, Colella S, Pecorelli A, Valacchi G. Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation. Int J Mol Sci. 2023;24(23):16674. doi: 10.3390/ijms242316674
31. Pambianchi E, Hagenberg Z, Pecorelli A, Pasqui A, Therrien JP, Valacchi G. Tension as a key factor in skin responses to pollution. Sci Rep. 2023;13(1):16013. doi: 10.1038/s41598-023-42629-6
32. Cervellati C, Casolari P, Pecorelli A, Sticozzi C, Nucera F, Papi A, Caramori G, Valacchi G. Scavenger receptor B1 involvement in chronic obstructive pulmonary disease pathogenesis. Redox Experimental Medicine 2023;1: e230012. DOI: https://doi.org/10.1530/REM-23-0012
33. Hoskin RT, Grace MH, Guiotto A, Pecorelli A, Valacchi G, Lila MA. Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach. Antioxidants (Basel). 2023;12(7):1431. doi: 10.3390/antiox12071431
34. Ferrara F, Pecorelli A, Valacchi G. Redox Regulation of Nucleotide-Binding and Oligomerization Domain-Like Receptors Inflammasome. Antioxid Redox Signal. 2023;39(10-12):744-770. doi: 10.1089/ars.2022.0180.
35. Vallese A, Cordone V, Pecorelli A, Valacchi G. Ox-inflammasome involvement in neuroinflammation. Free Radic Biol Med. 2023: S0891-5849(23)00528-2. doi: 10.1016/j.freeradbiomed.2023.07.010
36. Ivarsson J Jr., Pecorelli A, Lila MA, Valacchi G. Blueberry Supplementation and Skin Health. Antioxidants. 2023; 12(6):1261. https://doi.org/10.3390/antiox12061261
37. Nieman DC, Woo J, Sakaguchi CA, Omar AM, Tang Y, Davis K, Pecorelli A, Valacchi G, Zhang Q. Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins. Front Nutr. 2023; 10:1143385. doi: 10.3389/fnut.2023.1143385.
38. Sarkar P, Pecorelli A, Woodby B, Pambianchi E, Ferrara F, Duary RK, Valacchi G. Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii). Nutrients. 2023; 15(4):1035. https://doi.org/10.3390/nu15041035
39. Canella R, Benedusi M, Vallese A, Pecorelli A, Guiotto A, Ferrara F, Rispoli G, Cervellati F, Valacchi G. The role of potassium current in the pulmonary response to environmental oxidative stress. Arch Biochem Biophys. 2023:109534. doi: 10.1016/j.abb.2023.109534.
40. Ferrara F, Cordone V, Pecorelli A, Benedusi M, Pambianchi E, Guiotto A, Vallese A, Cervellati F, Valacchi G. Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox inflammasome activation. Redox Biol. 2022; 56:102440. doi: 10.1016/j.redox.2022.102440.
41. Pecorelli A, Valacchi G. Oxidative-Stress-Sensitive microRNAs in UV-Promoted Development of Melanoma. Cancers (Basel). 2022; 14(13):3224. doi: 10.3390/cancers14133224.
42. Cordone V, Ferrara F, Pecorelli A, Guiotto A, Vitale A, Amicarelli F, Cervellati C, Hayek J, Valacchi G. The constitutive activation of TLR4-IRAK1- NFκB axis is involved in the early NLRP3 inflammasome response in peripheral blood mononuclear cells of Rett syndrome patients. Free Radic Biol Med. 2022:S0891-5849(22)00028-4. doi: 10.1016/j.freeradbiomed.2022.01.017.
43. Pambianchi E, Pecorelli A, Valacchi G. Gastrointestinal tissue as a "new" target of pollution exposure. IUBMB Life. 2022;74(1):62-73. doi: 10.1002/iub.2530.
44. Pambianchi E, Ferrara F, Pecorelli A, Benedusi M, Choudhary H, Therrien JP, Valacchi G. Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure. Antioxidants (Basel). 2021; 10(12):1928. doi: 10.3390/antiox10121928.
45. Pambianchi E, Hagenberg Z, Pecorelli A, Grace M, Therrien J-P, Lila MA, Valacchi G. Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage. Cosmetics. 2021; 8(4):112. https://doi.org/10.3390/cosmetics8040112
46. Valacchi G, Pecorelli A, Toyokuni S. Mitochondrial involvement in the development and progression of diseases. Arch Biochem Biophys. 2021; 711:109006. doi: 10.1016/j.abb.2021.109006.
47. Hoskin R, Pambianchi E, Pecorelli A, Grace M, Therrien JP, Valacchi G, Lila MA. Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage. Molecules. 2021 Jun 22;26(13):3781. doi: 10.3390/molecules26133781.
48. Pecorelli A, Cordone V, Schiavone ML, Caffarelli C, Cervellati C, Cerbone G, Gonnelli S, Hayek J, Valacchi G. Altered Bone Status in Rett Syndrome. Life (Basel). 2021 Jun 3;11(6):521. doi: 10.3390/life11060521.
49. Grillo A, Fezza F, Chemi G, Colangeli R, Brogi S, Fazio D, Federico S, Papa A, Relitti N, Di Maio R, Giorgi G, Lamponi S, Valoti M, Gorelli B, Saponara S, Benedusi M, Pecorelli A, Minetti P, Valacchi G, Butini S, Campiani G, Gemma S, Maccarrone M, Di Giovanni G. Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents. ACS Chem Neurosci. 2021 May 5;12(9):1716-1736. doi: 10.1021/acschemneuro.1c00192.
50. Woodby B, Pambianchi E, Ferrara F, Messano N, Pecorelli A, Therrien JP, Lila MA, Valacchi G. Cutaneous Antimicrobial Peptides: new “actors” in pollution related inflammatory conditions. Redox Biol. 2021 May;41:101952. doi: 10.1016/j.redox.2021.101952.
51. Garcés M, Magnani ND, Pecorelli A, Calabró V, Marchini T, Cáceres L, Pambianchi E, Galdoporpora J, Vico T, Salgueiro J, Zubillaga M, Moretton MA, Desimone MF, Alvarez S, Valacchi G, Evelson P. Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure. Free Radic Biol Med. 2021;166:324-336. doi: 10.1016/j.freeradbiomed.2021.02.008.
52. Crivellari I, Pecorelli A, Cordone V, Marchi S, Pinton P, Cervellati F, Hayek J, Cervellati C, Valacchi G. Impaired mitochondrial quality control in Rett Syndrome. Arch Biochem Biophys. 2021;700:108790. doi: 10.1016/j.abb.2021.108790.
53. Ferrara F, Pambianchi E, Woodby B, Messano N, Therrien JP, Pecorelli A, Canella R, Valacchi G. Evaluating the effect of ozone in UV induced skin damage. Toxicol Lett. 2021 Mar 1;338:40-50. doi: 10.1016/j.toxlet.2020.11.023.
54. Cicaloni V, Pecorelli A, Cordone V, Tinti L, Rossi M, Hayek J, Salvini L, Tinti C, Valacchi G. A proteomics approach to further highlight the altered inflammatory condition in Rett syndrome Arch Biochem Biophys. 2020;696:108660. doi: 10.1016/j.abb.2020.108660.
55. Nieman DC, Ferrara F, Pecorelli A, Woodby B, Hoyle AT, Simonson A, Valacchi G. Postexercise Inflammasome Activation and IL-1β Production Mitigated by Flavonoid Supplementation in Cyclists. Int J Sport Nutr Exerc Metab. 2020 15:1-9. doi: 10.1123/ijsnem.2020-0084.
56. Pambianchi E, Ferrara F, Pecorelli A, Woodby B, Grace M, Therrien JP, Lila MA, Valacchi G. Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation. Oxid Med Cell Longev. 2020 13;2020:9571490. doi: 10.1155/2020/9571490.
57. Schiavone ML1, Pecorelli A1, Woodby B, Ferrara F, Pambianchi E, Santucci A, Valacchi G. Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria. Arch Biochem Biophys. 2020 15;690:108416. doi: 10.1016/j.abb.2020.108416.
1co-first authors
58. Cicaloni V, Pecorelli A, Tinti L, Rossi M, Benedusi M, Cervellati C, Spiga O, Santucci A, Hayek J, Salvini L, Tinti C, Valacchi G. Proteomic profiling reveals mitochondrial alterations in Rett syndrome. Free Radic Biol Med. 2020 1;155:37-48. doi: 10.1016/j.freeradbiomed.2020.05.014.
59. Pecorelli A, McDaniel DH, Wortzman M, Nelson DB. Protective effects of a comprehensive topical antioxidant against ozone-induced damage in a reconstructed human skin model. Arch Dermatol Res. 2021;313(3):139-146. doi: 10.1007/s00403-020-02083-0.
60. Woodby B, Schiavone ML, Pambianchi E, Mastaloudis A, N Hester S, M Wood S, Pecorelli A, Valacchi G. Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model. Int J Environ Res Public Health. 2020;17(9):3234. doi: 10.3390/ijerph17093234.
61. Ferrara F, Woodby B, Pecorelli A, Schiavone ML, Pambianchi E, Messano N, Therrien JP, Choudhary H, Valacchi G. Additive effect of combined pollutants to UV induced skin OxInflammation damage. Evaluating the protective topical application of a cosmeceutical mixture formulation. Redox Biol. 2020;34:101481. doi: 10.1016/j.redox.2020.101481.
62. Sbardella D, Tundo GR, Cunsolo V, Grasso G, Cascella R, Caputo V, Santoro AM, Milardi D, Pecorelli A, Ciaccio C, Di Pierro D, Leoncini S, Campagnolo L, Pironi V, Oddone F, Manni P, Foti S, Giardina E, De Felice C, Hayek J, Curatolo P, Galasso C, Valacchi G, Coletta M, Graziani G, Marini S. Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations. Biochim Biophys Acta Mol Basis Dis. 2020;1866(7):165793. doi: 10.1016/j.bbadis.2020.165793.
63. Pecorelli A, Ferrara F, Messano N, Cordone V, Schiavone ML, Cervellati F, Woodby B, Cervellati C, Hayek J, Valacchi G. Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder. FASEB J. 2020;34(5):6521-6538. doi: 10.1096/fj.201902677R.
64. Cervellati C, Trentini A, Pecorelli A, Valacchi G. Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery. Antioxid Redox Signal. 2020;33(3):191-210. doi: 10.1089/ars.2020.8076.
65. Pecorelli A, Cervellati C, Cordone V, Hayek J, Valacchi G. Compromised immune/inflammatory responses in Rett syndrome. Free Radic Biol Med. 2020; 152:100-106. doi: 10.1016/j.freeradbiomed.2020.02.023.
66. Woodby B, Penta K, Pecorelli A, Lila MA, Valacchi G. Skin Health from the Inside Out. Annu Rev Food Sci Technol. 2020; 11:235-254. doi: 10.1146/annurev-food-032519-051722.
67. Ferrara F, Pambianchi E, Pecorelli A, Woodby B, Messano N, Therrien JP, Lila MA, Valacchi G. Redox regulation of cutaneous inflammasome by ozone exposure. Free Radic Biol Med. 2020;152:561-570. doi: 10.1016/j.freeradbiomed.2019.11.031.
68. Cordone V, Pecorelli A, Amicarelli F, Hayek J, Valacchi G. The complexity of Rett syndrome models: Primary fibroblasts as a disease-in-a-dish reliable approach. Drug Discovery Today: Disease Models. 2020;31:11-19. doi.org/10.1016/j.ddmod.2019.11.001
69. Nieman DC, Valacchi G, Wentz LM, Ferrara F, Pecorelli A, Woodby B, Sakaguchi CA, Simonson A. Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes. Int J Sport Nutr Exerc Metab. 2019 21:1-8. doi: 10.1123/ijsnem.2019-0171.
70. Sguizzato M, Valacchi G, Pecorelli A, Boldrini P, Simelière F, Huang N, Cortesi R, Esposito E. Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study. Colloids Surf B Biointerfaces. 2020;185:110613. doi: 10.1016/j.colsurfb.2019.110613.
71. Pecorelli A1, Cordone V1, Messano N, Zhang C, Falone S, Amicarelli F, Hayek J, Valacchi G. Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation. Redox Biol. 2020;28:101334. doi: 10.1016/j.redox.2019.101334. 1 co-first authors
72. Grillo A, Chemi G, Brogi S, Brindisi M, Relitti N, Fezza F, Fazio D, Castelletti L, Perdona E, Wong A, Lamponi S, Pecorelli A, Benedusi M, Fantacci M, Valoti M, Valacchi G, Micheli F, Novellino E, Campiani G, Butini S, Maccarrone M, Gemma S. Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems. Eur J Med Chem. 2019;183:111674. doi: 10.1016/j.ejmech.2019.111674.
73. Ietta F, Valacchi G, Benincasa L, Pecorelli A, Cresti L, Maioli E. Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells. Biofactors. 2019;45(6):920-929. doi: 10.1002/biof.1551.
74. Pecorelli A, Woodby B, Prieux R, Valacchi G. Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage. Biofactors. 2019;45(4):536-547. doi: 10.1002/biof.1513.
75. Cordone V, Pecorelli A, Benedusi M, Santini S Jr, Falone S, Hayek J, Amicarelli F, Valacchi G. Antiglycative Activity and RAGE Expression in Rett Syndrome. Cells. 2019;8(2):161. doi: 10.3390/cells8020161
76. Pecorelli A, Cervellati C, Cordone V, Amicarelli F, Hayek J, Valacchi G. 13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation. Free Radic Biol Med. 2019; 134:598-603. doi: 10.1016/j.freeradbiomed.2019.02.007.
77. Brindisi M, Borrelli G, Brogi S, Grillo A, Maramai S, Paolino M, Benedusi M, Pecorelli A, Valacchi G, Di Cesare Mannelli L, Ghelardini C, Allarà M, Ligresti A, Minetti P, Campiani G, di Marzo V, Butini S, Gemma S. Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain. ChemMedChem. 2018;13(19):2090-2103. doi: 10.1002/cmdc.201800397.
78. Sticozzi C1, Pecorelli A1, Romani A, Belmonte G, Cervellati F, Maioli E, Lila MA, Cervellati C, Valacchi G. Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells. Free Radic Biol Med. 2018;126:287-295. doi: 10.1016/j.freeradbiomed.2018.07.007. 1 co-first authors
79. Dissette V, Bignozzi GS, Valacchi G, Pecorelli A, Manfredini S, Vertuani S. Evaluation of the transepidermal penetration of the carnosine complex in a cosmetic product in 3D-skin models. Cosmetics 2018, 5(4), 67. doi.org/10.3390/cosmetics5040067
80. Valacchi G, Virgili F, Cervellati C, Pecorelli A*. OxInflammation: From Subclinical Condition to Pathological Biomarker. Front Physiol. 2018 Jul 9;9:858. doi: 10.3389/fphys.2018.00858. *Corresponding author
81. Molesini S, Urto F, Cvetkovska AD, Bettoli V, Valacchi G, Pecorelli A, Manfredini S, Vertuani S. Influences of the vehicle in the spreading and release of betamethasone. Ther Deliv. 2018;9(3):177-184. doi: 10.4155/tde-2017-0070.
