Curriculum Alessia Finotti
Short Biography
Alessia Finotti is an Assistant Professor (RTD-B) at the Life Sciences and Biotechnology Department of Ferrara University (Italy). She works at Ferrara University since 2005 (from 2005 to 2012 at the Department of Biochemistry and Molecular Biology, currently at the Department of Life Sciences and Biotechnology). She is also Professor of "Cellular and Molecular Therapies” (Degree in Biotechnologies and Pharmacy) at Ferrara University.
She is author of more than 95 papers published in peer-reviewed International Journals.
Her research interests are focused on molecular basis of human cancer and hereditary diseases, gene therapy, pharmaceutical biology and pharmacogenomics.
Curriculum Vitae
EDUCATION
2005 Ph.D. Research Doctorate in Biotechnology, University of Ferrara.
2001 Master Degree in Chemistry and in Chemical and Pharmaceutical Technologies, University of Ferrara, (110/110 magna cum laude).
PROFESSIONAL RESEARCH EXPERIENCE
June 1,2021-date: Assistant Professor (RTD-B) in Biochemistry, SSD BIO/10, University of Ferrara, Department of Life Sciences and Biotechnology, Ferrara, Italy.
2016-2021: Assistant Professor (RTD-A) in Biochemistry, SSD BIO/10, University of Ferrara, Department of Life Sciences and Biotechnology, Ferrara, Italy.
2005-2016: Post-doctoral fellow/Research fellow at Ferrara University, Department of Life Sciences and Biotechnology and Department of Biochemistry and Molecular Biology, Ferrara, Italy.
TEACHING EXPERIENCE
2015-date: Professor of the Courses: Cellular and Molecular Therapies, Recombinant and Molecular Technologies, Omics and Molecular Diagnosis, Advanced Biomolecular Technologies (Biotechnology Degree); Biomolecular Drugs (Pharmacy Degree); Molecular Biology of the Cell (Biological Sciences Degree); Applied Biochemistry (Chemical and Pharmaceutical Technologies Degree, laboratory
FUNDING (Most recent)
-2020-2023: Principal Investigator (PI) FAR (Fondo di Ateneo per la Ricerca Scientifica) project. Title: Development of CRISPR/Cas9 based Genome Editing strategies for genetic diseases alone or in combined treatments with other gene therapy approaches (ComboGenE).
-2018-2023: Internal Collaborator/Member of Operative Unit. Project AIFA-2016-02364887 funded by Italian Medicines Agency. Title: Treatment of beta-thalassemia patients with Rapamycin (Sirolimus): from pre-clinical research to a clinical trial (THAL-RAP).
-2020-2021: Principal Investigator (PI) FIR (Fondo per l’incentivazione alla ricerca MIUR) project. Title: Use of microRNA targeting strategies combined with natural derived compounds with antiproliferative and pro-apoptotic activities: in-vitro study of antitumoral effects on colon-rectal cancer, glioblastoma and breast carcinoma cellular models (NaturalMiR-Combo).
-2020-2021: Principal Investigator (PI) of the project funded by Associazione Italiana Sindrome di Shwachman (AISS). Title: Combined approaches for Shwachman-Diamond Syndrome: microRNA targeting, gene editing and read-through correction (miRCOMBO-SDS).
-2019-2020: Internal Collaborator of project FFC #7/2018 (Fondazione Fibrosi Cistica). Title: Revealing the microRNAs-transcription factors network in cystic fibrosis: from microRNA therapeutics to precision medicine (CF-miRNA-THER).
-2019-2020: External Collaborator of project FFC #7/2019 (Fondazione Fibrosi Cistica). Title: Targeting the signalling network controlling proteostasis and inflammation to rescue F508del-CFTR.
-2018-2020 Principal Investigator (PI) FAR (Fondo di Ateneo per la Ricerca Scientifica) project. Title: Theranostic approaches: microRNAs targeting in: (a) genetic diseases (cystic fibrosis, beta-thalassemia, and Shwachman-Diamond Syndrome); (b) blood infusion in athletes and (c) neoplastic diseases.
-2018-2020: Co-investigator of project from Wellcome Trust Innovator Award 2018. Title: A personalized medicine approach for beta-thalassemia patients: testing sirolimus in a first pilot clinical trial (sirthalaclin).
-2018-2019: Principal Investigator (PI) FIR (Fondo per l’incentivazione alla ricerca MIUR) project. Title: Peptide Nucleic Acids for genome editing in beta-thalassemia.
-2018-2019: Co-Investigator WADA (World Anti-Doping Agency) Research Grant. Title: Development of micro RNA based protocols for detection of autologous blood transfusion in sport.
-2016-2018: Internal Collaborator of project FFC #1/2016 (Fondazione Fibrosi Cistica). Title: New generation trimethylangelicin (TMA) analogues for selective modulation of defective CFTR or inflammation.
-2015-2018: Internal Collaborator in project n° 633937-H2020-PHC-2014-two-stage. Title: “ULTRAPLACAD” (ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis).
-2017-2018: Principal Investigator (PI) FAR (Fondo di Ateneo per la Ricerca Scientifica) project. Title: Biosensors and novel technological platforms for liquid biopsy and circulating miRNAs analysis.
-2016-2017: Principal Investigator (PI) FIR (Fondo per l’Incentivazione alla Ricerca MIUR) project. Title: MicroRNA profiling in liquid biopsy from patients with Shwachman-Diamond Syndrome: identification of molecular basis of the pathology and novel prognostic biomarkers.
-2016-2017: Internal Collaborator FFC3#2016 (Fondazione Fibrosi Cistica) project. Title: MicroRNA Therapeutics in CF: Targeting CFTR and inflammation networks (MicroRNA-CF).
-2014-2017: External Collaborator FFC#17/2014 (Fondazione Fibrosi Cistica) project. Title: TRPA1 channels as novel molecular targets for anti-inflammatory therapies in CF lung.
-2015-2016: Co-Investigator WADA (World Anti-Doping Agency - Health, Medical and Research Committee Research Program) Project. Title: Novel molecular biomarkers for detection of autologous blood transfusion.
-2012-2016: Internal Collaborator in Project n° 306201-FP7-HEALTH-2012-INNOVATION-1. Title: “THALAMOSS “(THALAssemia MOdular Stratification System for personalized therapy of beta-thalassemia).
