<span lang="IT" style="font-family:"Arial","sans-serif";mso-fareast-font-family:Arial;
text-decoration:none;text-underline:none"><span style="mso-list:Ignore"><span style="font:7.0pt "Times New Roman""> </span></span></span><span lang="IT" style="font-family:"Arial","sans-serif""><u>PUBBLICAZIONI:</u></span></h4> <p class="MsoNormal"><span lang="IT"> </span></p> <h3><span style="font-family:"Arial","sans-serif";
mso-ansi-language:EN-US">Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate</span></h3> <h5><span style="font-family:"Arial","sans-serif";
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;
font-family:"Arial","sans-serif";mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-US">Elisabeth Mangold<span style="mso-bidi-font-weight:
bold">1,26</span>, Kerstin U Ludwig<span style="mso-bidi-font-weight:bold">1,2,26</span>, Stefanie Birnbaum<span style="mso-bidi-font-weight:bold">1,26</span>, <b style="mso-bidi-font-weight:normal"><u>Carlotta Baluardo</u></b><span style="mso-bidi-font-weight:bold">3</span>, Melissa Ferrian<span style="mso-bidi-font-weight:bold">3</span>, Stefan Herms<span style="mso-bidi-font-weight:
bold">1,2</span>, Heiko Reutter<span style="mso-bidi-font-weight:bold">1</span>, Nilma Almeida de Assis<span style="mso-bidi-font-weight:bold">1</span>, Taofik Al Chawa<span style="mso-bidi-font-weight:bold">1</span>, Manuel Mattheisen<span style="mso-bidi-font-weight:bold">1,2,4</span>, Michael Steffens<span style="mso-bidi-font-weight:bold">4</span>, Sandra Barth<span style="mso-bidi-font-weight:
bold">1,2</span>, Nadine Kluck<span style="mso-bidi-font-weight:bold">1,2</span>, Anna Paul<span style="mso-bidi-font-weight:bold">5</span>, Jessica Becker<span style="mso-bidi-font-weight:bold">1,2</span>, Carola Lauster<span style="mso-bidi-font-weight:bold">6</span>, Gül Schmidt<span style="mso-bidi-font-weight:
bold">6</span>, Bert Braumann<span style="mso-bidi-font-weight:bold">7</span>, Martin Scheer<span style="mso-bidi-font-weight:bold">8</span>, Rudolf H Reich<span style="mso-bidi-font-weight:bold">9</span>, Alexander Hemprich<span style="mso-bidi-font-weight:bold">10</span>, Simone Pötzsch<span style="mso-bidi-font-weight:bold">11</span>, Bettina Blaumeiser<span style="mso-bidi-font-weight:bold">12</span>, Susanne Moebus<span style="mso-bidi-font-weight:bold">13</span>, Michael Krawczak<span style="mso-bidi-font-weight:bold">14</span>, Stefan Schreiber<span style="mso-bidi-font-weight:bold">14</span>, Thomas Meitinger<span style="mso-bidi-font-weight:bold">15</span>, Hans-Erich Wichmann<span style="mso-bidi-font-weight:bold">16–18</span>, Regine P Steegers-Theunissen<span style="mso-bidi-font-weight:bold">19–23</span>, Franz-Josef Kramer<span style="mso-bidi-font-weight:bold">24</span>, Sven Cichon<span style="mso-bidi-font-weight:
bold">1,2</span>, Peter Propping<span style="mso-bidi-font-weight:bold">1</span>, Thomas F Wienker<span style="mso-bidi-font-weight:bold">4</span>, Michael Knapp<span style="mso-bidi-font-weight:bold">4</span>, Michele Rubini<span style="mso-bidi-font-weight:bold">3</span>, Peter A Mossey<span style="mso-bidi-font-weight:bold">25</span>, Per Hoffmann<span style="mso-bidi-font-weight:bold">1,2 </span>& Markus M Nöthen<span style="mso-bidi-font-weight:bold">1,2</span></span></h5> <p class="MsoNormal" style="text-align:justify"><b style="mso-bidi-font-weight:
normal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";
mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-bidi-font-style:
italic">Nature Genetics, December 2009</span></b><span style="font-size:10.0pt;
font-family:"Arial","sans-serif";mso-bidi-font-family:"Times New Roman";
mso-ansi-language:EN-US"></span></p> <p class="MsoNormal" style="margin-left:21.6pt;text-align:justify;text-indent:
-21.6pt"><span style="mso-ansi-language:EN-US"> </span></p> <h3><span style="font-family:"Arial","sans-serif";
