Curriculum
CURRICULUM VITAE
Christian Furlan Freguia
(freguia@scripps.edu; c_furlanfreguia@hotmail.com)
Birth: May 12, 1979
30016 Jesolo (VE)
ITALY
Home address: 4090 Rosenda Ct, Apt 190
San Diego, CA, 92122
USA
Work Address: The Scripps Research Institute
10550 North Torrey Pines Rd.
SP 258
La Jolla, CA, 92037
USA
EDUCATION
2007 Ph.D. in Biochemistry, Molecular Biology and Biotechnology.
University of Ferrara, Ferrara, Italy.
2005 University of Pennsylvania (UPENN), Philadelphia, PA, USA.
- Certificate: “Written communication Practice, advance course”.
- Certificate: “Listening and speaking with confidence, advance course”.
- Certificate: “Grammar practice, advance course”.
2003 Master’s degree in Biology.
University of Ferrara, Ferrara, Italy.
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS
2007-present The Scripps Research Institute, Dept. of Immunology and Microbial Science, CA, USA. Post-doctoral fellow: “Study of interaction of coagulation and inflammation”.
2006 - 2007 Enrolled in the “Gene Therapy & Vaccines Trainee” program.
2004 - 2007 The Children’s Hospital of Philadelphia, Department of Hematology, PA, USA. Pre-doctoral fellowship: “Expression and characterization of protein variants to use in hemophilia murine model; development of a new pro-thrombotic murine model”. Advisor: Prof. K. A. High e V. R. Arruda.
2004 University of Ferrara, Ferrara, Italy. Ph.D. candidate in Biochemistry, Molecular Biology and Biotechnology.
2003 Department of Biochemistry and Molecular Biology. University of Ferrara, Ferrara, Italy. Telethon Foundation Fellowship Research grant: ”Genetic and biochemical components which modulate the individual risk of bleeding in coagulation FVII deficiency; In vitro evaluation of amino-glycosides as a potential therapeutic tool for FVII deficiency”. Advisor: Prof. F. Bernardi.
2003 The Children’s Hospital of Philadelphia, Department of Hematology, PA, USA. “In vivo evaluation of half-life of recombinant FVII proteins in a mouse model”. Advisor: Dr. V. R. Arruda.
2001-2003 Department of Biochemistry and Molecular Biology. University of Ferrara, Ferrara, Italy. Internship: Philo-genetic studies and characterization of coagulation factors variants involved in hemorrhagic and pro-thrombotic disorders. Advisors: Prof. F. Bernardi and Dr. M. Pinotti.
AWARDS
2008 Recipient of American Heart Association post-doctoral fellowship (80,000$ / 2 years).
2005 Based-on-merit “Travel Award”, 47th Annual Meeting of the American Society of Hematology, December 10-13, Atlanta, GA.
2003 University of Ferrara, Ferrara, Italy.
Graduated summa cum laude.
LECTURES BY INVITATION
2006 Invited Speaker, “Gene therapy in the rare coagulation diseases: the example of hemophilia B”. National meeting in collaboration with the Department of Cell Therapy and Hematology of the San Bortolo Hospital and the foundation “Progetto ematologia”: “Rare diseases in hemostasis and thrombosis: management, costs and innovative therapies” April, 7th, Vicenza, Italy.
RESEARCH PUBLICATIONS
1. Furlan Freguia C, Toso R, Pinotti M, Gemmati D, Bernardi F. Comparison among natural (Arg304Gln, Arg304Trp) and artificial (Arg290His, Arg290Lys) mutations in coagulation Factor VII loops. J Thromb Haem 2003; 11: 2455-2457.
2. Furlan Freguia C, Toso R, Ferraresi P, Pinotti, Bernardi F. Variation of Factor VII 140s and 170s loops in fishes: Evolutionary aspects and comparison with mutations found in FVII deficiency. Thromb Haem 2003; 90: 1220-1222.
3. Furlan Freguia C, Toso R, Pollak ES, Arruda VR, Pinotti M, Bernardi F. Characterization of mild coagulation factor VII deficiency: activity and clearance of the Arg315Trp and Arg315Lys variants in the Cys310-Cys329 loop (c170s).
Haematologica. 2004 Dec; 89 (12):1504-9.