OTHER LEADERSHIP EXPERIENCE
-Academic tutor and supervisor of the Ph.D. students Dr. Matteo Zurlo and Dr. Chiara Papi. Supervisor of the Researcher fellow Dr. Lucia Carmela Cosenza. Supervisor of Dr. Jessica Gasparello (FIRC – Fondazione Italiana per la Ricerca sul Cancro-AIRC fellowship).
-Coordinator and Scientific Manager of the Institutional Research Project between Rare Partners S.r.l. and Dipartimento di Scienze della Vita e Biotecnologie dell'Università di Ferrara. Title of the Project “Activity of Sirolimus in combination whit other biomolecules used in precision medicine and personalized therapy of beta-thalassemia patients), 01/12/2017-31/03/2019.
-Group Leader position in coordinating and experimental design of WP1, Task 1.2 (Specifications of colorectal cancer biomarkers and samples requirements) and WP4, Task 4.1 (Recruitment and validation of clinical samples for microRNAs), European Project Progetto n° 633937-H2020-PHC-2014-two-stage-ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis (ULTRAPLACAD), 01/05/2015-31/10/2018.
-Coordinator and supervisor of experiments’ execution in the Project of Animal Experimentation “Characterization and use of murine models for thalassemia (Auth. from Italian Healthy Minister number° 362-2015-PR), 2015-2020.
PRINCIPAL RESEARCH TOPICS
-Molecular strategies to modulate gene expression in the treatment of genetic rare diseases (e.g. beta-thalassemia, cystic fibrosis, Shwachman-Diamond Syndrome);
-Study of microRNAs involved in human pathologies for the development of new approaches of microRNA targeting and miRNA replacement;
-Gene editing in beta-thalassemia, SCD, Shwachman-Diamond Syndrome and cystic fibrosis;
-Biological evaluation of novel compounds as inducers of erythroid differentiation in the therapy of hematological diseases;
-Proteomics and transcriptomics (microRNA and mRNA NGS) analysis in genetic diseases (cystic fibrosis, beta-thalassemia, Shwachman-Diamond Syndrome) and in neoplastic pathologies (glioblastoma, colon cancer);
-Biomedical and biotechnological applications of peptide nucleic acids (PNA) and structural analogues directed against mRNA and microRNA;
-Development of novel therapeutic strategies using microRNA targeting and combined approaches (miRNA and antitumoral drugs) in oncology;
-Identification of novel therapeutic approaches against SARS-Cov-2 cytokine storm;
-Molecular analysis of peripheral blood (liquid biopsy) biomarkers (circulating microRNAs) in cancer patients.
-Development of innovative systems for the delivery of biodrugs;
-Read-through strategy for the treatments of genetic rare diseases caused by nonsense mutations;
-SPR-based molecular diagnosis of genetic diseases;
-Identification of changed levels in circulating (plasma) microRNA in auto-hemotransfused athletes;
-Study of transcription factors in gene transcriptional regulation;
PATENTS
Co-inventor of two Patents concerning the development of novel systems for nucleic acids/peptide nucleic acids (PNA) delivery:
- Patent N°102017000139871, 14 Feb 2020, title “Transfection agents for microRNA and antagomiRNA”
- Patent N°102017000139872, 14 Feb 2020, title “Transfection agents for peptide nucleic acids (PNA)”
OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIP
2020-date Member of the Steering Committee (Vice Director for Instruments & Technological resources) of Center for Innovative Therapies for Cystic Fibrosis, Ferrara University, Italy
2016-date Member of the Biomedical and Biotechnological Sciences Ph.D. Academic Board at Ferrara University.
2005-date Member of Thal-Lab: Laboratorio per lo sviluppo di terapie farmacologiche e farmacogenomiche per la Talassemia, Ferrara University, Italy
2021-date Member of the American Society of Gene and Cell Therapy (ASGCT).
2019-date Member of the “International Society of Precision Cancer Medicine (ISPCM), Italy.
2016-date Member of Stem Cell Research (SCR) Italy Association.
2013-date Member of the Italian Society of Biochemistry and Molecular Biology (SIB).
2015-date Scientific Reviewer for ASSAY and Drug Development Technologies, Experimental & Clinical Cancer Research, Experimental and Therapeutic Medicine, Assay and Drug Development Technology, Cancer Gene Therapy, Frontiers in Genome Editing, Journal of Clinical Medicine, Molecular Oncology, Plos One, International Journal of Molecular Medicine, Oncology Letters, Molecular Medicine Reports, Molecular Biotechnology, African Journal of Biotechnology, Amino Acids, Genomics Data, Cell & Gene Therapy Insight, Biomedical Reports.
2016-date Member of the Editorial Board of “Experimental and Therapeutic Medicine” journal (Online ISSN: 1792-1015), and Editorial Board of “Oncology Letters” (Online ISSN: 1792-1082).
AWARDS, HONORS, and ACADEMIC TITLES
2017-date Assignee of Eligibilities from Italian MIUR for the Associate Professor positions in General Biochemistry and in Clinical Biochemistry-Clinical Molecular Biology
2008 Title of “Cultore della materia” (Expert in teaching) for the disciplinary scientific sector (SSD) of Biochemistry, Ferrara University, Italy
2016 Winner of the prize entitled "Prof. Paolo Bianco Award" for the best abstract and poster presented at "VII Meeting Stem Cell Research Italy", Bologna, Italy, June 21th-23th, 2016.
NATIONAL/INTERNATIONAL CONFERENCES/MEETINGS
Oral communications at 15 National/International Conferences/Meetings. Member of the Organization Board and Scientific Board of 4 National/International Conferences/Meeting.
SCIENTIFIC PUBLICATIONS (Updated: June 2021, from Scopus)
More than 96 full article publications in peer-reviewed International Journals (h-index 23, total citations 1562; Source: Scopus); 8 book chapters, more than 50 meeting abstract published in indexed journals.
ORCID ID: https://orcid.org/0000-0002-7638-515X, WOS/Researcher ID: C-6268-2012, Scopus Author ID: 6506289571
COMPLETE PUBLICATIONS LIST
Cosenza LC, Gasparello J, Romanini N, Zurlo M, Zuccato C, Gambari R, Finotti A.
Efficient CRISPR-Cas9 based genome editing of β-globin gene on erythroid cells from homozygous β039-thalassemia patients.