mso-ansi-language:EN-US">Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24</span></h3> <h5><span style="font-size:10.0pt;
mso-ansi-language:EN-US"> </span><span style="font-size:10.0pt;font-family:"Arial","sans-serif";
mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US">Stefanie Birnbaum<sup>1,2,19</sup>, Kerstin U Ludwig<sup>3,19</sup>, Heiko Reutter<sup>1</sup>, Stefan Herms<sup>3</sup>, Michael Steffens<sup>4</sup>, Michele Rubini<sup>5</sup>, <u><b>Carlotta Baluardo</b></u><sup>5</sup>, Melissa Ferrian<sup>5</sup>, Nilma Almeida de Assis<sup>1</sup>, Margrieta A Alblas<sup>3</sup>, Sandra Barth<sup>3</sup>, Jan Freudenberg<sup>6</sup>, Carola Lauster<sup>7</sup>, Gül Schmidt<sup>7</sup>, Martin Scheer<sup>8</sup>, Bert Braumann<sup>9</sup> , Stefaan J Bergé<sup>10</sup>, Rudolf H Reich<sup>11</sup>, Franziska Schiefke<sup>12</sup>, Alexander Hemprich<sup>12</sup>, Simone Pötzsch<sup>13</sup>, Regine P Steegers-Theunissen<sup>14</sup>, Bernd Pötzsch<sup>15</sup>, Susanne Moebus<sup>16</sup>, Bernhard Horsthemke<sup>17</sup>, Franz-Josef Kramer<sup>2</sup>, Thomas F Wienker<sup>4</sup>, Peter A Mossey<sup>18</sup>, Peter Propping<sup>1</sup>, Sven Cichon<sup>1,3</sup>, Per Hoffmann<sup>1,3</sup>, Michael Knapp<sup>4</sup>, Markus M Nöthen<sup>1,3,19</sup> & Elisabeth Mangold<sup>1,19</sup></span></h5><h4><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-US;mso-bidi-font-style:italic">Nature Genetics, March 2009</span></b></h4> <p class="MsoNormal" style="margin-left:21.6pt;text-align:justify;text-indent:
-21.6pt"><span style="mso-ansi-language:EN-US"> </span></p> <p class="MsoNormal" style="margin-left:21.6pt;text-align:justify;text-indent:
-21.6pt"><span style="mso-ansi-language:EN-US"> </span></p> <p class="MsoNormal" style="margin-left:21.6pt;text-align:justify;text-indent:
-21.6pt"><span style="mso-ansi-language:EN-US"> </span></p> <p class="MsoNormal" style="margin-left:21.6pt;text-align:justify"><u><span lang="IT" style="font-family:"Arial","sans-serif"">ABSTRACT:</span></u></p><p class="MsoNormal" style="margin-left:21.6pt;text-align:justify"><u><span lang="IT" style="font-family:"Arial","sans-serif""></span></u><u><br /></u></p> <h3><span style="font-family:"Arial","sans-serif";mso-ansi-language:
EN-US">Gender-specific gene-gene interactions in the response to methotrexate therapy of </span><span style="font-family:"Arial","sans-serif";mso-ansi-language:
EN-US"><b><p class="MsoNormal" style="display: inline !important; "><span lang="IT" style="font-family:"Arial","sans-serif"">rheumatoid arthritis patients</span></p></b></span></h3> <div><span lang="IT" style="font-family:"Arial","sans-serif""> </span><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif";
mso-fareast-language:EN-US">M. Rubini<sup>1*</sup>, M. Ferrian<sup>1</sup>, <u><b style="mso-bidi-font-weight:normal">C. Baluardo</b></u><sup>1</sup>, L. Marullo<sup>1</sup>, D. Balestra<sup>1</sup>, M. Padovan<sup>2</sup>, M. Govoni<sup>2</sup>, F. Trotta<sup>2</sup></span></div> <div><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif";
mso-fareast-language:EN-US"> </span><span lang="IT" style="font-size:
10.0pt;font-family:"Arial","sans-serif";mso-fareast-language:EN-US">1) Dip. Medicina Sperimentale e Diagnostica, 2) Dip. Medicina Clinica e Sperimentale, University of Ferrara, Ferrara,Italy. </span></div><div> </div><div><b style="mso-bidi-font-weight:normal"><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;
font-family:"Arial","sans-serif"">EULAR Roma June 2010</span></i></b><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif""></span></div> <h3> </h3><h3> </h3><h3><span lang="IT" style="font-family:"Arial","sans-serif"">Identificato sul cromosoma 8q24.21 il principale locus per le labiopalatoschisi non-sindromiche</span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span><u><b style="mso-bidi-font-weight:normal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif";mso-ansi-language:
EN-US;mso-bidi-font-style:italic">C. Baluardo</span></b></u><sup><span style="font-size:10.0pt;font-family:"Arial","sans-serif";mso-ansi-language:
EN-US;mso-bidi-font-style:italic">1</span></sup><span style="font-size:10.0pt;
font-family:"Arial","sans-serif";mso-ansi-language:EN-US;mso-bidi-font-style:
italic">,<span style="mso-spacerun:yes"> </span>M. Ferrian<sup>1</sup>, S. Birnbaum<sup>2</sup>, E. Mangold<sup>2</sup>, K.U. Ludwig<sup>3</sup></span><span style="font-size:10.0pt;font-family:"Arial","sans-serif";mso-fareast-font-family:
Calibri;mso-ansi-language:EN-US;mso-fareast-language:EN-US">, </span><span style="font-size:10.0pt;font-family:"Arial","sans-serif";mso-ansi-language:
EN-US;mso-bidi-font-style:italic">M.M. Nöthen<sup>3</sup>, M. Rubini<sup>1 </sup><span style="mso-tab-count:1"> </span><span style="mso-tab-count:3"> </span><span style="mso-spacerun:yes"> </span><span style="mso-spacerun:yes"> </span><span style="mso-spacerun:yes"> </span><span style="mso-spacerun:yes"> </span><span style="mso-spacerun:yes"> </span></span></h3> <h3><span lang="IT" style="font-size:
10.0pt;font-family:"Arial","sans-serif"">1) Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Genetica Medica, Università di<span style="mso-spacerun:yes"> </span>Ferrara, Ferrara; 2)Dipartimento di Chirurgia Orale e Maxillofacciale, Università di Gottingen, Gottingen, Germania; 3) Dipartimento di Genomica, Life and Brain Center, Università di Bonn, Bonn, Germania. </span></h3><h3> </h3><h3><span lang="IT" style="font-size:
10.0pt;font-family:"Arial","sans-serif""><b style="mso-bidi-font-weight:normal"><i style="mso-bidi-font-style:
normal">SIGU Torino<span style="mso-spacerun:yes"> </span>Nov. 2009</i></b></span></h3> <h3> </h3><h3><span lang="IT" style="font-family:"Arial","sans-serif"">Ricerca di varianti geniche in IRF6 che sopprimono siti AP-2α e causano rischio per schisi orofacciali non-sindromiche</span></h3> <h3><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif""> </span><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif"">D. Balestra<sup><span style="mso-bidi-font-style:italic">1</span></sup>, <u><b style="mso-bidi-font-weight:
normal">C. Baluardo</b></u><sup><span style="mso-bidi-font-style:italic">1</span></sup>, M. Ferrian<sup><span style="mso-bidi-font-style:italic">1</span></sup>, P.A. Mossey<sup><span style="mso-bidi-font-style:italic">1</span></sup>, J.C. Murray<sup><span style="mso-bidi-font-style:italic">1</span></sup>, M. Rubini<sup><span style="mso-bidi-font-style:italic">1</span></sup></span></h3> <h3><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif""> </span><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif"">1) Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Genetica Medica, Università di<span style="mso-spacerun:yes"> </span>Ferrara, Ferrara; 2) Dept. of Dental<span style="mso-spacerun:yes"> </span>Health, University of Dundee, UK; 3) Dept. of Pediatrics, University of Iowa, Iowa City,USA. </span></h3><h3> </h3><h3><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif""><b style="mso-bidi-font-weight:normal"><i style="mso-bidi-font-style:normal">SIGU Torino<span style="mso-spacerun:yes"> </span>Nov. 2009</i></b></span></h3> <h3><span lang="IT" style="font-family:
"Arial","sans-serif""> </span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif"">Associazione tra HLA-G e rischio di Labiopalatoschisi non-sindromica</span></h3> <h3><span lang="IT"> </span><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif"">E. Mari<sup>1</sup> , M. Ferrian<sup>1</sup>, <u><b style="mso-bidi-font-weight:normal">C. Baluardo</b></u><sup>1</sup>, A. Franchella<sup>2</sup>, M. Rubini<sup>1<br /> </sup> 1) Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Genetica Medica, Università di Ferrara, Ferrara; 2) Unità di Chirurgia Pediatrica, Az. Osp. S.Anna, Ferrara. </span></h3> <h3> </h3><h3><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif""><b style="mso-bidi-font-weight:normal"><i style="mso-bidi-font-style:normal">SIGU Torino<span style="mso-spacerun:yes"> </span>Nov. 2009</i></b></span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif"">Network di interazioni geniche e supplementazione in gravidanza con acido folico nelle labiopalatoschisi e palatoschisi non-sindromiche</span></h3> <h3><span lang="IT" style="mso-bidi-language:HE"> </span><span lang="IT" style="font-size:10.0pt;font-family:
"Arial","sans-serif"">M. Ferrian<sup>1</sup>, <u><b style="mso-bidi-font-weight:
normal">C. Baluardo</b></u><sup>1</sup>, M. Bottoni<sup>1</sup>, Giovanna Garattini<sup>2</sup>, R. Brusati<sup>2</sup>, M. Accordi<sup>3</sup>, E. Calzolari<sup>1</sup>, A. Franchella<sup>4</sup>, M. Rubini<sup>1</sup></span></h3> <h3><span lang="IT" style="font-size:10.0pt;font-family:
"Arial","sans-serif""> </span><span lang="IT" style="font-size:10.0pt;font-family:
"Arial","sans-serif"">1) Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Genetica Medica, Università di Ferrara, Ferrara; 2) Dipartimento di Chirurgia Maxillo-facciale, Università di Milano, Milano; 3) Centro di Foniatria, Padova; 4) Unità di Chirurgia Pediatrica, Az. Osp. S.Anna, Ferrara. </span></h3><h3> </h3><h3><span lang="IT" style="font-size:10.0pt;font-family:
"Arial","sans-serif""><b style="mso-bidi-font-weight:normal"><i style="mso-bidi-font-style:
normal">SIGU Torino<span style="mso-spacerun:yes"> </span>Nov. 2009</i></b></span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif"">Associazione tra FAS-ASSOCIATED FACTOR-1 (FAF1) e la palatoschisi non-sindromica</span></h3> <h3><span lang="IT" style="mso-bidi-language:HE"> </span><span lang="IT" style="font-size:10.0pt;font-family:
"Arial","sans-serif"">S. Michelini<sup>1</sup>, <u><b style="mso-bidi-font-weight:
normal">C. Baluardo</b></u><sup>1</sup>, M. Ferrian<sup>1</sup>, M. Ghassibe<sup>2</sup>, M. Vikkula<sup>2</sup>, P.A. Mossey<sup>3</sup>, M. Rubini<sup>1</sup></span></h3> <h3><span lang="IT" style="font-size:10.0pt;font-family:
"Arial","sans-serif""> </span><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif"">1) Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Genetica Medica, Università di Ferrara, Ferrara; 2) Laboratory of Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, Louvain, Belgium; 3) Dept. of Dental<span style="mso-spacerun:yes"> </span>Health, University of Dundee, UK. </span></h3><h3> </h3><h3><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif""><b style="mso-bidi-font-weight:normal"><i style="mso-bidi-font-style:
normal">SIGU Torino<span style="mso-spacerun:yes"> </span>Nov. 2009</i></b></span></h3> <h3><i style="mso-bidi-font-style:
normal"><span lang="IT" style="font-size:9.0pt;font-family:"Tahoma","sans-serif";
color:#333333"> </span></i></h3> <h3><span lang="IT" style="font-family:
"Arial","sans-serif"">Identificata in un enhancer di IRF6 la principale variante comune che causa le Labioschisi non sindromiche<u></u></span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span><u><b><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif";
mso-bidi-font-style:italic">Carlotta Baluardo</span></b></u><b><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif";
mso-bidi-font-style:italic"><sup>1</sup></span></b><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif";mso-bidi-font-style:
italic">, Melissa Ferrian<sup>1</sup>, Peter Mossey<sup>2</sup>, Fedik Rahimov<sup>3</sup>, Jeffrey Murray<sup>3</sup>, Michele Rubini<sup>1</sup></span></h3> <h3><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif"">1) Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Genetica Medica, Università di<span style="mso-spacerun:yes"> </span>Ferrara, Ferrara; 2) Dept. of Dental<span style="mso-spacerun:yes"> </span>Health, University of Dundee, UK; 3) Dept. Of Pediatrics, University of Iowa, Iowa City,USA. </span></i></h3><h3> </h3><h3><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif""><b style="mso-bidi-font-weight:
normal">SIGU Genova<span style="mso-spacerun:yes"> </span>Nov. 2008</b></span></i></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span></h3> <h3><span lang="IT" style="mso-bidi-font-size:10.0pt;font-family:"Arial","sans-serif"">Elevato rischio di SICCA in pazienti con Artrite Reumatoide portatori della delezione TaqI nel gene TGFA</span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif";
mso-bidi-font-style:italic"> </span><span lang="IT" style="font-size:10.0pt;mso-bidi-font-size:
12.0pt;font-family:"Arial","sans-serif";mso-bidi-font-style:italic">Melissa Ferrian<sup>1</sup>, <u><b>Carlotta Baluardo</b></u><b><sup>1</sup></b>, Delia L. Maruccia<sup>1</sup>, Michela Arbustini<sup>1</sup>, Simona Bosi<sup>2</sup>, Francesco Trotta<sup>2</sup>, Michele Rubini<sup>1</sup></span></h3> <h3><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;mso-bidi-font-size:12.0pt;font-family:"Arial","sans-serif";
text-decoration:none;text-underline:none">1) Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Genetica Medica, Università di<span style="mso-spacerun:yes"> </span>Ferrara; 2) Dipartimento di Medicina Clinica e Sperimentale, Sezione di Reumatologia, Università di Ferrara.</span></i><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;
font-family:"Arial","sans-serif";text-decoration:none;text-underline:none"> </span></i></h3><h3> </h3><h3><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;
font-family:"Arial","sans-serif";text-decoration:none;text-underline:none"><b style="mso-bidi-font-weight:normal">SIGU Genova<span style="mso-spacerun:yes"> </span>Nov. 2008</b></span></i><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;mso-bidi-font-size:12.0pt;font-family:"Arial","sans-serif";
text-decoration:none;text-underline:none"></span></i></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif";mso-fareast-font-family:Arial;
text-decoration:none;text-underline:none"><span style="mso-list:Ignore"><span style="font:7.0pt "Times New Roman""> </span></span></span><span lang="IT" style="font-family:"Arial","sans-serif""><span style="text-decoration:none"> </span></span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span></h3> <h3><span lang="IT" style="mso-bidi-font-size:14.0pt;font-family:
"Arial","sans-serif";mso-bidi-font-weight:bold">Ecogenetica delle schisi orofacciali non-sindromiche: la somministrazione di acido folico durante la gravidanza si associa ad incrementato rischio di labio-palatoschisi nella prole di madri MTHFR:c.1298CC.</span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif";
mso-bidi-font-style:italic">Michele Rubini<sup>1</sup>, Martina Bottoni<sup>1</sup>, <u><b>Carlotta Baluardo</b></u><b><sup>1</sup></b>, Melissa Ferrian<sup>1</sup>, Elisa Calzolari<sup>1</sup>, Andrea Franchella<sup>2</sup>, Maurizio Accordi<sup>3</sup>, Giovanna Garattini<sup>4</sup>, Roberto Brusati<sup>4</sup></span></h3> <p><span lang="IT">1) Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Genetica Medica, Università di<span style="mso-spacerun:yes"> </span>Ferrara, Ferrara; 2) Unità di Chirurgia Pediatrica, Osp. S.Anna, Ferrara; 3) Centro di Foniatria, Padova; 4) Dipartimento di Chirurgia Maxillo-facciale, Università di Milano, Milano.</span><span lang="IT" style="font-style:normal"> </span></p><p> </p><div><b style="mso-bidi-font-weight:normal"><span lang="IT">SIGU Genova<span style="mso-spacerun:yes"> </span>Nov. 2008</span></b></div> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif""> </span></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif"">L’associazione tra il polimorfismo TaqI di TGFA nelle schisi orofacciali non-sindromiche si manifesta con effetti opposti nei due sessi</span></h3> <h3><span lang="IT" style="mso-bidi-font-size:10.0pt;font-family:
"Arial","sans-serif";mso-bidi-font-style:italic"> </span><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif";
mso-bidi-font-style:italic">Michela Arbustini<sup>1</sup>, Melissa Ferrian<sup>1</sup>, <u><b>Carlotta Baluardo</b></u><b><sup>1</sup></b>, Julian Little<sup>2</sup>, Peter Mossey<sup>3</sup>, Michele Rubini<sup>1</sup></span></h3> <h3><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif";text-decoration:none;
text-underline:none">1) Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Genetica Medica, Università di<span style="mso-spacerun:yes"> </span>Ferrara, Ferrara; 2) Dept. of Epidemiology and Community Medicine,University of Ottawa,Ottawa, Canada;.3) Dept. of Dental<span style="mso-spacerun:yes"> </span>Health, University of Dundee, UK. </span></i></h3><h3> </h3><h3><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;font-family:"Arial","sans-serif";text-decoration:none;
text-underline:none"><b style="mso-bidi-font-weight:normal">SIGU Genova<span style="mso-spacerun:yes"> </span>Nov. 2008</b></span></i></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif";mso-fareast-font-family:Arial;
text-decoration:none;text-underline:none"><span style="mso-list:Ignore"><span style="font:7.0pt "Times New Roman""> </span></span></span><span lang="IT" style="font-family:"Arial","sans-serif""><span style="text-decoration:none"> </span></span></h3> <h3><span lang="IT" style="font-family:
"Arial","sans-serif""> </span></h3> <h3><span lang="IT" style="font-family:
"Arial","sans-serif"">Ecogenetica dell’acido folico nelle schisi orofacciali non-sindromiche: l’efficacia della integrazione con acido folico in gravidanza dipende dal profilo genetico della madre.</span></h3><h3><span lang="IT" style="font-family:
"Arial","sans-serif""></span><u><b style="mso-bidi-font-weight:
normal"><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:
10.0pt;font-family:"Arial","sans-serif"">C. Baluardo</span></i></b></u><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;
font-family:"Arial","sans-serif"">, M. Ferrian, M. Bottoni, G. Garattini, R. Brusati, E. Calzolari, A. Franchella, M. Accordi, M. Rubini. </span></i></h3><h3> </h3><h3><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;
font-family:"Arial","sans-serif"">ISS - Workshop Annuale del Network Italiano Promozione Acido Folico, <b style="mso-bidi-font-weight:
normal">Roma, 2008</b></span></i></h3> <h3><span lang="IT" style="font-family:"Arial","sans-serif";mso-fareast-font-family:Arial"><span style="mso-list:Ignore"><span style="font:7.0pt "Times New Roman""> </span></span></span><span lang="IT" style="font-family:"Arial","sans-serif""> </span></h3> <h3><span lang="EN-GB" style="font-family:"Arial","sans-serif";mso-ansi-language:EN-GB"> </span></h3> <h3><span lang="EN-GB" style="font-family:"Arial","sans-serif";mso-ansi-language:EN-GB">Folic acid supplementation during pregnancy in MTHFR c.1298CC homozygote mothers associates with an increased the risk of cleft lip and palate in the offspring. </span></h3> <h3><span style="font-size:10.0pt;
font-family:"Arial","sans-serif";mso-ansi-language:EN-US"> </span><b><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;
font-family:"Arial","sans-serif";mso-fareast-font-family:"Times New Roman";
mso-ansi-language:IT;mso-fareast-language:AR-SA;mso-bidi-language:AR-SA">M. Rubini, <u><b style="mso-bidi-font-weight:normal">C. Baluardo</b></u>, M. Ferrian, E. Calzolari, A. Franchella, M. Accordi, G. Garattini, R. Brusati. </span></i></b></h3><h3> </h3><h3><b><i style="mso-bidi-font-style:normal"><span lang="IT" style="font-size:10.0pt;
font-family:"Arial","sans-serif";mso-fareast-font-family:"Times New Roman";
mso-ansi-language:IT;mso-fareast-language:AR-SA;mso-bidi-language:AR-SA">ASHG, <b style="mso-bidi-font-weight:normal">Philadelphia, 2008</b></span></i></b></h3> </b></div><h3> </h3>