4. Alexander Schlachterman, Joerg Schuettrumpf, Jian-Hua Liu, Christian Furlan Freguia, Raffaella Toso, Mortimer Poncz, Rodney M Camire, Valder R Arruda. Factor V Leiden improves in vivo hemostasis in murine hemophilia models. J Thromb Haemost 2005; 3: 2730-7.
5. Cao O, Furlan-Freguia C, Arruda VR, Herzog RW. Emerging role of regulatory T cells in gene transfer. Curr Gene Ther. 2007 Oct;7(5):381-90.
6. Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature. 2008 Apr 3; 452 (7187):654-8.
7. Furlan-Freguia C, Niessen F, Fernandez JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood. 2009 Jan 13. [Epub ahead of print].
ABSTRACTS (last three years)
1. Protease-Activated Receptor 2 as a Novel Target for Immune Modulation for AAV-Mediated Gene Transfer to Skeletal Muscle. Stefano Baila, Christian Furlan Freguia, Danielle Dunn, Federico Mingozzi, Joerg Schuettrumpf, Valder R. Arruda. American Society of Gene Therapy (ASGT), Baltimore (MD) 2006.
2. Effects of Continuous Expression of Activated Protein C (APC) in Novel Murine Thrombosis Models. Christian Furlan Freguia, Joerg Schuettrumpf, Stefano Baila, Jianhua Liu, Ralph Bunte, Rodney M. Camire, Valder R. Arruda. American Society of Gene Therapy (ASGT), Baltimore (MD) 2006.
3. Differences in the anticoagulant activity of murine and human activated protein C (APC) in mouse thrombosis models. Christian Furlan Freguia, Joerg Schuettrumpf, Stefano Baila, Alexander Schlachterman, Jianxang Zou, Shangzhen Zhou and Valder R Arruda. American Society of Hematology (ASH), Orlando (FL) 2006.
4. Protease-activated receptor 2 (PAR-2) as novel target to prevent inhibitor formation to FIX. Stefano Baila, Christian Furlan Freguia, Nicholas Iacobelli, Daniele Dunn, Federico Mingozzi. Joerg Schuettrumpf, Patricia Andrade-Gordon, Valder R Arruda. American Society of Hematology (ASH), Orlando (FL) 2006.
5. Placental Pathology in Mouse Model of Thrombophilia due to Factor V Leiden and high Levels of Factor IX. Linda M Ernst, Christian Furlan Freguia, Valder R Arruda. Society for Pediatric Pathology Spring Meeting, San Diego (CA) 2007.
6. Vivo Effects Of Murine And Human APC. C. Furlan Freguia, J. Schuettrumpf, J. Zou, A. Schlachterman, H.D. Downey, S. Baila, S. Zhou, V.R. Arruda. International Society of Thrombosis and Hemostasis (ISTH), Geneva (SUI) 2007. (Oral presentation)
7. Molecular And Functional Characterization Of FVIII Mutations In A Female With Severe Hemophilia A. A. dos Santos, S.A.L. Montalvão, C. Furlan Freguia, E.V. de Paula, J.M. Annichino-Bizzacchi, R.M. Camire, M.C. Ozelo. International Society of Thrombosis and Hemostasis (ISTH), Geneva (SUI) 2007.
8. Protease-Activated Receptor 2 (Par-2) A Novel Target To Prevent FIX Inhibitor Formation. S. Baila, C. Furlan Freguia, P. Favaro, J. Schuettrumpf, F. Mingozzi, P. Andrade-Gordon, V. Arruda. International Society of Thrombosis and Hemostasis (ISTH), Geneva (SUI) 2007.
9. Novel Models Of Thrombophilia Result In Spontaneous Peripheral Thrombosis And Pregnancy-Related Complications. C. Furlan Freguia, J. Schuettrumpf, S. Baila, J. Liu, R. Bunte, R.M. Camire, V.R. Arruda. International Society of Thrombosis and Hemostasis (ISTH), Geneva (SUI) 2007.
10. Successful Production of Canine FVIII: Biochemical and Functional Characterization in Hemophilia A Dogs. Christian Furlan Freguia, Denise E. Sabatino, Andrey Santos, Amy Lange, Raffaella Toso, Timothy C. Nichols, Rodney M. Camire, Valder R. Arruda. American Society of Hematology (ASH), Atlanta 2007. (Oral presentation).