Mol Ther Methods Clin Dev, 2021 June 11,21:507-523. doi.org/10.1016/j.omtm.2021.03.025
Gasparello J, D'Aversa E, Papi C, Gambari L, Grigolo B, Borgatti M, Finotti A, Gambari R.
Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein.
Phytomedicine. 2021 May 4;87:153583. doi: 10.1016/j.phymed.2021.153583. Online ahead of print.
Gasparello J, Fabbri E, Gambari R, Finotti A.
Differential effects on the miRNome of the treatment of human airway epithelial Calu-3 cells with peptide-nucleic acids (PNAs) targeting microRNAs miR-101-3p and miR-145-5p: Next generation sequencing datasets.
Data Brief. 2021 Jan 9;35:106718. doi: 10.1016/j.dib.2021.106718. eCollection 2021 Apr.
Tamanini A, Fabbri E, Jakova T, Gasparello J, Manicardi A, Corradini R, Finotti A, Borgatti M, Lampronti I, Munari S, Dechecchi MC, Cabrini G, Gambari R.
A Peptide-Nucleic Acid Targeting miR-335-5p Enhances Expression of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene with the Possible Involvement of the CFTR Scaffolding Protein NHERF1.
Biomedicines. 2021 Jan 26;9(2):117. doi: 10.3390/biomedicines9020117.
Gasparello J, Finotti A, Gambari R.
Tackling the COVID-19 "cytokine storm" with microRNA mimics directly targeting the 3'UTR of pro-inflammatory mRNAs.
Med Hypotheses. 2021 Jan;146:110415. doi: 10.1016/j.mehy.2020.110415. Epub 2020 Nov 25.
Finotti A, Gasparello J, Casnati A, Corradini R, Gambari R, Sansone F.
Delivery of Peptide Nucleic Acids Using an Argininocalix[4]arene as Vector.
Methods Mol Biol. 2021;2211:123-143. doi: 10.1007/978-1-0716-0943-9_10.
Fabbri E, Tamanini A, Jakova T, Gasparello J, Manicardi A, Corradini R, Finotti A, Borgatti M, Lampronti I, Munari S, Dechecchi MC, Cabrini G, Gambari R.
Treatment of human airway epithelial Calu-3 cells with a peptide-nucleic acid (PNA) targeting the microRNA miR-101-3p is associated with increased expression of the cystic fibrosis Transmembrane Conductance Regulator (CFTR) gene.
Eur J Med Chem. 2021 Jan 1;209:112876. doi: 10.1016/j.ejmech.2020.112876.
Lampronti I, Simoni D, Rondanin R, Baruchello R, Scapoli C, Finotti A, Borgatti M, Tupini C, Gambari R. Pro-apoptotic activity of novel synthetic isoxazole derivatives exhibiting inhibitory activity against tumor cell growth in vitro.
Oncol Lett. 2020 Nov;20(5):151. doi: 10.3892/ol.2020.12002. Epub 2020 Aug 24.
Gasparello J, Papi C, Allegretti M, Giordani E, Carboni F, Zazza S, Pescarmona E, Romania P, Giacomini P, Scapoli C, Gambari R, Finotti A.
A Distinctive microRNA (miRNA) Signature in the Blood of Colorectal Cancer (CRC) Patients at Surgery. Cancers (Basel). 2020 Aug 25;12(9):2410. doi: 10.3390/cancers12092410.
Cabrini G, Rimessi A, Borgatti M, Lampronti I, Finotti A, Pinton P, Gambari R.
Role of Cystic Fibrosis Bronchial Epithelium in Neutrophil Chemotaxis.
Front Immunol. 2020 Aug 4;11:1438. doi: 10.3389/fimmu.2020.01438. eCollection 2020.
Romagnoli R, Prencipe F, Oliva P, Cacciari B, Balzarini J, Liekens S, Hamel E, Brancale A, Ferla S, Manfredini S, Zurlo M, Finotti A, Gambari R.
Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold.
Molecules. 2020 Apr 7;25(7):1690. doi: 10.3390/molecules25071690.
Sultan S, Rozzi A, Gasparello J, Manicardi A, Corradini R, Papi C, Finotti A, Lampronti I, Reali E, Cabrini G, Gambari R, Borgatti M.
A Peptide Nucleic Acid (PNA) Masking the miR-145-5p Binding Site of the 3'UTR of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) mRNA Enhances CFTR Expression in Calu-3 Cells. Molecules. 2020 Apr 5;25(7):1677. doi: 10.3390/molecules25071677.
Gambari R, Gasparello J, Fabbri E, Borgatti M, Tamanini A, Finotti A.
Peptide Nucleic Acids for MicroRNA Targeting.
Methods Mol Biol. 2020;2105:199-215. doi: 10.1007/978-1-0716-0243-0_12.
Gasparello J, Gambari L, Papi C, Rozzi A, Manicardi A, Corradini R, Gambari R, Finotti A.
High Levels of Apoptosis Are Induced in the Human Colon Cancer HT-29 Cell Line by Co-Administration of Sulforaphane and a Peptide Nucleic Acid Targeting miR-15b-5p.
Nucleic Acid Ther. 2020 Jun;30(3):164-174. doi: 10.1089/nat.2019.0825.
Gasparello J, Lomazzi M, Papi C, D'Aversa E, Sansone F, Casnati A, Donofrio G, Gambari R, Finotti A. Efficient Delivery of MicroRNA and AntimiRNA Molecules Using an Argininocalix[4]arene Macrocycle. Mol Ther Nucleic Acids. 2019 Dec 6;18:748-763. doi: 10.1016/j.omtn.2019.09.029.
Gasparello J, Papi C, Zurlo M, Corradini R, Gambari R, Finotti A.
Demonstrating specificity of bioactive peptide nucleic acids (PNAs) targeting microRNAs for practical laboratory classes of applied biochemistry and pharmacology.
PLoS One. 2019 Sep 11;14(9):e0221923. doi: 10.1371/journal.pone.0221923. eCollection 2019.
Gemmo C, Breveglieri G, Marzaro G, Lampronti I, Cosenza LC, Gasparello J, Zuccato C, Fabbri E, Borgatti M, Chilin A, Finotti A, Gambari R.
Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Agamma-globin gene sequences mutated in beta-thalassemia.
