1   2   3   4   5   6  
Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: a preliminary receptor-driven SAR profile
G. Pastorin; S. Federico; F. Cateni; B. Cacciari; K.N. Klotz; Z.G. Gao; K. A. Jacobson; M. Corradino; S. Paoletta; S. Moro; G. Spalluto     dettagli >>
PURINERGIC SIGNALLING
Vol. 6, No. 1, pp: 80-80, Anno: 2010

A novel class of pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as A3 adenosine receptor antagonists
S. Federico; G. Spalluto; K.N. Klotz; B. Cacciari; S. Moro; E. Morizzo     dettagli >>
PURINERGIC SIGNALLING
Vol. 6, No. 1, pp: 79-80, Anno: 2010

Combining selectivity and affinity predictions using an integrated support vector machine (SVM) approach: a novel tool to discriminate between the human adenosine A2A and A3 receptor pyrazolo-triazolo-pyrimidine antagonists binding sites
L. Michielan; C. Bolcato; S. Federico; B. Cacciari; M. Bacilieri; K.N. Klotz; S. Kachler; G. Pastorin; A. Sperduti; G. Spalluto; S. Moro     dettagli >>
PURINERGIC SIGNALLING
Vol. 6, No. 1, pp: 81-81, Anno: 2010

Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors
Cacciari, Barbara; Crepaldi, Pamela; Cheng, Chun Yan; Bossi, Elena; Spalluto, Giampiero; Federico, Stephanie; Jacobson, Kenneth A; Cattaneo, Marco     dettagli >>
MEDICINAL CHEMISTRY
Vol. 15, No. 1, pp: 1-10, Anno: 2019

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach
Preti, Delia; Romagnoli, Romeo; Rondanin, Riccardo; Cacciari, Barbara; Hamel, Ernest; Balzarini, Jan; Liekens, Sandra; Schols, Dominique; Estévez-Sarmiento, Francisco; Quintana, José; Estévez, Francisco     dettagli >>
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Vol. 33, No. 1, pp: 1225-1238, Anno: 2018

Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists
Redenti, Sara; Ciancetta, Antonella; Pastorin, Giorgia; Cacciari, Barbara; Moro, Stefano; Spalluto, Giampiero; Federico, Stephanie     dettagli >>
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Vol. 16, No. 27, pp: 3224-3257, Anno: 2016

5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors
Federico, Stephanie; Ciancetta, Antonella; Porta, Nicola; Redenti, Sara; Pastorin, Giorgia; Cacciari, Barbara; Klotz, Karl Norbert; Moro, Stefano; Spalluto, Giampiero     dettagli >>
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Vol. 108, No. 1, pp: 529-541, Anno: 2016

The influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl moiety on the adenosine receptors affinity profile of pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c] pyrimidine derivatives
Federico, Stephanie; Redenti, Sara; Sturlese, Mattia; Ciancetta, Antonella; Kachler, Sonja; Klotz, Karl-Norbert; Cacciari, Barbara; Moro, Stefano; Spalluto, Giampiero     dettagli >>
PLOS ONE
Vol. 10, No. 12, pp: e0143504-1-e0143504/15, Anno: 2015

Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study
Federico, Stephanie; Ciancetta, Antonella; Porta, Nicola; Redenti, Sara; Pastorin, Giorgia; Cacciari, Barbara; Klotz, Karl Norbert; Moro, Stefano; Spalluto, Giampiero     dettagli >>
JOURNAL OF MEDICINAL CHEMISTRY
Vol. 57, No. 14, pp: 6210-6225, Anno: 2014

8-(2-Furyl)adenine derivatives as A₂A adenosine receptor ligands
Dal Ben D; Buccioni M; Lambertucci C; Thomas A; Klotz KN; Federico S; Cacciari B; Spalluto G; Volpini R     dettagli >>
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Vol. 70, No. 1, pp: 525-535, Anno: 2013

Revisiting a receptor-based pharmacophore hypothesis for human A(2A) adenosine receptor antagonists
Bacilieri M; Ciancetta A; Paoletta S; Federico S; Cosconati S; Cacciari B; Taliani S; Da Settimo F; Novellino E; Klotz KN; Spalluto G; Moro S.     dettagli >>
JOURNAL OF CHEMICAL INFORMATION AND MODELING
Vol. 53, No. 7, pp: 1620-1637, Anno: 2013

