Pubblicazioni
Articoli su riviste peer-reviewed
Bottin, M.; Di Carmine, G.; Bortolini, O.; De Risi, C.; Bertoldo, M.; Cataldi, T. R. I.; Calvano, C. D.; Massi, A.; Ragno, D.* Oxidative NHC Catalysis: An Unconventional Tool for Macrocyclic Oligoesters Synthesis. Chem. Eur. J., 2023, 29, e202301416.
Poletti, L.; Massi, A.; Ragno, D.; Droghetti, F.; Natali, M.; De Risi, C.; Bortolini, O.; Di Carmine, G. Modulable Photocatalyzed Strategies for the Synthesis of α-C-Glycosyl Alanine Analogues via the Giese Reaction with Dehydroalanine Derivates. Org. Lett., 2023, 25, 26, 4862-4867.
De Risi, C.; Brandolese, A.; Di Carmine, G.; Ragno, D.; Massi, A.; Bortolini, O. Oxidative N-Heterocyclic Carbene Catalysis. Chem. Eur. J., 2023, 29, e202202467.
Poletti, L.; Rovegno, C.; Di Carmine, G.; Vacchi, F.; Ragno, D.; Brandolese, A.; Massi, A.; Dambruoso, P. Efficiency in Carbon Dioxide Fixation into Cyclic Carbonates: Operating Bifunctional Polyhydroxylated Pyridinium Organocatalysts in Segmented Flow Conditions. Molecules, 2023, 28, 1530.
Wesphal, H.; Warias, R.; Weise, C.; Ragno, D.; Becker, H.; Spanka, M.; Massi, A.; Gläser, R.; Schneider, C.; Belder, D. An integrated resource-efficient microfluidic device for parallelised studies of immobilised chiral catalysts in continuous flow via miniaturized LC/MS-analysis. React. Chem. Eng., 2022, 7, 1936-1944 (featured on Journal Cover).
Ragno, D.*; Di Carmine, G.; Vannini, M.; Bortolini, O.; Perrone, D.; Buoso, S.; Bertoldo, M.; Massi, A*. Organocatalytic synthesis of poly (hydroxymethylfuroate) via ring-opening polymerization of 5-hydroxymethylfurfural-based cyclic oligoesters. Polym. Chem., 2022, 13, 1350-1358.
Ragno, D.; De Risi, C.; Massi, A.; Di Carmine, G.; Toldo, S.; Leonardi, C.; Bortolini, O. Regiodivergent Synthesis of Benzothiazole-Based Isosorbide Imidates by Oxidative N-Heterocyclic Carbene Catalysis. Eur. J. Org. Chem., 2022, e202200482 (VIP Paper).
Poletti, L.; Ragno, D.; Bortolini, O.; Presini, F.; Pesciaioli, F.; Carli, S.; Caramori, S.; Molinari, A.; Massi, A.; Di Carmine, G. Photoredox Cross-Dehydrogenative Coupling of N‑Aryl Glycines Mediated by Mesoporous Graphitic Carbon Nitride: An Environmentally Friendly Approach to the Synthesis of Non - Proteinogenic α‑Amino Acids (NPAAs) Decorated with Indoles. J. Org. Chem., 2022, 87, 7826-7837.
Buoso, S.; Belletti, G.; Ragno, D.; Castelvetro, V.; Bertoldo, M. Rheological Response of Polylactic Acid Dispersions in Water with Xanthan Gum. ACS Omega, 2022, 7, 12536-12548.
Wesphal, H.; Warias, R.; Becker, H.; Spanka, M.; Ragno, D.; Gläser, R.; Schneider, C.; Massi, A.; Belder, D. Unveiling Organocatalysts Action - Investigating Immobilized Catalysts at Steady-State Operation via Lab-on-a-Chip Technology. ChemCatChem, 2021, 13, 5089-5096 (featured on Journal Cover).
Leonardi, C.; Brandolese, A.; Preti, L.; Bortolini, O.; Polo, E.; Dambruoso, P.; Ragno, D.; Di Carmine, G.; Massi, A. Expanding the Toolbox of Heterogeneous Asymmetric Organocatalysts: Bifunctional Cyclopropenimine Superbases for Enantioselective Catalysis in Batch and Continuous Flow. Adv. Synth. Catal., 2021, 363, 5473-5485.
Ragno, D.*; Leonardi, C.; Di Carmine, G.; Bortolini, O.; Brandolese, A.; De Risi, C.; Massi, A*. Regiodivergent Isosorbide Acylation by Oxidative N‑Heterocyclic Carbene Catalysis in Batch and Continuous Flow. ACS Sustainable Chem. Eng., 2021, 9, 8295-8305.
Forlani, G.; Sabbioni, G.; Ragno, D.; Petrollino, D.; Borgatti, M. Phenyl-substituted aminomethylenebisphosphonates inhibit human P5C reductase and show antiproliferative activity against prolinehyperproducing tumour cells. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36:1, 1248-1257.