Anal Bioanal Chem. 2019 Nov;411(29):7699-7707. doi: 10.1007/s00216-019-01987-9. (Co-corresponding)
Breveglieri G, Salvatori F, Finotti A, Cosenza LC, Zuccato C, Bianchi N, Breda L, Rivella S, Bresciani A, Bisbocci M, Borgatti M, Gambari R.
Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters. Anal Bioanal Chem. 2019 Nov;411(29):7669-7680. doi: 10.1007/s00216-019-01959-z.
Gasparello J, Lamberti N, Papi C, Lampronti I, Cosenza LC, Fabbri E, Bianchi N, Zambon C, Dalla Corte F, Govoni M, Reverberi M, Manfredini F, Gambari R, Finotti A.
Altered erythroid-related miRNA levels as a possible novel biomarker for detection of autologous blood transfusion misuse in sport.
Transfusion. 2019 Aug;59(8):2709-2721. doi: 10.1111/trf.15383.
Gasparello J, Allegretti M, Papi C, Giordani E, Giacomini P, Gambari R, Finotti A.
Circulating microRNAs and liquid biopsy: murine xenograft models for technical validation of clinical protocols.
J Cancer Metastasis Treat 2019;5:52. doi: 10.20517/2394-4722.2019.1
Milani R, Brognara E, Fabbri E, Manicardi A, Corradini R, Finotti A, Gasparello J, Borgatti M, Cosenza LC, Lampronti I, Dechecchi MC, Cabrini G.
Targeting miR-155-5p and miR-221-3p by Peptide Nucleic Acids (PNAs): Induction of Caspase-3 and Apoptosis in Temozolomide-Resistant T98G glioma cells.
Int J Oncol. 2019 Jul;55(1):59-68. doi: 10.3892/ijo.2019.4810.
Gasparello J, Manicardi A, Casnati A, Corradini R, Gambari R, Finotti A, Sansone F.
Efficient cell penetration and delivery of peptide nucleic acids by an argininocalix[4]arene.
Sci Rep. 2019 Feb 28;9(1):3036. doi: 10.1038/s41598-019-39211-4. (Co-corresponding Author).
Finotti A, Gasparello J, Fabbri E, Tamanini A, Corradini R, Dechecchi MC, Cabrini G, Gambari R.
Enhancing the Expression of CFTR Using Antisense Molecules Against MicroRNA miR-145-5p.
Am J Respir Crit Care Med. 2019 Feb 27. doi: 10.1164/rccm.201901-0019LE.
Breveglieri G, D'Aversa E, Finotti A, Borgatti M.
Non-invasive Prenatal Testing Using Fetal DNA.
Mol Diagn Ther. 2019 Apr;23(2):291-299. doi: 10.1007/s40291-019-00385-2
Finotti A, Fabbri E, Lampronti I, Gasparello J, Borgatti M, Gambari R.
MicroRNAs and Long Non-coding RNAs in Genetic Diseases.
Mol Diagn Ther. 2019 Jan 4. doi: 10.1007/s40291-018-0380-6.
Chung PY, Lam PL, Zhou YY, Gasparello J, Finotti A, Chilin A, Marzaro G, Gambari R, Bian ZX, Kwok WM, Wong WY, Wang X, Lam AK, Chan AS, Li X, Ma JY, Chui CH, Lam KH, Tang JC.
Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma.
Cells. 2018 Oct 22;7(10). pii: E177. doi: 10.3390/cells7100177.
Finotti A, Allegretti M, Gasparello J, Giacomini P, Spandidos DA, Spoto G, Gambari R.
Liquid biopsy and PCR-free ultrasensitive detection systems in oncology (Review).
Int J Oncol. 2018 Oct;53(4):1395-1434. doi: 10.3892/ijo.2018.4516.
Gasparello J, Allegretti M, Tremante E, Fabbri E, Amoreo CA, Romania P, Melucci E, Messana K, Borgatti M, Giacomini P, Gambari R, Finotti A.
Liquid biopsy in mice bearing colorectal carcinoma xenografts: gateways regulating the levels of circulating tumor DNA (ctDNA) and miRNA (ctmiRNA).
J Exp Clin Cancer Res. 2018 Jun 26;37(1):124. doi: 10.1186/s13046-018-0788-1.
Salvatori F, Pappadà M, Breveglieri G, D'Aversa E, Finotti A, Lampronti I, Gambari R, Borgatti M.
UPF1 silenced cellular model systems for screening of read-through agents active on β039 thalassemia point mutation.
BMC Biotechnol. 2018 May 15;18(1):28. doi: 10.1186/s12896-018-0435-0
Lamberti N, Finotti A, Gasparello J, Lampronti I, Zambon C, Cosenza LC, Fabbri E, Bianchi N, Dalla Corte F, Govoni M, Reverberi R, Gambari R, Manfredini F. Changes in hemoglobin profile reflect autologous blood transfusion misuse in sports. Intern Emerg Med. 2018 Mar 23. doi: 10.1007/s11739-018-1837-7. (Co-first author)
Breveglieri, G, D'Aversa, E, Gallo, T, Pellegatti, P, Guerra, G, Cosenza, LC, Finotti, A, Gambari, R, Borgatti, M.
A novel and efficient protocol for Surface Plasmon Resonance based detection of four Β-thalassemia point mutations in blood samples and salivary swabs.
Sensors and Actuators, B: Chemical, Volume 260, 1 May 2018, Pages 710-718.
doi: 10.1016/j.snb.2017.12.209
Fabbri E, Tamanini A, Jakova T, Gasparello J, Manicardi A, Corradini R, Sabbioni G, Finotti A, Borgatti M, Lampronti I, Munari S, Dechecchi MC, Cabrini G, Gambari R.
A Peptide Nucleic Acid against MicroRNA miR-145-5p Enhances the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Calu-3 Cells.
Molecules. 2017 Dec 29;23(1). pii: E71. doi: 10.3390/molecules23010071.
Finotti A, Gasparello J, Lampronti I, Cosenza LC, Maconi G, Matarese V, Gentili V, Di Luca D, Gambari R, Caselli M.
PCR detection of segmented filamentous bacteria in the terminal ileum of patients with ulcerative colitis.
BMJ Open Gastroenterol. 2017 Dec 4;4(1):e000172. doi: 10.1136/bmjgast-2017-000172.
