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Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions
Papa, Alessandro; Pasquini, Silvia; Galvani, Francesca; Cammarota, Mariarosaria; Contri, Chiara; Carullo, Gabriele; Gemma, Sandra; Ramunno, Anna; Lamponi, Stefania; Gorelli, Beatrice; Saponara, Simona; Varani, Katia; Mor, Marco; Campiani, Giuseppe; Boscia, Francesca; Vincenzi, Fabrizio; Lodola, Alessio; Butini, Stefania
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Vol. 246, No. 1, pp: 1-22, Anno: 2023 |
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In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice
Tirri, Micaela; Arfè, Raffaella; Bilel, Sabrine; Corli, Giorgia; Marchetti, Beatrice; Fantinati, Anna; Vincenzi, Fabrizio; De-Giorgio, Fabio; Camuto, Cristian; Mazzarino, Monica; Barbieri, Mario; Gaudio, Rosa Maria; Varani, Katia; Borea, Pier Andrea; Botrè, Francesco; Marti, Matteo
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Vol. 23, No. 14, pp: 8030-8059, Anno: 2022 |
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2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors
Mari, Michele; Elisi, Gian Marco; Bedini, Annalida; Lucarini, Simone; Retini, Michele; Lucini, Valeria; Scaglione, Francesco; Vincenzi, Fabrizio; Varani, Katia; Castelli, Riccardo; Mor, Marco; Rivara, Silvia; Spadoni, Gilberto
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Vol. 243, No. 1, pp: 1-15, Anno: 2022 |
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Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition
Papa, A.; Pasquini, S.; Contri, C.; Gemma, S.; Campiani, G.; Butini, S.; Varani, K.; Vincenzi, F.
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CELLS
Vol. 11, No. 3, pp: 1-38, Anno: 2022 |
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Adenosine Receptors in Neuropsychiatric Disorders: Fine Regulators of Neurotransmission and Potential Therapeutic Targets
Pasquini, S.; Contri, C.; Merighi, S.; Gessi, S.; Borea, P. A.; Varani, K.; Vincenzi, F.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Vol. 23, No. 3, pp: 1-18, Anno: 2022 |
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A2A Adenosine Receptor: A Possible Therapeutic Target for Alzheimer's Disease by Regulating NLRP3 Inflammasome Activity?
Merighi, Stefania; Nigro, Manuela; Travagli, Alessia; Pasquini, Silvia; Borea, Pier Andrea; Varani, Katia; Vincenzi, Fabrizio; Gessi, Stefania
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Vol. 23, No. 9, pp: 5056-5067, Anno: 2022 |
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Pathophysiological Role and Medicinal Chemistry of A2A Adenosine Receptor Antagonists in Alzheimer's Disease
Merighi, Stefania; Borea, Pier Andrea; Varani, Katia; Vincenzi, Fabrizio; Travagli, Alessia; Nigro, Manuela; Pasquini, Silvia; Suresh, R Rama; Kim, Sung Won; Volkow, Nora D; Jacobson, Kenneth A; Gessi, Stefania
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MOLECULES
Vol. 27, No. 9, pp: 2680-2694, Anno: 2022 |
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A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases
Merighi, Stefania; Borea, Pier Andrea; Varani, Katia; Vincenzi, Fabrizio; Jacobson, Kenneth A; Gessi, Stefania
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CURRENT MEDICINAL CHEMISTRY
Vol. 29, No. 24, pp: 4138-4151, Anno: 2022 |
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Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability
Federico, S.; Khan, T.; Fontana, A.; Brogi, S.; Benedetti, R.; Sarno, F.; Carullo, G.; Pezzotta, A.; Saraswati, A. P.; Passaro, E.; Pozzetti, L.; Papa, A.; Relitti, N.; Gemma, S.; Butini, S.; Pistocchi, A.; Ramunno, A.; Vincenzi, F.; Varani, K.; Tatangelo, V.; Patrussi, L.; Baldari, C. T.; Saponara, S.; Gorelli, B.; Lamponi, S.; Valoti, M.; Saccoccia, F.; Giannaccari, M.; Ruberti, G.; Herp, D.; Jung, M.; Altucci, L.; Campiani, G.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Vol. 238, No. 1, pp: 1-20, Anno: 2022 |
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4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives
Catarzi, D.; Varano, F.; Vigiani, E.; Calenda, S.; Melani, F.; Varani, K.; Vincenzi, F.; Pasquini, S.; Mennini, N.; Nerli, G.; Dal Ben, D.; Volpini, R.; Colotta, V.