Giovannini, P.P.; Müller, M.; Presini, F.; Baraldi, S.; Ragno, D.; Di Carmine, G.; Jacoby, C.; Bernacchia, G.; Bortolini, O. A one-pot two-step enzymatic pathway for the synthesis of enantiomerically enriched vicinal diols. Eur. J. Org. Chem., 2021, 6, 973-978.
Ragno, D.; Brandolese, A.; Di Carmine, G.; Buoso, S.; Belletti, G.; Leonardi, C.; Bortolini, O.; Bertoldo, M.; Massi, A. Exploring Oxidative NHC-Catalysis as Organocatalytic Polymerization Strategy towards Polyamide Oligomers. Chem. Eur. J., 2021, 27, 1839-1848.
Warias, D.; Ragno, D.; Massi, A.; Belder, D. A Visible-Light-Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors. Chem. Eur. J., 2020, 26, 13152-13156.
Di Carmine, G.; Ragno, D.; Massi, A.; D’Agostino, C. Oxidative Coupling of Aldehydes with Alcohol for the Synthesis of Esters Promoted by Polystyrene-Supported N-Heterocyclic Carbene: Unraveling the Solvent Effect on the Catalyst Behavior Using NMR Relaxation. Org. Lett., 2020, 22, 4927−4931 (featured on Journal Cover).
De Risi, C.; Bortolini, O.; Brandolese, A.; Di Carmine, G.; Ragno, D.; Massi, A. Recent advances in continuous-flow organocatalysis for process intensification. React. Chem. Eng., 2020, 5, 1017-1052.
Brandolese, A.; Ragno, D.; Leonardi, C.; Di Carmine G.; Bortolini, O.; De Risi, C.; Massi, A. Enantioselective N-Acylation of Biginelli Dihydropyrimidines by Oxidative NHC Catalysis. Eur. J. Org. Chem. 2020, 2439-2447.
Gallo, V.; Ragno, D. et al. A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy. Talanta, 2020, 214, 120855.
Ragno, D.; Di Carmine, G.; Brandolese, A.; Bortolini, O.; Giovannini, P.P.; Fantin, G.; Bertoldo, M.; Massi, A. Oxidative NHC-Catalysis as Organocatalytic Platform for the Synthesis of Polyester Oligomers by Step-Growth Polymerization. Chem. Eur. J., 2019, 25, 14701-14710 (Hot Paper).
Di Carmine, G.; Ragno, D.; Brandolese, A.; Bortolini, O.; Pecorari, D.; Sabuzi, F.; Mazzanti, A.; Massi, A. Enantioselective Desymmetrization of 1,4-Dihydropyridines by Oxidative NHC Catalysis. Chem. Eur. J., 2019, 25, 7469-7474 (Hot Paper).
Baraldi, S.; Fantin, G.; Di Carmine, G.; Ragno, D.; Brandolese, A.; Massi, A.; Bortolini, O.; Marchetti N.; Giovannini, P.P. Enzymatic synthesis of biobased aliphatic-aromatic oligoesters using 5,5’-bis(hydroxymethyl)furoin as a building block. RSC Adv., 2019, 9, 29044-29050.
De Risi, C.; Bortolini, O.; Di Carmine, G.; Ragno, D.; Massi, A. Kinetic Resolution, Dynamic Kinteic Resolution and Asymmetric Desymmetrization by N-Heterocyclic Carbene Catalysis. Synthesis, 2019, 51, 1871-1891.
Bellau, M. L. A.; Bortolini, O.; Fantin, G.; Fogagnolo, M.; Ragno, D.; Delso, I.; Merino, P. Native Quercetin as a Chloride Receptor in an Organic Solvent. Molecules, 2018, 23, 3366
Brandolese, A.; Ragno, D.; Di Carmine, C.; Bernardi, T.; Bortolini, O.; Giovannini, P. P.; Pandoli, O. G.; Altomare, A.; Massi, A. Aerobic oxidation of 5-hydroxymethylfurfural to 5-hydroxymethyl-2-furancarboxylic acid and its derivatives by heterogeneous NHC-catalysis. Org. Biomol. Chem., 2018, 16, 8955-8964.
Ragno, D.; Brandolese, A.; Urbani, D.; Di Carmine, G.; De Risi, C., Bortolini, O.; Giovannini P. P.; Massi, A., Esterification of Glycerol and Solketal by Oxidative NHC-Catalysis under Heterogeneous Batch and Flow Conditions. React. Chem. Eng., 2018, 3, 816-825.
Di Carmine, G.; Ragno, D.; Bortolini, O.; Giovannini, P.P.; Mazzanti, A.; Massi, A.; Fogagnolo, M., Enantioselective Dearomatization of Alkylpyridiniums by N-Heterocyclic Carbene-Catalyzed Nucleophilic Acylation. Journal of Organic Chemistry, 2018, 83, 4, 2050-2057.