82. Esposito E, Pecorelli A, Sguizzato M, Drechsler M, Mariani P, Carducci F, Cervellati F, Nastruzzi C, Cortesi R, Valacchi G. Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing. Curr Drug Deliv. 2018;15(8):1172-1182. doi: 10.2174/1567201815666180518123926.
83. Fallacara A, Vertuani S, Panozzo G, Pecorelli A, Valacchi G, Manfredini S. Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study. Molecules. 2017;22(12):2104. doi: 10.3390/molecules22122104.
84. Romani A, Cervellati C, Muresan XM, Belmonte G, Pecorelli A, Cervellati F, Benedusi M, Evelson P, Valacchi G. Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure. Mech Ageing Dev. 2018;172:86-95. doi: 10.1016/j.mad.2017.11.007.
85. Brogi S, Ramunno A, Savi L, Chemi G, Alfano G, Pecorelli A, Pambianchi E, Galatello P, Compagnoni G, Focher F, Biamonti G, Valacchi G, Butini S, Gemma S, Campiani G, Brindisi M. First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents. Eur J Med Chem. 2017 Sep 29;138:438-457. doi: 10.1016/j.ejmech.2017.06.017.
86. Cortesi R, Cappellozza E, Drechsler M, Contado C, Baldisserotto A, Mariani P, Carducci F, Pecorelli A, Esposito E, Valacchi G. Monoolein aqueous dispersions as a delivery system for quercetin. Biomed Microdevices. 2017 Jun;19(2):41. doi: 10.1007/s10544-017-0185-0.
87. Valacchi G, Pecorelli A, Belmonte G, Pambianchi E, Cervellati F, Lynch S, Krol Y, Oresajo C. Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin. J Invest Dermatol. 2017 Jun;137(6):1373-1375. doi: 10.1016/j.jid.2017.01.034.
88. Cheleschi S, De Palma A, Pecorelli A, Pascarelli NA, Valacchi G, Belmonte G, Carta S, Galeazzi M, Fioravanti A. Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway. Int J Mol Sci. 2017 Jan 12;18(1):133. doi: 10.3390/ijms18010133.
89. Valacchi G1, Pecorelli A1, Cervellati C, Hayek J. 4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation. Free Radic Biol Med. 2017 Oct;111:270-280. doi: 10.1016/j.freeradbiomed.2016.12.045. 1 co-first authors
90. Hayek J, Cervellati C, Crivellari I, Pecorelli A, Valacchi G. Lactonase Activity and Lipoprotein-Phospholipase A2 as Possible Novel Serum Biomarkers for the Differential Diagnosis of Autism Spectrum Disorders and Rett Syndrome: Results from a Pilot Study. Oxid Med Cell Longev. 2017;2017:5694058. doi: 10.1155/2017/5694058.
91. Cavicchio C, Benedusi M, Pambianchi E, Pecorelli A, Cervellati F, Savelli V, Calamandrei D, Maellaro E, Rispoli G, Maioli E, Valacchi G. Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment. Oxid Med Cell Longev. 2017;2017:4256519. doi: 10.1155/2017/4256519.
92. Crivellari I, Sticozzi C, Belmonte G, Muresan XM, Cervellati F, Pecorelli A, Cavicchio C, Maioli E, Zouboulis CC, Benedusi M, Cervellati C, Valacchi G. SRB1 as a new redox target of cigarette smoke in human sebocytes. Free Radic Biol Med. 2017;102:47-56. doi: 10.1016/j.freeradbiomed.2016.11.021.
93. Pecorelli A, Cervellati C, Cortelazzo A, Cervellati F, Sticozzi C, Mirasole C, Guerranti R, Trentini A, Zolla L, Savelli V, Hayek J, Valacchi G. Proteomic analysis of 4-hydroxynonenal and nitrotyrosine modified proteins in RTT fibroblasts. Int J Biochem Cell Biol. 2016 Dec;81(Pt B):236-245. doi: 10.1016/j.biocel.2016.08.001.
94. Pecorelli A, Cervellati C, Hayek J, Valacchi G. OxInflammation in Rett syndrome. Int J Biochem Cell Biol. 2016 Dec;81(Pt B):246-253. doi: 10.1016/j.biocel.2016.07.015.
95. Valacchi G, Muresan XM, Sticozzi C, Belmonte G, Pecorelli A, Cervellati F, Demaude J, Krol Y, Oresajo C. Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application. J Dermatol Sci. 2016;82(3):209-12. doi: 10.1016/j.jdermsci.2016.02.007
96. Ciccoli L, De Felice C, Leoncini S, Signorini C, Cortelazzo A, Zollo G, Pecorelli A, Rossi M, Hayek J. Red blood cells in Rett syndrome: oxidative stress, morphological changes and altered membrane organization. Biol Chem. 2015;396(11):1233-40. doi: 10.1515/hsz-2015-0117.
97. Magnani ND, Muresan XM, Belmonte G, Cervellati F, Sticozzi C, Pecorelli A, Miracco C, Marchini T, Evelson P, Valacchi G. Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure. Toxicol Sci. 2016;149(1):227-36. doi: 10.1093/toxsci/kfv230.
98. Pecorelli A, Cervellati F, Belmonte G, Montagner G, Waldon P, Hayek J, Gambari R, Valacchi G. Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients. Cytokine. 2016; 77:180-8. doi: 10.1016/j.cyto.2015.10.002.
99. Cortelazzo A, De Felice C, Guerranti R, Signorini C, Leoncini S, Pecorelli A, Scalabrì F, Madonna M, Filosa S, Della Giovampaola C, Capone A, Durand T, Mirasole C, Zolla L, Valacchi G, Ciccoli L, Guy J, D'Esposito M, Hayek J. Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome. Neurosci Res. 2016 Apr;105:28-34. doi: 10.1016/j.neures.2015.10.002.
100. Cervellati C, Sticozzi C, Romani A, Belmonte G, De Rasmo D, Signorile A, Cervellati F, Milanese C, Mastroberardino PG, Pecorelli A, Savelli V, Forman HJ, Hayek J, Valacchi G. Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage. Biochim Biophys Acta Mol Basis Dis. 2015 Oct;1852(10 Pt A):2066-74. doi: 10.1016/j.bbadis.2015.07.014.
101. Pecorelli A, Belmonte G, Meloni I, Cervellati F, Gardi C, Sticozzi C, De Felice C, Signorini C, Cortelazzo A, Leoncini S, Ciccoli L, Renieri A, Jay Forman H, Hayek J, Valacchi G. Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder. Free Radic Biol Med. 2015 Sep;86:156-65. doi: 10.1016/j.freeradbiomed.2015.05.010.
102. Filosa S1, Pecorelli A1, D'Esposito M, Valacchi G, Hajek J. Exploring the possible link between MeCP2 and oxidative stress in Rett syndrome. Free Radic Biol Med. 2015 Nov;88(Pt A):81-90. doi: 10.1016/j.freeradbiomed.2015.04.019.
1 co-first authors
103. Ahlqvist KJ, Leoncini S, Pecorelli A, Wortmann SB, Ahola S, Forsström S, Guerranti R, De Felice C, Smeitink J, Ciccoli L, Hämäläinen RH, Suomalainen A. MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction. Nat Commun. 2015 Mar 9;6:6494. doi: 10.1038/ncomms7494.
104. Valacchi G, Maioli E, Sticozzi C, Cervellati F, Pecorelli A, Cervellati C, Hayek J. Exploring the link between scavenger receptor B1 expression and chronic obstructive pulmonary disease pathogenesis. Ann N Y Acad Sci. 2015 Mar;1340:47-54. doi: 10.1111/nyas.12714.
105. Rom O, Pecorelli A, Valacchi G, Reznick AZ. Are E-cigarettes a safe and good alternative to cigarette smoking? Ann N Y Acad Sci. 2015 Mar;1340:65-74. doi: 10.1111/nyas.12609.
106. Pecorelli A, Natrella F, Belmonte G, Miracco C, Cervellati F, Ciccoli L, Mariottini A, Rocchi R, Vatti G, Bua A, Canitano R, Hayek J, Forman HJ, Valacchi G. NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy. Biochim Biophys Acta Mol Basis Dis. 2015 Mar;1852(3):507-19. doi: 10.1016/j.bbadis.2014.11.016.
107. Signorini C, De Felice C, Leoncini S, Durand T, Galano JM, Cortelazzo A, Zollo G, Guerranti R, Gonnelli S, Caffarelli C, Rossi M, Pecorelli A, Valacchi G, Ciccoli L, Hayek J. Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: effects of omega-3 polyunsaturated fatty acid supplementation. Prostaglandins Leukot Essent Fatty Acids. 2014;91(5):183-93. doi: 10.1016/j.plefa.2014.08.002.
108. De Felice C, Della Ragione F, Signorini C, Leoncini S, Pecorelli A, Ciccoli L, Scalabrì F, Marracino F, Madonna M, Belmonte G, Ricceri L, De Filippis B, Laviola G, Valacchi G, Durand T, Galano JM, Oger C, Guy A, Bultel-Poncé V, Guy J, Filosa S, Hayek J, D'Esposito M. Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. Neurobiol Dis. 2014;68(100):66-77. doi: 10.1016/j.nbd.2014.04.006.
109. Cortelazzo A, De Felice C, Pecorelli A, Belmonte G, Signorini C, Leoncini S, Zollo G, Capone A, Giovampaola CD, Sticozzi C, Valacchi G, Ciccoli L, Guerranti R, Hayek J. Beta-actin deficiency with oxidative posttranslational modifications in Rett syndrome erythrocytes: insights into an altered cytoskeletal organization. PLoS One. 2014 Mar 26;9(3):e93181. doi: 10.1371/journal.pone.0093181.
110. De Felice C, Signorini C, Leoncini S, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. La sindrome di Rett: ruolo dello stress ossidativo [Oxidative stress and Rett syndrome]. Minerva Pediatr. 2014 Feb;66(1):41-62.
111. Papini AM, Nuti F, Real-Fernandez F, Rossi G, Tiberi C, Sabatino G, Pandey S, Leoncini S, Signorini C, Pecorelli A, Guerranti R, Lavielle S, Ciccoli L, Rovero P, De Felice C, Hayek J. Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction. J Immunol Res. 2014;2014:260973. doi: 10.1155/2014/260973.
112. Signorini C, Leoncini S, De Felice C, Pecorelli A, Meloni I, Ariani F, Mari F, Amabile S, Paccagnini E, Gentile M, Belmonte G, Zollo G, Valacchi G, Durand T, Galano JM, Ciccoli L, Renieri A, Hayek J. Redox imbalance and morphological changes in skin fibroblasts in typical Rett syndrome. Oxid Med Cell Longev. 2014;2014:195935. doi: 10.1155/2014/195935.
113. De Felice C, Rossi M, Leoncini S, Chisci G, Signorini C, Lonetti G, Vannuccini L, Spina D, Ginori A, Iacona I, Cortelazzo A, Pecorelli A, Valacchi G, Ciccoli L, Pizzorusso T, Hayek J. Inflammatory lung disease in Rett syndrome. Mediators Inflamm. 2014;2014:560120. doi: 10.1155/2014/560120.
114. Maffei S, De Felice C, Cannarile P, Leoncini S, Signorini C, Pecorelli A, Montomoli B, Lunghetti S, Ciccoli L, Durand T, Favilli R, Hayek J. Effects of ω-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome. Mediators Inflamm. 2014;2014:983178. doi: 10.1155/2014/983178.
115. Cortelazzo A, De Felice C, Guerranti R, Signorini C, Leoncini S, Pecorelli A, Zollo G, Landi C, Valacchi G, Ciccoli L, Bini L, Hayek J. Subclinical inflammatory status in Rett syndrome. Mediators Inflamm. 2014;2014:480980. doi: 10.1155/2014/480980.
116. Sticozzi C, Belmonte G, Pecorelli A, Cervellati F, Leoncini S, Signorini C, Ciccoli L, De Felice C, Hayek J, Valacchi G. Scavenger receptor B1 post-translational modifications in Rett syndrome. FEBS Lett. 2013 Jul 11;587(14):2199-204. doi: 10.1016/j.febslet.2013.05.042.
117. Cortelazzo A, Guerranti R, De Felice C, Signorini C, Leoncini S, Pecorelli A, Landi C, Bini L, Montomoli B, Sticozzi C, Ciccoli L, Valacchi G, Hayek J. A plasma proteomic approach in Rett syndrome: classical versus preserved speech variant. Mediators Inflamm. 2013;2013:438653. doi: 10.1155/2013/438653.
118. Ciccoli L, De Felice C, Paccagnini E, Leoncini S, Pecorelli A, Signorini C, Belmonte G, Guerranti R, Cortelazzo A, Gentile M, Zollo G, Durand T, Valacchi G, Rossi M, Hayek J. Erythrocyte shape abnormalities, membrane oxidative damage, and β-actin alterations: an unrecognized triad in classical autism. Mediators Inflamm. 2013;2013:432616. doi: 10.1155/2013/432616.
119. Pecorelli A, Leoni G, Cervellati F, Canali R, Signorini C, Leoncini S, Cortelazzo A, De Felice C, Ciccoli L, Hayek J, Valacchi G. Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patients. Mediators Inflamm. 2013;2013:137629. doi: 10.1155/2013/137629.
120. De Felice C, Cortelazzo A, Signorini C, Guerranti R, Leoncini S, Pecorelli A, Durand T, Galano JM, Oger C, Zollo G, Montomoli B, Landi C, Bini L, Valacchi G, Ciccoli L, Hayek J. Effects of ω-3 polyunsaturated fatty acids on plasma proteome in Rett syndrome. Mediators Inflamm. 2013;2013:723269. doi: 10.1155/2013/723269.
121. Signorini C, De Felice C, Durand T, Oger C, Galano JM, Leoncini S, Pecorelli A, Valacchi G, Ciccoli L, Hayek J. Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder. Oxid Med Cell Longev. 2013;2013:343824. doi: 10.1155/2013/343824.
122. Volpi N, Pecorelli A, Lorenzoni P, Di Lazzaro F, Belmonte G, Aglianò M, Cantarini L, Giannini F, Grasso G, Valacchi G. Antiangiogenic VEGF isoform in inflammatory myopathies. Mediators Inflamm. 2013;2013:219313. doi: 10.1155/2013/219313.