Gasparello J, Fabbri E, Bianchi N, Breveglieri G, Zuccato C, Borgatti M, Gambari R, Finotti A. (Corresponding Author)
BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression.
Int J Mol Sci. 2017 Nov 26;18(12). pii: E2530. doi: 10.3390/ijms18122530.
Lampronti I, Manzione MG, Sacchetti G, Ferrari D, Spisani S, Bezzerri V, Finotti A, Borgatti M, Dechecchi MC, Miolo G, Marzaro G, Cabrini G, Gambari R, Chilin A.
Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells.
Mediators Inflamm. 2017;2017:2389487. doi: 10.1155/2017/2389487
Montagner G, Bezzerri V, Cabrini G, Fabbri E, Borgatti M, Lampronti I, Finotti A, Nielsen PE, Gambari R.
An antisense peptide nucleic acid against Pseudomonas aeruginosa inhibiting bacterial-induced inflammatory responses in the cystic fibrosis IB3-1 cellular model system.
Int J Biol Macromol. 2017 Jun;99:492-498. doi: 10.1016/j.ijbiomac.2017.02.011
Breveglieri G, Bianchi N, Cosenza LC, Gamberini MR, Chiavilli F, Zuccato C, Montagner G, Borgatti M, Lampronti I, Finotti A, Gambari R.
An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production.
BMC Med Genet. 2017 Aug 29;18(1):93. doi: 10.1186/s12881-017-0450-3.
Milani R, Brognara E, Fabbri E, Finotti A, Borgatti M, Lampronti I, Marzaro G, Chilin A, Lee KK, Kok SH, Chui CH, Gambari R.
Corilagin Induces High Levels of Apoptosis in the Temozolomide-Resistant T98G Glioma Cell Line.
Oncol Res. 2017 May 4. doi: 10.3727/096504017X14928634401187.
Ground state naïve pluripotent stem cells and CRISPR/Cas9 gene correction for β-thalassemia.
Finotti A, Borgatti M, Gambari R.
Stem Cell Investig. 2016 Oct 25;3:66. eCollection 2016. doi: 10.21037/sci.2016.09.21
Cosenza LC, Breda L, Breveglieri G, Zuccato C, Finotti A, Lampronti I, Borgatti M, Chiavilli F, Gamberini MR, Satta S, Manunza L, De Martis FR, Moi P, Rivella S, Gambari R, Bianchi N.
A validated cellular biobank for β-thalassemia.
J Transl Med. 2016 Sep 2;14:255. doi: 10.1186/s12967-016-1016-4.
Bezzerri V, Vella A, Calcaterra E, Finotti A, Gasparello J, Gambari R, Assael BM, Cipolli M, Sorio C.
New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes.
Sci Rep. 2016 Sep 23;6:33165. doi: 10.1038/srep33165
Prandini P, De Logu F, Fusi C, Provezza L, Nassini R, Montagner G, Materazzi S, Munari S, Gilioli E, Bezzerri V, Finotti A, Lampronti I, Tamanini A, Dechecchi M, Lippi G, Ribeiro CM, Rimessi A, Pinton P, Gambari R, Geppetti P, Cabrini G.
TRPA1 Channels Modulate Inflammatory Response in Respiratory Cells from Cystic Fibrosis Patients.
Am J Respir Cell Mol Biol. 2016 Nov;55(5):645-656. doi: 10.1165/rcmb.2016-0089OC
Khalil S, Fabbri E, Santangelo A, Bezzerri V, Cantù C, Di Gennaro G, Finotti A, Ghimenton C, Eccher A, Dechecchi M, Scarpa A, Hirshman B, Chen C, Ferracin M, Negrini M, Gambari R, Cabrini G.
miRNA array screening reveals cooperative MGMT-regulation between miR-181d-5p and miR-409-3p in glioblastoma.
Oncotarget. 2016 May 10;7(19):28195-206. doi: 10.18632/oncotarget.8618.
Fabbri E, Montagner G, Bianchi N, Finotti A, Borgatti M, Lampronti I, Cabrini G, Gambari R.
MicroRNA miR-93-5p regulates expression of IL-8 and VEGF in neuroblastoma SK-N-AS cells.
Oncol Rep. 2016 May;35(5):2866-72. doi: 10.3892/or.2016.4676.
Finotti, Alessia; Borgatti, Monica; Bianchi, Nicoletta; Zuccato, Cristina; Lampronti, Ilaria; Gambari, Roberto.
Orphan Drugs and Potential Novel Approaches for Therapies of beta-Thalassemia: Current Status and Future Expectations.
Expert Opin Orphan Drugs. 2016;4(3):299-315. doi: 10.1517/21678707.2016.1135793
Bianchi N, Cosenza LC, Lampronti I, Finotti A, Breveglieri G, Zuccato C, Fabbri E, Marzaro G, Chilin A, De Angelis G, Borgatti M, Gallucci C, Alfieri C, Ribersani M, Isgrò A, Marziali M, Gaziev J, Morrone A, Sodani P, Lucarelli G, Gambari R, Paciaroni K.
Structural and Functional Insights on an Uncharacterized Aγ-Globin-Gene Polymorphism Present in Four β0-Thalassemia Families with High Fetal Hemoglobin Levels.
Mol Diagn Ther. 2016 Apr;20(2):161-73. doi: 10.1007/s40291-016-0187-2.
Breveglieri G, Bassi E, Carlassara S, Cosenza LC, Pellegatti P, Guerra G, Finotti A, Gambari R, Borgatti M.
Y-chromosome identification in circulating cell-free fetal DNA using surface plasmon resonance.
Prenat Diagn. 2016 Apr;36(4):353-61. doi: 10.1002/pd.4788
Altamura E, Borgatti M, Finotti A, Gasparello J, Gambari R, Spinelli M, Castaldo R, Altamura N.
Chemical-Induced Read-Through at Premature Termination Codons Determined by a Rapid Dual-Fluorescence System Based on S. cerevisiae.
PLoS One. 2016 Apr 27;11(4):e0154260. doi: 10.1371/journal.pone.0154260. eCollection 2016.
Brognara E, Fabbri E, Montagner G, Gasparello J, Manicardi A, Corradini R, Bianchi N, Finotti A, Breveglieri G, Borgatti M, Lampronti I, Milani R, Dechecchi MC, Cabrini G, Gambari R.