Di Carmine, G.; Bortolini, O.; Massi, A.; Müller, M.; Bernacchia, G.; Fantin, G.; Ragno, D.; Giovannini, P.P. Enzymatic Cross‐Benzoin‐Type Condensation of Aliphatic Aldehydes: Enantioselective Synthesis of 1‐Alkyl‐1‐hydroxypropan‐2‐ones and 1‐Alkyl‐1‐hydroxybutan‐2‐ones. Advanced Synthesis & Catalysis, 2018, 21, 4132-4141.
Di Carmine, G.; Ragno, D.; De Risi, C.; Bortolini, O.; Giovannini, P.P.; Fantin, G.; Massi, A., Synthesis of Functionalized Imidazolidine-2-Thiones via NHC/Base-Promoted Aza-Benzoin/Aza-Acetalization Domino Reactions. Organic & Biomolecular Chemistry, 2017,15, 8788-8801.
Ragno, D.; Di Carmine, G.; Brandolese, A.; Bortolini, O.; Giovannini P.P.; Massi, A., Immobilization of Privileged Triazolium Carbene Catalyst for Batch and Flow Stereoselective Umpolung Processes. ACS Catalysis, 2017, 7, 6365-6375.
Massi, A.; Bortolini, O.; Ragno, D.; Bernardi, T.; Sacchetti, G.; Tacchini, M; De Risi, C., Research Progress in the Modification of Quercetin Leading to Anticancer Agents. Molecules, 2017, 22, 1270.
Massarenti, C.; Bortolini, O.; Fantin, G.; Cristofaro, D.; Ragno, D.; Perrone, D.; Marchesi, E.; Toniolo, G.; Massi, A., Fluorous-tag assisted synthesis of bile acid–bisphosphonate conjugates via orthogonal click reactions: an access to potential anti-resorption bone drugs. Organic & Biomolecular Chemistry, 2017,15, 4907-4920.
Zaghi, A.; Ragno, D.; Di Carmine, G.; De Risi, C.; Bortolini, O.; Giovannini, P.P.; Fantin, G.; Massi, Electron-transfer-initiated benzoin- and Stetter like reactions in packed-bed reactors for process intensification. Beilstein Journal of Organic Chemistry, 2016, 12, 2719–2730.
Ragno, D.; Zaghi, A.; Di Carmine, G.; Giovannini, P.P.; Bortolini, O.; Fogagnolo, M.; Molinari, A.; Venturini, A.; Massi, A., Cross-benzoin and Stetter-type reactions mediated by KOtBu-DMF via an electron-transfer process. Organic & Biomolecular Chemistry, 2016, 14, 9823-9835.
Rapozzi, V.; Ragno, D.; Guerrini, A.; Ferroni, C.; della Pietra, E.; Cesselli, D.; Castoria, G.; Di Donato, M.; Saracino, E.; Benfenati, V.; Varchi, G., Androgen Receptor Targeted Conjugate for Bimodal Photodynamic Therapy of Prostate Cancer in Vitro. Bioconjugate Chemistry, 2015, 26, 1662-1671.
Ragno, D.; Bortolini, O.; Fantin, G.; Fogagnolo, M.; Giovannini, P. P.; Massi, A. Nucleophilic and Electrophilic Double Aroylation of Chalcones with Benzils Promoted by the Dimsyl Anion as a Route to All Carbon Tetrasubstituted Olefins. Journal of Organic Chemistry, 2015, 80, 1937-1945.
Ragno, D.; Bortolini, O.; Giovannini, P. P.; Massi, A.; Pacifico, S.; Zaghi, A. One-pot, two-step desymmetrization of symmetrical benzils catalyzed by the methylsulfinyl (dimsyl) anion. Organic & Biomolecular Chemistry, 2014, 12, 5733-5744.
Bortolini, O.; Chiappe, C.; Fogagnolo, M.; Giovannini, P. P.; Massi, A.; Pomelli C. S.; Ragno, D. An insight into the mechanism of the aerobic oxidation of aldehydes catalyzed by N-heterocyclic carbenes. Chemical Communications, 2014, 50, 2008-2011.
Bortolini, O.; Fantin, G.; Ferretti, V.; Fogagnolo, M.; Giovannini, P. P.; Massi, A.; Pacifico, S.; Ragno, D. Methylsulfinyl (Dimsyl) Anion as Umpolung Catalyst for the Chemoselective Cross-Benzoin Reaction of a-Diketones with Aldehydes. Advanced Synthesis & Catalysis, 2013, 355, 3244-3252.
Bortolini, O.; Cavazzini, A.; Dambruoso, P.; Giovannini, P. P.; Caciolli, L.; Massi, A.; Pacifico, S.; Ragno, D. Thiazolium-functionalized polystyrene monolithic microreactors for continuous-flow umpolung catalysis. Green Chemistry, 2013, 15, 2981-2992.
Brevetti:
Patent n° WO2022/064351A1, “Process for Producing Levulinic Acid”.
Patent n° IT202100021014A1, “Procedimento di realizzazione, metodo d’uso e composizione antifungina a base di nano complessi rame-tannini”.