123. Grillo E, Lo Rizzo C, Bianciardi L, Bizzarri V, Baldassarri M, Spiga O, Furini S, De Felice C, Signorini C, Leoncini S, Pecorelli A, Ciccoli L, Mencarelli MA, Hayek J, Meloni I, Ariani F, Mari F, Renieri A. Revealing the complexity of a monogenic disease: rett syndrome exome sequencing. PLoS One. 2013;8(2):e56599. doi: 10.1371/journal.pone.0056599.
124. Pecorelli A, Bocci V, Acquaviva A, Belmonte G, Gardi C, Virgili F, Ciccoli L, Valacchi G. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells. Toxicol Appl Pharmacol. 2013 Feb 15;267(1):30-40. doi: 10.1016/j.taap.2012.12.001.
125. Valacchi G, Sticozzi C, Pecorelli A, Cervellati F, Cervellati C, Maioli E. Cutaneous responses to environmental stressors. Ann N Y Acad Sci. 2012 Oct;1271(1):75-81. doi: 10.1111/j.1749-6632.2012.06724.x.
126. Durand T, De Felice C, Signorini C, Oger C, Bultel-Poncé V, Guy A, Galano JM, Leoncini S, Ciccoli L, Pecorelli A, Valacchi G, Hayek J. F(2)-Dihomo-isoprostanes and brain white matter damage in stage 1 Rett syndrome. Biochimie. 2013 Jan;95(1):86-90. doi: 10.1016/j.biochi.2012.09.017.
127. De Felice C, Signorini C, Leoncini S, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. The role of oxidative stress in Rett syndrome: an overview. Ann N Y Acad Sci. 2012 Jul;1259:121-35. doi: 10.1111/j.1749-6632.2012.06611.x.
128. Pecorelli A, Leoncini S, De Felice C, Signorini C, Cerrone C, Valacchi G, Ciccoli L, Hayek J. Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic autism. Brain Dev. 2013;35(2):146-54. doi: 10.1016/j.braindev.2012.03.011.
129. De Felice C, Signorini C, Durand T, Ciccoli L, Leoncini S, D'Esposito M, Filosa S, Oger C, Guy A, Bultel-Poncé V, Galano JM, Pecorelli A, De Felice L, Valacchi G, Hayek J. Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil. Genes Nutr. 2012;7(3):447-58. doi: 10.1007/s12263-012-0285-7.
130. Sticozzi C, Belmonte G, Pecorelli A, Arezzini B, Gardi C, Maioli E, Miracco C, Toscano M, Forman HJ, Valacchi G. Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS One. 2012;7(3):e33592. doi: 10.1371/journal.pone.0033592. Epub 2012 Mar 19. Erratum in: PLoS One. 2020;15(1):e0228663.
131. Ciccoli L, De Felice C, Paccagnini E, Leoncini S, Pecorelli A, Signorini C, Belmonte G, Valacchi G, Rossi M, Hayek J. Morphological changes and oxidative damage in Rett Syndrome erythrocytes. Biochim Biophys Acta. General Subjects 2012;1820(4):511-20. doi: 10.1016/j.bbagen.2011.12.002.
132. Sticozzi C1, Pecorelli A1, Lim Y, Maioli E, Pagnin E, Davis PA, Valacchi G. Modulation of skin oxidative stress and inflammatory markers by environmental stressors. Differences between young and old. J Dermatol Sci. 2012;65(3):226-8. doi: 10.1016/j.jdermsci.2011.11.004. 1co-first authors
133. De Felice C, Signorini C, Durand T, Oger C, Guy A, Bultel-Poncé V, Galano JM, Ciccoli L, Leoncini S, D'Esposito M, Filosa S, Pecorelli A, Valacchi G, Hayek J. F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome. J Lipid Res. 2011;52(12):2287-97. doi: 10.1194/jlr.P017798.
134. Valacchi G, Sticozzi C, Lim Y, Pecorelli A. Scavenger receptor class B type I: a multifunctional receptor. Ann N Y Acad Sci. 2011;1229:E1-7. doi: 10.1111/j.1749-6632.2011.06205.x.
135. Valacchi G, Pecorelli A, Sticozzi C, Torricelli C, Muscettola M, Aldinucci C, Maioli E. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011;77(6):460-70. doi: 10.1111/j.1747-0285.2011.01121.x.
136. Signorini C, De Felice C, Leoncini S, Giardini A, D'Esposito M, Filosa S, Della Ragione F, Rossi M, Pecorelli A, Valacchi G, Ciccoli L, Hayek J. F₄-neuroprostanes mediate neurological severity in Rett syndrome. Clin Chim Acta. 2011;412(15-16):1399-406. doi: 10.1016/j.cca.2011.04.016.
137. Pastore S, Mariani V, Lulli D, Gubinelli E, Raskovic D, Mariani S, Stancato A, de Luca C, Pecorelli A, Valacchi G, Potapovich AI, Kostyuk VA, Korkina LG. Glutathione peroxidase activity in the blood cells of psoriatic patients correlates with their responsiveness to Efalizumab. Free Radic Res. 2011;45(5):585-99. doi: 10.3109/10715762.2011.560150.
138. Pecorelli A, Ciccoli L, Signorini C, Leoncini S, Giardini A, D'Esposito M, Filosa S, Hayek J, De Felice C, Valacchi G. Increased levels of 4HNE-protein plasma adducts in Rett syndrome. Clin Biochem. 2011;44(5-6):368-71. doi: 10.1016/j.clinbiochem.2011.01.007.
139. Leoncini S, De Felice C, Signorini C, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. Oxidative stress in Rett syndrome: natural history, genotype, and variants. Redox Rep. 2011;16(4):145-53. doi: 10.1179/1351000211Y.0000000004.
140. Sticozzi C, Pecorelli A, Belmonte G, Valacchi G. Cigarette smoke affects ABCAl expression via liver X receptor nuclear translocation in human keratinocytes. Int J Mol Sci. 2010 Sep;11(9):3375-86. doi: 10.3390/ijms11093375.
141. Kostyuk VA, Potapovich AI, Cesareo E, Brescia S, Guerra L, Valacchi G, Pecorelli A, Deeva IB, Raskovic D, De Luca C, Pastore S, Korkina LG. Dysfunction of glutathione S-transferase leads to excess 4-hydroxy-2-nonenal and H(2)O(2) and impaired cytokine pattern in cultured keratinocytes and blood of vitiligo patients. Antioxid Redox Signal. 2010;13(5):607-20. doi: 10.1089/ars.2009.2976.
142. Vecchio D, Arezzini B, Pecorelli A, Valacchi G, Martorana PA, Gardi C. Reactivity of mouse alveolar macrophages to cigarette smoke is strain dependent. Am J Physiol Lung Cell Mol Physiol. 2010;298(5):L704-13. doi: 10.1152/ajplung.00013.2009.
143. Bonifazi M, Mencarelli M, Fedele V, Ceccarelli I, Pecorelli A, Grasso G, Aloisi AM, Muscettola M. Glucocorticoid receptor mRNA expression in peripheral blood mononuclear cells in high trained compared to low trained athletes and untrained subjects. J Endocrinol Invest. 2009;32(10):816-20. doi: 10.1007/BF03345751.
144. Mencarelli M1, Pecorelli A1, Carbotti P, Valacchi G, Grasso G, Muscettola M. Endothelin receptor A expression in human inflammatory cells. Regul Pept. 2009;158(1-3):1-5. doi: 10.1016/j.regpep.2009.06.004. 1 co-first authors
145. Valacchi G, Davis PA, Khan EM, Lanir R, Maioli E, Pecorelli A, Cross CE, Goldkorn T. Cigarette smoke exposure causes changes in Scavenger Receptor B1 level and distribution in lung cells. Int J Biochem Cell Biol. 2011;43(7):1065-70. doi: 10.1016/j.biocel.2009.05.014.
146. Valacchi G, Pecorelli A, Mencarelli M, Carbotti P, Fortino V, Muscettola M, Maioli E. Rottlerin: a multifaced regulator of keratinocyte cell cycle. Exp Dermatol. 2009;18(6):516-21. doi: 10.1111/j.1600-0625.2008.00816.x.
147. Valacchi G, Pecorelli A, Mencarelli M, Maioli E, Davis PA. Beta-carotene prevents ozone-induced proinflammatory markers in murine skin. Toxicol Ind Health. 2009;25(4-5):241-7. doi: 10.1177/0748233709103030.
148. Maioli E, Greci L, Soucek K, Hyzdalova M, Pecorelli A, Fortino V, Valacchi G. Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells. J Biomed Biotechnol. 2009;2009:742936. doi: 10.1155/2009/742936.
149. Massai L, Volpi N, Carbotti P, Fruschelli M, Mencarelli M, Pecorelli A, Muscettola M, Aglianò M, Alessandrini C, Grasso G. Endothelin-1 and endothelin-converting enzyme-1 in human granulomatous pathology of eyelid: an immunohistochemical and in situ hybridization study in chalazia. Histol Histopathol. 2007;22(12):1343-54. doi: 10.14670/HH-22.1343.
National Journals
1. Cortelazzo A, De Felice C, Guerranti R., Leoncini R., Barducci A., Leoncini S., Signorini C., Zollo G., Pecorelli A., Braccianti C., Gagliardi A., Armini A., Paccagnini E., Gentile M., Bini L., Durand T., Galano J.-M., Rossi M., Ciccoli L., Hayek J. Sindrome di Rett: effetti degli acidi grassi polinsaturi ω-3 sulle proteine di membrana • Proteomica delle membrane eritrocitarie. L’integratore Nutrizionale. 2016.
2. Cortelazzo A, De Felice C, Signorini C, Guerranti R, Leoncini S, Pecorelli A, Durand T, Galano JM, Oger C, Zollo G, Montomoli B, Landi C, Bini L, Valacchi G, Ciccoli C, Hayek J. Acidi Grassi Polinsaturi omega-3 e stato infiammatorio subclinico nella Sindrome di Rett. Un approccio proteomico. L’integratore Nutrizionale. 2014.
3. De Felice C, Signorini C, Leoncini S, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. [Oxidative stress and Rett syndrome.]. Minerva Pediatr. 2014; 66(1):41-62.
4. Hayek J, Signorini C, Leoncini S, Zollo G, Cortelazzo A, Belmonte G, Sticozzi C, Pecorelli A, Valacchi G, Rossi M, Ciccoli L, De Felice C. Stress ossidativo nella Sindrome di Rett: dalle bimbe ai modelli murini. Vivirett, 68, 15-16, 2014.
5. Cortelazzo A, De Felice C, Pecorelli A, Belmonte G, Signorini C, Leoncini S, Zollo G, Capone A, Della Giovampaola C, Sticozzi C, Valacchi G, Ciccoli L, Guerranti R, Hayek J. Espressione, ossidazione e distribuzione della beta-actina nei globuli rossi delle pazienti con Sindrome di Rett. Vivirett, 67, 18-20, 2014.
6. De Felice C, Rossi M, Leoncini S, Chisci G, Signorini C, Lonetti G, Vannuccini L, Spina D, Ginori A, Iacona I, Cortelazzo A, Pecorelli A, Valacchi G, Ciccoli L, Pizzorusso T, Hayek J. La malattia infiammatoria polmonare nella Sindrome di Rett. Vivirett, 67, 21-24, 2014.
7. Cortelazzo A, Guerranti R, Bini L, Landi C, Pecorelli A, Signorini C, Leoncini S, Zollo G, Ciccoli L, Hayek J, De Felice C. Infiammazione subclinica, acidi grassi polinsaturi omega-3 (PUFA ω-3) e PUFA ω-3 nella sindrome di Rett: primo approccio proteomico. Vivirett, 66, 18-20, 2014.
8. Pecorelli A, Leoni G, Cervellati F, Canali R, Signorini C, Leoncini S, Cortelazzo A, De Felice C, Ciccoli L, Hayek J, Valacchi G. Alterata espressione di geni collegati alle funzioni mitocondriali, alla degradazione proteica e all’organizzazione della cromatina in linfomonociti di pazienti Rett. Vivirett, 66, 22-25, 2014.
9. De Felice C, Leoncini S, Signorini C, Pecorelli A, Durand T, Galano JM, Oger C, Cortelazzo A, Montomoli B, Zollo G, Valacchi G, Ciccoli L, Hayek J. Acidi grassi ω-3 nella sindrome di Rett. Studio clinico al primo stadio della malattia. L’integratore Nutrizionale. 2013.
10. Ciccoli L, De Felice C, Paccagnini E, Leoncini S, Pecorelli A, Signorini C, Belmonte G, Valacchi G, Rossi M, Cerrone C, Hayek J. Anomalia di forma dei globuli rossi e danno ossidativo nella membrane eritrocitaria nella sindrome di Rett. Vivirett, 63, 14-17, 2012.
11. De Felice C, Signorini C, Durand T, Ciccoli L, Leoncini S, D’Esposito M, Filosa S, Oger C, Guy A, Bultel-Poncé V, Galano JM, Pecorelli A, De Felice L, Valacchi G, Cerrone C, Hayek J. Effetti della somministrazione di acidi grassi polinsaturi ω-3 nella sindrome di Rett in stadio I. Vivirett, 61, 16-19, 2012.
BOOK CHAPTERS
1. Pecorelli A, Valacchi G. Microplastics and Nanoplastics Contamination. An Emerging Environmental Issue for Skin Health. In: Environmental Stressors and OxInflammatory tissue responses. Eds. Giuseppe Valacchi, Andreas Daiber. Taylor & Francis Group. Chapter 12, Pages 136-153; 2023
2. Cordone V, Pecorelli A, Valacchi G. Omega-3 nutritional intervention as therapeutic co-adjuvant approach to improve Rett syndrome clinical and biochemical features. In: Modulation of Oxidative Stress. Biochemical, Physiological and Pharmacological Aspects. 1st Edition - August 4, 2023 Eds. Luciano Saso, Alessandro Giuffrè, Giuseppe Valacchi, Mauro Maccarrone. Pages 211-223. Elsevier. Academic Press, ISBN: 9780443192470. 2023
3. Cervellati C, Pecorelli A. Fluid redox biomarkers in neurological disease. In: Modulation of Oxidative Stress. Biochemical, Physiological and Pharmacological Aspects. 1st Edition - August 4, 2023 Eds. Luciano Saso, Alessandro Giuffrè, Giuseppe Valacchi, Mauro Maccarrone. Pages 43-57. Elsevier. Academic Press, ISBN: 9780443192470. 2023
4. De Felice C, Leoncini S, Signorini C, Pecorelli A, Durand T, Galano JM, Guy A, Valacchi G, Ciccoli L, Hayek J. Biomarkers of lipid oxidative damage in Rett syndrome. The Comprehensive Guide to Autism. Eds. Vinood B Patel, Victor R Preedy, Colin R Martin. SPRINGER. Pg. 2617-2632. ISBN: 978-1-4614-4787-0 (Print) 978-1-4614-4788-7 (Online). 2014
5. De Felice C, Leoncini S, Signorini C, Pecorelli A, Durand T, Galano JM, Guy A, Valacchi G, Ciccoli L, Hayek J. Neuroprostanes and neurological severity in Rett syndrome. The Comprehensive Guide to Autism. Eds. Vinood B Patel, Victor R Preedy, Colin R Martin. SPRINGER. Pp. 2633-2645. ISBN: 978-1-4614-4787-0 (Print) 978-1-4614-4788-7 (Online). 2014
6. Valacchi G, Pecorelli A, Signorini C, Leoncini S, Ciccoli L, De Felice C, Hayek J. 4HNE protein adducts in Autistic Spectrum Disorders: Rett syndrome and Autism. The Comprehensive Guide to Autism. Eds. Vinood B Patel, Victor R Preedy, Colin R Martin. SPRINGER. Pp. 2667-2687. ISBN: 978-1-4614-4787-0 (Print) 978-1-4614-4788-7 (Online). 2014
WORK ADDRESS
University of Ferrara
Dept. of Environmental and Prevention Sciences
Via Luigi Borsari, 46
44121 Ferrara, Italy
E-mail: pcrlsn1@unife.it; ale.pecorelli@gmail.com; apecore@ncsu.edu
Mobile Phone: +39 333 3299724
NATIONALITY: Italian
EDUCATION
Ph.D. in Cell Biology and Pathophysiology (Pathophysiology and Cellular Pathology Section), University of Siena, Siena, Italy. 13 February 2013.