High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222.
Int J Oncol. 2016 Mar;48(3):1029-38. doi: 10.3892/ijo.2015.3308.
Fabbri E, Brognara E, Montagner G, Ghimenton C, Eccher A, Cantù C, Khalil S, Bezzerri V, Provezza L, Bianchi N, Finotti A, Borgatti M, Moretto G, Chilosi M, Cabrini G, Gambari R.
Regulation of IL-8 gene expression in gliomas by microRNA miR-93. (2015) Bmc Cancer, 15: 661. doi: 10.1186/s12885-015-1659-1
Breveglieri G, Finotti A, Borgatti M, Gambari R.
Recent patents and technology transfer for molecular diagnosis of β-thalassemia and other hemoglobinopathies.
(2015) Expert Opin Ther Pat, 25(12)1453-1476. doi: 10.1517/13543776.2015.1090427
Finotti A, Gasparello J, Breveglieri G, Cosenza LC, Montagner G, Bresciani A, Altamura S, Bianchi N, Martini E, Gallerani E, Borgatti M, Gambari R.
Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin.
(2015) Exp Hematol, 43(12):1062-1071. doi: 10.1016/j.exphem.2015.08.011.
Breveglieri G, Mancini I, Bianchi N, Lampronti I, Salvatori F, Fabbri E, Zuccato C, Cosenza LC, Montagner G, Borgatti M, Altruda F, Fagoonee S, Carandina G, Rubini M, Aiello V, Breda L, Rivella S, Gambari R, Finotti A. (Corresponding Author)
Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β –Globin Gene with the IVSI-6 Thalassemia Mutation.
(2015) Biomed Res Int, 2015:687635.
DOI: 10.1155/2015/687635.
Rokach, O., Sekulic-Jablanovic, M., Voermans, N., Wilmshurst, J., Pillay, K., Heytens, L., Zhou, H., Muntoni, F., Gautel, M., Nevo, Y., Mitrani-Rosenbaum, S., Attali, R., Finotti, A., Gambari, R., Mosca, B., Jungbluth, H., Zorzato, F., Treves, S.
Epigenetic changes as a common trigger of muscle weakness in congenital myopathies
(2015) Hum Mol Genet, 24(16):4636-47.
DOI: 10.1093/hmg/ddv195
Bianchi, N., Finotti, A., Ferracin, M., Lampronti, I., Zuccato, C., Breveglieri, G., Brognara, E., Fabbri, E., Borgatti, M., Negrini, M., Gambari, R.
Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells
(2015) PLoS One, 10(4), e0121567.
DOI: 10.1371/journal.pone.0121567
Finotti, A., Breda, L., Lederer, C.W., Bianchi, N., Zuccato, C., Kleanthous, M., Rivella, S., Gambari, R.
Recent trends in the gene therapy of β-thalassemia
(2015) J Blood Med, 6, pp. 69-85.
DOI: 10.2147/JBM.S46256
Finotti, A., Bianchi, N., Fabbri, E., Borgatti, M., Breveglieri, G., Gasparello, J., Gambari, R.
Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions
(2015) Pharmacological Research, 91, pp. 57-68.
DOI: 10.1016/j.phrs.2014.11.005
Giuffrida, M.C., Zanoli, L.M., D’Agata, R., Finotti, A., Gambari, R., Spoto, G.
Isothermal circular-strand-displacement polymerization of DNA and microRNA in digital microfluidic devices
(2015) Analytical and Bioanalytical Chemistry, 407 (6): 1533-1543.
DOI: 10.1007/s00216-014-8405-4
Montagner, G., Gemmo, C., Fabbri, E., Manicardi, A., Accardo, I., Bianchi, N., Finotti, A., Breveglieri, G., Salvatori, F., Borgatti, M., Lampronti, I., Bresciani, A., Altamura, S., Corradini, R., Gambari, R.
Peptide nucleic acids targeting β-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cells
(2015) International Journal of Molecular Medicine, 35 (1), pp. 51-58.
DOI: 10.3892/ijmm.2014.2005
Fabbri, E., Borgatti, M., Montagner, G., Bianchi, N., Finotti, A., Lampronti, I., Bezzerri, V., Dechecchi, M.C., Cabrini, G., Gambari, R.
Expression of microRNA-93 and interleukin-8 during Pseudomonas aeruginosa-mediated induction of proinflammatory responses
(2014) American Journal of Respiratory Cell and Molecular Biology, 50 (6), pp. 1144-1155.
DOI: 10.1165/rcmb.2013-0160OC
Brognara, E., Fabbri, E., Bazzoli, E., Montagner, G., Ghimenton, C., Eccher, A., Cantù, C., Manicardi, A., Bianchi, N., Finotti, A., Breveglieri, G., Borgatti, M., Corradini, R., Bezzerri, V., Cabrini, G., Gambari, R.
Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221
(2014) Journal of Neuro-Oncology, 118 (1), pp. 19-28.
DOI: 10.1007/s11060-014-1405-6
Breveglieri, G., Bianchi, N., Finotti, A., Gambari, R.
SPR-based identification of microRNAs
(2014) Minerva Biotecnologica, 26 (2), pp. 93-102.
Finotti, A., Gambari, R.
Recent trends for novel options in experimental biological therapy of β-thalassemia
(2014) Expert Opinion on Biological Therapy, 14 (10), pp. 1443-1454.
DOI: 10.1517/14712598.2014.927434
Brognara, E., Fabbri, E., Breveglieri, G., Finotti, A., Bianchi, N., Zuccato, C., Gambari, R.
Targeting the miR-221/miR-222 cluster in cancer therapy
(2014) Minerva Biotecnologica, 26 (2), pp. 67-74.
Altamura, N., Castaldo, R., Finotti, A., Breveglieri, G., Salvatori, F., Zuccato, C., Gambari, R., Panin, G.C., Borgatti, M.
Tobramycin is a suppressor of premature termination codons
(2013) Journal of Cystic Fibrosis, 12 (6), pp. 806-811.
DOI: 10.1016/j.jcf.2013.02.007
Saab, A.M., Dobmeier, M., Koenig, B., Fabri, E., Finotti, A., Borgatti, M., Lampronti, I., Bernardi, F., Efferth, T., Gambari, R.
