First name:                 CLAUDIO

Last name:                  TRAPELLA

Place of birth:             Ferrara

Date of birth:             December 27^th 1972

June 15^th, 1990 – July 31^st , 1990: Stage business at the quality control laboratories of the chemical farm “ENICHEM” in Ferrara on the subject: Quality control of plastic and industrial waste through technical gas cromatography and viscosimetry”.

July 1991: Diploma as chemical expert achieved at the “N. Copernico” Technical Institute of Ferrara with the vote of 46/60

July 20^th, 1995: Biotecnology degree, with full marks and honours, achieved in the University of Ferrara discussing the thesis: “Synthesis  and cytotoxicity studies of bioactive compounds from Melodorum Fruticosum (Annonaceae)”. The thesis work has been developed at the laboratories of Organic Chemistry of the Department of Pharmaceutical Sciences of the University of Ferrara under the guide of Prof. V. Zanirato.

October 2^nd, 1996 – April 30^th, 1997: Education grant (CARIFE’) at the Department of Biochemistry and Molecular Biology of the University of Ferrara on the subject: Development of a new methodology of in situ RT-PCR”.

October 25^th , 1999: Full honours degree in Chemistry and Pharmaceutical Technology (Italian CTF) achieved at the University of Ferrara discussing the thesis: “Studies toward the synthesis of Eleuthesides” developed in the Organic Chemistry laboratories  of the Department of Pharmaceutical Sciences, under the supervision of Prof. G.P. Pollini.

February 12^th, 2003 PhD in Pharmaceutical Science achieved at the Department of Pharmaceutical Science of the University of Ferrara discussing a thesis entitled “Synthesis of non-peptide antagonists of the ORL-1 receptor”. I spent my last year of PhD working in the laboratory of organic chemistry of Cambridge University under the supervision of Prof S. Ley.

March 2003 Fellow from the SPINNER (FSE).

June 2003- December 2005: CEO of UFPeptides s.r.l. Spin-off company of the University of Ferrara.

March 2004-March 2006. Research fellow at the department of Pharmaceutical Science of  University of Ferrara under the guidance of Prof. S. Salvadori for the synthesis of 1,3,4 trisubstituted piperidine.

From January 2006 till December 2007 contractors for UFPeptides s.r.l. using a found PRRIITT Regione Emilia Romagna 2005-2007 to develop solid phase synthesis and mass spectrometry analysis.

March 2008. Research fellow at the Department of Pharmaceutical Science of the University of Ferrara under the guidance of Prof. S. Salvadori for the synthesis of NOP ligands (agonists and antagonists).

November  17^th , 2008: Full honours degree in Medical-Pharmaceutical Biotechnology achieved at the University of Ferrara discussing the thesis: “Synthesis of non peptide agonists of the Nociceptin Orphanin F/Q receptor” developed in the Medicinal Chemistry laboratories  of the Department of Pharmaceutical Sciences, under the supervision of Prof. S. Salvadori.

October 1^st, 2010, Researcher at the Department of Pharmaceutical Science of the University of Ferrara SSD CHIM/06, Organic Chemistry.

April 1^st, 2016, Associate Professor at the Department of Chemical and Pharmaceutical Sciences of the University of Ferrara SSD CHIM/06, Organic Chemistry.

January 25^th 2017, President of the spin off company HelixPharma CF/PIVA: 01992110385 of the University of Ferrara.

Congress and seminars

1.         C. Trapella “Synthesis of J-113397 a new potent and selective antagonist of ORL-1 receptor” (Ferrara, “Bayer Day”, 18^th September 2001)

2.         C. De Risi, G.P. Pollini, C. Trapella, I. Peretto, S. Ronzoni, G.A.M. Giardina “A new approach at the synthesis of 1-[(3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one

(J-113397), first non-peptidic antagonist of the ORL-1 receptor” (Riccione, “1^st Sigma Aldrich Young Chemists Symposium”, 18^th-19^th October 2001)

3.         C. Trapella “Message/Address sequence modifications of Nociceptin/Orphanin FQ generate new higly potent ligands for the NOP receptor” (Camerino, “VIII Monothematic Meeting on Nociceptin/Orphanin FQ”, 15^th-16^th September 2003).

4.         C. Trapella “Mechanistic studies of a non usual Wittig reaction” (Pavia, XXXIV Congresso della Divisione di Chimica Organica,  Società Chimica Italiana, 10^th-14^th September 2012).

Specialization School

1.         XXV° Summer Course  “A. Corbella” (Organic Synthesis Seminar), Gargnano (Bs) – 12^th-16^th June 2000 -

2.                    XXVI° Summer Course “A. Corbella” (Organic Synthesis Seminar), Gargnano (Bs) – 18^th- 22^th June 2001 -

3.         XX° Advanced Course in Pharmaceutical Chemistry and National PhD Seminar “E. Duranti”, Urbino- 2^nd-6^th July 2000 -

4.         XXI° Advanced Course in Pharmaceutical Chemistry and National PhD Seminar “E. Duranti”, Urbino- 1^st-6^th July 2001 –

5.         XXII° Advanced Course in Pharmaceutical Chemistry and National PhD Seminar “E. Duranti”, Urbino- 1^st-5^th July 2002 – – Presentation of a poster entitled: “Synthesis of J-113397 a non peptidic antagonist of ORL-1 receptor”.

6.         Merck’s  lecture, 20^th-24^th September 2002, Department of Chemistry of the University of Cambridge (UK).

7.         XXVIII° Summer Course “A. Corbella” (Organic Synthesis Seminar), Gargnano (Bs) – 16^th- 20^th June 2003 -

1. Polish-Austrian-German-Hungarian-Italian Joint meeting on Medicinal Chemistry, 15^th-18^th October 2003, Kracov (Poland).

1. XXIX° Summer Course “A. Corbella” (Organic Synthesis Seminar), Gargnano (Bs) – 14^th- 18^th June 2004 -

1. XXX° Summer Course “A. Corbella” (Organic Synthesis Seminar), Gargnano (Bs) – 13^th- 17^th June 2005 -. Oral presentation entitled: “A new synthetic approach to 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one (J-113397), the first non-peptide NOP receptor antagonist.

1. IASOC 2006 (Ischia Advanced School of Organic Chemistry) Ischia (Naples) 16^th-21^st September 2006.

1. XIII° Meeting SERF, (HSMC) Heterocyclic Structure in Medicinal Chemistry, Palermo (Italy) 18^th-21^st May 2008.

1. 2^nd European Chemistry Congress Turin (Italy) 16^th-20^th September 2008.

1. 16^th European Symposium on Organic Chemistry (ESOC 2009) Praga (Czech Republic) 12^th-16^th July 2009.
2. XXXIV° Italian Organic Chemistry Meeting, Pavia (Italy), 10^th-14^th September 2012.
3. Advanced in Synthetic and Medicinal Chemistry, Moscow (Russia) 05^th-09^th May 2013.
4. EFMC, International Symposium on Medicinal Chemistry, Lisbon, Portugal, 07^th-11^th September 2014.
5. 22° ICOS IUPAC International Conference on Organic Synthesis, Florence (Italy) 16^th-21^st September 2018.