Pharm.D. degree, 110/110 Magna Cum Laude, University of Siena, Siena, Italy. 15 December 2004.
ACADEMIC APPOINTMENTS
Associate Professor (GSD 06/MEDS-08 - Endocrinologia, Nefrologia e Scienze dell'Alimentazione e del Benessere, SSD MEDS-08/C - Scienza dell'Alimentazione e delle Tecniche Dietetiche Applicate; SSD 2015, MED/49, SC 2015, 06/D2) at University of Ferrara, Dept. of Environmental and Prevention Sciences, Ferrara, Italy. From 01/10/25- Present.
Adjunct Professor. Department of Food, Bioprocessing and Nutrition Sciences, College of Agriculture and Life Sciences, Plants for Human Health Institute, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 1st December 2023 - Present.
PREVIOUS ACADEMIC AND PROFESSIONAL APPOINTMENTS
-Assistant Professor (Ricercatore a tempo determinato L.240/10 tipo B, GSD 06/MEDS-08 - Endocrinologia, Nefrologia e Scienze dell'alimentazione e del Benessere, SSD MEDS-08/C - Scienza dell'alimentazione e delle tecniche dietetiche applicate) at University of Ferrara, Dept. of Environmental and Prevention Sciences, Ferrara, Italy, NC, USA. From 01/10/22- 30/09/2025.
-Short Term Research Scholar. Plants for Human Health Institute, College of Agriculture and Life Sciences, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 05/05/25 to 04/09/25.
-Visiting Scholar. Plants for Human Health Institute, College of Agriculture and Life Sciences, Department of Animal Science, Valacchi’s Laboratory, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 10/02/25 to 14/02/25.
Short Term Research Scholar. Plants for Human Health Institute, College of Agriculture and Life Sciences, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 02/03/24 to 21/06/24.
Short Term Research Scholar. Plants for Human Health Institute, College of Agriculture and Life Sciences, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 05/05/23 to 13/08/23.
Senior Research Scholar (PI status). Plants for Human Health Institute, Animal Science Department, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 03/19- 09/22.
Postdoctoral Research Scholar. Plants for Human Health Institute, Animal Science Department, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 01/18- 02/19.
Temp Research Tech'n/Paraprof. Plants for Human Health Institute, Animal Science Department, North Carolina State University, NC Research Campus, Kannapolis, NC, USA. From 12/16- 12/17.
Research Scholar. Child Neuropsychiatry Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy. From 03/2016 – to 11/2016.
Research Scholar. Department of Life Science and Biotechnologies, University of Ferrara, Ferrara, Italy. From 10/2015 – to 12/ 2015.
Research Scholar. Child Neuropsychiatry Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy. From 12/2014 - to 09/2015.
Research Scholar. Child Neuropsychiatry Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy. From 11/2012 - to 08/2014.
Ph.D. Student in “Cell Biology and Pathophysiology” graduate program, Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. From 10/2009 - to 09/2012.
Research Fellow. Department of Physiology, University of Siena, Siena, Italy. From 09/2005 - to 08/2009.
TEACHING EXPERIENCE
[52657] COMMUNITY NUTRITION, Module of [52673] ORGANIZATION OF COLLECTIVE CATERING SERVICES, Degree Program: DIETETICS (QUALIFYING FOR THE HEALTHCARE PROFESSION OF DIETITIAN), (2025/2026), University of Ferrara, Ferrara, Italy.
[73618] FOOD AND NUTRITION ACROSS DIFFERENT AGES AND PATHOLOGICAL CONDITIONS, Module of [178613] FOOD, METABOLISM AND MOVEMENT ACROSS DIFFERENT AGES, Master’s Degree Program: SCIENCES AND TECHNIQUES OF PREVENTIVE AND ADAPTED PHYSICAL ACTIVITY, (2025/2026), University of Ferrara, Ferrara, Italy.
[56509] NUTRITIONAL AND PSYCHOLOGICAL ASPECTS OF SCHOOL CATERING, Degree Program: DIETETICS (QUALIFYING FOR THE HEALTHCARE PROFESSION OF DIETITIAN), (2024/2025, 2025/2026), University of Ferrara, Ferrara, Italy.
[73618] FOOD AND NUTRITION ACROSS DIFFERENT AGES AND PATHOLOGICAL CONDITIONS, Module of [73616] METABOLISM, FOOD AND NUTRITION, Master’s Degree Program: SCIENCES AND TECHNIQUES OF PREVENTIVE AND ADAPTED PHYSICAL ACTIVITY, (2023-2024, 2024/2025), University of Ferrara, Ferrara, Italy.
[008719/1] HUMAN NUTRITION, Module of [52665] FOOD AND HUMAN NUTRITION I, Degree Program: DIETETICS (QUALIFYING FOR THE HEALTHCARE PROFESSION OF DIETITIAN), (2022-2023, 2023/2024, 2024/2025, 2025/2026), University of Ferrara, Ferrara, Italy.
[65961] OPTIMAL NUTRITION FOR SPORTS EXERCISE, Module of [65959] GENERAL PRINCIPLES OF FOOD COMPOSITION AND NUTRITION, Degree Program: SPORTS SCIENCES, (2023/2024, 2024/2025, 2025/2026), University of Ferrara, Ferrara, Italy.
“Skin Physiology” for the Master COSMAST (Scienza e Tecnologia Cosmetiche), (2016-2017; 2018-2019, 2020-2021), University of Ferrara, Ferrara, Italy.
Lectures for the Animal Ecophysiology class, “Environmental Sciences” Graduate Group in the School of Biology, (2009-2010), University of Siena, Siena, Italy.
AWARDS AND HONORS
Winner of the “2021 SfRBM Trainee Award” for the abstract titled “Aberrant Mitochondrial Bioenergetics Fuels Inflammasome Machinery in Autism Spectrum Disorder” at the “28th Annual Conference of the Society for Redox Biology & Medicine (SfRBM 2021)”. Virtual Conference. November 15-18, 2021.
Winner of the “Young Investigator Award” for the narrated communication titled “Mitochondrial dysfunction fuels inflammasome machinery in Autism Spectrum Disorder” at the “20th Biennial Meeting for the Society for Free Radical Research International (SFRRI 2021)”. Virtual Conference. March 15-18, 2021.
Winner of the “2019 SFRR Europe Catherine Pasquier Award" Society for Free Radical Research (SFRR) – Europe Meeting “Redox Homeostasis: from Signaling to Damage” in Ferrara, Italy, June 19-21, 2019.
Winner of the “Young Investigator Award” by OCC (Oxygen Club of California) for poster titled “Alteration of serum lipid profile, SRB1 loss and impaired Nrf2 activation in CDKL5 disorder” at the World Congress "Oxidants and Antioxidants in Biology", Valencia, Spain, June 24-26, 2015.
Winner of the “Young Investigator Award” by OCC (Oxygen Club of California) for poster titled “Increased Oxidative Stress Levels and MMPs Activation In Drug-resistant Epileptic Brain”. “Second International Conference on Environmental Stressors in Biology and Medicine”, Siena, Italy, October 5-7, 2011.
ORAL PRESENTATION AND INVITED TALKS
– “MAM proteomics identifies progressive ER–mitochondria signaling disfunction in Rett Syndrome”, at 2026 SFRR Europe Annual Meeting hosted by the Society for Free Radical Research Europe: “Redox Biology, Environmental Exposures and Lifestyle”. Mainz, Germany, June 03 – 05, 2026.
– “Targeting exposome-induced oxinflammatory responses: bioactives as a strategy for improved human health”, I Congresso de Medicina da UFV / IX Semana Acadêmica de Medicina (SAM): “Medicine and the New World: Health, Technology, and Well-Being in the 21st Century”, at the Federal University of Viçosa (UFV), Brazil, November 7th, 2025. (Invited Speaker)
– “Unraveling the Role of mitochondrial-associated ER membranes (MAMs) Proteins in RTT Brain Signaling”, Seminar at North Carolina State University, Plants for Human Health Institute, NC Research Campus, Kannapolis, NC, USA. August 1st, 2025.
– “Abnormal MAMs proteins can disrupt finely tuned signaling between ER and mitochondria in RTT brain”, at 22nd SFRRI Biennial Meeting hosted by the Society for Free Radical Research – Europe: “The New Era of Redox Biology: from Basic Biochemistry to Redox Omics”. Galway, Ireland, June 03 – 06, 2025.
– “Evidence of compromised redox homeostasis and ferritinophagy in Rett syndrome”, at 22nd SFRRI Biennial Meeting hosted by the Society for Free Radical Research – Europe: “The New Era of Redox Biology: from Basic Biochemistry to Redox Omics”. Galway, Ireland, June 03 – 06, 2025.
– “Deregulated Nrf2/BACH1 axis in Autism Spectrum Disorder”, MNESYS Spoke 6 & 7 Joint Meeting, «Neuro-immune interactions in the development of neurodegenerative diseases». Università di Verona, Verona, Italy. January 31, 2025.
– “Food and Diet to modulate OxInflammatory Conditions”, 2nd International Conference BioExperience 2024. Universidade Federal de Viçosa - Viçosa - Minas Gerais – Brazil. November 18-20, 2024. (Invited Speaker)
– “Involvement of lipid peroxidation byproducts in neurological conditions: from clinical severity to pathological mechanisms”, at the “HNE Club Meeting: Lipid Oxidation: New Biochemical Insights and Clinical Applications”. Genoa, Italy. October 10-12, 2024. (Invited Speaker)
– “Cutaneous cell junctions’ responses to dietary oxysterols”, at the “11th International Conference on Oxidative Stress in Skin Medicine and Biology”. Andros, Greece. September 12-15, 2024.
– “Abnormal MAMs proteins can disrupt finely tuned signaling between ER and mitochondria in RTT brain”, Flash Talk at the “2024 IRSF Rett Syndrome Scientific Meeting”. Westminster, CO, USA. June 18-19, 2024.
– “Phytochemicals and nutritional approaches as modulators of the OxInflammation phenomenon”, Seminar for Adjunct Professor Appointment at NC State's Department of Food, Bioprocessing and Nutrition Sciences, Kannapolis, NC, USA. July 20, 2023.
– “Oxidative-mediated loss of Scavenger Receptor B1 in the brain of a Mecp2 mouse model of Rett Syndrome”, Flash Talk at the “2023 IRSF Rett Syndrome Scientific Meeting”. Nashville, TN, USA. June 5-7, 2023.
– “Dietary supplementation with omega−3 fatty acids as coadjuvant strategy to ameliorate Rett syndrome phenotype”, at the “Bioactives and Health Symposium”. Core Laboratory, NC Research Campus, Kannapolis, NC, USA. May 19, 2023. (Invited Speaker)
– “A possible role for the loss of brain Scavenger Receptor B1 (SR-B1) in Rett syndrome”, at the “Redox Biology Congress 2022”. Ghent, Belgium. August 24-26, 2022.
– “Mitochondria and inflammasome involvement in Autism Spectrum Disorder”, at “The Future in Redox Biology”. Siena, Italy. June 17-19, 2022. (Invited Speaker)
– “A possible role for the loss of brain Scavenger Receptor B1 (SR-B1) in Rett syndrome”, Flash Talk at the “2022 IRSF Rett Syndrome Scientific Meeting”. Nashville, TN, USA. April 26-27, 2022.
– “Mitochondrial impairment in Autism Spectrum Disorders”, Webinar on "Aberrant redox responses in neurodevelopmental conditions: the case of autism and Rett Syndrome” 16 December, 2021.
– “Aberrant Mitochondrial Bioenergetics Fuels Inflammasome Machinery in Autism Spectrum Disorder”, at the “28th Annual Conference of the Society for Redox Biology & Medicine (SfRBM 2021)”. Virtual Conference. November 15-18, 2021.
– “Mitochondrial dynamics and quality control pathways impairment in Rett Syndrome and Autism Spectrum Disorder”, at the “Annual Virtual Meeting SFRR-E 2021. Redox Biology in the 21st Century: A New Scientific Discipline”. Virtual Conference. Belgrade, Serbia. June 15-18, 2021.
– “A role for Mitochondrial Dysfunction in Inflammasome Activation in Autism Spectrum Disorder”, at the “2021 SfRBM & MCW Redox Biology Symposium”. Virtual Conference. Medical College of Wisconsin, Wauwatosa, WI, USA. May 13-14, 2021.
– “Proteomic profiling reveals mitochondrial alterations in Rett Syndrome”, at the “9th Annual Catalyst Spring Symposium - Looking at the big picture: the application of “-omics” techniques in health and disease”. Virtual Conference. Kannapolis, NC, USA. March 25-26, 2021.
– "Mitochondrial dysfunction fuels inflammasome machinery in Autism Spectrum Disorder", at the “20th Biennial Meeting for the Society for Free Radical Research International (SFRRI 2021)”. Virtual Conference. March 15-18, 2021.
– "Involvement of redox imbalance in Rett syndrome pathogenesis and clinical severity" Catherine Pasquier Award Lecture at the Society for Free Radical Research (SFRR) – Europe Meeting “Redox Homeostasis: from Signaling to Damage” in Ferrara, Italy, 19-21 June 2019. (Invited Speaker).
– “Evaluation of protective effects of topical vitamin C compound mixtures against ozone-induced damage in different cutaneous models” American Council for Medicinally Active Plants (ACMAP), Clemson University, Clemson, SC, USA. June 20-23, 2017. (Invited Speaker).