Antiproliferative and erythroid differentiation of piperazine and triphenyl derivatives against K-562 human chronic myelogenous leukemia
(2013) Anticancer Research, 33 (8), pp. 3027-3032.
Marzaro, G., Guiotto, A., Borgatti, M., Finotti, A., Gambari, R., Breveglieri, G., Chilin, A.
Psoralen derivatives as inhibitors of NF-κB/DNA interaction: Synthesis, molecular modeling, 3D-QSAR, and biological evaluation
(2013) Journal of Medicinal Chemistry, 56 (5), pp. 1830-1842.
DOI: 10.1021/jm3009647
Brognara, E., Fabbri, E., Aimi, F., Manicardi, A., Bianchi, N., Finotti, A., Breveglieri, G., Borgatti, M., Corradini, R., Marchelli, R., Gambari, R.
Peptide nucleic acids targeting miR-221 modulate p27Kip1 expression in breast cancer MDA-MB-231 cells
(2012) International Journal of Oncology, 41 (6), pp. 2119-2127.
DOI: 10.3892/ijo.2012.1632
Saab, A.M., Lampronti, I., Borgatti, M., Finotti, A., Harb, F., Safi, S., Gambari, R.
Invitro evaluation of the anti-proliferative activities of the wood essential oils of three Cedrus species against K562 human chronic myelogenous leukaemia cells
(2012) Natural Product Research, 26 (23), pp. 2227-2231.
DOI: 10.1080/14786419.2011.643885
Saab, A.M., Lampronti, I., Finotti, A., Borgatti, M., Gambari, R., Esseily, F., Safi, S., Diab-Assaf, M., Rabenau, H., Cinatl, J., Doerr, H.W.
In vitro evaluation of the biological activity of Lebanese medicinal plants extracts against herpes simplex virus type 1
(2012) Minerva Biotecnologica, 24 (3), pp. 117-121.
Fibach, E., Prus, E., Bianchi, N., Zuccato, C., Breveglieri, G., Salvatori, F., Finotti, A., Di Paola, M.L., Brognara, E., Lampronti, I., Borgatti, M., Gambari, R.
Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients
(2012) International Journal of Molecular Medicine, 29 (6), pp. 974-982.
DOI: 10.3892/ijmm.2012.928
Finotti, A., Borgatti, M., Bezzerri, V., Nicolis, E., Lampronti, I., Dechecchi, M.C., Mancini, I., Cabrini, G., Saviano, M., Avitabile, C., Romanelli, A., Gambari, R.
Effects of decoy molecules targeting NFkappaB transcription factors in Cystic fibrosis IB3-1 cells: Recruitment of NFkappaB to the IL-8 gene promoter and transcription of the IL-8 gene
(2012) Artificial DNA: PNA and XNA, 3 (2), pp. 1-8.
Bianchi, N., Zuccato, C., Finotti, A., Lampronti, I., Borgatti, M., Gambari, R.
Involvement of miRNA in erythroid differentiation
(2012) Epigenomics, 4 (1), pp. 51-65.
DOI: 10.2217/epi.11.104
Fabbri, E., Manicardi, A., Tedeschi, T., Sforza, S., Bianchi, N., Brognara, E., Finotti, A., Breveglieri, G., Borgatti, M., Corradini, R., Marchelli, R., Gambari, R.
Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs)
(2011) ChemMedChem, 6 (12), pp. 2192-2202.
DOI: 10.1002/cmdc.201100270
Bezzerri, V., Borgatti, M., Finotti, A., Tamanini, A., Gambari, R., Cabrini, G.
Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells
(2011) Journal of Immunology, 187 (11), pp. 6069-6081.
DOI: 10.4049/jimmunol.1100821
Fabbri, E., Brognara, E., Borgatti, M., Lampronti, I., Finotti, A., Bianchi, N., Sforza, S., Tedeschi, T., Manicardi, A., Marchelli, R., Corradini, R., Gambari, R.
miRNA therapeutics: Delivery and biological activity of peptide nucleic acids targeting miRNAs
(2011) Epigenomics, 3 (6), pp. 733-745.
DOI: 10.2217/epi.11.90
Gambari, R., Fabbri, E., Borgatti, M., Lampronti, I., Finotti, A., Brognara, E., Bianchi, N., Manicardi, A., Marchelli, R., Corradini, R.
Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development
(2011) Biochemical Pharmacology, 82 (10), pp. 1416-1429.
DOI: 10.1016/j.bcp.2011.08.007
Tamanini, A., Borgatti, M., Finotti, A., Piccagli, L., Bezzerri, V., Favia, M., Guerra, L., Lampronti, I., Bianchi, N., Dall'Acqua, F., Vedaldi, D., Salvador, A., Fabbri, E., Mancini, I., Nicolis, E., Casavola, V., Cabrini, G., Gambari, R.
Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function
(2011) American Journal of Physiology - Lung Cellular and Molecular Physiology, 300 (3), pp. L380-L390.
DOI: 10.1152/ajplung.00129.2010
Salvatori, F., Breveglieri, G., Zuccato, C., Finotti, A., Bianchi, N., Borgatti, M., Feriotto, G., Destro, F., Canella, A., Brognara, E., Lampronti, I., Breda, L., Rivella, S., Gambari, R.
Production of β-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous β039 thalassemia patients
(2009) American Journal of Hematology, 84 (11), pp. 720-728.
DOI: 10.1002/ajh.21539
Salvatori, F., Cantale, V., Breveglieri, G., Zuccato, C., Finotti, A., Bianchi, N., Borgatti, M., Feriotto, G., Destro, F., Canella, A., Breda, L., Rivella, S., Gambari, R.
Development of K562 cell clones expressing β-globin mRNA carrying the β039 thalassaemia mutation for the screening of correctors of stop-codon mutations
(2009) Biotechnology and Applied Biochemistry, 54 (1), pp. 41-52.
DOI: 10.1042/BA20080266
Lampronti, I., Bianchi, N., Zuccato, C., Dall'Acqua, F., Vedaldi, D., Viola, G., Potenza, R., Chiavilli, F., Breveglieri, G., Borgatti, M., Finotti, A., Feriotto, G., Salvatori, F., Gambari, R.