A Novel Conjugated Agent between Dopamine and an A(2A) Adenosine Receptor Antagonist as a Potential Anti-Parkinson Multitarget Approach.
Dalpiaz A.; Cacciari B.; Vicentini C.B.; Bortolotti F.; Spalluto G.; Federico S.; Pavan B;. Vincenzi F.; Borea P.A.; Varani K.     dettagli >>
MOLECULAR PHARMACEUTICS
Vol. 9, No. 3, pp: 591-604, Anno: 2012

Exploring the Directionality of 5-Substitutions in a New Series of 5-Alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a Strategy To Design Novel Human A3 Adenosine Receptor Antagonists
Federico, Stephanie; Ciancetta, Antonella; Sabbadin, Davide; Paoletta, Silvia; Pastorin, Giorgia; Cacciari, Barbara; Klotz Karl, Norbert; Moro, Stefano; Spalluto, Giampiero     dettagli >>
JOURNAL OF MEDICINAL CHEMISTRY
Vol. 55, No. 22, pp: 9654-9668, Anno: 2012

New 9-methyl-8-(4-hydroxyphenyl)adenine derivatives as A1 adenosine receptor antagonists
C. Lambertucci; M. Buccioni; B. Cacciari; D. Dal Ben; S. Federico; K.N. Klotz;G. Marucci; R. Volpini; G. Spalluto; G. Cristalli     dettagli >>
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
Vol. 76, No. 1, pp: 1379-1393, Anno: 2011

Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A2A Adenosine Receptor Antagonists with Improved Water Solubility
S. Federico; S. Paoletta; S.L. Cheong; G. Pastorin; B. Cacciari; S. Stragliotto; 
K.N. Klotz; J. Siegel; Z.-G. Gao; K. A. Jacobson; S. Moro; G. Spalluto     dettagli >>
JOURNAL OF MEDICINAL CHEMISTRY
Vol. 54, No. 3, pp: 877-889, Anno: 2011

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process
Pastorin G.; Federico S.; Paoletta S.; Corradino M.; Cateni F.; Cacciari B.; Klotz K.N.; Gao Z.G.; Jacobson K. A.; Spalluto G.; Moro S.     dettagli >>
BIOORGANIC & MEDICINAL CHEMISTRY
Vol. 18, No. 7, pp: 2524-2536, Anno: 2010

The Significance of 2-Furyl Ring Substitution with a 2-(para-substituted) Aryl Group in a New Series of Pyrazolo-triazolo-pyrimidines as Potent and Highly Selective hA3 Adenosine Receptors Antagonists: New Insights into Structure-Affinity Relationship and Receptor-Antagonist Recognition
Cheong S. L.; Dolzhenko A.; Kachler S.; Paoletta S.; Federico S.; Cacciari B.; Dolzhenko A.; Klotz K.N.; Moro S.; Spalluto G. Pastorin G.     dettagli >>
JOURNAL OF MEDICINAL CHEMISTRY
Vol. 53, No. 8, pp: 3361-3375, Anno: 2010

Solid Lipid Microparticles for the Stability Enhancement of a Dopamine Prodrug.
Dalpiaz, Alessandro; Cacciari, Barbara; Mezzena, Matteo; Strada, Mariangela; Scalia, Santo     dettagli >>
JOURNAL OF PHARMACEUTICAL SCIENCES
Vol. 99, No. 11, pp: 4730-4737, Anno: 2010

Exploring Potency and Selectivity Receptor Antagonist Profiles Using a Multilabel Classification Approach: The Human Adenosine Receptors as a Key Study
Michielan, L.; Federico S.; Terfloth, L.; Hristozov, D.; Cacciari, B.; Klotz, K.N.; Spalluto, G.; Gasteiger, J.; Moro, S.     dettagli >>
JOURNAL OF CHEMICAL INFORMATION AND MODELING
Vol. 49, No. 1, pp: 2820-2836, Anno: 2009

6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors.
CREPALDI P.; CACCIARI B.; BONACHE M.C.; SPALLUTO G.; VARANI K.; BOREA P.A.; KÜGELGEN I.; HOFFMANN K.; PUGLIANO M.; RAZZARI C.; CATTANEO M.     dettagli >>
BIOORGANIC & MEDICINAL CHEMISTRY
Vol. 17, No. 13, pp: 4612-4621, Anno: 2009

1   2   3   4   5   6