EDITORIAL WORK
Guest Editor for the Special Issue on "Molecular and Cellular Mechanisms Involved in Redox Responses to Environmental Pollution”. Journal: Frontiers in Molecular Biosciences. January 2021.
Guest Editor for the Special Issue on "Mitochondrial involvement in the development and progression of diseases”. Journal: Archives of Biochemistry and Biophysics. May 2020.
Review Editor for the section Molecular Diagnostics and Therapeutics of Frontiers in Molecular Biosciences. January 2021.
INTERNATIONAL JOURNAL BOARD MEMBER
Member of the Editorial Board for the journal “BioFactors”, 2022 – Present
ACADEMIC SERVICES
Examiner for the thesis titled “European Food Safety Authority (EFSA) concerns on botanicals: characterization and safety evaluation of anthraquinone and red yeast rice food supplements”, for the award of Doctor of Philosophy. Doctoral Course in Biochemistry and Molecular Biology, Department of Biotechnology, Chemistry and Pharmacy. University of Siena, Italy. February 2025.
Co-Tutor in the PhD thesis “Evaluation of new molecular and cellular mechanisms related to oxinflammatory pathways in Neurodevelopmental Disorders”, – XL Cycle - a.y. 2024/2025, Doctoral Course in Environmental and Health Sciences, University of Ferrara, Ferrara, Italy.
Co-Tutor in the PhD thesis “Modulation of inflammatory pathways in neurodevelopmental disorders by the use of in vitro, ex-vivo and in vivo approaches”, – XXXIX Cycle - a.y. 2023/2024, Doctoral Course in Environmental and Health Sciences, University of Ferrara, Ferrara, Italy.
Member of the Academic Board of the Doctoral Course in Environmental and Health Sciences, University of Ferrara, Ferrara, Italy. From 05/11/2023 – Present.
Examiner for the thesis titled “SIRT1-Dependent Cytoprotective Effect of Resveratrol in HG-Challenged Human Endothelial Cells Involves Antiglycative and Antioxidant Responses”, for the award of Doctor of Philosophy. Doctoral Course in Cellular and Molecular Biotechnologies, Faculty of Bioscience and Technology for Food, Agriculture and Environment, Horizon 2020 MSCA-COFUND- Rep-Eat Project. University of Teramo, Italy. June 2020.
Examiner for the thesis titled “Effects of environmental ozone exposure on mice olfactory bulb. Immunochemical, electrophysiological and behavioral studies”, for the award of Doctor of Philosophy. Doctoral Course in Biomedical Sciences and Biotechnology, Department of Life Science, University of Ferrara, Italy. December 2016.
CONFERENCE ORGANIZATION
Poster Judge for the Second Annual PhD Day, PhD in Environmental and Health Sciences, Ferrara, Italy, June 26, 2025.
Chairman for the 22nd SFRRI Biennial Meeting hosted by the Society for Free Radical Research – Europe: “The New Era of Redox Biology: from Basic Biochemistry to Redox Omics”. Galway, Ireland, June 03 – 06, 2025.
Member of the Local Organizing Committee for the SFRR-E annual conference “Redox homeostasis: from signaling to damage” in Ferrara, Italy, 19-21 June 2019.
Organizer of the Symposium "Lifestyle and Nutrition as OxInflammation Modulators" at NC Research Campus, Kannapolis, USA. Speakers: Dr. Henry J Forman, University of Southern California, Los Angeles, CA, USA; Dr. Fabio Virgili, Research Centre for Food and Nutrition- Council for Agricultural Research and Economics (CREA), Rome, Italy; Dr. Giuseppe Valacchi, Plants for Human Health Institute, NC Research Campus, NC State University, NC, USA. Kannapolis, NC, USA 04/05/2017 May 4, 2017
Member of the Local Organizing Committee for the “Second International Conference on Environmental Stressors in Biology and Medicine”. University of Siena, Siena, Italy, 5-7 October 2011.
Member of the Local Organizing Committee for the “International Conference on Environmental Stressors in Biology and Medicine”. University of Siena, Siena, Italy, 4-6 June 2008.
PEER REVIEW ACTIVITIES
MANUSCRIPTS
Annals of the New York Academy of Sciences
Antioxidants
Archives of Biochemistry and Biophysics
BioFactors
BioMed Research International
Environment International
Free Radical Biology and Medicine
Frontiers in Genetics
Frontiers in Molecular Biosciences
Genes & Nutrition
Marine Drugs
Mediators of Inflammation
Nutrition Research
Oxidative Medicine and Cellular Longevity
Pharmaceuticals
SOCIETY MEMBERSHIPS
Women In Nutraceuticals (WIN) (2025 – present)
American Society for Nutrition (ASN) (2023 – present)
Society for Redox Biology and Medicine (SfRBM) (2018 - present)
SFRR Europe- Society for Free Radicals Research (2016- present)
PUBLICATIONS
Full Articles in Peer-reviewed International Journals
3. Cordone V, Vallese A, Bianchi A, Guiotto A, Pecorelli A, Valacchi G. Impaired NF κB/Nrf2 crosstalk in Rett Syndrome. The FASEB Journal. 2026
4. Alghamdi M, Gemmo L, Guiotto A, Pecorelli A, Valacchi G. FOXO3 Involvement in Neurological OxInflammation. Redox Experimental Medicine. 2026
5. Garcés M, Pecorelli A, Vallese A, Magnani N, Ferrara F, Benedusi M, Cervellati F, Evelson P, Valacchi G. Indoor pollution induced Oxinflammatory responses in lung tissues. Chemico-Biological Interactions 2026
6. Sarandy MM, Guiotto A, Ivarsson J, Pecorelli A, Valacchi G. Keratinocytes exposed to Ozone induce a bystander oxinflammatory response in dermal fibroblasts. Toxicology. 2026;523:154447. doi: 10.1016/j.tox.2026.154447
7. Ivarsson J, Guiotto A, Trinchera G, Pecorelli A, Shiota G, Valacchi G. Therapeutic Potential of Ozonized Glycerin in Skin Inflammation and Repair. Cosmetics. 2026; 13(1):42. https://doi.org/10.3390/cosmetics13010042
8. Mastaloudis A, Holcomb L, Fahey JW, Olson C, Nieman DC, Kay C, O'Donnell R, Pecorelli A, Kinney M, Li Y, Ishaq SL, Valacchi G. Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study. Sci Rep. 2026. doi: 10.1038/s41598-026-39389-4.
9. Pecorelli A*, Guiotto A, Casoni A, Ruzza M, Beltrami L, Canepa B, Biasi F, Poli G, Valacchi G. Oxysterol-induced oxidative disruption of skin junction integrity. Oxysterol-induced oxidative disruption of skin junction integrity. Free Radic Biol Med. 2026:S0891-5849(26)00067-5. doi: 10.1016/j.freeradbiomed.2026.01.047 *Corresponding author
10. Mengarelli F, Cordone V, Pecorelli A, Benedusi M, Valacchi G, Morresi C, Bacchetti T, Orlando P, Tiano L, Silvestri S. Mitochondrial redox imbalance and CoQ10 deficiency in Rett syndrome: insights from patient-derived fibroblasts. Arch Biochem Biophys. 2025:110636. doi: 10.1016/j.abb.2025.110636.
11. Guiotto A, Vallese A, Cordone V, Cervellati F, Benedusi M, Hayek J, Pecorelli A*, Valacchi G*. Lipid peroxidation-induced cell death in Rett syndrome. Free Radic Biol Med. 2025; 241:243-257. doi: 10.1016/j.freeradbiomed.2025.09.033. *Co-corresponding authors
12. Vallese A, Melija S, Hayek J, Pecorelli A*, Valacchi G.* Deregulated Nrf2-Keap1-BACH1 axis in autism spectrum disorder. Redox Biol. 2025; 86:103837. doi: 10.1016/j.redox.2025.103837. *Co-corresponding authors
13. Ivarsson J, Yan X, Guiotto A, Pecorelli A, Sarandy MM, Lynch S, Anderias S, Choudhary H, White S, Ferrara F, Valacchi G. Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate Matter. J Cosmet Dermatol. 2025;24(7):e70306. doi: 10.1111/jocd.70306.
14. Ivarsson J, Pambianchi E, Pecorelli A, Lim Y, Valacchi G. Redox regulation of cutaneous AMPs by ozone in tensioned skin models. Arch Biochem Biophys. 2025;769:110409. doi: 10.1016/j.abb.2025.110409.
15. Valacchi G, Pecorelli A*. Role of Scavenger Receptor B1 (SR-B1) in Improving Food Benefits for Human Health. Annu Rev Food Sci Technol. 2025;16(1):403-432. doi: 10.1146/annurev-food-111523-121935. *Corresponding author
16. Pula W, Pepe A, Ferrara F, Bondi A, Mariani P, Ortore MG, Pecorelli A, Ivarsson J, Valacchi G, Esposito E. In situ forming gels as subcutaneous delivery systems of curcumin and piperine. Sci Rep. 2025;15(1):3046. doi: 10.1038/s41598-025-87750-w
17. Guiotto A, Pecorelli A*, Draelos ZD, Gueniche A, Yatskayer M, Nelson DB. Reversing Oxinflammation Associated with Glycative Stress and Formation of Advanced Glycation End Products with a Dietary Supplement Containing Rosemary Extract. J Clin Aesthet Dermatol. 2025;18(3):34-38. *Corresponding author
18. Ivarsson, J; Pecorelli, A; Guiotto, A; Souza, M M; Choundhary, H; Brieva, P; Ferrara, F; Valacchi, G. Comparing UV and diesel damage in cutaneous tissue and the protective role of a topical antioxidant containing vitamin C, E and ferulic acid against premature skin aging. Exp Dermatol. 2025;34(3):e70069. doi: 10.1111/exd.70069
19. Vallese A, Cordone V, Ferrara F, Guiotto A, Gemmo L, Cervellati F, Hayek J, Pecorelli A*, Valacchi G*. NLRP3 inflammasome-mitochondrion loop in autism spectrum disorder. Free Radic Biol Med. 2024 Nov 20;225: 581-594. doi: 10.1016/j.freeradbiomed.2024.10.297. *Co-corresponding authors
20. Cordone V, Guiotto A, Bucay V, Pecorelli A, Valacchi G. Evidence of altered redox homeostasis in trichothiodystrophy. Redox Experimental Medicine. 2024. DOI: 10.1530/REM-24-0010
21. Venezia V, Pota G, Argenziano R, Alfieri ML, Moccia F, Ferrara F, Pecorelli A, Esposito R, Di Girolamo R, D'Errico G, Valacchi G, Luciani G, Panzella L, Napolitano A. Design of a hybrid nanoscaled skin photoprotector by boosting the antioxidant properties of food waste-derived lignin through molecular combination with TiO2 nanoparticles. Int J Biol Macromol. 2024;280(Pt 3):135946. doi: 10.1016/j.ijbiomac.2024.135946
22. Pignatelli A, Benedusi M, Barbieri M, Pecorelli A, Valacchi G. Tropospheric ozone effect on olfactory perception and olfactory bulb dopaminergic interneuron excitability. Neurotoxicology. 2024;104:36-44. doi: 10.1016/j.neuro.2024.07.003
23. Ivarsson J, Bennett A, Ferrara F, Strauch R, Vallese A, Iorizzo M, Pecorelli A, Lila MA, Valacchi G. Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage. Food Funct. 2024;15(15):7849-7864. doi: 10.1039/d4fo01874e
24. Esposito E, Pecorelli A, Ferrara F, Lila MA, Valacchi G. Feeding the Body Through the Skin: Ethosomes and Transethosomes as a New Topical Delivery System for Bioactive Compounds. Annu Rev Food Sci Technol. 2024 Jun;15(1):53-78. doi: 10.1146/annurev-food-072023-034528.
25. Ferrara F, Yan X, Pecorelli A, Guiotto A, Colella S, Pasqui A, Ivarrson J, Lynch S, Anderias S, Choundhary H, White S, Valacchi G. Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study. J Cosmet Dermatol. 2024. doi: 10.1111/jocd.16321
26. Ferrara F, Pecorelli A, Pambianchi E, White S, Choudhary H, Casoni A, Valacchi G. Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multipollutant exposure. Exp Dermatol. 2024;33(1):e15000. doi: 10.1111/exd.15000
27. Esposito E, Ferrara F, Drechsler M, Bortolini O, Ragno D, Toldo S, Bondi A, Pecorelli A, Voltan R, Secchiero P, Zauli G, Valacchi G. Nutlin-3 Loaded Ethosomes and Transethosomes to Prevent UV-Associated Skin Damage. Life (Basel). 2024;14(1):155. doi: 10.3390/life14010155
28. El-Khodor BF, Zang W, Gorby H, Dominique A, Hamrock M, Metzer B, Pecorelli A, Varadharaj S, Valacchi G. A Plant-Based Dietary Supplement Improves Measures of Metabolic Detoxification and the Quality of Life: A Phase II Multicenter Randomized, Blinded, Placebo-Controlled Clinical Trial. Integr Med (Encinitas). 2023;22(5):28-39
29. Pasqui A, Cicaloni V, Tinti L, Guiotto A, Tinti C, Mori A, Bruttini M, Hayek J, Pecorelli A, Salvini L, Valacchi G. A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways. Arch Biochem Biophys. 2024; 752:109860. doi: 10.1016/j.abb.2023.109860
30. Ivarsson J, Ferrara F, Vallese A, Guiotto A, Colella S, Pecorelli A, Valacchi G. Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation. Int J Mol Sci. 2023;24(23):16674. doi: 10.3390/ijms242316674
31. Pambianchi E, Hagenberg Z, Pecorelli A, Pasqui A, Therrien JP, Valacchi G. Tension as a key factor in skin responses to pollution. Sci Rep. 2023;13(1):16013. doi: 10.1038/s41598-023-42629-6
32. Cervellati C, Casolari P, Pecorelli A, Sticozzi C, Nucera F, Papi A, Caramori G, Valacchi G. Scavenger receptor B1 involvement in chronic obstructive pulmonary disease pathogenesis. Redox Experimental Medicine 2023;1: e230012. DOI: https://doi.org/10.1530/REM-23-0012
33. Hoskin RT, Grace MH, Guiotto A, Pecorelli A, Valacchi G, Lila MA. Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach. Antioxidants (Basel). 2023;12(7):1431. doi: 10.3390/antiox12071431
34. Ferrara F, Pecorelli A, Valacchi G. Redox Regulation of Nucleotide-Binding and Oligomerization Domain-Like Receptors Inflammasome. Antioxid Redox Signal. 2023;39(10-12):744-770. doi: 10.1089/ars.2022.0180.