Increase in γ-globin mRNA content in human erythroid cells treated with angelicin analogs
(2009) International Journal of Hematology, 90 (3), pp. 318-327.
DOI: 10.1007/s12185-009-0422-2
Borgatti, M., Finotti, A., Falzarano, S., Selvatici, R.
Structural characterization of promoter sequences of the gene coding human PKI55 protein, a protein kinase C inhibitor
(2009) Biochimie, 91 (4), pp. 466-474.
DOI: 10.1016/j.biochi.2008.11.007
Finotti, A., Treves, S., Zorzato, F., Gambari, R., Feriotto, G.
Upstream stimulatory factors are involved in the P1 promoter directed transcription of the AbetaH-J-J locus
(2008) BMC Molecular Biology, 9, art. no. 110.
DOI: 10.1186/1471-2199-9-110
Finotti, A., Breveglieri, G., Gkritzapi, S., Gambari, R., Feriotto, G.
Gene silencing in the study of transcriptional regulation: The AβH-J-J locus
(2008) Minerva Biotecnologica, 20 (2), pp. 85-88.
Feriotto, G., Salvatori, F., Finotti, A., Breveglieri, G., Venturi, M., Zuccato, C., Bianchi, N., Borgatti, M., Lampronti, I., Mancini, I., Massei, F., Favre, C., Gambari, R.
A novel frameshift mutation (+A) at codon 18 of the β-globin gene associated with high persistence of fetal hemoglobin phenotype and δβ-thalassemia
(2008) Acta Haematologica, 119 (1), pp. 28-37.
DOI: 10.1159/000114204
Breveglieri, G., Salvatori, F., Finotti, A., Bertuzzi, I., Destro, F., Falzoni, S., Bianchi, N., Borgatti, M., Zuccato, C., Feriotto, G., Breda, L., Rivella, S., Gambari, R.
Cellular biosensors for the identification of fetal hemoglobin inducers
(2007) Minerva Biotecnologica, 19 (4), pp. 123-132.
Feriotto, G., Finotti, A., Breveglieri, G., Treves, S., Zorzato, F., Gambari, R.
Transcriptional activity and Sp 1/3 transcription factor binding to the P1 promoter sequences of the human AβH-J-J locus
(2007) FEBS Journal, 274 (17), pp. 4476-4490.
DOI: 10.1111/j.1742-4658.2007.05976.x
Feriotto, G., Finotti, A., Breveglieri, G., Treves, S., Zorzato, F., Gambari, R.
Multiple levels of control of the expression of the human AβH-J-J locus encoding aspartyl-β-hydroxylase, junctin, and junctate
(2006) Annals of the New York Academy of Sciences, 1091, pp. 184-190.
DOI: 10.1196/annals.1378.065
Fibach, E., Bianchi, N., Borgatti, M., Zuccato, C., Finotti, A., Lampronti, I., Prus, E., Mischiati, C., Gambari, R.
Effects of rapamycin on accumulation of α-, β- and γ-globin mRNAs in erythroid precursor cells from β-thalassaemia patients
(2006) European Journal of Haematology, 77 (5), pp. 437-441.
DOI: 10.1111/j.1600-0609.2006.00731.x
Feriotto, G., Finotti, A., Volpe, P., Treves, S., Ferrari, S., Angelelli, C., Zorzato, F., Gambari, R.
Myocyte enhancer factor 2 activates promoter sequences of the human AβH-J-J locus, encoding aspartyl-β-hydroxylase, junctin, and junctate
(2005) Molecular and Cellular Biology, 25 (8), pp. 3261-3275.
DOI: 10.1128/MCB.25.8.3261-3275.2005
Borgatti, M., Finotti, A., Romanelli, A., Saviano, M., Bianchi, N., Lampronti, I., Lambertini, E., Penolazzi, L., Nastruzzi, C., Mischiati, C., Piva, R., Pedone, C., Gambari, R.
Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression
(2004) Current Drug Targets, 5 (8), pp. 735-744.
DOI: 10.2174/1389450043345155
Mischiati, C., Sereni, A., Finotti, A., Breda, L., Cortesi, R., Nastruzzi, C., Romanelli, A., Saviano, M., Bianchi, N., Pedone, C., Borgatti, M., Gambari, R.
Complexation to cationic microspheres of double-stranded peptide nucleic acid-DNA chimeras exhibiting decoy activity
(2004) Journal of Biomedical Science, 11 (5), pp. 697-704.
DOI: 10.1159/000079683
Gardenghi, S., Finotti, A., Gambari, R., Feriotto, G.
Real-time detection of genetically modified maize Bt-176 genomic sequences by surface plasmon resonance-based biospecific interaction analysis
(2004) Minerva Biotecnologica, 16 (3), pp. 203-210.
Penolazzi, L., Borgatti, M., Lambertini, E., Mischiati, C., Finotti, A., Romanelli, A., Saviano, M., Pedone, C., Piva, R., Gambari, R.
Peptide nucleic acid-DNA decoy chimeras targeting NF-kappaB transcription factors: Induction of apoptosis in human primary osteoclasts.
(2004) International journal of molecular medicine, 14 (2), pp. 145-152.
Feriotto, G., Breveglieri, G., Finotti, A., Gardenghi, S., Gambari, R.
Real-time multiplex analysis of four beta-thalassemia mutations employing surface plasmon resonance and biosensor technology
(2004) Laboratory Investigation, 84 (6), pp. 796-803.
DOI: 10.1038/labinvest.3700106
Mischiati, C., Finotti, A., Sereni, A., Boschetti, S., Baraldi, P.G., Romagnoli, R., Feriotto, G., Jeang, K.-T., Bianchi, N., Borgatti, M., Gambari, R.
Binding of hybrid molecules containing pyrrolo [2,1-c][1,4]benzodiazepine (PBD) and oligopyrrole carriers to the human immunodeficiency type 1 virus TAR-RNA
(2004) Biochemical Pharmacology, 67 (3), pp. 401-410.
DOI: 10.1016/j.bcp.2003.09.009
Tomasetti, M., Feriotto, G., Giacomini, P., Giorda, E., Bianchi, N., Borgatti, M., Finotti, A., Mischiati, C., Gambar,i R. Identification of a novel DNase I hypersensitive site within the far upstream region of the human HLA-DRA gene.
(2003) International Journal of Molecular Medicine, 12, pp. 929-934.