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PHARMACEUTICALS
Vol. 15, No. 4, pp: 1-29, Anno: 2022 |
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Update on the recent development of allosteric modulators for adenosine receptors and their therapeutic applications
Pasquini, Silvia; Contri, Chiara; Cappello, Martina; Borea, Pier Andrea; Varani, Katia; Vincenzi, Fabrizio
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FRONTIERS IN PHARMACOLOGY
Vol. 13, No. 1, pp: 1-11, Anno: 2022 |
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Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice
Domenicale, Chiara; Mercatelli, Daniela; Albanese, Federica; Novello, Salvatore; Vincenzi, Fabrizio; Varani, Katia; Morari, Michele
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BIOMEDICINES
Vol. 10, No. 4, pp: 881-1-881-16, Anno: 2022 |
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Synthesis of Unsymmetrical Squaramides as Allosteric GSK-3β Inhibitors Promoting β-Catenin-Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells
Carullo, G.; Bottoni, L.; Pasquini, S.; Papa, A.; Contri, C.; Brogi, S.; Calderone, V.; Orlandini, M.; Gemma, S.; Varani, K.; Butini, S.; Galvagni, F.; Vincenzi, F.; Campiani, G.
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CHEMMEDCHEM
Vol. 17, No. 24, pp: 1-11, Anno: 2022 |
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Behavioral and binding studies on the quinolinyl ester indoles 5F-PB22 (5F-QUPIC) and BB-22 (QUCHIC) in the mouse model
Corli, Giorgia; Tirri, Micaela; Arfè, Raffaella; Bilel, Sabrine; Marchetti, Beatrice; Gregori, Adolfo; Di Rosa, Fabiana; Vincenzi, Fabrizio; De-Giorgio, Fabio; Borea, Pier Andrea; Varani, Katia; Marti, Matteo
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EMERGING TRENDS IN DRUGS, ADDICTIONS, AND HEALTH
Vol. 2, No. 1, pp: 100039-100059, Anno: 2022 |
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Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia
Capone, F.; Salati, S.; Vincenzi, F.; Liberti, M.; Aicardi, G.; Apollonio, F.; Varani, K.; Cadossi, R.; Di Lazzaro, V.
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NEUROMODULATION
Vol. -, No. 1, pp: 1-8, Anno: 2021 |
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Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice
Ferrante, A.; Boussadia, Z.; Borreca, A.; Mallozzi, C.; Pedini, G.; Pacini, L.; Pezzola, A.; Armida, M.; Vincenzi, F.; Varani, K.; Bagni, C.; Popoli, P.; Martire, A.
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TRANSLATIONAL PSYCHIATRY
Vol. 11, No. 1, pp: 1-13, Anno: 2021 |
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An Open Question: Is the A2A Adenosine Receptor a Novel Target for Alzheimer's Disease Treatment?
Merighi, Stefania; Poloni, Tino Emanuele; Pelloni, Lucia; Pasquini, Silvia; Varani, Katia; Vincenzi, Fabrizio; Borea, Pier Andrea; Gessi, Stefania
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FRONTIERS IN PHARMACOLOGY
Vol. 12, No. 1, pp: 652455--, Anno: 2021 |
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Adenosine and inflammation: Here, there and everywhere
Pasquini, S.; Contri, C.; Borea, P. A.; Vincenzi, F.; Varani, K.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Vol. 22, No. 14, pp: 7685-1-7685-24, Anno: 2021 |
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L-DOPA promotes striatal dopamine release through D1 receptors and reversal of dopamine transporter
Viaro, R.; Longo, F.; Vincenzi, F.; Varani, K.; Morari, M.
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BRAIN RESEARCH
Vol. 1768, No. 1, pp: 147583--, Anno: 2021 |
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Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications
Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; Blo, Irene; Salati, Simona; Cadossi, Matteo; De Mattei, Monica
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Vol. 22, No. 2, pp: 809-1-809-17, Anno: 2021 |
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