35. Vallese A, Cordone V, Pecorelli A, Valacchi G. Ox-inflammasome involvement in neuroinflammation. Free Radic Biol Med. 2023: S0891-5849(23)00528-2. doi: 10.1016/j.freeradbiomed.2023.07.010
36. Ivarsson J Jr., Pecorelli A, Lila MA, Valacchi G. Blueberry Supplementation and Skin Health. Antioxidants. 2023; 12(6):1261. https://doi.org/10.3390/antiox12061261
37. Nieman DC, Woo J, Sakaguchi CA, Omar AM, Tang Y, Davis K, Pecorelli A, Valacchi G, Zhang Q. Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins. Front Nutr. 2023; 10:1143385. doi: 10.3389/fnut.2023.1143385.
38. Sarkar P, Pecorelli A, Woodby B, Pambianchi E, Ferrara F, Duary RK, Valacchi G. Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii). Nutrients. 2023; 15(4):1035. https://doi.org/10.3390/nu15041035
39. Canella R, Benedusi M, Vallese A, Pecorelli A, Guiotto A, Ferrara F, Rispoli G, Cervellati F, Valacchi G. The role of potassium current in the pulmonary response to environmental oxidative stress. Arch Biochem Biophys. 2023:109534. doi: 10.1016/j.abb.2023.109534.
40. Ferrara F, Cordone V, Pecorelli A, Benedusi M, Pambianchi E, Guiotto A, Vallese A, Cervellati F, Valacchi G. Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox inflammasome activation. Redox Biol. 2022; 56:102440. doi: 10.1016/j.redox.2022.102440.
41. Pecorelli A, Valacchi G. Oxidative-Stress-Sensitive microRNAs in UV-Promoted Development of Melanoma. Cancers (Basel). 2022; 14(13):3224. doi: 10.3390/cancers14133224.
42. Cordone V, Ferrara F, Pecorelli A, Guiotto A, Vitale A, Amicarelli F, Cervellati C, Hayek J, Valacchi G. The constitutive activation of TLR4-IRAK1- NFκB axis is involved in the early NLRP3 inflammasome response in peripheral blood mononuclear cells of Rett syndrome patients. Free Radic Biol Med. 2022:S0891-5849(22)00028-4. doi: 10.1016/j.freeradbiomed.2022.01.017.
43. Pambianchi E, Pecorelli A, Valacchi G. Gastrointestinal tissue as a "new" target of pollution exposure. IUBMB Life. 2022;74(1):62-73. doi: 10.1002/iub.2530.
44. Pambianchi E, Ferrara F, Pecorelli A, Benedusi M, Choudhary H, Therrien JP, Valacchi G. Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure. Antioxidants (Basel). 2021; 10(12):1928. doi: 10.3390/antiox10121928.
45. Pambianchi E, Hagenberg Z, Pecorelli A, Grace M, Therrien J-P, Lila MA, Valacchi G. Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage. Cosmetics. 2021; 8(4):112. https://doi.org/10.3390/cosmetics8040112
46. Valacchi G, Pecorelli A, Toyokuni S. Mitochondrial involvement in the development and progression of diseases. Arch Biochem Biophys. 2021; 711:109006. doi: 10.1016/j.abb.2021.109006.
47. Hoskin R, Pambianchi E, Pecorelli A, Grace M, Therrien JP, Valacchi G, Lila MA. Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage. Molecules. 2021 Jun 22;26(13):3781. doi: 10.3390/molecules26133781.
48. Pecorelli A, Cordone V, Schiavone ML, Caffarelli C, Cervellati C, Cerbone G, Gonnelli S, Hayek J, Valacchi G. Altered Bone Status in Rett Syndrome. Life (Basel). 2021 Jun 3;11(6):521. doi: 10.3390/life11060521.
49. Grillo A, Fezza F, Chemi G, Colangeli R, Brogi S, Fazio D, Federico S, Papa A, Relitti N, Di Maio R, Giorgi G, Lamponi S, Valoti M, Gorelli B, Saponara S, Benedusi M, Pecorelli A, Minetti P, Valacchi G, Butini S, Campiani G, Gemma S, Maccarrone M, Di Giovanni G. Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents. ACS Chem Neurosci. 2021 May 5;12(9):1716-1736. doi: 10.1021/acschemneuro.1c00192.
50. Woodby B, Pambianchi E, Ferrara F, Messano N, Pecorelli A, Therrien JP, Lila MA, Valacchi G. Cutaneous Antimicrobial Peptides: new “actors” in pollution related inflammatory conditions. Redox Biol. 2021 May;41:101952. doi: 10.1016/j.redox.2021.101952.
51. Garcés M, Magnani ND, Pecorelli A, Calabró V, Marchini T, Cáceres L, Pambianchi E, Galdoporpora J, Vico T, Salgueiro J, Zubillaga M, Moretton MA, Desimone MF, Alvarez S, Valacchi G, Evelson P. Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure. Free Radic Biol Med. 2021;166:324-336. doi: 10.1016/j.freeradbiomed.2021.02.008.
52. Crivellari I, Pecorelli A, Cordone V, Marchi S, Pinton P, Cervellati F, Hayek J, Cervellati C, Valacchi G. Impaired mitochondrial quality control in Rett Syndrome. Arch Biochem Biophys. 2021;700:108790. doi: 10.1016/j.abb.2021.108790.
53. Ferrara F, Pambianchi E, Woodby B, Messano N, Therrien JP, Pecorelli A, Canella R, Valacchi G. Evaluating the effect of ozone in UV induced skin damage. Toxicol Lett. 2021 Mar 1;338:40-50. doi: 10.1016/j.toxlet.2020.11.023.
54. Cicaloni V, Pecorelli A, Cordone V, Tinti L, Rossi M, Hayek J, Salvini L, Tinti C, Valacchi G. A proteomics approach to further highlight the altered inflammatory condition in Rett syndrome Arch Biochem Biophys. 2020;696:108660. doi: 10.1016/j.abb.2020.108660.
55. Nieman DC, Ferrara F, Pecorelli A, Woodby B, Hoyle AT, Simonson A, Valacchi G. Postexercise Inflammasome Activation and IL-1β Production Mitigated by Flavonoid Supplementation in Cyclists. Int J Sport Nutr Exerc Metab. 2020 15:1-9. doi: 10.1123/ijsnem.2020-0084.
56. Pambianchi E, Ferrara F, Pecorelli A, Woodby B, Grace M, Therrien JP, Lila MA, Valacchi G. Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation. Oxid Med Cell Longev. 2020 13;2020:9571490. doi: 10.1155/2020/9571490.
57. Schiavone ML1, Pecorelli A1, Woodby B, Ferrara F, Pambianchi E, Santucci A, Valacchi G. Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria. Arch Biochem Biophys. 2020 15;690:108416. doi: 10.1016/j.abb.2020.108416.
1co-first authors
58. Cicaloni V, Pecorelli A, Tinti L, Rossi M, Benedusi M, Cervellati C, Spiga O, Santucci A, Hayek J, Salvini L, Tinti C, Valacchi G. Proteomic profiling reveals mitochondrial alterations in Rett syndrome. Free Radic Biol Med. 2020 1;155:37-48. doi: 10.1016/j.freeradbiomed.2020.05.014.
59. Pecorelli A, McDaniel DH, Wortzman M, Nelson DB. Protective effects of a comprehensive topical antioxidant against ozone-induced damage in a reconstructed human skin model. Arch Dermatol Res. 2021;313(3):139-146. doi: 10.1007/s00403-020-02083-0.
60. Woodby B, Schiavone ML, Pambianchi E, Mastaloudis A, N Hester S, M Wood S, Pecorelli A, Valacchi G. Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model. Int J Environ Res Public Health. 2020;17(9):3234. doi: 10.3390/ijerph17093234.
61. Ferrara F, Woodby B, Pecorelli A, Schiavone ML, Pambianchi E, Messano N, Therrien JP, Choudhary H, Valacchi G. Additive effect of combined pollutants to UV induced skin OxInflammation damage. Evaluating the protective topical application of a cosmeceutical mixture formulation. Redox Biol. 2020;34:101481. doi: 10.1016/j.redox.2020.101481.
62. Sbardella D, Tundo GR, Cunsolo V, Grasso G, Cascella R, Caputo V, Santoro AM, Milardi D, Pecorelli A, Ciaccio C, Di Pierro D, Leoncini S, Campagnolo L, Pironi V, Oddone F, Manni P, Foti S, Giardina E, De Felice C, Hayek J, Curatolo P, Galasso C, Valacchi G, Coletta M, Graziani G, Marini S. Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations. Biochim Biophys Acta Mol Basis Dis. 2020;1866(7):165793. doi: 10.1016/j.bbadis.2020.165793.
63. Pecorelli A, Ferrara F, Messano N, Cordone V, Schiavone ML, Cervellati F, Woodby B, Cervellati C, Hayek J, Valacchi G. Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder. FASEB J. 2020;34(5):6521-6538. doi: 10.1096/fj.201902677R.
64. Cervellati C, Trentini A, Pecorelli A, Valacchi G. Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery. Antioxid Redox Signal. 2020;33(3):191-210. doi: 10.1089/ars.2020.8076.
65. Pecorelli A, Cervellati C, Cordone V, Hayek J, Valacchi G. Compromised immune/inflammatory responses in Rett syndrome. Free Radic Biol Med. 2020; 152:100-106. doi: 10.1016/j.freeradbiomed.2020.02.023.
66. Woodby B, Penta K, Pecorelli A, Lila MA, Valacchi G. Skin Health from the Inside Out. Annu Rev Food Sci Technol. 2020; 11:235-254. doi: 10.1146/annurev-food-032519-051722.
67. Ferrara F, Pambianchi E, Pecorelli A, Woodby B, Messano N, Therrien JP, Lila MA, Valacchi G. Redox regulation of cutaneous inflammasome by ozone exposure. Free Radic Biol Med. 2020;152:561-570. doi: 10.1016/j.freeradbiomed.2019.11.031.
68. Cordone V, Pecorelli A, Amicarelli F, Hayek J, Valacchi G. The complexity of Rett syndrome models: Primary fibroblasts as a disease-in-a-dish reliable approach. Drug Discovery Today: Disease Models. 2020;31:11-19. doi.org/10.1016/j.ddmod.2019.11.001
69. Nieman DC, Valacchi G, Wentz LM, Ferrara F, Pecorelli A, Woodby B, Sakaguchi CA, Simonson A. Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes. Int J Sport Nutr Exerc Metab. 2019 21:1-8. doi: 10.1123/ijsnem.2019-0171.
70. Sguizzato M, Valacchi G, Pecorelli A, Boldrini P, Simelière F, Huang N, Cortesi R, Esposito E. Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study. Colloids Surf B Biointerfaces. 2020;185:110613. doi: 10.1016/j.colsurfb.2019.110613.
71. Pecorelli A1, Cordone V1, Messano N, Zhang C, Falone S, Amicarelli F, Hayek J, Valacchi G. Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation. Redox Biol. 2020;28:101334. doi: 10.1016/j.redox.2019.101334. 1 co-first authors
72. Grillo A, Chemi G, Brogi S, Brindisi M, Relitti N, Fezza F, Fazio D, Castelletti L, Perdona E, Wong A, Lamponi S, Pecorelli A, Benedusi M, Fantacci M, Valoti M, Valacchi G, Micheli F, Novellino E, Campiani G, Butini S, Maccarrone M, Gemma S. Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems. Eur J Med Chem. 2019;183:111674. doi: 10.1016/j.ejmech.2019.111674.
73. Ietta F, Valacchi G, Benincasa L, Pecorelli A, Cresti L, Maioli E. Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells. Biofactors. 2019;45(6):920-929. doi: 10.1002/biof.1551.
74. Pecorelli A, Woodby B, Prieux R, Valacchi G. Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage. Biofactors. 2019;45(4):536-547. doi: 10.1002/biof.1513.
75. Cordone V, Pecorelli A, Benedusi M, Santini S Jr, Falone S, Hayek J, Amicarelli F, Valacchi G. Antiglycative Activity and RAGE Expression in Rett Syndrome. Cells. 2019;8(2):161. doi: 10.3390/cells8020161
76. Pecorelli A, Cervellati C, Cordone V, Amicarelli F, Hayek J, Valacchi G. 13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation. Free Radic Biol Med. 2019; 134:598-603. doi: 10.1016/j.freeradbiomed.2019.02.007.
77. Brindisi M, Borrelli G, Brogi S, Grillo A, Maramai S, Paolino M, Benedusi M, Pecorelli A, Valacchi G, Di Cesare Mannelli L, Ghelardini C, Allarà M, Ligresti A, Minetti P, Campiani G, di Marzo V, Butini S, Gemma S. Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain. ChemMedChem. 2018;13(19):2090-2103. doi: 10.1002/cmdc.201800397.
78. Sticozzi C1, Pecorelli A1, Romani A, Belmonte G, Cervellati F, Maioli E, Lila MA, Cervellati C, Valacchi G. Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells. Free Radic Biol Med. 2018;126:287-295. doi: 10.1016/j.freeradbiomed.2018.07.007. 1 co-first authors
79. Dissette V, Bignozzi GS, Valacchi G, Pecorelli A, Manfredini S, Vertuani S. Evaluation of the transepidermal penetration of the carnosine complex in a cosmetic product in 3D-skin models. Cosmetics 2018, 5(4), 67. doi.org/10.3390/cosmetics5040067
80. Valacchi G, Virgili F, Cervellati C, Pecorelli A*. OxInflammation: From Subclinical Condition to Pathological Biomarker. Front Physiol. 2018 Jul 9;9:858. doi: 10.3389/fphys.2018.00858. *Corresponding author
81. Molesini S, Urto F, Cvetkovska AD, Bettoli V, Valacchi G, Pecorelli A, Manfredini S, Vertuani S. Influences of the vehicle in the spreading and release of betamethasone. Ther Deliv. 2018;9(3):177-184. doi: 10.4155/tde-2017-0070.
82. Esposito E, Pecorelli A, Sguizzato M, Drechsler M, Mariani P, Carducci F, Cervellati F, Nastruzzi C, Cortesi R, Valacchi G. Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing. Curr Drug Deliv. 2018;15(8):1172-1182. doi: 10.2174/1567201815666180518123926.
83. Fallacara A, Vertuani S, Panozzo G, Pecorelli A, Valacchi G, Manfredini S. Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study. Molecules. 2017;22(12):2104. doi: 10.3390/molecules22122104.
84. Romani A, Cervellati C, Muresan XM, Belmonte G, Pecorelli A, Cervellati F, Benedusi M, Evelson P, Valacchi G. Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure. Mech Ageing Dev. 2018;172:86-95. doi: 10.1016/j.mad.2017.11.007.
85. Brogi S, Ramunno A, Savi L, Chemi G, Alfano G, Pecorelli A, Pambianchi E, Galatello P, Compagnoni G, Focher F, Biamonti G, Valacchi G, Butini S, Gemma S, Campiani G, Brindisi M. First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents. Eur J Med Chem. 2017 Sep 29;138:438-457. doi: 10.1016/j.ejmech.2017.06.017.
86. Cortesi R, Cappellozza E, Drechsler M, Contado C, Baldisserotto A, Mariani P, Carducci F, Pecorelli A, Esposito E, Valacchi G. Monoolein aqueous dispersions as a delivery system for quercetin. Biomed Microdevices. 2017 Jun;19(2):41. doi: 10.1007/s10544-017-0185-0.
87. Valacchi G, Pecorelli A, Belmonte G, Pambianchi E, Cervellati F, Lynch S, Krol Y, Oresajo C. Protective Effects of Topical Vitamin C Compound Mixtures against Ozone-Induced Damage in Human Skin. J Invest Dermatol. 2017 Jun;137(6):1373-1375. doi: 10.1016/j.jid.2017.01.034.
88. Cheleschi S, De Palma A, Pecorelli A, Pascarelli NA, Valacchi G, Belmonte G, Carta S, Galeazzi M, Fioravanti A. Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway. Int J Mol Sci. 2017 Jan 12;18(1):133. doi: 10.3390/ijms18010133.
89. Valacchi G1, Pecorelli A1, Cervellati C, Hayek J. 4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation. Free Radic Biol Med. 2017 Oct;111:270-280. doi: 10.1016/j.freeradbiomed.2016.12.045. 1 co-first authors
90. Hayek J, Cervellati C, Crivellari I, Pecorelli A, Valacchi G. Lactonase Activity and Lipoprotein-Phospholipase A2 as Possible Novel Serum Biomarkers for the Differential Diagnosis of Autism Spectrum Disorders and Rett Syndrome: Results from a Pilot Study. Oxid Med Cell Longev. 2017;2017:5694058. doi: 10.1155/2017/5694058.
91. Cavicchio C, Benedusi M, Pambianchi E, Pecorelli A, Cervellati F, Savelli V, Calamandrei D, Maellaro E, Rispoli G, Maioli E, Valacchi G. Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment. Oxid Med Cell Longev. 2017;2017:4256519. doi: 10.1155/2017/4256519.
92. Crivellari I, Sticozzi C, Belmonte G, Muresan XM, Cervellati F, Pecorelli A, Cavicchio C, Maioli E, Zouboulis CC, Benedusi M, Cervellati C, Valacchi G. SRB1 as a new redox target of cigarette smoke in human sebocytes. Free Radic Biol Med. 2017;102:47-56. doi: 10.1016/j.freeradbiomed.2016.11.021.
93. Pecorelli A, Cervellati C, Cortelazzo A, Cervellati F, Sticozzi C, Mirasole C, Guerranti R, Trentini A, Zolla L, Savelli V, Hayek J, Valacchi G. Proteomic analysis of 4-hydroxynonenal and nitrotyrosine modified proteins in RTT fibroblasts. Int J Biochem Cell Biol. 2016 Dec;81(Pt B):236-245. doi: 10.1016/j.biocel.2016.08.001.
94. Pecorelli A, Cervellati C, Hayek J, Valacchi G. OxInflammation in Rett syndrome. Int J Biochem Cell Biol. 2016 Dec;81(Pt B):246-253. doi: 10.1016/j.biocel.2016.07.015.
95. Valacchi G, Muresan XM, Sticozzi C, Belmonte G, Pecorelli A, Cervellati F, Demaude J, Krol Y, Oresajo C. Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application. J Dermatol Sci. 2016;82(3):209-12. doi: 10.1016/j.jdermsci.2016.02.007
96. Ciccoli L, De Felice C, Leoncini S, Signorini C, Cortelazzo A, Zollo G, Pecorelli A, Rossi M, Hayek J. Red blood cells in Rett syndrome: oxidative stress, morphological changes and altered membrane organization. Biol Chem. 2015;396(11):1233-40. doi: 10.1515/hsz-2015-0117.
97. Magnani ND, Muresan XM, Belmonte G, Cervellati F, Sticozzi C, Pecorelli A, Miracco C, Marchini T, Evelson P, Valacchi G. Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure. Toxicol Sci. 2016;149(1):227-36. doi: 10.1093/toxsci/kfv230.
98. Pecorelli A, Cervellati F, Belmonte G, Montagner G, Waldon P, Hayek J, Gambari R, Valacchi G. Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients. Cytokine. 2016; 77:180-8. doi: 10.1016/j.cyto.2015.10.002.
99. Cortelazzo A, De Felice C, Guerranti R, Signorini C, Leoncini S, Pecorelli A, Scalabrì F, Madonna M, Filosa S, Della Giovampaola C, Capone A, Durand T, Mirasole C, Zolla L, Valacchi G, Ciccoli L, Guy J, D'Esposito M, Hayek J. Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome. Neurosci Res. 2016 Apr;105:28-34. doi: 10.1016/j.neures.2015.10.002.
100. Cervellati C, Sticozzi C, Romani A, Belmonte G, De Rasmo D, Signorile A, Cervellati F, Milanese C, Mastroberardino PG, Pecorelli A, Savelli V, Forman HJ, Hayek J, Valacchi G. Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage. Biochim Biophys Acta Mol Basis Dis. 2015 Oct;1852(10 Pt A):2066-74. doi: 10.1016/j.bbadis.2015.07.014.
101. Pecorelli A, Belmonte G, Meloni I, Cervellati F, Gardi C, Sticozzi C, De Felice C, Signorini C, Cortelazzo A, Leoncini S, Ciccoli L, Renieri A, Jay Forman H, Hayek J, Valacchi G. Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder. Free Radic Biol Med. 2015 Sep;86:156-65. doi: 10.1016/j.freeradbiomed.2015.05.010.
102. Filosa S1, Pecorelli A1, D'Esposito M, Valacchi G, Hajek J. Exploring the possible link between MeCP2 and oxidative stress in Rett syndrome. Free Radic Biol Med. 2015 Nov;88(Pt A):81-90. doi: 10.1016/j.freeradbiomed.2015.04.019.
1 co-first authors
103. Ahlqvist KJ, Leoncini S, Pecorelli A, Wortmann SB, Ahola S, Forsström S, Guerranti R, De Felice C, Smeitink J, Ciccoli L, Hämäläinen RH, Suomalainen A. MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction. Nat Commun. 2015 Mar 9;6:6494. doi: 10.1038/ncomms7494.
104. Valacchi G, Maioli E, Sticozzi C, Cervellati F, Pecorelli A, Cervellati C, Hayek J. Exploring the link between scavenger receptor B1 expression and chronic obstructive pulmonary disease pathogenesis. Ann N Y Acad Sci. 2015 Mar;1340:47-54. doi: 10.1111/nyas.12714.
105. Rom O, Pecorelli A, Valacchi G, Reznick AZ. Are E-cigarettes a safe and good alternative to cigarette smoking? Ann N Y Acad Sci. 2015 Mar;1340:65-74. doi: 10.1111/nyas.12609.
106. Pecorelli A, Natrella F, Belmonte G, Miracco C, Cervellati F, Ciccoli L, Mariottini A, Rocchi R, Vatti G, Bua A, Canitano R, Hayek J, Forman HJ, Valacchi G. NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy. Biochim Biophys Acta Mol Basis Dis. 2015 Mar;1852(3):507-19. doi: 10.1016/j.bbadis.2014.11.016.
107. Signorini C, De Felice C, Leoncini S, Durand T, Galano JM, Cortelazzo A, Zollo G, Guerranti R, Gonnelli S, Caffarelli C, Rossi M, Pecorelli A, Valacchi G, Ciccoli L, Hayek J. Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: effects of omega-3 polyunsaturated fatty acid supplementation. Prostaglandins Leukot Essent Fatty Acids. 2014;91(5):183-93. doi: 10.1016/j.plefa.2014.08.002.
108. De Felice C, Della Ragione F, Signorini C, Leoncini S, Pecorelli A, Ciccoli L, Scalabrì F, Marracino F, Madonna M, Belmonte G, Ricceri L, De Filippis B, Laviola G, Valacchi G, Durand T, Galano JM, Oger C, Guy A, Bultel-Poncé V, Guy J, Filosa S, Hayek J, D'Esposito M. Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. Neurobiol Dis. 2014;68(100):66-77. doi: 10.1016/j.nbd.2014.04.006.
109. Cortelazzo A, De Felice C, Pecorelli A, Belmonte G, Signorini C, Leoncini S, Zollo G, Capone A, Giovampaola CD, Sticozzi C, Valacchi G, Ciccoli L, Guerranti R, Hayek J. Beta-actin deficiency with oxidative posttranslational modifications in Rett syndrome erythrocytes: insights into an altered cytoskeletal organization. PLoS One. 2014 Mar 26;9(3):e93181. doi: 10.1371/journal.pone.0093181.
110. De Felice C, Signorini C, Leoncini S, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. La sindrome di Rett: ruolo dello stress ossidativo [Oxidative stress and Rett syndrome]. Minerva Pediatr. 2014 Feb;66(1):41-62.
111. Papini AM, Nuti F, Real-Fernandez F, Rossi G, Tiberi C, Sabatino G, Pandey S, Leoncini S, Signorini C, Pecorelli A, Guerranti R, Lavielle S, Ciccoli L, Rovero P, De Felice C, Hayek J. Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction. J Immunol Res. 2014;2014:260973. doi: 10.1155/2014/260973.
112. Signorini C, Leoncini S, De Felice C, Pecorelli A, Meloni I, Ariani F, Mari F, Amabile S, Paccagnini E, Gentile M, Belmonte G, Zollo G, Valacchi G, Durand T, Galano JM, Ciccoli L, Renieri A, Hayek J. Redox imbalance and morphological changes in skin fibroblasts in typical Rett syndrome. Oxid Med Cell Longev. 2014;2014:195935. doi: 10.1155/2014/195935.
113. De Felice C, Rossi M, Leoncini S, Chisci G, Signorini C, Lonetti G, Vannuccini L, Spina D, Ginori A, Iacona I, Cortelazzo A, Pecorelli A, Valacchi G, Ciccoli L, Pizzorusso T, Hayek J. Inflammatory lung disease in Rett syndrome. Mediators Inflamm. 2014;2014:560120. doi: 10.1155/2014/560120.
114. Maffei S, De Felice C, Cannarile P, Leoncini S, Signorini C, Pecorelli A, Montomoli B, Lunghetti S, Ciccoli L, Durand T, Favilli R, Hayek J. Effects of ω-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome. Mediators Inflamm. 2014;2014:983178. doi: 10.1155/2014/983178.
115. Cortelazzo A, De Felice C, Guerranti R, Signorini C, Leoncini S, Pecorelli A, Zollo G, Landi C, Valacchi G, Ciccoli L, Bini L, Hayek J. Subclinical inflammatory status in Rett syndrome. Mediators Inflamm. 2014;2014:480980. doi: 10.1155/2014/480980.
116. Sticozzi C, Belmonte G, Pecorelli A, Cervellati F, Leoncini S, Signorini C, Ciccoli L, De Felice C, Hayek J, Valacchi G. Scavenger receptor B1 post-translational modifications in Rett syndrome. FEBS Lett. 2013 Jul 11;587(14):2199-204. doi: 10.1016/j.febslet.2013.05.042.
117. Cortelazzo A, Guerranti R, De Felice C, Signorini C, Leoncini S, Pecorelli A, Landi C, Bini L, Montomoli B, Sticozzi C, Ciccoli L, Valacchi G, Hayek J. A plasma proteomic approach in Rett syndrome: classical versus preserved speech variant. Mediators Inflamm. 2013;2013:438653. doi: 10.1155/2013/438653.
118. Ciccoli L, De Felice C, Paccagnini E, Leoncini S, Pecorelli A, Signorini C, Belmonte G, Guerranti R, Cortelazzo A, Gentile M, Zollo G, Durand T, Valacchi G, Rossi M, Hayek J. Erythrocyte shape abnormalities, membrane oxidative damage, and β-actin alterations: an unrecognized triad in classical autism. Mediators Inflamm. 2013;2013:432616. doi: 10.1155/2013/432616.
119. Pecorelli A, Leoni G, Cervellati F, Canali R, Signorini C, Leoncini S, Cortelazzo A, De Felice C, Ciccoli L, Hayek J, Valacchi G. Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patients. Mediators Inflamm. 2013;2013:137629. doi: 10.1155/2013/137629.
120. De Felice C, Cortelazzo A, Signorini C, Guerranti R, Leoncini S, Pecorelli A, Durand T, Galano JM, Oger C, Zollo G, Montomoli B, Landi C, Bini L, Valacchi G, Ciccoli L, Hayek J. Effects of ω-3 polyunsaturated fatty acids on plasma proteome in Rett syndrome. Mediators Inflamm. 2013;2013:723269. doi: 10.1155/2013/723269.
121. Signorini C, De Felice C, Durand T, Oger C, Galano JM, Leoncini S, Pecorelli A, Valacchi G, Ciccoli L, Hayek J. Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder. Oxid Med Cell Longev. 2013;2013:343824. doi: 10.1155/2013/343824.
122. Volpi N, Pecorelli A, Lorenzoni P, Di Lazzaro F, Belmonte G, Aglianò M, Cantarini L, Giannini F, Grasso G, Valacchi G. Antiangiogenic VEGF isoform in inflammatory myopathies. Mediators Inflamm. 2013;2013:219313. doi: 10.1155/2013/219313.
123. Grillo E, Lo Rizzo C, Bianciardi L, Bizzarri V, Baldassarri M, Spiga O, Furini S, De Felice C, Signorini C, Leoncini S, Pecorelli A, Ciccoli L, Mencarelli MA, Hayek J, Meloni I, Ariani F, Mari F, Renieri A. Revealing the complexity of a monogenic disease: rett syndrome exome sequencing. PLoS One. 2013;8(2):e56599. doi: 10.1371/journal.pone.0056599.
124. Pecorelli A, Bocci V, Acquaviva A, Belmonte G, Gardi C, Virgili F, Ciccoli L, Valacchi G. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells. Toxicol Appl Pharmacol. 2013 Feb 15;267(1):30-40. doi: 10.1016/j.taap.2012.12.001.
125. Valacchi G, Sticozzi C, Pecorelli A, Cervellati F, Cervellati C, Maioli E. Cutaneous responses to environmental stressors. Ann N Y Acad Sci. 2012 Oct;1271(1):75-81. doi: 10.1111/j.1749-6632.2012.06724.x.
126. Durand T, De Felice C, Signorini C, Oger C, Bultel-Poncé V, Guy A, Galano JM, Leoncini S, Ciccoli L, Pecorelli A, Valacchi G, Hayek J. F(2)-Dihomo-isoprostanes and brain white matter damage in stage 1 Rett syndrome. Biochimie. 2013 Jan;95(1):86-90. doi: 10.1016/j.biochi.2012.09.017.
127. De Felice C, Signorini C, Leoncini S, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. The role of oxidative stress in Rett syndrome: an overview. Ann N Y Acad Sci. 2012 Jul;1259:121-35. doi: 10.1111/j.1749-6632.2012.06611.x.
128. Pecorelli A, Leoncini S, De Felice C, Signorini C, Cerrone C, Valacchi G, Ciccoli L, Hayek J. Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic autism. Brain Dev. 2013;35(2):146-54. doi: 10.1016/j.braindev.2012.03.011.
129. De Felice C, Signorini C, Durand T, Ciccoli L, Leoncini S, D'Esposito M, Filosa S, Oger C, Guy A, Bultel-Poncé V, Galano JM, Pecorelli A, De Felice L, Valacchi G, Hayek J. Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil. Genes Nutr. 2012;7(3):447-58. doi: 10.1007/s12263-012-0285-7.
130. Sticozzi C, Belmonte G, Pecorelli A, Arezzini B, Gardi C, Maioli E, Miracco C, Toscano M, Forman HJ, Valacchi G. Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS One. 2012;7(3):e33592. doi: 10.1371/journal.pone.0033592. Epub 2012 Mar 19. Erratum in: PLoS One. 2020;15(1):e0228663.
131. Ciccoli L, De Felice C, Paccagnini E, Leoncini S, Pecorelli A, Signorini C, Belmonte G, Valacchi G, Rossi M, Hayek J. Morphological changes and oxidative damage in Rett Syndrome erythrocytes. Biochim Biophys Acta. General Subjects 2012;1820(4):511-20. doi: 10.1016/j.bbagen.2011.12.002.
132. Sticozzi C1, Pecorelli A1, Lim Y, Maioli E, Pagnin E, Davis PA, Valacchi G. Modulation of skin oxidative stress and inflammatory markers by environmental stressors. Differences between young and old. J Dermatol Sci. 2012;65(3):226-8. doi: 10.1016/j.jdermsci.2011.11.004. 1co-first authors
133. De Felice C, Signorini C, Durand T, Oger C, Guy A, Bultel-Poncé V, Galano JM, Ciccoli L, Leoncini S, D'Esposito M, Filosa S, Pecorelli A, Valacchi G, Hayek J. F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome. J Lipid Res. 2011;52(12):2287-97. doi: 10.1194/jlr.P017798.
134. Valacchi G, Sticozzi C, Lim Y, Pecorelli A. Scavenger receptor class B type I: a multifunctional receptor. Ann N Y Acad Sci. 2011;1229:E1-7. doi: 10.1111/j.1749-6632.2011.06205.x.
135. Valacchi G, Pecorelli A, Sticozzi C, Torricelli C, Muscettola M, Aldinucci C, Maioli E. Rottlerin exhibits antiangiogenic effects in vitro. Chem Biol Drug Des. 2011;77(6):460-70. doi: 10.1111/j.1747-0285.2011.01121.x.
136. Signorini C, De Felice C, Leoncini S, Giardini A, D'Esposito M, Filosa S, Della Ragione F, Rossi M, Pecorelli A, Valacchi G, Ciccoli L, Hayek J. F₄-neuroprostanes mediate neurological severity in Rett syndrome. Clin Chim Acta. 2011;412(15-16):1399-406. doi: 10.1016/j.cca.2011.04.016.
137. Pastore S, Mariani V, Lulli D, Gubinelli E, Raskovic D, Mariani S, Stancato A, de Luca C, Pecorelli A, Valacchi G, Potapovich AI, Kostyuk VA, Korkina LG. Glutathione peroxidase activity in the blood cells of psoriatic patients correlates with their responsiveness to Efalizumab. Free Radic Res. 2011;45(5):585-99. doi: 10.3109/10715762.2011.560150.
138. Pecorelli A, Ciccoli L, Signorini C, Leoncini S, Giardini A, D'Esposito M, Filosa S, Hayek J, De Felice C, Valacchi G. Increased levels of 4HNE-protein plasma adducts in Rett syndrome. Clin Biochem. 2011;44(5-6):368-71. doi: 10.1016/j.clinbiochem.2011.01.007.
139. Leoncini S, De Felice C, Signorini C, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. Oxidative stress in Rett syndrome: natural history, genotype, and variants. Redox Rep. 2011;16(4):145-53. doi: 10.1179/1351000211Y.0000000004.
140. Sticozzi C, Pecorelli A, Belmonte G, Valacchi G. Cigarette smoke affects ABCAl expression via liver X receptor nuclear translocation in human keratinocytes. Int J Mol Sci. 2010 Sep;11(9):3375-86. doi: 10.3390/ijms11093375.
141. Kostyuk VA, Potapovich AI, Cesareo E, Brescia S, Guerra L, Valacchi G, Pecorelli A, Deeva IB, Raskovic D, De Luca C, Pastore S, Korkina LG. Dysfunction of glutathione S-transferase leads to excess 4-hydroxy-2-nonenal and H(2)O(2) and impaired cytokine pattern in cultured keratinocytes and blood of vitiligo patients. Antioxid Redox Signal. 2010;13(5):607-20. doi: 10.1089/ars.2009.2976.
142. Vecchio D, Arezzini B, Pecorelli A, Valacchi G, Martorana PA, Gardi C. Reactivity of mouse alveolar macrophages to cigarette smoke is strain dependent. Am J Physiol Lung Cell Mol Physiol. 2010;298(5):L704-13. doi: 10.1152/ajplung.00013.2009.
143. Bonifazi M, Mencarelli M, Fedele V, Ceccarelli I, Pecorelli A, Grasso G, Aloisi AM, Muscettola M. Glucocorticoid receptor mRNA expression in peripheral blood mononuclear cells in high trained compared to low trained athletes and untrained subjects. J Endocrinol Invest. 2009;32(10):816-20. doi: 10.1007/BF03345751.
144. Mencarelli M1, Pecorelli A1, Carbotti P, Valacchi G, Grasso G, Muscettola M. Endothelin receptor A expression in human inflammatory cells. Regul Pept. 2009;158(1-3):1-5. doi: 10.1016/j.regpep.2009.06.004. 1 co-first authors
145. Valacchi G, Davis PA, Khan EM, Lanir R, Maioli E, Pecorelli A, Cross CE, Goldkorn T. Cigarette smoke exposure causes changes in Scavenger Receptor B1 level and distribution in lung cells. Int J Biochem Cell Biol. 2011;43(7):1065-70. doi: 10.1016/j.biocel.2009.05.014.
146. Valacchi G, Pecorelli A, Mencarelli M, Carbotti P, Fortino V, Muscettola M, Maioli E. Rottlerin: a multifaced regulator of keratinocyte cell cycle. Exp Dermatol. 2009;18(6):516-21. doi: 10.1111/j.1600-0625.2008.00816.x.
147. Valacchi G, Pecorelli A, Mencarelli M, Maioli E, Davis PA. Beta-carotene prevents ozone-induced proinflammatory markers in murine skin. Toxicol Ind Health. 2009;25(4-5):241-7. doi: 10.1177/0748233709103030.
148. Maioli E, Greci L, Soucek K, Hyzdalova M, Pecorelli A, Fortino V, Valacchi G. Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells. J Biomed Biotechnol. 2009;2009:742936. doi: 10.1155/2009/742936.
149. Massai L, Volpi N, Carbotti P, Fruschelli M, Mencarelli M, Pecorelli A, Muscettola M, Aglianò M, Alessandrini C, Grasso G. Endothelin-1 and endothelin-converting enzyme-1 in human granulomatous pathology of eyelid: an immunohistochemical and in situ hybridization study in chalazia. Histol Histopathol. 2007;22(12):1343-54. doi: 10.14670/HH-22.1343.
National Journals
1. Cortelazzo A, De Felice C, Guerranti R., Leoncini R., Barducci A., Leoncini S., Signorini C., Zollo G., Pecorelli A., Braccianti C., Gagliardi A., Armini A., Paccagnini E., Gentile M., Bini L., Durand T., Galano J.-M., Rossi M., Ciccoli L., Hayek J. Sindrome di Rett: effetti degli acidi grassi polinsaturi ω-3 sulle proteine di membrana • Proteomica delle membrane eritrocitarie. L’integratore Nutrizionale. 2016.
2. Cortelazzo A, De Felice C, Signorini C, Guerranti R, Leoncini S, Pecorelli A, Durand T, Galano JM, Oger C, Zollo G, Montomoli B, Landi C, Bini L, Valacchi G, Ciccoli C, Hayek J. Acidi Grassi Polinsaturi omega-3 e stato infiammatorio subclinico nella Sindrome di Rett. Un approccio proteomico. L’integratore Nutrizionale. 2014.
3. De Felice C, Signorini C, Leoncini S, Pecorelli A, Durand T, Valacchi G, Ciccoli L, Hayek J. [Oxidative stress and Rett syndrome.]. Minerva Pediatr. 2014; 66(1):41-62.
4. Hayek J, Signorini C, Leoncini S, Zollo G, Cortelazzo A, Belmonte G, Sticozzi C, Pecorelli A, Valacchi G, Rossi M, Ciccoli L, De Felice C. Stress ossidativo nella Sindrome di Rett: dalle bimbe ai modelli murini. Vivirett, 68, 15-16, 2014.
5. Cortelazzo A, De Felice C, Pecorelli A, Belmonte G, Signorini C, Leoncini S, Zollo G, Capone A, Della Giovampaola C, Sticozzi C, Valacchi G, Ciccoli L, Guerranti R, Hayek J. Espressione, ossidazione e distribuzione della beta-actina nei globuli rossi delle pazienti con Sindrome di Rett. Vivirett, 67, 18-20, 2014.
6. De Felice C, Rossi M, Leoncini S, Chisci G, Signorini C, Lonetti G, Vannuccini L, Spina D, Ginori A, Iacona I, Cortelazzo A, Pecorelli A, Valacchi G, Ciccoli L, Pizzorusso T, Hayek J. La malattia infiammatoria polmonare nella Sindrome di Rett. Vivirett, 67, 21-24, 2014.
7. Cortelazzo A, Guerranti R, Bini L, Landi C, Pecorelli A, Signorini C, Leoncini S, Zollo G, Ciccoli L, Hayek J, De Felice C. Infiammazione subclinica, acidi grassi polinsaturi omega-3 (PUFA ω-3) e PUFA ω-3 nella sindrome di Rett: primo approccio proteomico. Vivirett, 66, 18-20, 2014.
8. Pecorelli A, Leoni G, Cervellati F, Canali R, Signorini C, Leoncini S, Cortelazzo A, De Felice C, Ciccoli L, Hayek J, Valacchi G. Alterata espressione di geni collegati alle funzioni mitocondriali, alla degradazione proteica e all’organizzazione della cromatina in linfomonociti di pazienti Rett. Vivirett, 66, 22-25, 2014.
9. De Felice C, Leoncini S, Signorini C, Pecorelli A, Durand T, Galano JM, Oger C, Cortelazzo A, Montomoli B, Zollo G, Valacchi G, Ciccoli L, Hayek J. Acidi grassi ω-3 nella sindrome di Rett. Studio clinico al primo stadio della malattia. L’integratore Nutrizionale. 2013.
10. Ciccoli L, De Felice C, Paccagnini E, Leoncini S, Pecorelli A, Signorini C, Belmonte G, Valacchi G, Rossi M, Cerrone C, Hayek J. Anomalia di forma dei globuli rossi e danno ossidativo nella membrane eritrocitaria nella sindrome di Rett. Vivirett, 63, 14-17, 2012.
11. De Felice C, Signorini C, Durand T, Ciccoli L, Leoncini S, D’Esposito M, Filosa S, Oger C, Guy A, Bultel-Poncé V, Galano JM, Pecorelli A, De Felice L, Valacchi G, Cerrone C, Hayek J. Effetti della somministrazione di acidi grassi polinsaturi ω-3 nella sindrome di Rett in stadio I. Vivirett, 61, 16-19, 2012.
BOOK CHAPTERS
1. Pecorelli A, Valacchi G. Microplastics and Nanoplastics Contamination. An Emerging Environmental Issue for Skin Health. In: Environmental Stressors and OxInflammatory tissue responses. Eds. Giuseppe Valacchi, Andreas Daiber. Taylor & Francis Group. Chapter 12, Pages 136-153; 2023
2. Cordone V, Pecorelli A, Valacchi G. Omega-3 nutritional intervention as therapeutic co-adjuvant approach to improve Rett syndrome clinical and biochemical features. In: Modulation of Oxidative Stress. Biochemical, Physiological and Pharmacological Aspects. 1st Edition - August 4, 2023 Eds. Luciano Saso, Alessandro Giuffrè, Giuseppe Valacchi, Mauro Maccarrone. Pages 211-223. Elsevier. Academic Press, ISBN: 9780443192470. 2023
3. Cervellati C, Pecorelli A. Fluid redox biomarkers in neurological disease. In: Modulation of Oxidative Stress. Biochemical, Physiological and Pharmacological Aspects. 1st Edition - August 4, 2023 Eds. Luciano Saso, Alessandro Giuffrè, Giuseppe Valacchi, Mauro Maccarrone. Pages 43-57. Elsevier. Academic Press, ISBN: 9780443192470. 2023
4. De Felice C, Leoncini S, Signorini C, Pecorelli A, Durand T, Galano JM, Guy A, Valacchi G, Ciccoli L, Hayek J. Biomarkers of lipid oxidative damage in Rett syndrome. The Comprehensive Guide to Autism. Eds. Vinood B Patel, Victor R Preedy, Colin R Martin. SPRINGER. Pg. 2617-2632. ISBN: 978-1-4614-4787-0 (Print) 978-1-4614-4788-7 (Online). 2014
5. De Felice C, Leoncini S, Signorini C, Pecorelli A, Durand T, Galano JM, Guy A, Valacchi G, Ciccoli L, Hayek J. Neuroprostanes and neurological severity in Rett syndrome. The Comprehensive Guide to Autism. Eds. Vinood B Patel, Victor R Preedy, Colin R Martin. SPRINGER. Pp. 2633-2645. ISBN: 978-1-4614-4787-0 (Print) 978-1-4614-4788-7 (Online). 2014
6. Valacchi G, Pecorelli A, Signorini C, Leoncini S, Ciccoli L, De Felice C, Hayek J. 4HNE protein adducts in Autistic Spectrum Disorders: Rett syndrome and Autism. The Comprehensive Guide to Autism. Eds. Vinood B Patel, Victor R Preedy, Colin R Martin. SPRINGER. Pp. 2667-2687. ISBN: 978-1-4614-4787-0 (Print) 978-1-4614-4788-7 (Online). 2014
